Gene FABP5 - ENSG00000164687 | NCBI Gene ID: 2171

Details for: FABP5

Gene ID: 2171

Symbol: FABP5

Ensembl ID: ENSG00000164687

Description: fatty acid binding protein 5

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Neutrophil degranulation
(R-HSA-6798695)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by retinoic acid
(R-HSA-5362517)
Signal transduction
(R-HSA-162582)
Triglyceride catabolism
(R-HSA-163560)
Triglyceride metabolism
(R-HSA-8979227)
Azurophil granule lumen
(GO:0035578)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epidermis development
(GO:0008544)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Fatty acid binding
(GO:0005504)
Fatty acid transport
(GO:0015908)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Identical protein binding
(GO:0042802)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Lipid transport across blood-brain barrier
(GO:1990379)
Long-chain fatty acid transport
(GO:0015909)
Long-chain fatty acid transporter activity
(GO:0005324)
Negative regulation of glucose transmembrane transport
(GO:0010829)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylcholine biosynthetic process
(GO:0006656)
Plasma membrane
(GO:0005886)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Regulation of prostaglandin biosynthetic process
(GO:0031392)
Regulation of retrograde trans-synaptic signaling by endocanabinoid
(GO:0099178)
Regulation of sensory perception of pain
(GO:0051930)
Retinoic acid binding
(GO:0001972)
Secretory granule membrane
(GO:0030667)
Synapse
(GO:0045202)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.58
Marker Score: 27991
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.57
Marker Score: 23259
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 3.15
Marker Score: 27174
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.96
Marker Score: 4754
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.91
Marker Score: 18561
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.9
Marker Score: 74255
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.83
Marker Score: 2522
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.63
Marker Score: 844
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.58
Marker Score: 19225
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.55
Marker Score: 10450
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.52
Marker Score: 2653.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.52
Marker Score: 3619
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.49
Marker Score: 3664
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.49
Marker Score: 2817
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.48
Marker Score: 2780.5
Cell Name: basal cell (CL0000646)
Fold Change: 2.42
Marker Score: 3128
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.4
Marker Score: 8873
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.38
Marker Score: 2238
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.32
Marker Score: 2178
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.31
Marker Score: 30433
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.29
Marker Score: 6225
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.28
Marker Score: 2441
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.26
Marker Score: 546
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.23
Marker Score: 931
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.21
Marker Score: 3522.5
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.21
Marker Score: 3059
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.19
Marker Score: 1204
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.18
Marker Score: 6838
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.17
Marker Score: 1364
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.13
Marker Score: 12649
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.11
Marker Score: 12817.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.07
Marker Score: 2697
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.06
Marker Score: 20766
Cell Name: motor neuron (CL0000100)
Fold Change: 2.05
Marker Score: 1218
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.04
Marker Score: 687
Cell Name: stem cell (CL0000034)
Fold Change: 2.03
Marker Score: 4831
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 2.03
Marker Score: 492
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.03
Marker Score: 2318.5
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.99
Marker Score: 1142
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.97
Marker Score: 3328
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.94
Marker Score: 1949
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.92
Marker Score: 2062
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.91
Marker Score: 5657
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.9
Marker Score: 3234
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.85
Marker Score: 3872
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.82
Marker Score: 11855
Cell Name: decidual cell (CL2000002)
Fold Change: 1.82
Marker Score: 7857
Cell Name: club cell (CL0000158)
Fold Change: 1.82
Marker Score: 2122
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.82
Marker Score: 1215
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.8
Marker Score: 2548
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.8
Marker Score: 1795.5
Cell Name: osteoclast (CL0000092)
Fold Change: 1.79
Marker Score: 894
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.79
Marker Score: 4863.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.79
Marker Score: 4631
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.76
Marker Score: 832
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.75
Marker Score: 504
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.74
Marker Score: 492
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.72
Marker Score: 1898
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.72
Marker Score: 19319
Cell Name: Unknown (CL0002371)
Fold Change: 1.71
Marker Score: 1821
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.71
Marker Score: 629
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.7
Marker Score: 1416
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.69
Marker Score: 3825
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.68
Marker Score: 679
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.68
Marker Score: 1753
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.67
Marker Score: 1510
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.67
Marker Score: 549
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.67
Marker Score: 16888
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.67
Marker Score: 3921
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.65
Marker Score: 57220
Cell Name: centrocyte (CL0009111)
Fold Change: 1.64
Marker Score: 391
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.64
Marker Score: 8600
Cell Name: plasmablast (CL0000980)
Fold Change: 1.61
Marker Score: 2139
Cell Name: leukocyte (CL0000738)
Fold Change: 1.58
Marker Score: 909.5
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.58
Marker Score: 1196
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.58
Marker Score: 819
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.58
Marker Score: 644
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 1.57
Marker Score: 429
Cell Name: lactocyte (CL0002325)
Fold Change: 1.55
Marker Score: 24862
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.52
Marker Score: 1518
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.52
Marker Score: 745
Cell Name: mature T cell (CL0002419)
Fold Change: 1.5
Marker Score: 14903
Cell Name: secretory cell (CL0000151)
Fold Change: 1.5
Marker Score: 2746
Cell Name: enteric neuron (CL0007011)
Fold Change: 1.5
Marker Score: 799
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.5
Marker Score: 936
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.49
Marker Score: 317
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.48
Marker Score: 1598
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.48
Marker Score: 613
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.48
Marker Score: 424
Cell Name: male germ cell (CL0000015)
Fold Change: 1.47
Marker Score: 424
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.46
Marker Score: 505
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.46
Marker Score: 720
Cell Name: mural cell (CL0008034)
Fold Change: 1.44
Marker Score: 165716
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.44
Marker Score: 463
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.44
Marker Score: 959
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 1.44
Marker Score: 661
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.43
Marker Score: 501
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.42
Marker Score: 1721
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.42
Marker Score: 1011
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.42
Marker Score: 1777.5

Hover over a box to see details here...

**Key characteristics:** * FABP5 is a transmembrane protein with a molecular weight of approximately 150 kDa. * It is expressed in a variety of cell types, including epithelial cells, immune cells, and endothelial cells. * FABP5 is a key regulator of lipid uptake, utilization, and trafficking. * It plays a role in the regulation of inflammation and immune responses. **Pathways and functions:** * FABP5 is involved in the regulation of fatty acid metabolism. It is a key regulator of the uptake of fatty acids from the extracellular environment and their utilization within the cell. * FABP5 is also involved in the regulation of inflammation and immune responses. It is a key regulator of the migration and activation of immune cells, and it plays a role in the regulation of inflammation. * FABP5 is a key regulator of lipid trafficking. It is responsible for the sorting and transport of fatty acids to their appropriate destinations in the cell. **Clinical significance:** * Mutations in the FABP5 gene have been linked to a number of human diseases, including obesity, diabetes, and inflammation. * FABP5 is a potential target for the treatment of these diseases. * By understanding the role of FABP5 in fatty acid metabolism and immune responses, it may be possible to develop new therapeutic strategies for these diseases. **Additional notes:** * FABP5 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * FABP5 is a member of the FAB family of proteins, which are involved in the regulation of lipid metabolism. * FABP5 is a relatively new protein, with the majority of its sequence being encoded by novel exons.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fatty acid-binding protein, epidermal

Genular Protein ID: 358276115

Symbol: FABP5_HUMAN

Name: Fatty acid-binding protein, epidermal

UniProtKB Accession Codes:

Q01469 B2R4K0

Database IDs:

Citations:

PubMed ID: 1512466

Title: Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins.

PubMed ID: 1512466

DOI: 10.1111/1523-1747.ep12616641

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8092987

Title: Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro.

PubMed ID: 8092987

DOI: 10.1042/bj3020363

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21395585

Title: Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.

PubMed ID: 21395585

DOI: 10.1111/j.1471-4159.2011.07245.x

PubMed ID: 22170058

Title: Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors.

PubMed ID: 22170058

DOI: 10.1074/jbc.m111.304907

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10493790

Title: Expression, purification and crystal structure determination of recombinant human epidermal-type fatty acid-binding protein.

PubMed ID: 10493790

DOI: 10.1021/bi990305u

PubMed ID: 12049637

Title: Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).

PubMed ID: 12049637

DOI: 10.1042/bj20020039

PubMed ID: 24692551

Title: Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPARbeta/delta) signaling pathway.

PubMed ID: 24692551

DOI: 10.1074/jbc.m113.514646

PubMed ID: 24531463

Title: Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.

PubMed ID: 24531463

DOI: 10.1107/s1399004713026795

Sequence Information:

Length: 135
Mass: 15164
Checksum: 77D38F8806143D63
Sequence:

MATVQQLEGR WRLVDSKGFD EYMKELGVGI ALRKMGAMAK PDCIITCDGK NLTIKTESTL 
KTTQFSCTLG EKFEETTADG RKTQTVCNFT DGALVQHQEW DGKESTITRK LKDGKLVVEC 
VMNNVTCTRI YEKVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FABP5

Associated with

Cells (max top 100)

Other Information

Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. PubMed ID: 1512466

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro. PubMed ID: 8092987

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells. PubMed ID: 21395585

Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors. PubMed ID: 22170058

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Expression, purification and crystal structure determination of recombinant human epidermal-type fatty acid-binding protein. PubMed ID: 10493790

Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP). PubMed ID: 12049637

Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPARbeta/delta) signaling pathway. PubMed ID: 24692551

Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. PubMed ID: 24531463