Details for: EZH2

Gene ID: 2146

Symbol: EZH2

Ensembl ID: ENSG00000106462

Description: enhancer of zeste 2 polycomb repressive complex 2 subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.2742
    Cell Significance Index: -16.8100
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.8037
    Cell Significance Index: -8.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.7447
    Cell Significance Index: -22.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.3131
    Cell Significance Index: -17.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.1410
    Cell Significance Index: -17.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3209
    Cell Significance Index: -18.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4957
    Cell Significance Index: -20.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0303
    Cell Significance Index: -19.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.1540
    Cell Significance Index: 233.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1316
    Cell Significance Index: -12.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6273
    Cell Significance Index: -5.7500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.4577
    Cell Significance Index: 13.9700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.6733
    Cell Significance Index: 16.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5996
    Cell Significance Index: 17.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5959
    Cell Significance Index: 44.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4256
    Cell Significance Index: 19.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4193
    Cell Significance Index: 281.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.2373
    Cell Significance Index: 31.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1582
    Cell Significance Index: 30.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1273
    Cell Significance Index: 69.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1102
    Cell Significance Index: 130.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0720
    Cell Significance Index: 174.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9876
    Cell Significance Index: 28.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9011
    Cell Significance Index: 813.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8667
    Cell Significance Index: 101.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8614
    Cell Significance Index: 23.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8590
    Cell Significance Index: 17.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7543
    Cell Significance Index: 26.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7326
    Cell Significance Index: 47.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7114
    Cell Significance Index: 32.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5225
    Cell Significance Index: 12.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4069
    Cell Significance Index: 28.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2659
    Cell Significance Index: 53.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2504
    Cell Significance Index: 15.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2317
    Cell Significance Index: 7.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2270
    Cell Significance Index: 100.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2180
    Cell Significance Index: 7.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2162
    Cell Significance Index: 118.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2116
    Cell Significance Index: 11.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2113
    Cell Significance Index: 38.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1709
    Cell Significance Index: 4.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1580
    Cell Significance Index: 19.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1171
    Cell Significance Index: 2.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1149
    Cell Significance Index: 1.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1140
    Cell Significance Index: 21.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0639
    Cell Significance Index: 1.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0618
    Cell Significance Index: 22.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0578
    Cell Significance Index: 7.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0530
    Cell Significance Index: 5.2400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0451
    Cell Significance Index: 0.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0187
    Cell Significance Index: 0.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0160
    Cell Significance Index: 24.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0079
    Cell Significance Index: 14.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0052
    Cell Significance Index: 3.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0139
    Cell Significance Index: -0.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0144
    Cell Significance Index: -1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0227
    Cell Significance Index: -10.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0232
    Cell Significance Index: -17.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0240
    Cell Significance Index: -17.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0295
    Cell Significance Index: -3.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0357
    Cell Significance Index: -20.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0363
    Cell Significance Index: -22.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0373
    Cell Significance Index: -6.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0403
    Cell Significance Index: -0.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0416
    Cell Significance Index: -1.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0516
    Cell Significance Index: -1.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0579
    Cell Significance Index: -8.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0580
    Cell Significance Index: -16.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0607
    Cell Significance Index: -6.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0642
    Cell Significance Index: -8.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0659
    Cell Significance Index: -1.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0791
    Cell Significance Index: -4.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0848
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1078
    Cell Significance Index: -22.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1234
    Cell Significance Index: -14.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1252
    Cell Significance Index: -9.6100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1322
    Cell Significance Index: -0.8300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1693
    Cell Significance Index: -2.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1756
    Cell Significance Index: -11.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1794
    Cell Significance Index: -13.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1809
    Cell Significance Index: -18.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1810
    Cell Significance Index: -8.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2318
    Cell Significance Index: -18.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2373
    Cell Significance Index: -14.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2481
    Cell Significance Index: -10.9800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2520
    Cell Significance Index: -3.5400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2582
    Cell Significance Index: -1.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2657
    Cell Significance Index: -10.0600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2739
    Cell Significance Index: -2.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3051
    Cell Significance Index: -6.6100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3061
    Cell Significance Index: -0.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3112
    Cell Significance Index: -4.8200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.3275
    Cell Significance Index: -3.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3365
    Cell Significance Index: -9.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3608
    Cell Significance Index: -7.4900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3755
    Cell Significance Index: -2.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EZH2 is a member of the Polycomb group (PcG) family of proteins, which are involved in the regulation of gene expression through the modification of chromatin structure. It is a catalytic subunit of PRC2, which is composed of EZH2, EED, and Suz12 proteins. EZH2 is a histone methyltransferase that specifically targets histone H3 lysine 27 (H3K27) for trimethylation, leading to the formation of a repressive chromatin structure. This epigenetic modification is associated with the silencing of target genes and is essential for the maintenance of cellular identity and the regulation of cell fate decisions. **Pathways and Functions** EZH2 is involved in a wide range of cellular processes, including: 1. **Development and differentiation**: EZH2 plays a crucial role in the regulation of gene expression during development and differentiation, particularly in the context of neural and muscle development. 2. **Cell cycle regulation**: EZH2 is involved in the regulation of the cell cycle, particularly in the G1/S transition, and is associated with the promotion of cell proliferation. 3. **Epigenetic regulation of gene expression**: EZH2 is a key component of the PRC2 complex, which is responsible for the trimethylation of histone H3 lysine 27 (H3K27me3), leading to the silencing of target genes. 4. **Stem cell maintenance**: EZH2 is involved in the maintenance of stem cells, particularly in the context of neural and muscle stem cells. 5. **Cancer and tumorigenesis**: EZH2 has been implicated in the development and progression of various cancers, including leukemia, lymphoma, and breast cancer. **Clinical Significance** EZH2 dysregulation has been implicated in several diseases, including: 1. **Cancer**: EZH2 overexpression has been associated with the development and progression of various cancers, including leukemia, lymphoma, and breast cancer. 2. **Neurological disorders**: EZH2 has been implicated in the pathogenesis of neurological disorders, including Parkinson's disease, Alzheimer's disease, and schizophrenia. 3. **Cardiovascular diseases**: EZH2 has been associated with the development of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 4. **Immune system disorders**: EZH2 has been implicated in the regulation of immune responses and has been associated with the development of autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. In conclusion, EZH2 is a critical regulator of epigenetic gene expression and plays a key role in various cellular processes, including development, differentiation, and cell cycle regulation. Its dysregulation has been implicated in several diseases, highlighting the importance of EZH2 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3917042194

Symbol: EZH2_HUMAN

Name: ENX-1

UniProtKB Accession Codes:

Q15910 B2RAQ1 B3KS30 B7Z1D6 B7Z7L6 Q15755 Q75MG3 Q92857 Q96FI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 14 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 12 EMDB 4 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 72 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 28 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 8 RefSeq 6 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8954776

Title: Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2.

PubMed ID: 8954776

DOI: 10.1006/geno.1996.0588

PubMed ID: 9214638

Title: Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.

PubMed ID: 9214638

DOI: 10.1093/emboj/16.11.3219

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8649418

Title: Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.

PubMed ID: 8649418

DOI: 10.1128/mcb.16.6.3066

PubMed ID: 9499421

Title: Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.

PubMed ID: 9499421

DOI: 10.1093/hmg/7.4.679

PubMed ID: 9584199

Title: Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.

PubMed ID: 9584199

DOI: 10.1128/mcb.18.6.3586

PubMed ID: 10581039

Title: Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation.

PubMed ID: 10581039

DOI: 10.1038/70602

PubMed ID: 11158321

Title: The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos.

PubMed ID: 11158321

DOI: 10.1128/mcb.21.4.1360-1369.2001

PubMed ID: 12435631

Title: Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

PubMed ID: 12435631

DOI: 10.1101/gad.1035902

PubMed ID: 12101246

Title: Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.

PubMed ID: 12101246

DOI: 10.1128/mcb.22.15.5539-5553.2002

PubMed ID: 12351676

Title: Role of histone H3 lysine 27 methylation in Polycomb-group silencing.

PubMed ID: 12351676

DOI: 10.1126/science.1076997

PubMed ID: 14532106

Title: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.

PubMed ID: 14532106

DOI: 10.1093/emboj/cdg542

PubMed ID: 15385962

Title: Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.

PubMed ID: 15385962

DOI: 10.1038/sj.emboj.7600402

PubMed ID: 15231737

Title: Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

PubMed ID: 15231737

DOI: 10.1101/gad.1200204

PubMed ID: 15099518

Title: Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.

PubMed ID: 15099518

DOI: 10.1016/s1097-2765(04)00185-6

PubMed ID: 15225548

Title: SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

PubMed ID: 15225548

DOI: 10.1016/j.molcel.2004.06.020

PubMed ID: 15208672

Title: Activated p53 suppresses the histone methyltransferase EZH2 gene.

PubMed ID: 15208672

DOI: 10.1038/sj.onc.1207706

PubMed ID: 16179254

Title: The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.

PubMed ID: 16179254

DOI: 10.1016/j.cell.2005.07.003

PubMed ID: 15684044

Title: Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.

PubMed ID: 15684044

DOI: 10.1073/pnas.0409875102

PubMed ID: 16224021

Title: Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

PubMed ID: 16224021

DOI: 10.1126/science.1118947

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16618801

Title: Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.

PubMed ID: 16618801

DOI: 10.1101/gad.381706

PubMed ID: 16431907

Title: Substrate preferences of the EZH2 histone methyltransferase complex.

PubMed ID: 16431907

DOI: 10.1074/jbc.m513425200

PubMed ID: 16717091

Title: The polycomb group protein EZH2 is required for mammalian circadian clock function.

PubMed ID: 16717091

DOI: 10.1074/jbc.m603722200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16357870

Title: The Polycomb group protein EZH2 directly controls DNA methylation.

PubMed ID: 16357870

DOI: 10.1038/nature04431

PubMed ID: 16936726

Title: Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.

PubMed ID: 16936726

DOI: 10.1038/nsmb1142

PubMed ID: 17210787

Title: pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

PubMed ID: 17210787

DOI: 10.1101/gad.1499407

PubMed ID: 17344414

Title: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

PubMed ID: 17344414

DOI: 10.1101/gad.415507

PubMed ID: 17200670

Title: Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.

PubMed ID: 17200670

DOI: 10.1038/ng1950

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19026781

Title: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

PubMed ID: 19026781

DOI: 10.1016/j.molcel.2008.11.004

PubMed ID: 18086877

Title: Role of hPHF1 in H3K27 methylation and Hox gene silencing.

PubMed ID: 18086877

DOI: 10.1128/mcb.01589-07

PubMed ID: 18285464

Title: Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.

PubMed ID: 18285464

DOI: 10.1128/mcb.02017-07

PubMed ID: 18628979

Title: The polycomb repressive complex 2 is a potential target of SUMO modifications.

PubMed ID: 18628979

DOI: 10.1371/journal.pone.0002704

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20935635

Title: Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.

PubMed ID: 20935635

DOI: 10.1038/ncb2116

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22009739

Title: Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.

PubMed ID: 22009739

DOI: 10.1074/jbc.m111.271064

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23063525

Title: EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.

PubMed ID: 23063525

DOI: 10.1016/j.molcel.2012.09.004

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24474760

Title: O-GlcNAcylation regulates EZH2 protein stability and function.

PubMed ID: 24474760

DOI: 10.1073/pnas.1323226111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30026490

Title: Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4.

PubMed ID: 30026490

DOI: 10.1038/s41467-018-05286-2

PubMed ID: 31086175

Title: PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.

PubMed ID: 31086175

DOI: 10.1038/s41467-019-09981-6

PubMed ID: 31451685

Title: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

PubMed ID: 31451685

DOI: 10.1038/s41467-019-11800-x

PubMed ID: 30923826

Title: EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.

PubMed ID: 30923826

DOI: 10.1093/neuonc/noz058

PubMed ID: 33323928

Title: Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.

PubMed ID: 33323928

DOI: 10.1038/s41419-020-03129-x

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 36064715

Title: ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation.

PubMed ID: 36064715

DOI: 10.1038/s41419-022-05212-x

PubMed ID: 20081860

Title: Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

PubMed ID: 20081860

DOI: 10.1038/ng.518

PubMed ID: 20601953

Title: Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.

PubMed ID: 20601953

DOI: 10.1038/ng.621

PubMed ID: 21190999

Title: Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

PubMed ID: 21190999

DOI: 10.1182/blood-2010-11-321208

PubMed ID: 21828135

Title: Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

PubMed ID: 21828135

DOI: 10.1182/blood-2010-10-311019

PubMed ID: 22190405

Title: Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height.

PubMed ID: 22190405

DOI: 10.18632/oncotarget.385

PubMed ID: 22177091

Title: Mutations in EZH2 cause Weaver syndrome.

PubMed ID: 22177091

DOI: 10.1016/j.ajhg.2011.11.018

PubMed ID: 22323599

Title: Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).

PubMed ID: 22323599

DOI: 10.1073/pnas.1116418109

PubMed ID: 23239504

Title: Weaver syndrome and defective cortical development: a rare association.

PubMed ID: 23239504

DOI: 10.1002/ajmg.a.35660

PubMed ID: 26694085

Title: Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro.

PubMed ID: 26694085

DOI: 10.1002/humu.22946

PubMed ID: 28229514

Title: Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome.

PubMed ID: 28229514

DOI: 10.1002/humu.23200

Sequence Information:

  • Length: 746
  • Mass: 85363
  • Checksum: 1B5029EB9D509BE5
  • Sequence:
    • MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTEILNQEW 
KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT LNAVASVPIM YSWSPLQQNF 
MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALGQ 
YNDDDDDDDG DDPEEREEKQ KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL 
KEKYKELTEQ QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH 
ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP GGRRRGRLPN 
NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK KDETSSSSEA NSRCQTPIKM 
KPNIEPPENV EWSGAEASMF RVLIGTYYDN FCAIARLIGT KTCRQVYEFR VKESSIIAPA 
PAEDVDTPPR KKKRKHRLWA AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ 
NFCEKFCQCS SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS 
CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE ADRRGKVYDK 
YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM MVNGDHRIGI FAKRAIQTGE 
ELFFDYRYSQ ADALKYVGIE REMEIP

Genular Protein ID: 2285955426

Symbol: S4S3R8_HUMAN

Name: N/A

UniProtKB Accession Codes:

S4S3R8

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 ExpressionAtlas 1 GO 7 Gene3D 2 HOGENOM 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 5 RefSeq 1 Rhea 3 SAM 1 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

Sequence Information:

  • Length: 707
  • Mass: 81038
  • Checksum: 48EAF1393A9EA4F2
  • Sequence:
    • MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTEILNQEW 
KQRRIQPVHI LTSVSSLRGT REVEDETVLH NIPYMGDEVL DQDGTFIEEL IKNYDGKVHG 
DRECGFINDE IFVELVNALG QYNDDDDDDD GDDPEEREEK QKDLEDHRDD KESRPPRKFP 
SDKIFEAISS MFPDKGTAEE LKEKYKELTE QQLPGALPPE CTPNIDGPNA KSVQREQSLH 
SFHTLFCRRC FKYDCFLHPF HATPNTYKRK NTETALDNKP CGPQCYQHLE GAKEFAAALT 
AERIKTPPKR PGGRRRGRLP NNSSRPSTPT INVLESKDTD SDREAGTETG GENNDKEEEE 
KKDETSSSSE ANSRCQTPIK MKPNIEPPEN VEWSGAEASM FRVLIGTYYD NFCAIARLIG 
TKTCRQVYEF RVKESSIIAP APAEDVDTPP RKKKRKHRLW AAHCRKIQLK KDGSSNHVYN 
YQPCDHPRQP CDSSCPCVIA QNFCEKFCQC SSECQNRFPG CRCKAQCNTK QCPCYLAVRE 
CDPDLCLTCG AADHWDSKNV SCKNCSIQRG SKKHLLLAPS DVAGWGIFIK DPVQKNEFIS 
EYCGEIISQD EADRRGKVYD KYMCSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV 
MMVNGDHRIG IFAKRAIQTG EELFFDYRYS QADALKYVGI EREMEIP

Genular Protein ID: 4225890619

Symbol: A0A090N8E9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A090N8E9

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 BindingDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 48 Gene3D 2 InterPro 11 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 5 PhylomeDB 1 RefSeq 2 Rhea 3 SAM 1 SMART 3 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

Sequence Information:

  • Length: 751
  • Mass: 86018
  • Checksum: D885CF02E60EF836
  • Sequence:
    • MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTEILNQEW 
KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT LNAVASVPIM YSWSPLQQNF 
MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALGQ 
YNDDDDDDDG DDPEEREEKQ KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL 
KEKYKELTEQ QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHRKC 
NYSFHATPNT YKRKNTETAL DNKPCGPQCY QHLEGAKEFA AALTAERIKT PPKRPGGRRR 
GRLPNNSSRP STPTINVLES KDTDSDREAG TETGGENNDK EEEEKKDETS SSSEANSRCQ 
TPIKMKPNIE PPENVEWSGA EASMFRVLIG TYYDNFCAIA RLIGTKTCRQ VYEFRVKESS 
IIAPAPAEDV DTPPRKKKRK HRLWAAHCRK IQLKKDGSSN HVYNYQPCDH PRQPCDSSCP 
CVIAQNFCEK FCQCSSECQN RFPGCRCKAQ CNTKQCPCYL AVRECDPDLC LTCGAADHWD 
SKNVSCKNCS IQRGSKKHLL LAPSDVAGWG IFIKDPVQKN EFISEYCGEI ISQDEADRRG 
KVYDKYMCSF LFNLNNDFVV DATRKGNKIR FANHSVNPNC YAKVMMVNGD HRIGIFAKRA 
IQTGEELFFD YRYSQADALK YVGIEREMEI P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.