Details for: FANCD2

Gene ID: 2177

Symbol: FANCD2

Ensembl ID: ENSG00000144554

Description: FA complementation group D2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.1785
    Cell Significance Index: -6.6400
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 17.4869
    Cell Significance Index: -2.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.2480
    Cell Significance Index: -6.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4828
    Cell Significance Index: -6.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7661
    Cell Significance Index: -7.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8474
    Cell Significance Index: -7.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7842
    Cell Significance Index: -5.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1826
    Cell Significance Index: 116.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9778
    Cell Significance Index: -2.1400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7165
    Cell Significance Index: 5.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6871
    Cell Significance Index: 111.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6416
    Cell Significance Index: 122.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6358
    Cell Significance Index: 69.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5947
    Cell Significance Index: 33.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5901
    Cell Significance Index: 16.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4771
    Cell Significance Index: 94.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4619
    Cell Significance Index: 27.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4359
    Cell Significance Index: 11.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3872
    Cell Significance Index: 45.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3165
    Cell Significance Index: 8.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2890
    Cell Significance Index: 33.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2785
    Cell Significance Index: 3.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2527
    Cell Significance Index: 6.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2504
    Cell Significance Index: 226.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2248
    Cell Significance Index: 3.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2166
    Cell Significance Index: 11.2500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2088
    Cell Significance Index: 2.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1719
    Cell Significance Index: 10.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1686
    Cell Significance Index: 11.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1674
    Cell Significance Index: 1.8200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1597
    Cell Significance Index: 0.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1593
    Cell Significance Index: 4.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1416
    Cell Significance Index: 25.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1212
    Cell Significance Index: 4.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0963
    Cell Significance Index: 11.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0948
    Cell Significance Index: 19.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0868
    Cell Significance Index: 2.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0746
    Cell Significance Index: 40.7600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0656
    Cell Significance Index: 0.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0639
    Cell Significance Index: 2.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0593
    Cell Significance Index: 26.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0505
    Cell Significance Index: 18.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0448
    Cell Significance Index: 1.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0400
    Cell Significance Index: 1.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0357
    Cell Significance Index: 2.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0350
    Cell Significance Index: 1.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0314
    Cell Significance Index: 0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0310
    Cell Significance Index: 58.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0301
    Cell Significance Index: 20.8300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0251
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0196
    Cell Significance Index: 30.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0178
    Cell Significance Index: 32.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0142
    Cell Significance Index: 0.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0080
    Cell Significance Index: 5.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0066
    Cell Significance Index: 0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0064
    Cell Significance Index: 0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0059
    Cell Significance Index: 8.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0034
    Cell Significance Index: 0.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0017
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0080
    Cell Significance Index: -1.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0096
    Cell Significance Index: -7.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0119
    Cell Significance Index: -1.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0132
    Cell Significance Index: -8.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0167
    Cell Significance Index: -2.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0183
    Cell Significance Index: -5.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0250
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0257
    Cell Significance Index: -2.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0278
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0280
    Cell Significance Index: -1.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0294
    Cell Significance Index: -0.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0325
    Cell Significance Index: -3.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0343
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0387
    Cell Significance Index: -8.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0506
    Cell Significance Index: -3.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0549
    Cell Significance Index: -5.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0577
    Cell Significance Index: -4.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0726
    Cell Significance Index: -1.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0788
    Cell Significance Index: -1.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0847
    Cell Significance Index: -5.1900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0874
    Cell Significance Index: -1.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0933
    Cell Significance Index: -7.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1029
    Cell Significance Index: -3.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1085
    Cell Significance Index: -5.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1117
    Cell Significance Index: -2.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1203
    Cell Significance Index: -1.2500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1258
    Cell Significance Index: -0.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1299
    Cell Significance Index: -6.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1330
    Cell Significance Index: -3.6200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1403
    Cell Significance Index: -2.0100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1425
    Cell Significance Index: -1.4100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1452
    Cell Significance Index: -1.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1456
    Cell Significance Index: -3.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1472
    Cell Significance Index: -2.7200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1529
    Cell Significance Index: -1.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure and expression**: FANCD2 is a phosphoprotein encoded by a single gene, with its expression primarily restricted to somatic cells, including oogonial cells, GABAergic interneurons, and intestinal epithelial cells. 2. **Protein structure and function**: The FANCD2 protein is a heterodimer composed of two subunits, FANCD2A and FANCD2B, which interact with other FA proteins to form a complex. This complex is responsible for recognizing and repairing interstrand cross-links. 3. **Phosphorylation and activation**: FANCD2 undergoes phosphorylation upon activation, which is crucial for its function in DNA repair and chromosomal stability. **Pathways and Functions:** 1. **DNA repair**: FANCD2 is a key player in the FA pathway, which is responsible for repairing interstrand cross-links, double-strand breaks, and chromosomal rearrangements. This process involves the recognition and processing of DNA damage, followed by the recruitment of repair proteins. 2. **Chromatin remodeling**: FANCD2 is involved in chromatin remodeling, which is essential for the regulation of gene expression and cellular development. 3. **Developmental regulation**: FANCD2 plays a critical role in the development and differentiation of various cell types, including oogonial cells, GABAergic interneurons, and intestinal epithelial cells. 4. **Cellular response to oxidative stress**: FANCD2 is activated in response to oxidative stress, which is a critical regulator of cellular survival and adaptation. **Clinical Significance:** 1. **Fanconi anemia**: Mutations in the FANCD2 gene are associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, congenital abnormalities, and increased risk of malignancies. 2. **Cancer**: Aberrant FANCD2 expression has been linked to various cancers, including breast, ovarian, and colon cancer, where it may contribute to genomic instability and tumorigenesis. 3. **Neurological disorders**: Mutations in FANCD2 have been associated with neurological disorders, such as spinocerebellar ataxia type 2, which may be linked to chromosomal instability and neuronal dysfunction. In conclusion, FANCD2 is a multifunctional gene that plays a critical role in maintaining genomic stability, regulating cellular development, and responding to oxidative stress. Its dysregulation has been implicated in various diseases, including Fanconi anemia, cancer, and neurological disorders. Further research is necessary to fully elucidate the complex functions of FANCD2 and its implications for human health and disease.

Genular Protein ID: 854674707

Symbol: FACD2_HUMAN

Name: Fanconi anemia group D2 protein

UniProtKB Accession Codes:

Q9BXW9 Q2LA86 Q69YP9 Q6PJN7 Q9BQ06 Q9H9T9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 66 EMDB 14 Ensembl 4 ExpressionAtlas 1 GO 21 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11239453

Title: Positional cloning of a novel Fanconi anemia gene, FANCD2.

PubMed ID: 11239453

DOI: 10.1016/s1097-2765(01)00172-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11239454

Title: Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

PubMed ID: 11239454

DOI: 10.1016/s1097-2765(01)00173-3

PubMed ID: 12239151

Title: S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.

PubMed ID: 12239151

DOI: 10.1182/blood-2002-01-0278

PubMed ID: 12086603

Title: Convergence of the Fanconi anemia and ataxia telangiectasia signaling pathways.

PubMed ID: 12086603

DOI: 10.1016/s0092-8674(02)00747-x

PubMed ID: 12093742

Title: FANCE: the link between Fanconi anaemia complex assembly and activity.

PubMed ID: 12093742

DOI: 10.1093/emboj/cdf355

PubMed ID: 12649160

Title: Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems.

PubMed ID: 12649160

DOI: 10.1182/blood-2002-11-3517

PubMed ID: 12874027

Title: Menin associates with FANCD2, a protein involved in repair of DNA damage.

PubMed ID: 12874027

PubMed ID: 14517836

Title: FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia.

PubMed ID: 14517836

DOI: 10.1002/path.1450

PubMed ID: 12973351

Title: A novel ubiquitin ligase is deficient in Fanconi anemia.

PubMed ID: 12973351

DOI: 10.1038/ng1241

PubMed ID: 14988723

Title: The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways.

PubMed ID: 14988723

DOI: 10.1038/sj.emboj.7600113

PubMed ID: 15257300

Title: BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.

PubMed ID: 15257300

DOI: 10.1038/sj.emboj.7600277

PubMed ID: 15314022

Title: ATR couples FANCD2 monoubiquitination to the DNA-damage response.

PubMed ID: 15314022

DOI: 10.1101/gad.1196104

PubMed ID: 15115758

Title: Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.

PubMed ID: 15115758

DOI: 10.1093/hmg/ddh135

PubMed ID: 15377654

Title: A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.

PubMed ID: 15377654

DOI: 10.1074/jbc.m407160200

PubMed ID: 15199141

Title: Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.

PubMed ID: 15199141

DOI: 10.1128/mcb.24.13.5850-5862.2004

PubMed ID: 15502827

Title: X-linked inheritance of Fanconi anemia complementation group B.

PubMed ID: 15502827

DOI: 10.1038/ng1458

PubMed ID: 15454491

Title: Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.

PubMed ID: 15454491

DOI: 10.1182/blood-2003-11-3997

PubMed ID: 15661754

Title: The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.

PubMed ID: 15661754

DOI: 10.1093/hmg/ddi065

PubMed ID: 15671039

Title: FANCD2 functions independently of BRCA2 and RAD51 associated homologous recombination in response to DNA damage.

PubMed ID: 15671039

DOI: 10.1074/jbc.m414669200

PubMed ID: 15694335

Title: The deubiquitinating enzyme USP1 regulates the Fanconi Anemia pathway.

PubMed ID: 15694335

DOI: 10.1016/j.molcel.2005.01.008

PubMed ID: 16116422

Title: A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

PubMed ID: 16116422

DOI: 10.1038/ng1626

PubMed ID: 15650050

Title: Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.

PubMed ID: 15650050

DOI: 10.1073/pnas.0407796102

PubMed ID: 16916645

Title: UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.

PubMed ID: 16916645

DOI: 10.1016/j.molcel.2006.06.024

PubMed ID: 17412408

Title: Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

PubMed ID: 17412408

DOI: 10.1016/j.cell.2007.03.009

PubMed ID: 17460694

Title: FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.

PubMed ID: 17460694

DOI: 10.1038/nsmb1252

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19111657

Title: Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.

PubMed ID: 19111657

DOI: 10.1016/j.molcel.2008.12.003

PubMed ID: 18212739

Title: FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.

PubMed ID: 18212739

DOI: 10.1038/sj.onc.1211034

PubMed ID: 18469862

Title: Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.

PubMed ID: 18469862

DOI: 10.1038/onc.2008.139

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19465922

Title: Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

PubMed ID: 19465922

DOI: 10.1038/ncb1882

PubMed ID: 19465921

Title: The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities.

PubMed ID: 19465921

DOI: 10.1038/ncb1883

PubMed ID: 20603015

Title: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.

PubMed ID: 20603015

DOI: 10.1016/j.cell.2010.06.021

PubMed ID: 20603016

Title: Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

PubMed ID: 20603016

DOI: 10.1016/j.cell.2010.06.022

PubMed ID: 20603073

Title: A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

PubMed ID: 20603073

DOI: 10.1016/j.molcel.2010.06.023

PubMed ID: 19995904

Title: DNA polymerase POLN participates in cross-link repair and homologous recombination.

PubMed ID: 19995904

DOI: 10.1128/mcb.01124-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30335751

Title: Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.

PubMed ID: 30335751

DOI: 10.1371/journal.pgen.1007643

Sequence Information:

  • Length: 1451
  • Mass: 164128
  • Checksum: BF931980ADA67405
  • Sequence:
    • MVSKRRLSKS EDKESLTEDA SKTRKQPLSK KTKKSHIANE VEENDSIFVK LLKISGIILK 
TGESQNQLAV DQIAFQKKLF QTLRRHPSYP KIIEEFVSGL ESYIEDEDSF RNCLLSCERL 
QDEEASMGAS YSKSLIKLLL GIDILQPAII KTLFEKLPEY FFENKNSDEI NIPRLIVSQL 
KWLDRVVDGK DLTTKIMQLI SIAPENLQHD IITSLPEILG DSQHADVGKE LSDLLIENTS 
LTVPILDVLS SLRLDPNFLL KVRQLVMDKL SSIRLEDLPV IIKFILHSVT AMDTLEVISE 
LREKLDLQHC VLPSRLQASQ VKLKSKGRAS SSGNQESSGQ SCIILLFDVI KSAIRYEKTI 
SEAWIKAIEN TASVSEHKVF DLVMLFIIYS TNTQTKKYID RVLRNKIRSG CIQEQLLQST 
FSVHYLVLKD MCSSILSLAQ SLLHSLDQSI ISFGSLLYKY AFKFFDTYCQ QEVVGALVTH 
ICSGNEAEVD TALDVLLELV VLNPSAMMMN AVFVKGILDY LDNISPQQIR KLFYVLSTLA 
FSKQNEASSH IQDDMHLVIR KQLSSTVFKY KLIGIIGAVT MAGIMAADRS ESPSLTQERA 
NLSDEQCTQV TSLLQLVHSC SEQSPQASAL YYDEFANLIQ HEKLDPKALE WVGHTICNDF 
QDAFVVDSCV VPEGDFPFPV KALYGLEEYD TQDGIAINLL PLLFSQDFAK DGGPVTSQES 
GQKLVSPLCL APYFRLLRLC VERQHNGNLE EIDGLLDCPI FLTDLEPGEK LESMSAKERS 
FMCSLIFLTL NWFREIVNAF CQETSPEMKG KVLTRLKHIV ELQIILEKYL AVTPDYVPPL 
GNFDVETLDI TPHTVTAISA KIRKKGKIER KQKTDGSKTS SSDTLSEEKN SECDPTPSHR 
GQLNKEFTGK EEKTSLLLHN SHAFFRELDI EVFSILHCGL VTKFILDTEM HTEATEVVQL 
GPPELLFLLE DLSQKLESML TPPIARRVPF LKNKGSRNIG FSHLQQRSAQ EIVHCVFQLL 
TPMCNHLENI HNYFQCLAAE NHGVVDGPGV KVQEYHIMSS CYQRLLQIFH GLFAWSGFSQ 
PENQNLLYSA LHVLSSRLKQ GEHSQPLEEL LSQSVHYLQN FHQSIPSFQC ALYLIRLLMV 
ILEKSTASAQ NKEKIASLAR QFLCRVWPSG DKEKSNISND QLHALLCIYL EHTESILKAI 
EEIAGVGVPE LINSPKDASS STFPTLTRHT FVVFFRVMMA ELEKTVKKIE PGTAADSQQI 
HEEKLLYWNM AVRDFSILIN LIKVFDSHPV LHVCLKYGRL FVEAFLKQCM PLLDFSFRKH 
REDVLSLLET FQLDTRLLHH LCGHSKIHQD TRLTQHVPLL KKTLELLVCR VKAMLTLNNC 
REAFWLGNLK NRDLQGEEIK SQNSQESTAD ESEDDMSSQA SKSKATEDGE EDEVSAGEKE 
QDSDESYDDS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.