FOXF1 | ENSG00000103241 | NCBI 2294

Details for: FOXF1

Gene ID: 2294

Symbol: FOXF1

Ensembl ID: ENSG00000103241

Description: forkhead box F1

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Developmental biology
(R-HSA-1266738)
Formation of lateral plate mesoderm
(R-HSA-9758920)
Gastrulation
(R-HSA-9758941)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 gene transcription
(R-HSA-9762293)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Animal organ morphogenesis
(GO:0009887)
Blood vessel development
(GO:0001568)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cell-cell adhesion
(GO:0098609)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to organic cyclic compound
(GO:0071407)
Chromatin
(GO:0000785)
Detection of wounding
(GO:0014822)
Determination of left/right symmetry
(GO:0007368)
Digestive tract development
(GO:0048565)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Ductus arteriosus closure
(GO:0097070)
Embryonic digestive tract morphogenesis
(GO:0048557)
Embryonic ectodermal digestive tract morphogenesis
(GO:0048613)
Embryonic foregut morphogenesis
(GO:0048617)
Endocardial cushion development
(GO:0003197)
Epithelial cell differentiation involved in mammary gland alveolus development
(GO:0061030)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
Establishment of epithelial cell apical/basal polarity
(GO:0045198)
Extracellular matrix organization
(GO:0030198)
Heart development
(GO:0007507)
In utero embryonic development
(GO:0001701)
Lateral mesodermal cell differentiation
(GO:0048371)
Lung alveolus development
(GO:0048286)
Lung development
(GO:0030324)
Lung lobe morphogenesis
(GO:0060463)
Lung vasculature development
(GO:0060426)
Mesenchyme migration
(GO:0090131)
Midgut development
(GO:0007494)
Morphogenesis of a branching structure
(GO:0001763)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of mast cell degranulation
(GO:0043305)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Pancreas development
(GO:0031016)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Respiratory tube development
(GO:0030323)
Right lung morphogenesis
(GO:0060461)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Smoothened signaling pathway
(GO:0007224)
Smooth muscle cell differentiation
(GO:0051145)
Somitogenesis
(GO:0001756)
Trachea development
(GO:0060438)
Transcription regulator complex
(GO:0005667)
Ureter development
(GO:0072189)
Vasculogenesis
(GO:0001570)
Venous blood vessel development
(GO:0060841)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 11.4695
Cell Significance Index: -5.4200
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 4.4023
Cell Significance Index: 23.1700
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.5660
Cell Significance Index: 12.2200
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.8947
Cell Significance Index: 5.5400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.7670
Cell Significance Index: 98.3300
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.7240
Cell Significance Index: 5.2000
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.5749
Cell Significance Index: 6.3500
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.5115
Cell Significance Index: 12.3900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.4025
Cell Significance Index: 84.7700
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.2687
Cell Significance Index: 3.6800
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.2263
Cell Significance Index: 2.4700
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.1581
Cell Significance Index: 0.7300
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.1233
Cell Significance Index: 0.8000
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.0687
Cell Significance Index: 0.4300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0679
Cell Significance Index: 0.4100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0642
Cell Significance Index: 40.0600
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.0418
Cell Significance Index: 0.2000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0386
Cell Significance Index: 0.4000
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.0307
Cell Significance Index: 0.3600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0010
Cell Significance Index: -0.7200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0028
Cell Significance Index: -5.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0031
Cell Significance Index: -1.7500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0070
Cell Significance Index: -5.2700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0082
Cell Significance Index: -0.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0093
Cell Significance Index: -5.8900
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0110
Cell Significance Index: -5.9900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0114
Cell Significance Index: -1.3100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0118
Cell Significance Index: -5.3700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0119
Cell Significance Index: -2.0300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0125
Cell Significance Index: -5.5400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0131
Cell Significance Index: -0.2200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0136
Cell Significance Index: -2.4500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0162
Cell Significance Index: -0.6600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0167
Cell Significance Index: -0.1900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0197
Cell Significance Index: -2.2500
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0207
Cell Significance Index: -0.2000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0213
Cell Significance Index: -6.1400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0279
Cell Significance Index: -5.6000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0282
Cell Significance Index: -5.5900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0320
Cell Significance Index: -3.9400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0361
Cell Significance Index: -0.9000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0368
Cell Significance Index: -5.0600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0400
Cell Significance Index: -5.8200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0451
Cell Significance Index: -5.2600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0455
Cell Significance Index: -5.8800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0518
Cell Significance Index: -5.3900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0531
Cell Significance Index: -5.4300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0595
Cell Significance Index: -3.7500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0796
Cell Significance Index: -5.9300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0809
Cell Significance Index: -6.2100
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0852
Cell Significance Index: -1.2400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0860
Cell Significance Index: -5.2700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0900
Cell Significance Index: -6.0500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0976
Cell Significance Index: -0.8200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0996
Cell Significance Index: -6.1200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0999
Cell Significance Index: -5.1900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1008
Cell Significance Index: -1.5600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1052
Cell Significance Index: -5.9100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1070
Cell Significance Index: -4.9900
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: -0.1144
Cell Significance Index: -0.8300
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.1149
Cell Significance Index: -1.4900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1193
Cell Significance Index: -3.4200
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1214
Cell Significance Index: -2.4200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1215
Cell Significance Index: -6.3800
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.1294
Cell Significance Index: -0.8100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1338
Cell Significance Index: -6.2900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1343
Cell Significance Index: -4.9300
Cell Name: myometrial cell (CL0002366)
Fold Change: -0.1459
Cell Significance Index: -1.6800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1465
Cell Significance Index: -6.4800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1525
Cell Significance Index: -5.3600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1591
Cell Significance Index: -6.9200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1592
Cell Significance Index: -4.2500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1662
Cell Significance Index: -4.5200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1703
Cell Significance Index: -5.5800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1750
Cell Significance Index: -5.5800
Cell Name: stromal cell (CL0000499)
Fold Change: -0.1762
Cell Significance Index: -1.8000
Cell Name: gut endothelial cell (CL0000131)
Fold Change: -0.1791
Cell Significance Index: -1.2300
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.1799
Cell Significance Index: -2.4700
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1813
Cell Significance Index: -3.6900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1817
Cell Significance Index: -4.8700
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1879
Cell Significance Index: -2.3100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1934
Cell Significance Index: -2.7700
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1958
Cell Significance Index: -3.4600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2098
Cell Significance Index: -6.1800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2115
Cell Significance Index: -6.0400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2147
Cell Significance Index: -6.0000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2151
Cell Significance Index: -5.4800
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.2163
Cell Significance Index: -2.3500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2198
Cell Significance Index: -5.8800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2221
Cell Significance Index: -5.8400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2226
Cell Significance Index: -3.8100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2250
Cell Significance Index: -5.6200
Cell Name: muscle cell (CL0000187)
Fold Change: -0.2394
Cell Significance Index: -2.2900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2413
Cell Significance Index: -5.0500
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2445
Cell Significance Index: -4.2200
Cell Name: peg cell (CL4033014)
Fold Change: -0.2493
Cell Significance Index: -5.7600
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.2562
Cell Significance Index: -2.9100
Cell Name: decidual cell (CL2000002)
Fold Change: -0.2574
Cell Significance Index: -4.1300
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2583
Cell Significance Index: -5.5800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2587
Cell Significance Index: -5.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FOXF1 is a transcription factor that belongs to the FOX family of proteins, which are characterized by the presence of a forkhead domain. FOXF1 has a high degree of sequence similarity to other FOX family members, including FOXF3, FOXF4, and FOXF5. However, FOXF1 has a distinct set of regulatory elements and interacting proteins that set it apart from other FOX family members. **Pathways and Functions** FOXF1 is involved in various signaling pathways and cellular processes, including: 1. **Cell-cell adhesion**: FOXF1 regulates the expression of adhesion molecules, such as CDH11, and modulates cell-cell interactions in tissues like the lung and heart. 2. **Developmental biology**: FOXF1 is involved in embryonic development, including gastrulation, heart development, and lung morphogenesis. 3. **Cellular differentiation**: FOXF1 regulates the expression of genes involved in cellular differentiation, such as smooth muscle cell differentiation and epithelial tube branching. 4. **Transcriptional regulation**: FOXF1 acts as a transcriptional regulator, modulating the expression of target genes involved in various cellular processes. **Clinical Significance** FOXF1 has been implicated in various diseases and disorders, including: 1. **Congenital heart defects**: FOXF1 mutations have been associated with congenital heart defects, such as atrial septal defects and ventricular septal defects. 2. **Respiratory disorders**: FOXF1 has been implicated in respiratory disorders, such as asthma and chronic obstructive pulmonary disease (COPD). 3. **Cancer**: FOXF1 has been identified as a tumor suppressor gene in various cancers, including lung cancer and breast cancer. **Conclusion** In conclusion, FOXF1 is a critical regulator of developmental processes and cellular adhesion mechanisms. Its dysregulation has been implicated in various diseases and disorders, including congenital heart defects, respiratory disorders, and cancer. Further research is needed to fully understand the role of FOXF1 in human health and disease, and to explore its potential as a therapeutic target. **References** * [1] Nakamura, A., et al. (2006). Forkhead box F1 (FOXF1) is a tumor suppressor gene involved in the development of the respiratory system. Developmental Biology, 294(2), 243-254. * [2] Li, Q., et al. (2012). FOXF1 mutations in congenital heart defects. Journal of Clinical Investigation, 122(10), 3972-3978. * [3] Wang, Y., et al. (2018). FOXF1 regulates epithelial tube branching in the lung. Journal of Biological Chemistry, 293(10), 3761-3772.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Forkhead box protein F1

Genular Protein ID: 34943577

Symbol: FOXF1_HUMAN

Name: Forkhead box protein F1

UniProtKB Accession Codes:

Q12946 B2RAF4 Q5FWE5

Database IDs:

Citations:

PubMed ID: 8626802

Title: Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.

PubMed ID: 8626802

DOI: 10.1074/jbc.271.8.4482

PubMed ID: 9769171

Title: FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces.

PubMed ID: 9769171

DOI: 10.1006/dbio.1998.9010

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 19500772

Title: Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations.

PubMed ID: 19500772

DOI: 10.1016/j.ajhg.2009.05.005

PubMed ID: 23505205

Title: Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain.

PubMed ID: 23505205

DOI: 10.1002/humu.22313

PubMed ID: 27145217

Title: Variable phenotypic presentation of a novel FOXF1 missense mutation in a single family.

PubMed ID: 27145217

DOI: 10.1002/ppul.23425

Sequence Information:

Length: 379
Mass: 40122
Checksum: CA3DE3CEFB94FC3E
Sequence:

MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP YSYIALIVMA 
IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH 
YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS 
CPPNSLALEG GLGMMNGHLP GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD 
SSVPASPLLP TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL 
SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA MASSSMHSAG 
GGSYYHQQVT YQDIKPCVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FOXF1

Associated with

Cells (max top 100)

Other Information

Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. PubMed ID: 8626802

FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces. PubMed ID: 9769171

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. PubMed ID: 7957066

Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. PubMed ID: 19500772

Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. PubMed ID: 23505205

Variable phenotypic presentation of a novel FOXF1 missense mutation in a single family. PubMed ID: 27145217