Details for: FAU

Gene ID: 2197

Symbol: FAU

Ensembl ID: ENSG00000149806

Description: FAU ubiquitin like and ribosomal protein S30 fusion

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1416.8869
    Cell Significance Index: -220.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 846.2275
    Cell Significance Index: -214.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 707.5900
    Cell Significance Index: -291.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 646.7210
    Cell Significance Index: -262.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 588.3005
    Cell Significance Index: -277.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 566.7542
    Cell Significance Index: -291.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 416.0369
    Cell Significance Index: -279.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 280.2273
    Cell Significance Index: -267.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 208.1097
    Cell Significance Index: -256.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 92.3081
    Cell Significance Index: -283.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 72.2178
    Cell Significance Index: -284.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 47.3597
    Cell Significance Index: -126.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 11.9215
    Cell Significance Index: 220.3400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 11.7385
    Cell Significance Index: 124.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 11.4993
    Cell Significance Index: 307.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.1041
    Cell Significance Index: 521.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 9.6366
    Cell Significance Index: 276.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.4900
    Cell Significance Index: 96.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.8851
    Cell Significance Index: 1082.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.7753
    Cell Significance Index: 137.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.5709
    Cell Significance Index: 978.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.3188
    Cell Significance Index: 863.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.2471
    Cell Significance Index: 891.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.2326
    Cell Significance Index: 190.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.0403
    Cell Significance Index: 1269.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.5485
    Cell Significance Index: 2895.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.4964
    Cell Significance Index: 484.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.2060
    Cell Significance Index: 143.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.0854
    Cell Significance Index: 3323.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 5.9866
    Cell Significance Index: 423.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.9673
    Cell Significance Index: 278.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.7990
    Cell Significance Index: 374.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.6754
    Cell Significance Index: 166.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.6703
    Cell Significance Index: 154.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.1524
    Cell Significance Index: 65.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.9111
    Cell Significance Index: 629.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.0625
    Cell Significance Index: 693.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.6097
    Cell Significance Index: 125.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.5186
    Cell Significance Index: 184.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.0655
    Cell Significance Index: 159.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4135
    Cell Significance Index: 22.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1886
    Cell Significance Index: 45.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9711
    Cell Significance Index: 194.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.8932
    Cell Significance Index: 1433.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8014
    Cell Significance Index: 48.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2837
    Cell Significance Index: 7.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1009
    Cell Significance Index: 49.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.0145
    Cell Significance Index: 743.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7562
    Cell Significance Index: 39.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6961
    Cell Significance Index: 132.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6495
    Cell Significance Index: 586.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3002
    Cell Significance Index: 59.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0380
    Cell Significance Index: -3.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0393
    Cell Significance Index: -29.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0791
    Cell Significance Index: -148.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1726
    Cell Significance Index: -318.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1811
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1900
    Cell Significance Index: -118.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2093
    Cell Significance Index: -322.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2572
    Cell Significance Index: -349.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3395
    Cell Significance Index: -68.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3686
    Cell Significance Index: -234.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3733
    Cell Significance Index: -210.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.4042
    Cell Significance Index: -279.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.4118
    Cell Significance Index: -147.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5504
    Cell Significance Index: -43.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5546
    Cell Significance Index: -34.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5755
    Cell Significance Index: -261.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5835
    Cell Significance Index: -167.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6926
    Cell Significance Index: -19.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6981
    Cell Significance Index: -147.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1849
    Cell Significance Index: -74.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4592
    Cell Significance Index: -167.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.5200
    Cell Significance Index: -38.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.6153
    Cell Significance Index: -184.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.7167
    Cell Significance Index: -200.0600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.7260
    Cell Significance Index: -10.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.7635
    Cell Significance Index: -256.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0889
    Cell Significance Index: -36.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.1533
    Cell Significance Index: -120.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.1681
    Cell Significance Index: -69.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.3172
    Cell Significance Index: -38.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.5569
    Cell Significance Index: -63.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.7308
    Cell Significance Index: -284.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9684
    Cell Significance Index: -64.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.1216
    Cell Significance Index: -18.8600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -3.1258
    Cell Significance Index: -26.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.2274
    Cell Significance Index: -48.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.7532
    Cell Significance Index: -288.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -3.7797
    Cell Significance Index: -41.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.9219
    Cell Significance Index: -235.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.9767
    Cell Significance Index: -267.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.5288
    Cell Significance Index: -61.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.5708
    Cell Significance Index: -280.2400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -5.2516
    Cell Significance Index: -41.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -5.4268
    Cell Significance Index: -93.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.9176
    Cell Significance Index: -174.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.9239
    Cell Significance Index: -262.0300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.2591
    Cell Significance Index: -34.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.6411
    Cell Significance Index: -177.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin-like protein**: The RS30_HUMAN protein is a ubiquitin-like protein that plays a crucial role in protein degradation and regulation of protein function. 2. **Ribosomal protein S30 fusion**: The FAU gene encodes for a fusion protein that combines the ubiquitin-like protein with the ribosomal protein S30, which is a component of the 40S small ribosomal subunit. 3. **Eukaryotic translation initiation**: The FAU gene is involved in the regulation of eukaryotic translation initiation, a process that is essential for protein synthesis. 4. **Immune response**: The FAU gene has been implicated in the regulation of immune responses, including the activation of the antimicrobial humoral response mediated by antimicrobial peptides. **Pathways and Functions:** The FAU gene is involved in several cellular pathways, including: 1. **Activation of mRNA upon binding of the cap-binding complex and eIFs**: The FAU protein plays a crucial role in the activation of mRNA upon binding of the cap-binding complex and eIFs, which is a key step in eukaryotic translation initiation. 2. **Regulation of protein binding**: The FAU protein regulates protein binding, including the binding of proteins to the 40S small ribosomal subunit. 3. **Translation initiation complex formation**: The FAU protein is involved in the formation of the translation initiation complex, which is a complex of proteins that is required for protein synthesis. 4. **Antimicrobial humoral response**: The FAU gene has been implicated in the regulation of the antimicrobial humoral response mediated by antimicrobial peptides. **Clinical Significance:** The FAU gene has been implicated in several diseases, including: 1. **Influenza infection**: The FAU gene has been shown to play a crucial role in the regulation of viral RNA transcription and replication. 2. **SARS-CoV-1 and SARS-CoV-2 infections**: The FAU gene has been implicated in the modulation of host translation machinery by SARS-CoV-1 and SARS-CoV-2. 3. **Cancer**: The FAU gene has been shown to be overexpressed in malignant cells, suggesting its potential role in cancer development and progression. 4. **Immune disorders**: The FAU gene has been implicated in the regulation of immune responses, including the activation of the antimicrobial humoral response mediated by antimicrobial peptides. In conclusion, the FAU gene plays a multifaceted role in eukaryotic translation initiation and immune response, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms by which the FAU gene regulates eukaryotic translation initiation and immune response.

Genular Protein ID: 4005886140

Symbol: RS30_HUMAN

Name: Ubiquitin-like protein FUBI

UniProtKB Accession Codes:

P62861 P35544 Q05472 Q95261 Q9H5V4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 76 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 94 PDBsum 94 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 Pumba 1 Reactome 18 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1326960

Title: Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein.

PubMed ID: 1326960

DOI: 10.1016/0006-291x(92)91286-y

PubMed ID: 8395683

Title: fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus.

PubMed ID: 8395683

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21550398

Title: Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G.

PubMed ID: 21550398

DOI: 10.1016/j.bbadis.2011.04.009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34318747

Title: Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36.

PubMed ID: 34318747

DOI: 10.7554/elife.70560

Sequence Information:

  • Length: 133
  • Mass: 14390
  • Checksum: 5D2F81F2A355B559
  • Sequence:
    • MQLFVRAQEL HTFEVTGQET VAQIKAHVAS LEGIAPEDQV VLLAGAPLED EATLGQCGVE 
ALTTLEVAGR MLGGKVHGSL ARAGKVRGQT PKVAKQEKKK KKTGRAKRRM QYNRRFVNVV 
PTFGKKKGPN ANS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.