Details for: FABP5
Gene ID: 2171
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: FABP5
Ensembl ID: ENSG00000164687
Description: fatty acid binding protein 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 68.64rCSI 59.43%PRS 16.58
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CSI 67.27rCSI 52.15%PRS 14.08
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CSI 65.32rCSI 59.98%PRS 17.03
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CSI 58.53rCSI 47.33%PRS 14.67
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CSI 56.34rCSI 86.05%PRS 14.8
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CSI 49.11rCSI 44.35%PRS 13.16
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CSI 45.33rCSI 56.89%PRS 18.93
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CSI 45.31rCSI 61.74%PRS 13.18
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CSI 44.29rCSI 52.02%PRS 17.31
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CSI 42.27rCSI 40.76%PRS 10.4
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CSI 39.07rCSI 56.36%PRS 20.6
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CSI 38.21rCSI 25.4%PRS 17.71
-
CSI 37.45rCSI 70.7%PRS 18.44
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CSI 35.1rCSI 57.82%PRS 17.29
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CSI 35.07rCSI 44.09%PRS 22.63
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CSI 31.66rCSI 46.37%PRS 17.18
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CSI 31.61rCSI 26.49%PRS 17.65
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CSI 31.27rCSI 66.56%PRS 23.72
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CSI 30.78rCSI 27.03%PRS 16.7
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CSI 28.23rCSI 43.79%PRS 22.36
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CSI 28.1rCSI 32.17%PRS 30.08
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CSI 27.88rCSI 44.48%PRS 12.73
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CSI 25.42rCSI 21.07%PRS 13.92
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CSI 24.85rCSI 17.84%PRS 20.17
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CSI 24.63rCSI 37.66%PRS 23.96
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CSI 24.31rCSI 78.02%PRS 21.42
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CSI 23.16rCSI 24.26%PRS 15.78
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CSI 22.58rCSI 31.36%PRS 15.21
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CSI 22.32rCSI 38.24%PRS 19.94
-
CSI 21.89rCSI 22.88%PRS 15.45
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CSI 21.39rCSI 39.21%PRS 53.08
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CSI 21.05rCSI 30.84%PRS 61.62
-
CSI 19.94rCSI 30.65%PRS 20.77
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CSI 19.67rCSI 56.28%PRS 26.03
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CSI 19.33rCSI 34.47%PRS 24.95
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CSI 19.25rCSI 55.74%PRS 16.76
-
CSI 18.8rCSI 27.51%PRS 15.6
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CSI 18.2rCSI 26.24%PRS 23.58
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CSI 17.61rCSI 20.42%PRS 21.78
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CSI 17.27rCSI 16.99%PRS 16.05
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CSI 16.84rCSI 48.06%PRS 25.25
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CSI 16.71rCSI 33.12%PRS 42.24
-
CSI 16.55rCSI 46.56%PRS 20.72
-
CSI 16.42rCSI 12.92%PRS 17.65
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CSI 15.85rCSI 21.66%PRS 16.37
-
CSI 15.73rCSI 20.18%PRS 17.06
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CSI 15.59rCSI 34.05%PRS 29.52
-
CSI 15.53rCSI 18.64%PRS 14.56
-
CSI 15.23rCSI 12.04%PRS 10.16
-
CSI 15.05rCSI 59.92%PRS 25.84
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CSI 15.05rCSI 15.76%PRS 13.74
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CSI 15rCSI 13.14%PRS 19.58
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CSI 14.58rCSI 27.37%PRS 28.91
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CSI 14.1rCSI 11.68%PRS 14.82
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CSI 13.91rCSI 16.07%PRS 12.97
-
CSI 13.41rCSI 29.96%PRS 16.87
-
CSI 13.39rCSI 12.89%PRS 15.29
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CSI 13.19rCSI 11.71%PRS 14.76
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CSI 12.36rCSI 43.87%PRS 24.1
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CSI 11.94rCSI 14.42%PRS 17.49
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CSI 11.43rCSI 26.65%PRS 34.7
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CSI 11.32rCSI 58.44%PRS 28.8
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CSI 10.93rCSI 17.45%PRS 16.2
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CSI 10.73rCSI 15.74%PRS 19.39
-
CSI 10.73rCSI 14.34%PRS 28.15
-
CSI 10.71rCSI 18.33%PRS 29.56
-
CSI 10.64rCSI 42.93%PRS 13.17
-
CSI 10.61rCSI 10.42%PRS 23.15
-
CSI 10.35rCSI 13.84%PRS 16.17
-
CSI 10.18rCSI 9.62%PRS 15.41
-
CSI 9.96rCSI 6.93%PRS 17.39
-
CSI 9.88rCSI 54.82%PRS 41.33
-
CSI 9.82rCSI 7.47%PRS 19.39
-
CSI 9.78rCSI 13.96%PRS 16.63
-
CSI 9.75rCSI 48.06%PRS 20.05
-
CSI 9.62rCSI 7.48%PRS 21.37
-
CSI 9.6rCSI 21.95%PRS 14.33
-
CSI 9.59rCSI 26.18%PRS 53.55
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CSI 9.56rCSI 9.54%PRS 12.61
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CSI 9.33rCSI 8.63%PRS 26.87
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CSI 9.08rCSI 13.87%PRS 18.76
-
CSI 9.06rCSI 16.48%PRS 54.11
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CSI 9rCSI 11.13%PRS 12.95
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CSI 8.57rCSI 25.3%PRS 17.92
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CSI 8.44rCSI 11.54%PRS 16.74
-
CSI 8.44rCSI 39.58%PRS 38.33
-
CSI 8.41rCSI 7.02%PRS 41.29
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CSI 8.38rCSI 23.83%PRS 17.45
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CSI 8.21rCSI 43.79%PRS 51.65
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CSI 8.08rCSI 17.78%PRS 16.45
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CSI 7.9rCSI 54.24%PRS 28.75
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CSI 7.74rCSI 5.79%PRS 23.89
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CSI 7.63rCSI 19.88%PRS 13.54
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CSI 7.61rCSI 9.38%PRS 45.05
-
CSI 7.56rCSI 7.43%PRS 41.39
-
CSI 7.39rCSI 14.84%PRS 10.94
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CSI 7.39rCSI 55.48%PRS 26.84
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CSI 7.36rCSI 15.27%PRS 14.75
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CSI 7.24rCSI 9.29%PRS 14.38
-
CSI 7.22rCSI 78.55%PRS 53.37
-
CSI -4.2rCSI -11.6%PRS 22.8%
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CSI -2.8rCSI -12.6%PRS 61.2%
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CSI -1.5rCSI -6.2%PRS 18.2%
-
CSI -1.2rCSI -1.9%PRS 8.6%
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CSI -0.5rCSI -1.1%PRS 10.6%
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CSI -0.5rCSI -3.1%PRS 45.4%
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CSI -0.3rCSI -0.5%PRS 13.6%
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CSI -0.3rCSI -1.2%PRS 8.1%
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CSI 0.0rCSI 0.1%PRS 32.8%
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CSI 0.0rCSI 0.2%PRS 41.4%
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CSI 0.2rCSI 0.3%PRS 13.7%
-
CSI 0.2rCSI 0.2%PRS 30.3%
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CSI 0.2rCSI 1.6%PRS 64.4%
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CSI 0.2rCSI 5.3%PRS 77.7%
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CSI 0.3rCSI 0.5%PRS 13.8%
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CSI 0.3rCSI 6.1%PRS 74.9%
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CSI 0.3rCSI 1.0%PRS 9.3%
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CSI 0.3rCSI 0.5%PRS 12.6%
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CSI 0.4rCSI 0.4%PRS 18.6%
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CSI 0.4rCSI 2.1%PRS 35.8%
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CSI 0.4rCSI 0.7%PRS 11.4%
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CSI 0.5rCSI 5.6%PRS 53.5%
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CSI 0.5rCSI 1.7%PRS 26.5%
-
CSI 0.5rCSI 1.8%PRS 53.6%
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CSI 0.7rCSI 2.5%PRS 8.9%
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CSI 0.7rCSI 1.5%PRS 9.1%
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CSI 0.7rCSI 3.9%PRS 21.5%
-
CSI 0.7rCSI 6.7%PRS 40.2%
-
CSI 0.8rCSI 0.7%PRS 18.3%
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CSI 0.8rCSI 5.8%PRS 39.4%
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CSI 0.8rCSI 4.3%PRS 27.1%
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CSI 0.8rCSI 1.1%PRS 20.5%
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CSI 0.8rCSI 3.8%PRS 34.3%
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CSI 0.8rCSI 19.9%PRS 47.6%
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CSI 0.9rCSI 17.2%PRS 44.1%
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CSI 0.9rCSI 7.3%PRS 15.2%
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CSI 0.9rCSI 4.2%PRS 14.5%
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CSI 1.0rCSI 25.2%PRS 44.5%
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CSI 1.1rCSI 27.8%PRS 60.2%
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CSI 1.1rCSI 6.2%PRS 24.6%
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CSI 1.2rCSI 1.6%PRS 16.2%
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CSI 1.2rCSI 1.5%PRS 25.6%
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CSI 1.2rCSI 1.5%PRS 15.6%
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CSI 1.3rCSI 6.7%PRS 25.9%
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CSI 1.3rCSI 12.2%PRS 56.8%
-
CSI 1.4rCSI 9.2%PRS 68.5%
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CSI 1.5rCSI 6.8%PRS 38.2%
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CSI 1.5rCSI 1.7%PRS 10.8%
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CSI 1.5rCSI 1.6%PRS 13.6%
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CSI 1.5rCSI 2.2%PRS 20.3%
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CSI 1.5rCSI 2.1%PRS 23.8%
-
CSI 1.6rCSI 11.3%PRS 16.5%
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CSI 1.6rCSI 2.4%PRS 14.7%
-
CSI 1.6rCSI 9.0%PRS 45.6%
-
CSI 1.7rCSI 2.6%PRS 35.2%
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CSI 1.8rCSI 4.6%PRS 20.2%
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CSI 1.8rCSI 19.4%PRS 64.7%
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CSI 1.8rCSI 3.3%PRS 12.1%
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CSI 1.8rCSI 10.5%PRS 19.2%
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CSI 1.8rCSI 2.2%PRS 8.5%
-
CSI 1.9rCSI 32.2%PRS 54.8%
-
CSI 1.9rCSI 18.2%PRS 40.3%
-
CSI 1.9rCSI 8.6%PRS 56.0%
-
CSI 2.0rCSI 1.5%PRS 13.5%
-
CSI 2.0rCSI 7.9%PRS 31.8%
-
CSI 2.0rCSI 8.4%PRS 37.1%
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CSI 2.0rCSI 3.9%PRS 33.6%
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CSI 2.0rCSI 4.5%PRS 19.7%
-
CSI 2.1rCSI 5.5%PRS 24.1%
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CSI 2.1rCSI 10.5%PRS 67.4%
-
CSI 2.1rCSI 3.8%PRS 13.7%
-
CSI 2.2rCSI 7.4%PRS 24.3%
-
CSI 2.3rCSI 5.4%PRS 66.8%
-
CSI 2.3rCSI 20.1%PRS 53.5%
-
CSI 2.3rCSI 4.7%PRS 6.6%
-
CSI 2.3rCSI 4.4%PRS 32.0%
-
CSI 2.4rCSI 70.8%PRS 33.2%
-
CSI 2.4rCSI 13.8%PRS 22.2%
-
CSI 2.4rCSI 6.1%PRS 14.9%
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CSI 2.4rCSI 4.3%PRS 13.6%
-
CSI 2.5rCSI 3.1%PRS 17.2%
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CSI 2.5rCSI 6.7%PRS 19.0%
-
CSI 2.5rCSI 45.7%PRS 42.2%
-
CSI 2.5rCSI 12.8%PRS 54.5%
-
CSI 2.5rCSI 5.2%PRS 14.8%
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CSI 2.5rCSI 3.4%PRS 14.8%
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CSI 2.5rCSI 6.1%PRS 22.1%
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CSI 2.6rCSI 1.8%PRS 17.8%
-
CSI 2.8rCSI 4.3%PRS 16.9%
-
CSI 2.9rCSI 5.9%PRS 22.3%
-
CSI 2.9rCSI 4.4%PRS 13.8%
-
CSI 2.9rCSI 31.2%PRS 84.8%
-
CSI 2.9rCSI 12.7%PRS 26.2%
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CSI 3.0rCSI 7.6%PRS 37.9%
-
CSI 3.0rCSI 3.1%PRS 27.4%
-
CSI 3.0rCSI 13.7%PRS 49.9%
-
CSI 3.1rCSI 3.8%PRS 19.2%
-
CSI 3.2rCSI 11.3%PRS 45.0%
-
CSI 3.2rCSI 14.1%PRS 14.2%
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CSI 3.2rCSI 6.3%PRS 15.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 358276115
Symbol: FABP5_HUMAN
Name: Fatty acid-binding protein, epidermal
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1512466
Title: Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins.
PubMed ID: 1512466
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 8092987
Title: Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro.
PubMed ID: 8092987
DOI: 10.1042/bj3020363
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21395585
Title: Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.
PubMed ID: 21395585
PubMed ID: 22170058
Title: Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors.
PubMed ID: 22170058
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 10493790
Title: Expression, purification and crystal structure determination of recombinant human epidermal-type fatty acid-binding protein.
PubMed ID: 10493790
DOI: 10.1021/bi990305u
PubMed ID: 12049637
Title: Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).
PubMed ID: 12049637
DOI: 10.1042/bj20020039
PubMed ID: 24692551
Title: Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPARbeta/delta) signaling pathway.
PubMed ID: 24692551
PubMed ID: 24531463
Title: Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.
PubMed ID: 24531463
Sequence Information:
- Length: 135
- Mass: 15164
- Checksum: 77D38F8806143D63
- Sequence:
MATVQQLEGR WRLVDSKGFD EYMKELGVGI ALRKMGAMAK PDCIITCDGK NLTIKTESTL KTTQFSCTLG EKFEETTADG RKTQTVCNFT DGALVQHQEW DGKESTITRK LKDGKLVVEC VMNNVTCTRI YEKVE