Details for: FABP5

Gene ID: 2171

Symbol: FABP5

Ensembl ID: ENSG00000164687

Description: fatty acid binding protein 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.58
    Marker Score: 27,991
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.57
    Marker Score: 23,259
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.15
    Marker Score: 27,174
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.96
    Marker Score: 4,754
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.91
    Marker Score: 18,561
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.9
    Marker Score: 74,255
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.83
    Marker Score: 2,522
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.63
    Marker Score: 844
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.58
    Marker Score: 19,225
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.55
    Marker Score: 10,450
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.52
    Marker Score: 2,654
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.52
    Marker Score: 3,619
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.49
    Marker Score: 3,664
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.49
    Marker Score: 2,817
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.48
    Marker Score: 2,781
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.42
    Marker Score: 3,128
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.4
    Marker Score: 8,873
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.38
    Marker Score: 2,238
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.32
    Marker Score: 2,178
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.31
    Marker Score: 30,433
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.29
    Marker Score: 6,225
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.28
    Marker Score: 2,441
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.26
    Marker Score: 546
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.23
    Marker Score: 931
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.21
    Marker Score: 3,523
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.21
    Marker Score: 3,059
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.19
    Marker Score: 1,204
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.18
    Marker Score: 6,838
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.17
    Marker Score: 1,364
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.13
    Marker Score: 12,649
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.11
    Marker Score: 12,818
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.07
    Marker Score: 2,697
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.06
    Marker Score: 20,766
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.05
    Marker Score: 1,218
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.04
    Marker Score: 687
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.03
    Marker Score: 4,831
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.03
    Marker Score: 492
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.03
    Marker Score: 2,319
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.99
    Marker Score: 1,142
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.97
    Marker Score: 3,328
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.94
    Marker Score: 1,949
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.92
    Marker Score: 2,062
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.91
    Marker Score: 5,657
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.9
    Marker Score: 3,234
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.85
    Marker Score: 3,872
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.82
    Marker Score: 11,855
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.82
    Marker Score: 7,857
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.82
    Marker Score: 2,122
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.82
    Marker Score: 1,215
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.8
    Marker Score: 2,548
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.8
    Marker Score: 1,796
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.79
    Marker Score: 894
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.79
    Marker Score: 4,864
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.79
    Marker Score: 4,631
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.76
    Marker Score: 832
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.75
    Marker Score: 504
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.74
    Marker Score: 492
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.72
    Marker Score: 1,898
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.72
    Marker Score: 19,319
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.71
    Marker Score: 1,821
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.71
    Marker Score: 629
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.7
    Marker Score: 1,416
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.69
    Marker Score: 3,825
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.68
    Marker Score: 679
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.68
    Marker Score: 1,753
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.67
    Marker Score: 1,510
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.67
    Marker Score: 549
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.67
    Marker Score: 16,888
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.67
    Marker Score: 3,921
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.65
    Marker Score: 57,220
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.64
    Marker Score: 391
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.64
    Marker Score: 8,600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.61
    Marker Score: 2,139
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.58
    Marker Score: 910
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.58
    Marker Score: 1,196
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.58
    Marker Score: 819
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.58
    Marker Score: 644
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.57
    Marker Score: 429
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.55
    Marker Score: 24,862
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.52
    Marker Score: 1,518
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.52
    Marker Score: 745
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.5
    Marker Score: 14,903
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.5
    Marker Score: 2,746
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.5
    Marker Score: 799
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.5
    Marker Score: 936
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.49
    Marker Score: 317
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.48
    Marker Score: 1,598
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.48
    Marker Score: 613
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.48
    Marker Score: 424
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.47
    Marker Score: 424
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.46
    Marker Score: 505
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.46
    Marker Score: 720
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165,716
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.44
    Marker Score: 463
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.44
    Marker Score: 959
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.44
    Marker Score: 661
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.43
    Marker Score: 501
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.42
    Marker Score: 1,721
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.42
    Marker Score: 1,011
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.42
    Marker Score: 1,778

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Fatty Acid Binding**: FABP5 is a small, cytoplasmic protein that binds to long-chain fatty acids, facilitating their transport across cell membranes. 2. **Lipid Metabolic Processes**: FABP5 is involved in the regulation of glucose homeostasis, lipid metabolism, and triglyceride catabolism. 3. **Immune System Regulation**: FABP5 plays a critical role in the regulation of immune responses, including neutrophil degranulation, innate immune system function, and the regulation of prostaglandin biosynthesis. 4. **Cell-Specific Expression**: FABP5 is primarily expressed in stratified epithelial cells, type II pneumocytes, and immune cells, highlighting its importance in specific tissue types. **Pathways and Functions:** 1. **Fatty Acid Transport**: FABP5 binds to long-chain fatty acids, facilitating their transport across cell membranes. 2. **Glucose Homeostasis**: FABP5 regulates glucose homeostasis by modulating the transport of fatty acids, which are involved in glucose metabolism. 3. **Lipid Metabolism**: FABP5 is involved in the regulation of lipid metabolism, including triglyceride catabolism and phosphatidylcholine biosynthesis. 4. **Immune System Function**: FABP5 regulates immune responses, including neutrophil degranulation, innate immune system function, and the regulation of prostaglandin biosynthesis. 5. **Negative Regulation of Glucose Transmembrane Transport**: FABP5 inhibits the transport of glucose across cell membranes, modulating glucose homeostasis. **Clinical Significance:** 1. **Metabolic Disorders**: FABP5 dysregulation has been implicated in various metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. 2. **Inflammatory Diseases**: FABP5 plays a critical role in the regulation of immune responses, making it a potential target for the treatment of inflammatory diseases, such as arthritis and asthma. 3. **Cancer**: FABP5 expression is altered in various cancers, including colorectal and breast cancer, highlighting its potential role in cancer development and progression. 4. **Neurological Disorders**: FABP5 is involved in the regulation of fatty acid metabolism, which is critical for the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, FABP5 is a critical regulator of lipid metabolism and immune response, with significant implications for the development and progression of various diseases. Further research is needed to fully understand the mechanisms by which FABP5 regulates these processes and to explore its potential as a therapeutic target.

Genular Protein ID: 358276115

Symbol: FABP5_HUMAN

Name: Fatty acid-binding protein, epidermal

UniProtKB Accession Codes:

Q01469 B2R4K0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 17 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1512466

Title: Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins.

PubMed ID: 1512466

DOI: 10.1111/1523-1747.ep12616641

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8092987

Title: Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro.

PubMed ID: 8092987

DOI: 10.1042/bj3020363

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21395585

Title: Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.

PubMed ID: 21395585

DOI: 10.1111/j.1471-4159.2011.07245.x

PubMed ID: 22170058

Title: Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors.

PubMed ID: 22170058

DOI: 10.1074/jbc.m111.304907

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10493790

Title: Expression, purification and crystal structure determination of recombinant human epidermal-type fatty acid-binding protein.

PubMed ID: 10493790

DOI: 10.1021/bi990305u

PubMed ID: 12049637

Title: Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).

PubMed ID: 12049637

DOI: 10.1042/bj20020039

PubMed ID: 24692551

Title: Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPARbeta/delta) signaling pathway.

PubMed ID: 24692551

DOI: 10.1074/jbc.m113.514646

PubMed ID: 24531463

Title: Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.

PubMed ID: 24531463

DOI: 10.1107/s1399004713026795

Sequence Information:

  • Length: 135
  • Mass: 15164
  • Checksum: 77D38F8806143D63
  • Sequence:
    • MATVQQLEGR WRLVDSKGFD EYMKELGVGI ALRKMGAMAK PDCIITCDGK NLTIKTESTL 
KTTQFSCTLG EKFEETTADG RKTQTVCNFT DGALVQHQEW DGKESTITRK LKDGKLVVEC 
VMNNVTCTRI YEKVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.