Details for: FKBP4

Gene ID: 2288

Symbol: FKBP4

Ensembl ID: ENSG00000004478

Description: FKBP prolyl isomerase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.27
    Marker Score: 3413.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.38
    Marker Score: 4828.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2
    Marker Score: 5374
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.19
    Marker Score: 2648
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.06
    Marker Score: 7636
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.05
    Marker Score: 2944
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.04
    Marker Score: 69446
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.97
    Marker Score: 1860
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.95
    Marker Score: 9599
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.94
    Marker Score: 7616
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.91
    Marker Score: 1629
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.88
    Marker Score: 1272
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.81
    Marker Score: 6984
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.8
    Marker Score: 14065
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.77
    Marker Score: 3131
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.76
    Marker Score: 1862
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.75
    Marker Score: 1870
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.75
    Marker Score: 1166
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.72
    Marker Score: 14818
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.71
    Marker Score: 2427
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.7
    Marker Score: 2968
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.7
    Marker Score: 3549
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.68
    Marker Score: 2476
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.66
    Marker Score: 2082.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.65
    Marker Score: 688
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.63
    Marker Score: 471
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.63
    Marker Score: 6682
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.63
    Marker Score: 1718
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.61
    Marker Score: 3813
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.59
    Marker Score: 4334
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.58
    Marker Score: 1247
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.56
    Marker Score: 366
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.56
    Marker Score: 554
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.53
    Marker Score: 1542
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.53
    Marker Score: 52933
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.52
    Marker Score: 866
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5
    Marker Score: 3421
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.48
    Marker Score: 1239
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.47
    Marker Score: 4613
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.46
    Marker Score: 1093.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.44
    Marker Score: 839
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.43
    Marker Score: 3841.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.43
    Marker Score: 753
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.42
    Marker Score: 3582
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.42
    Marker Score: 351
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.41
    Marker Score: 2389
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.4
    Marker Score: 1569
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.38
    Marker Score: 1489
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.37
    Marker Score: 268
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.35
    Marker Score: 975
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.34
    Marker Score: 454
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.32
    Marker Score: 2186
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.31
    Marker Score: 13214
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.3
    Marker Score: 2002
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.3
    Marker Score: 544
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3
    Marker Score: 8451
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.27
    Marker Score: 2077.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.27
    Marker Score: 443
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.26
    Marker Score: 471
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.26
    Marker Score: 404
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.25
    Marker Score: 623
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.25
    Marker Score: 1297
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.24
    Marker Score: 714
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.24
    Marker Score: 1312
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.23
    Marker Score: 307
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.23
    Marker Score: 1309
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.23
    Marker Score: 1487
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.22
    Marker Score: 307
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.22
    Marker Score: 7405
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.2
    Marker Score: 467
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.2
    Marker Score: 1693
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.19
    Marker Score: 303
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.18
    Marker Score: 1196
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.17
    Marker Score: 538
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.17
    Marker Score: 348
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.15
    Marker Score: 1226
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.15
    Marker Score: 561
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.14
    Marker Score: 384
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.14
    Marker Score: 275
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.14
    Marker Score: 562
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.12
    Marker Score: 5389
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.12
    Marker Score: 748
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.11
    Marker Score: 754
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.1
    Marker Score: 515
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.1
    Marker Score: 566
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.09
    Marker Score: 532
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.08
    Marker Score: 721
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.08
    Marker Score: 2277
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.08
    Marker Score: 907
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.07
    Marker Score: 1010
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.07
    Marker Score: 674
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.07
    Marker Score: 401
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.06
    Marker Score: 3774
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.06
    Marker Score: 7883
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.06
    Marker Score: 499.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.06
    Marker Score: 335
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.06
    Marker Score: 11886
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.05
    Marker Score: 269
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.05
    Marker Score: 626
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.05
    Marker Score: 1399

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Other Information

**Key characteristics:** * It is a secreted protein that is expressed in a variety of cell types. * It is a key regulator of the heat shock response. * It is also involved in the regulation of estrogen-dependent gene expression. * It is a potential therapeutic target for cancer. **Pathways and functions:** * FKBP4 is involved in the attenuation phase of the heat shock response. * It is a key regulator of the unfolded protein response (UPR). * It is also involved in the regulation of the estrogen-dependent gene expression. * It is a potential therapeutic target for cancer. **Clinical significance:** FKBP4 is a potential therapeutic target for several diseases, including cancer. It is a key regulator of the heat shock response, and its inhibition can protect cells from damage caused by heat stress. This makes it a potential target for cancer treatment. FKBP4 is also involved in the regulation of estrogen-dependent gene expression, which makes it a potential target for diseases that are caused by estrogen. **Additional information:** * FKBP4 is a member of the FKBP family of prolyl isomerases. * It is a highly conserved protein that is found in all vertebrates. * It is a well-documented target for cancer therapy.

Genular Protein ID: 3660003840

Symbol: FKBP4_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP4

UniProtKB Accession Codes:

Q02790 D3DUQ1 Q9UCP1 Q9UCV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 11 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1279700

Title: Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

PubMed ID: 1279700

DOI: 10.1073/pnas.89.22.10974

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1376003

Title: Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex.

PubMed ID: 1376003

DOI: 10.1126/science.1376003

PubMed ID: 2378870

Title: The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins.

PubMed ID: 2378870

DOI: 10.1021/bi00473a021

PubMed ID: 1371107

Title: The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

PubMed ID: 1371107

DOI: 10.1016/s0021-9258(19)50664-0

PubMed ID: 1383226

Title: Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex.

PubMed ID: 1383226

DOI: 10.1016/s0021-9258(19)36676-1

PubMed ID: 9392437

Title: The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.

PubMed ID: 9392437

PubMed ID: 11583998

Title: Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.

PubMed ID: 11583998

DOI: 10.1074/jbc.m105931200

PubMed ID: 12604780

Title: The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis.

PubMed ID: 12604780

DOI: 10.1073/pnas.0438007100

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19945390

Title: Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening.

PubMed ID: 19945390

DOI: 10.1016/j.neuron.2009.09.025

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20188096

Title: S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.

PubMed ID: 20188096

DOI: 10.1016/j.febslet.2010.02.055

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21730050

Title: The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.

PubMed ID: 21730050

DOI: 10.1074/jbc.m111.256610

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 12499534

Title: Structure of the N-terminal domain of human FKBP52.

PubMed ID: 12499534

DOI: 10.1107/s0907444902017523

PubMed ID: 15159550

Title: 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.

PubMed ID: 15159550

DOI: 10.1073/pnas.0305969101

Sequence Information:

  • Length: 459
  • Mass: 51805
  • Checksum: 6A498105418D9435
  • Sequence:
    • MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW 
LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP 
KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD 
KLFDQRELRF EIGEGENLDL PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN 
AELKYELHLK SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKYKQAL LQYKKIVSWL 
EYESSFSNEE AQKAQALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG 
EAHLAVNDFE LARADFQKVL QLYPNNKAAK TQLAVCQQRI RRQLAREKKL YANMFERLAE 
EENKAKAEAS SGDHPTDTEM KEEQKSNTAG SQSQVETEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.