Details for: FABP5

Gene ID: 2171

Symbol: FABP5

Ensembl ID: ENSG00000164687

Description: fatty acid binding protein 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 443.6652
    Cell Significance Index: -69.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 179.3917
    Cell Significance Index: -73.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 177.1779
    Cell Significance Index: -44.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.6722
    Cell Significance Index: -72.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 134.6996
    Cell Significance Index: -69.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.2468
    Cell Significance Index: -71.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.4254
    Cell Significance Index: -69.5700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 42.4416
    Cell Significance Index: 364.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.1077
    Cell Significance Index: -67.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.0434
    Cell Significance Index: -71.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.5334
    Cell Significance Index: -47.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.7323
    Cell Significance Index: -21.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.9001
    Cell Significance Index: 136.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.4810
    Cell Significance Index: 79.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.0510
    Cell Significance Index: 498.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.0365
    Cell Significance Index: 727.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.8827
    Cell Significance Index: 42.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.7236
    Cell Significance Index: 77.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.5511
    Cell Significance Index: 184.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0033
    Cell Significance Index: 236.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.6648
    Cell Significance Index: 1260.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5738
    Cell Significance Index: 1421.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5069
    Cell Significance Index: 822.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4598
    Cell Significance Index: 94.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4172
    Cell Significance Index: 16.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3554
    Cell Significance Index: 35.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2309
    Cell Significance Index: 11.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2061
    Cell Significance Index: 74.1300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.1282
    Cell Significance Index: 16.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8296
    Cell Significance Index: 366.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7577
    Cell Significance Index: 74.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7148
    Cell Significance Index: 24.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6851
    Cell Significance Index: 87.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6078
    Cell Significance Index: 42.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4274
    Cell Significance Index: 69.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3891
    Cell Significance Index: 8.4300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3238
    Cell Significance Index: 2.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2957
    Cell Significance Index: 56.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2459
    Cell Significance Index: 33.7800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.2049
    Cell Significance Index: 3.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1125
    Cell Significance Index: 22.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0899
    Cell Significance Index: 2.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0808
    Cell Significance Index: 124.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0783
    Cell Significance Index: 15.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0782
    Cell Significance Index: 1.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0694
    Cell Significance Index: 1.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0399
    Cell Significance Index: 1.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0288
    Cell Significance Index: 10.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0166
    Cell Significance Index: 0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0031
    Cell Significance Index: 5.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0153
    Cell Significance Index: -9.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0157
    Cell Significance Index: -11.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0180
    Cell Significance Index: -24.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0326
    Cell Significance Index: -61.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0374
    Cell Significance Index: -1.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0442
    Cell Significance Index: -0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0623
    Cell Significance Index: -2.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0805
    Cell Significance Index: -8.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0891
    Cell Significance Index: -65.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0896
    Cell Significance Index: -56.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0997
    Cell Significance Index: -56.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1294
    Cell Significance Index: -58.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1484
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1659
    Cell Significance Index: -34.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1694
    Cell Significance Index: -48.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1706
    Cell Significance Index: -29.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1732
    Cell Significance Index: -25.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1832
    Cell Significance Index: -2.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1921
    Cell Significance Index: -24.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2282
    Cell Significance Index: -4.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2994
    Cell Significance Index: -9.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3063
    Cell Significance Index: -35.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3436
    Cell Significance Index: -18.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4126
    Cell Significance Index: -29.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4208
    Cell Significance Index: -11.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4639
    Cell Significance Index: -52.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4824
    Cell Significance Index: -27.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5379
    Cell Significance Index: -61.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5564
    Cell Significance Index: -7.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6375
    Cell Significance Index: -15.2900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6434
    Cell Significance Index: -4.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6547
    Cell Significance Index: -44.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6857
    Cell Significance Index: -52.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6878
    Cell Significance Index: -71.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7329
    Cell Significance Index: -54.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7804
    Cell Significance Index: -22.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8253
    Cell Significance Index: -50.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8275
    Cell Significance Index: -22.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8364
    Cell Significance Index: -66.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.1507
    Cell Significance Index: -16.5500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -1.2035
    Cell Significance Index: -10.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2182
    Cell Significance Index: -76.7800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -1.2545
    Cell Significance Index: -10.3800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.3500
    Cell Significance Index: -11.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.3553
    Cell Significance Index: -25.0500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.4473
    Cell Significance Index: -20.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4905
    Cell Significance Index: -65.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4909
    Cell Significance Index: -25.5500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -1.5116
    Cell Significance Index: -8.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.5522
    Cell Significance Index: -42.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Fatty Acid Binding**: FABP5 is a small, cytoplasmic protein that binds to long-chain fatty acids, facilitating their transport across cell membranes. 2. **Lipid Metabolic Processes**: FABP5 is involved in the regulation of glucose homeostasis, lipid metabolism, and triglyceride catabolism. 3. **Immune System Regulation**: FABP5 plays a critical role in the regulation of immune responses, including neutrophil degranulation, innate immune system function, and the regulation of prostaglandin biosynthesis. 4. **Cell-Specific Expression**: FABP5 is primarily expressed in stratified epithelial cells, type II pneumocytes, and immune cells, highlighting its importance in specific tissue types. **Pathways and Functions:** 1. **Fatty Acid Transport**: FABP5 binds to long-chain fatty acids, facilitating their transport across cell membranes. 2. **Glucose Homeostasis**: FABP5 regulates glucose homeostasis by modulating the transport of fatty acids, which are involved in glucose metabolism. 3. **Lipid Metabolism**: FABP5 is involved in the regulation of lipid metabolism, including triglyceride catabolism and phosphatidylcholine biosynthesis. 4. **Immune System Function**: FABP5 regulates immune responses, including neutrophil degranulation, innate immune system function, and the regulation of prostaglandin biosynthesis. 5. **Negative Regulation of Glucose Transmembrane Transport**: FABP5 inhibits the transport of glucose across cell membranes, modulating glucose homeostasis. **Clinical Significance:** 1. **Metabolic Disorders**: FABP5 dysregulation has been implicated in various metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. 2. **Inflammatory Diseases**: FABP5 plays a critical role in the regulation of immune responses, making it a potential target for the treatment of inflammatory diseases, such as arthritis and asthma. 3. **Cancer**: FABP5 expression is altered in various cancers, including colorectal and breast cancer, highlighting its potential role in cancer development and progression. 4. **Neurological Disorders**: FABP5 is involved in the regulation of fatty acid metabolism, which is critical for the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, FABP5 is a critical regulator of lipid metabolism and immune response, with significant implications for the development and progression of various diseases. Further research is needed to fully understand the mechanisms by which FABP5 regulates these processes and to explore its potential as a therapeutic target.

Genular Protein ID: 358276115

Symbol: FABP5_HUMAN

Name: Fatty acid-binding protein, epidermal

UniProtKB Accession Codes:

Q01469 B2R4K0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1512466

Title: Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins.

PubMed ID: 1512466

DOI: 10.1111/1523-1747.ep12616641

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8092987

Title: Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro.

PubMed ID: 8092987

DOI: 10.1042/bj3020363

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21395585

Title: Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.

PubMed ID: 21395585

DOI: 10.1111/j.1471-4159.2011.07245.x

PubMed ID: 22170058

Title: Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors.

PubMed ID: 22170058

DOI: 10.1074/jbc.m111.304907

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10493790

Title: Expression, purification and crystal structure determination of recombinant human epidermal-type fatty acid-binding protein.

PubMed ID: 10493790

DOI: 10.1021/bi990305u

PubMed ID: 12049637

Title: Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).

PubMed ID: 12049637

DOI: 10.1042/bj20020039

PubMed ID: 24692551

Title: Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPARbeta/delta) signaling pathway.

PubMed ID: 24692551

DOI: 10.1074/jbc.m113.514646

PubMed ID: 24531463

Title: Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.

PubMed ID: 24531463

DOI: 10.1107/s1399004713026795

Sequence Information:

  • Length: 135
  • Mass: 15164
  • Checksum: 77D38F8806143D63
  • Sequence:
    • MATVQQLEGR WRLVDSKGFD EYMKELGVGI ALRKMGAMAK PDCIITCDGK NLTIKTESTL 
KTTQFSCTLG EKFEETTADG RKTQTVCNFT DGALVQHQEW DGKESTITRK LKDGKLVVEC 
VMNNVTCTRI YEKVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.