Gene FAU - ENSG00000149806 | NCBI Gene ID: 2197

Details for: FAU

Gene ID: 2197

Symbol: FAU

Ensembl ID: ENSG00000149806

Description: FAU ubiquitin like and ribosomal protein S30 fusion

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Antibacterial humoral response
(GO:0019731)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular space
(GO:0005615)
Innate immune response in mucosa
(GO:0002227)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.02
Marker Score: 29559
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.72
Marker Score: 11986
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.69
Marker Score: 4451
Cell Name: malignant cell (CL0001064)
Fold Change: 5.61
Marker Score: 75434
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.34
Marker Score: 3871
Cell Name: mature T cell (CL0002419)
Fold Change: 5.3
Marker Score: 52476
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.28
Marker Score: 15420
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.24
Marker Score: 8063.5
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.23
Marker Score: 2687
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.15
Marker Score: 1897
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.1
Marker Score: 8754.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.04
Marker Score: 6570
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.96
Marker Score: 168653
Cell Name: naive T cell (CL0000898)
Fold Change: 4.93
Marker Score: 3172.5
Cell Name: naive B cell (CL0000788)
Fold Change: 4.92
Marker Score: 4394
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.86
Marker Score: 15344
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.75
Marker Score: 251136
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.74
Marker Score: 4038.5
Cell Name: theca cell (CL0000503)
Fold Change: 4.69
Marker Score: 3363.5
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.63
Marker Score: 2391
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.6
Marker Score: 257095
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.57
Marker Score: 2439
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.51
Marker Score: 11467
Cell Name: memory T cell (CL0000813)
Fold Change: 4.49
Marker Score: 1929
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.44
Marker Score: 1059.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.43
Marker Score: 23303
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.43
Marker Score: 4918
Cell Name: blood cell (CL0000081)
Fold Change: 4.39
Marker Score: 51068
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.38
Marker Score: 26643.5
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.38
Marker Score: 57801
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.37
Marker Score: 1420
Cell Name: granulocyte (CL0000094)
Fold Change: 4.35
Marker Score: 1952
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.35
Marker Score: 2646
Cell Name: acinar cell (CL0000622)
Fold Change: 4.32
Marker Score: 3050
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.28
Marker Score: 11814
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.23
Marker Score: 11868
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.23
Marker Score: 11332.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.22
Marker Score: 3004
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.21
Marker Score: 4071.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.16
Marker Score: 10172
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.15
Marker Score: 2433
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.09
Marker Score: 6024
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.09
Marker Score: 17524.5
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.08
Marker Score: 9953
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.08
Marker Score: 3198
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.07
Marker Score: 3474
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.07
Marker Score: 30297
Cell Name: supporting cell (CL0000630)
Fold Change: 4.04
Marker Score: 7587
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.01
Marker Score: 4286.5
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4
Marker Score: 3943
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 4
Marker Score: 1053
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 4
Marker Score: 4937
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.99
Marker Score: 3579
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.98
Marker Score: 14125
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.95
Marker Score: 918.5
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.94
Marker Score: 4241
Cell Name: club cell (CL0000158)
Fold Change: 3.92
Marker Score: 4576
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.9
Marker Score: 25434
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.9
Marker Score: 3196
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.9
Marker Score: 3681
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.9
Marker Score: 24878
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.89
Marker Score: 892.5
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.88
Marker Score: 8847
Cell Name: neutrophil (CL0000775)
Fold Change: 3.88
Marker Score: 2364
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.87
Marker Score: 3398
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.85
Marker Score: 3618
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.84
Marker Score: 4643
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.82
Marker Score: 3372
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.82
Marker Score: 1747
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.82
Marker Score: 2572
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.82
Marker Score: 6820.5
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.79
Marker Score: 1068.5
Cell Name: reticular cell (CL0000432)
Fold Change: 3.79
Marker Score: 1384
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.79
Marker Score: 3368.5
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.79
Marker Score: 1704
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.78
Marker Score: 3137
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.77
Marker Score: 9503
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.74
Marker Score: 3222
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.74
Marker Score: 2152.5
Cell Name: memory B cell (CL0000787)
Fold Change: 3.74
Marker Score: 2828
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.74
Marker Score: 4275.5
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.73
Marker Score: 4129
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 3.73
Marker Score: 1861
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.72
Marker Score: 3777.5
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 3.72
Marker Score: 2807.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.71
Marker Score: 2174
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.71
Marker Score: 1920
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.7
Marker Score: 1051.5
Cell Name: immature B cell (CL0000816)
Fold Change: 3.7
Marker Score: 2452
Cell Name: stromal cell (CL0000499)
Fold Change: 3.7
Marker Score: 4336.5
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.7
Marker Score: 3301
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.7
Marker Score: 5357
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.7
Marker Score: 24065.5
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.66
Marker Score: 1203
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 3.65
Marker Score: 2058.5
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.65
Marker Score: 967
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.64
Marker Score: 5796
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.64
Marker Score: 1038
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.63
Marker Score: 4370
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.63
Marker Score: 5949

Hover over a box to see details here...

**Key characteristics:** - The FAU gene is located on chromosome 17q21.1. - It is a large gene with a predicted protein of 1,550 amino acids. - The protein contains a ubiquitin-like domain and a ribosomal protein S30 domain. **Pathways and functions:** - The FAU gene is involved in the regulation of protein translation. - It is a key regulator of translation initiation, termination, and elongation. - It also plays a role in the processing of ribosomal RNA (rRNA) and messenger RNA (mRNA). **Clinical significance:** - Mutations in the FAU gene have been linked to several human diseases, including breast cancer, lung cancer, and heart disease. - These mutations can lead to the activation of oncogenes or the inhibition of tumor suppressor genes, resulting in uncontrolled cell growth and cancer development. **Conclusion:** The FAU gene is a critical regulator of protein translation that is involved in a variety of cellular processes, including development, differentiation, and cancer. Mutations in the FAU gene have significant clinical implications, as they can lead to the development of human diseases characterized by abnormal protein translation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin-like protein FUBI

Genular Protein ID: 4005886140

Symbol: RS30_HUMAN

Name: Ubiquitin-like protein FUBI

UniProtKB Accession Codes:

P62861 P35544 Q05472 Q95261 Q9H5V4

Database IDs:

Citations:

PubMed ID: 1326960

Title: Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein.

PubMed ID: 1326960

DOI: 10.1016/0006-291x(92)91286-y

PubMed ID: 8395683

Title: fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus.

PubMed ID: 8395683

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21550398

Title: Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G.

PubMed ID: 21550398

DOI: 10.1016/j.bbadis.2011.04.009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34318747

Title: Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36.

PubMed ID: 34318747

DOI: 10.7554/elife.70560

Sequence Information:

Length: 133
Mass: 14390
Checksum: 5D2F81F2A355B559
Sequence:

MQLFVRAQEL HTFEVTGQET VAQIKAHVAS LEGIAPEDQV VLLAGAPLED EATLGQCGVE 
ALTTLEVAGR MLGGKVHGSL ARAGKVRGQT PKVAKQEKKK KKTGRAKRRM QYNRRFVNVV 
PTFGKKKGPN ANS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FAU

Associated with

Cells (max top 100)

Other Information

Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein. PubMed ID: 1326960

fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. PubMed ID: 8395683

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G. PubMed ID: 21550398

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36. PubMed ID: 34318747