Details for: FOXF1

Gene ID: 2294

Symbol: FOXF1

Ensembl ID: ENSG00000103241

Description: forkhead box F1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.95
    Marker Score: 4265
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.86
    Marker Score: 37769
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.66
    Marker Score: 6753
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.3
    Marker Score: 5424
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.02
    Marker Score: 766
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.74
    Marker Score: 723
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.53
    Marker Score: 1318
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.52
    Marker Score: 1300
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.43
    Marker Score: 355
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.41
    Marker Score: 355
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.28
    Marker Score: 443
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.09
    Marker Score: 651
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.03
    Marker Score: 232
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5322
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.87
    Marker Score: 1257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.73
    Marker Score: 897
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.72
    Marker Score: 1443
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 687
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.7
    Marker Score: 183
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.65
    Marker Score: 635.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.6
    Marker Score: 351
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 470
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.58
    Marker Score: 580
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 180
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 267
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.53
    Marker Score: 644
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.51
    Marker Score: 484
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 208
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.48
    Marker Score: 124
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.46
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.43
    Marker Score: 813
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 183
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 370
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6212
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.38
    Marker Score: 347
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.36
    Marker Score: 388
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.36
    Marker Score: 489
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 708
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.33
    Marker Score: 153
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.33
    Marker Score: 93
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.32
    Marker Score: 146
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.31
    Marker Score: 202
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.3
    Marker Score: 126
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.3
    Marker Score: 787
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.29
    Marker Score: 161
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.29
    Marker Score: 64
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.28
    Marker Score: 83
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 168
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.25
    Marker Score: 156
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 103
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.21
    Marker Score: 110
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2
    Marker Score: 49
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.2
    Marker Score: 313
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.2
    Marker Score: 214
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 234
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2
    Marker Score: 3175
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.2
    Marker Score: 42
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.2
    Marker Score: 72
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.2
    Marker Score: 209
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.19
    Marker Score: 51
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1267
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.18
    Marker Score: 206
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.18
    Marker Score: 41
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.17
    Marker Score: 528
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.17
    Marker Score: 161
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.16
    Marker Score: 65
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.16
    Marker Score: 75
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 73.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.11
    Marker Score: 190
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 207
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 109

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Other Information

**Key characteristics** - FOXF1 is a transcription factor with a basic domain structure that contains a forkhead domain and a DNA-binding domain. - It is a member of the FOX family of transcription factors, which are characterized by their ability to regulate gene expression through the binding of DNA sequences known as forkhead motifs. - FOXF1 is a highly conserved protein, with a similar sequence in mice and humans. **Pathways and functions** - FOXF1 is involved in a variety of cellular processes, including cell adhesion, migration, and differentiation. - In endothelial cells, FOXF1 is essential for the formation and maintenance of blood vessels. It does this by binding to DNA sequences in the promoters of vascular endothelial growth factors (VEGFs), which are key growth factors for blood vessel formation. - In mesodermal cells, FOXF1 is required for the development of the mesoderm, which is responsible for the formation of the body's internal organs. - In the cardiovascular system, FOXF1 plays a role in regulating vascular development and remodeling. It does this by binding to DNA sequences in the promoters of vascular endothelial growth factors (VEGFs) and other genes involved in vascular development. **Clinical significance** - Mutations in the FOXF1 gene have been linked to a number of human diseases, including cardiovascular disease, cancer, and developmental disorders. - In recent years, there has been a growing interest in the role of FOXF1 in cancer development and progression. - FOXF1 inhibitors are being investigated as potential cancer drugs, as they could potentially inhibit the growth and metastasis of cancer cells.

Genular Protein ID: 34943577

Symbol: FOXF1_HUMAN

Name: Forkhead box protein F1

UniProtKB Accession Codes:

Q12946 B2RAF4 Q5FWE5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 56 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626802

Title: Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.

PubMed ID: 8626802

DOI: 10.1074/jbc.271.8.4482

PubMed ID: 9769171

Title: FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces.

PubMed ID: 9769171

DOI: 10.1006/dbio.1998.9010

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 19500772

Title: Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations.

PubMed ID: 19500772

DOI: 10.1016/j.ajhg.2009.05.005

PubMed ID: 23505205

Title: Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain.

PubMed ID: 23505205

DOI: 10.1002/humu.22313

PubMed ID: 27145217

Title: Variable phenotypic presentation of a novel FOXF1 missense mutation in a single family.

PubMed ID: 27145217

DOI: 10.1002/ppul.23425

Sequence Information:

  • Length: 379
  • Mass: 40122
  • Checksum: CA3DE3CEFB94FC3E
  • Sequence:
    • MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP YSYIALIVMA 
IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH 
YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS 
CPPNSLALEG GLGMMNGHLP GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD 
SSVPASPLLP TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL 
SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA MASSSMHSAG 
GGSYYHQQVT YQDIKPCVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.