Details for: FKBP5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 499.0188
Cell Significance Index: -77.6200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 287.7268
Cell Significance Index: -72.9800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 172.7161
Cell Significance Index: -71.1500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 164.3217
Cell Significance Index: -77.5800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 158.8403
Cell Significance Index: -64.5300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 142.0142
Cell Significance Index: -73.0500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 115.6743
Cell Significance Index: -77.6200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 65.4200
Cell Significance Index: -80.6600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 31.6593
Cell Significance Index: -97.2400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 27.7394
Cell Significance Index: -74.3100 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 26.2932
Cell Significance Index: 178.1500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 25.4868
Cell Significance Index: -55.7800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.6333
Cell Significance Index: -81.4200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 11.6664
Cell Significance Index: 196.5200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 9.2084
Cell Significance Index: 224.6800 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 9.1183
Cell Significance Index: 114.8200 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 8.2435
Cell Significance Index: 133.0100 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 5.2621
Cell Significance Index: 46.7100 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 4.8815
Cell Significance Index: 50.5600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 4.7833
Cell Significance Index: 102.2500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 4.7591
Cell Significance Index: 133.0000 - Cell Name: epidermal cell (CL0000362)
Fold Change: 3.9166
Cell Significance Index: 8.8300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.4246
Cell Significance Index: 262.8000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.9893
Cell Significance Index: 76.8400 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.5434
Cell Significance Index: 49.6400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.7205
Cell Significance Index: 111.0000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.5182
Cell Significance Index: 37.9500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.4500
Cell Significance Index: 1309.2400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4356
Cell Significance Index: 156.1500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1086
Cell Significance Index: 220.0000 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.0103
Cell Significance Index: 15.3700 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.9648
Cell Significance Index: 4.2000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.8751
Cell Significance Index: 555.8100 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.8698
Cell Significance Index: 12.4900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.7121
Cell Significance Index: 10.5100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7121
Cell Significance Index: 47.8800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6811
Cell Significance Index: 244.3000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.6793
Cell Significance Index: 308.3000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.6179
Cell Significance Index: 840.2100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.5497
Cell Significance Index: 1035.0300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5243
Cell Significance Index: 15.1100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5130
Cell Significance Index: 83.4400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5095
Cell Significance Index: 102.2000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4817
Cell Significance Index: 66.1500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4148
Cell Significance Index: 18.8000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2940
Cell Significance Index: 452.6400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.2907
Cell Significance Index: 30.2700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2630
Cell Significance Index: 485.0000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2208
Cell Significance Index: 42.0200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1681
Cell Significance Index: 74.3200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1570
Cell Significance Index: 115.1400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1447
Cell Significance Index: 100.0600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1209
Cell Significance Index: 3.2900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1202
Cell Significance Index: 14.7900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0919
Cell Significance Index: 3.2300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0467
Cell Significance Index: 0.6900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0164
Cell Significance Index: -2.9500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0312
Cell Significance Index: -17.0300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0422
Cell Significance Index: -4.1700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0448
Cell Significance Index: -33.1900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0790
Cell Significance Index: -49.3400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0827
Cell Significance Index: -6.1600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0904
Cell Significance Index: -51.0000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0956
Cell Significance Index: -72.3400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1126
Cell Significance Index: -11.5000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1342
Cell Significance Index: -15.8300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1653
Cell Significance Index: -28.2300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1772
Cell Significance Index: -22.9000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2084
Cell Significance Index: -30.2900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2471
Cell Significance Index: -71.1100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2495
Cell Significance Index: -31.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2627
Cell Significance Index: -55.3300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3514
Cell Significance Index: -17.7600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3811
Cell Significance Index: -17.7700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4378
Cell Significance Index: -34.6700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4915
Cell Significance Index: -30.9800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5215
Cell Significance Index: -24.5100 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.5263
Cell Significance Index: -7.5700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.6001
Cell Significance Index: -31.2600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6361
Cell Significance Index: -44.9900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6536
Cell Significance Index: -14.1600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6606
Cell Significance Index: -76.9900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.7079
Cell Significance Index: -80.8100 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.7710
Cell Significance Index: -12.3700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7901
Cell Significance Index: -90.5200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8310
Cell Significance Index: -50.9500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9265
Cell Significance Index: -51.9900 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.9532
Cell Significance Index: -13.3600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.0231
Cell Significance Index: -18.9100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.1611
Cell Significance Index: -51.3600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.2199
Cell Significance Index: -39.0700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.2270
Cell Significance Index: -75.4200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.3030
Cell Significance Index: -68.4100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.3423
Cell Significance Index: -50.8300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.4413
Cell Significance Index: -74.8700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.5571
Cell Significance Index: -45.7300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.6440
Cell Significance Index: -60.3500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.6845
Cell Significance Index: -48.0700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.7094
Cell Significance Index: -59.4000 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -1.7235
Cell Significance Index: -22.1000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3672286074
Symbol: FKBP5_HUMAN
Name: Peptidyl-prolyl cis-trans isomerase FKBP5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9125197
Title: Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition.
PubMed ID: 9125197
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9001212
Title: Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor.
PubMed ID: 9001212
DOI: 10.1128/mcb.17.2.594
PubMed ID: 7693698
Title: FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts.
PubMed ID: 7693698
PubMed ID: 11350175
Title: Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40.
PubMed ID: 11350175
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26101251
Title: FKBP51 employs both scaffold and isomerase functions to promote NF-kappaB activation in melanoma.
PubMed ID: 26101251
DOI: 10.1093/nar/gkv615
PubMed ID: 28147277
Title: Regulation of serine-threonine kinase Akt activation by NAD+-dependent deacetylase SIRT7.
PubMed ID: 28147277
PubMed ID: 28363942
Title: USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.
PubMed ID: 28363942
PubMed ID: 31434731
Title: Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses.
PubMed ID: 31434731
DOI: 10.1128/jvi.01159-19
PubMed ID: 12538866
Title: Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes.
PubMed ID: 12538866
Sequence Information:
- Length: 457
- Mass: 51212
- Checksum: 18A86608C6891A73
- Sequence:
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV
Genular Protein ID: 1777276483
Symbol: Q2TA84_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 457
- Mass: 51178
- Checksum: 7189EB6B4E203875
- Sequence:
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDLKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.