Details for: FKBP4

Gene ID: 2288

Symbol: FKBP4

Ensembl ID: ENSG00000004478

Description: FKBP prolyl isomerase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.8583
    Cell Significance Index: -36.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.9566
    Cell Significance Index: -36.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 114.8447
    Cell Significance Index: -47.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.5614
    Cell Significance Index: -39.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.2205
    Cell Significance Index: -45.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.4527
    Cell Significance Index: -44.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.3286
    Cell Significance Index: -45.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.8333
    Cell Significance Index: -39.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.0621
    Cell Significance Index: -43.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5047
    Cell Significance Index: -41.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4393
    Cell Significance Index: -45.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5790
    Cell Significance Index: -26.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.6232
    Cell Significance Index: 115.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2624
    Cell Significance Index: -7.1400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.2486
    Cell Significance Index: 25.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1407
    Cell Significance Index: 217.2000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.0500
    Cell Significance Index: 18.7700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.5369
    Cell Significance Index: 20.2600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.3731
    Cell Significance Index: 5.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0500
    Cell Significance Index: 55.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8625
    Cell Significance Index: 53.3900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.8621
    Cell Significance Index: 14.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6814
    Cell Significance Index: 182.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6665
    Cell Significance Index: 78.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6096
    Cell Significance Index: 84.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6066
    Cell Significance Index: 14.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4782
    Cell Significance Index: 16.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4781
    Cell Significance Index: 110.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4265
    Cell Significance Index: 232.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2615
    Cell Significance Index: 65.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2096
    Cell Significance Index: 156.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0321
    Cell Significance Index: 563.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0171
    Cell Significance Index: 47.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8933
    Cell Significance Index: 23.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8383
    Cell Significance Index: 103.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8261
    Cell Significance Index: 148.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8209
    Cell Significance Index: 37.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8103
    Cell Significance Index: 16.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7814
    Cell Significance Index: 107.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7075
    Cell Significance Index: 44.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6131
    Cell Significance Index: 43.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4853
    Cell Significance Index: 48.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4730
    Cell Significance Index: 94.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4617
    Cell Significance Index: 204.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4537
    Cell Significance Index: 15.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4524
    Cell Significance Index: 57.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4311
    Cell Significance Index: 11.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4017
    Cell Significance Index: 11.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3314
    Cell Significance Index: 3.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3163
    Cell Significance Index: 62.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2856
    Cell Significance Index: 48.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2820
    Cell Significance Index: 7.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2042
    Cell Significance Index: 3.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1887
    Cell Significance Index: 35.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1821
    Cell Significance Index: 65.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1151
    Cell Significance Index: 79.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0874
    Cell Significance Index: 3.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0658
    Cell Significance Index: 7.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0555
    Cell Significance Index: 0.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0343
    Cell Significance Index: 4.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0305
    Cell Significance Index: 22.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0247
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0075
    Cell Significance Index: -14.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0107
    Cell Significance Index: -6.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0156
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0237
    Cell Significance Index: -17.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0237
    Cell Significance Index: -43.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0280
    Cell Significance Index: -43.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0328
    Cell Significance Index: -44.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0404
    Cell Significance Index: -4.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0469
    Cell Significance Index: -42.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0470
    Cell Significance Index: -1.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0495
    Cell Significance Index: -31.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0518
    Cell Significance Index: -29.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0532
    Cell Significance Index: -0.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0870
    Cell Significance Index: -39.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0987
    Cell Significance Index: -20.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1179
    Cell Significance Index: -33.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1347
    Cell Significance Index: -8.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1367
    Cell Significance Index: -15.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1498
    Cell Significance Index: -3.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1599
    Cell Significance Index: -2.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2170
    Cell Significance Index: -2.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2314
    Cell Significance Index: -15.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2456
    Cell Significance Index: -5.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2664
    Cell Significance Index: -38.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2891
    Cell Significance Index: -7.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2985
    Cell Significance Index: -9.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3083
    Cell Significance Index: -35.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3265
    Cell Significance Index: -25.8600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3787
    Cell Significance Index: -4.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4091
    Cell Significance Index: -26.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4273
    Cell Significance Index: -44.4900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4915
    Cell Significance Index: -4.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5132
    Cell Significance Index: -28.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5269
    Cell Significance Index: -40.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5313
    Cell Significance Index: -15.6100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5706
    Cell Significance Index: -3.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6669
    Cell Significance Index: -17.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FKBP4 exhibits several key characteristics that distinguish it from other proteins: 1. **Peptidyl-prolyl cis-trans isomerase activity**: FKBP4 possesses the ability to catalyze the cis-trans isomerization of peptide bonds, which is essential for protein folding and stability. 2. **FK506 binding**: FKBP4 binds to FK506 (tacrolimus) and rapamycin, which are immunosuppressive compounds used to prevent organ rejection in transplant patients. 3. **Heat shock protein binding**: FKBP4 interacts with heat shock proteins (HSPs), which are molecular chaperones that help maintain protein homeostasis under stress conditions. 4. **Chaperone-mediated protein folding**: FKBP4 acts as a chaperone to facilitate the folding of proteins into their native conformation. **Pathways and Functions** FKBP4 is involved in various cellular pathways, including: 1. **Androgen receptor signaling pathway**: FKBP4 interacts with the androgen receptor, which is crucial for male sex differentiation and prostate gland development. 2. **Heat shock response**: FKBP4 regulates the heat shock response by interacting with HSF1, a transcription factor that responds to heat stress. 3. **Cellular responses to stimuli**: FKBP4 is involved in cellular responses to various stimuli, including heat shock, oxidative stress, and hypoxia. 4. **Protein folding and degradation**: FKBP4 plays a role in protein folding and degradation, which is essential for maintaining protein homeostasis. **Clinical Significance** FKBP4 has significant clinical implications, particularly in the context of: 1. **Transplant rejection**: FKBP4 is a target for immunosuppressive therapy, as it binds to FK506 (tacrolimus) and rapamycin. 2. **Prostate cancer**: FKBP4 is overexpressed in prostate cancer cells, which may contribute to the development and progression of the disease. 3. **Neurological disorders**: FKBP4 is involved in neuronal cell development and function, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: FKBP4 has been implicated in the regulation of the SARS-CoV infection pathway, suggesting its potential as a target for antiviral therapy. In conclusion, FKBP4 is a multifunctional protein that plays a crucial role in protein folding, cell signaling, and various physiological processes. Its clinical significance is reflected in its involvement in transplant rejection, prostate cancer, neurological disorders, and infectious diseases. Further research is necessary to fully elucidate the mechanisms by which FKBP4 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 3660003840

Symbol: FKBP4_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP4

UniProtKB Accession Codes:

Q02790 D3DUQ1 Q9UCP1 Q9UCV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 6 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1279700

Title: Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

PubMed ID: 1279700

DOI: 10.1073/pnas.89.22.10974

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1376003

Title: Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex.

PubMed ID: 1376003

DOI: 10.1126/science.1376003

PubMed ID: 2378870

Title: The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins.

PubMed ID: 2378870

DOI: 10.1021/bi00473a021

PubMed ID: 1371107

Title: The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

PubMed ID: 1371107

DOI: 10.1016/s0021-9258(19)50664-0

PubMed ID: 1383226

Title: Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex.

PubMed ID: 1383226

DOI: 10.1016/s0021-9258(19)36676-1

PubMed ID: 9392437

Title: The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.

PubMed ID: 9392437

PubMed ID: 11583998

Title: Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.

PubMed ID: 11583998

DOI: 10.1074/jbc.m105931200

PubMed ID: 12604780

Title: The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis.

PubMed ID: 12604780

DOI: 10.1073/pnas.0438007100

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19945390

Title: Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening.

PubMed ID: 19945390

DOI: 10.1016/j.neuron.2009.09.025

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20188096

Title: S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.

PubMed ID: 20188096

DOI: 10.1016/j.febslet.2010.02.055

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21730050

Title: The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.

PubMed ID: 21730050

DOI: 10.1074/jbc.m111.256610

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 12499534

Title: Structure of the N-terminal domain of human FKBP52.

PubMed ID: 12499534

DOI: 10.1107/s0907444902017523

PubMed ID: 15159550

Title: 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.

PubMed ID: 15159550

DOI: 10.1073/pnas.0305969101

Sequence Information:

  • Length: 459
  • Mass: 51805
  • Checksum: 6A498105418D9435
  • Sequence:
    • MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW 
LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP 
KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD 
KLFDQRELRF EIGEGENLDL PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN 
AELKYELHLK SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKYKQAL LQYKKIVSWL 
EYESSFSNEE AQKAQALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG 
EAHLAVNDFE LARADFQKVL QLYPNNKAAK TQLAVCQQRI RRQLAREKKL YANMFERLAE 
EENKAKAEAS SGDHPTDTEM KEEQKSNTAG SQSQVETEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.