Details for: FOXI1

Gene ID: 2299

Symbol: FOXI1

Ensembl ID: ENSG00000168269

Description: forkhead box I1

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding, bending
    (GO:0008301)
  • Embryo development ending in birth or egg hatching
    (GO:0009792)
  • Inner ear morphogenesis
    (GO:0042472)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Nucleolus
    (GO:0005730)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 6.0878
    Cell Significance Index: 23.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9592
    Cell Significance Index: 94.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2599
    Cell Significance Index: 48.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9181
    Cell Significance Index: 41.6200
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.8778
    Cell Significance Index: 5.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7666
    Cell Significance Index: 145.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5511
    Cell Significance Index: 54.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5205
    Cell Significance Index: 11.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4185
    Cell Significance Index: 377.8900
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.3531
    Cell Significance Index: 2.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3017
    Cell Significance Index: 32.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3006
    Cell Significance Index: 48.9000
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.2894
    Cell Significance Index: 2.3100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2222
    Cell Significance Index: 2.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2194
    Cell Significance Index: 13.1700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1991
    Cell Significance Index: 2.8900
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.1765
    Cell Significance Index: 1.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1661
    Cell Significance Index: 11.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0909
    Cell Significance Index: 4.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0878
    Cell Significance Index: 2.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0642
    Cell Significance Index: 3.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0232
    Cell Significance Index: 2.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0219
    Cell Significance Index: 2.8300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.0210
    Cell Significance Index: 0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0090
    Cell Significance Index: 0.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0062
    Cell Significance Index: -2.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0074
    Cell Significance Index: -0.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0099
    Cell Significance Index: -0.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0127
    Cell Significance Index: -1.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0177
    Cell Significance Index: -3.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0211
    Cell Significance Index: -4.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0222
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0238
    Cell Significance Index: -4.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0244
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0267
    Cell Significance Index: -3.2800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0376
    Cell Significance Index: -0.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0431
    Cell Significance Index: -3.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0475
    Cell Significance Index: -3.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0479
    Cell Significance Index: -1.2200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0488
    Cell Significance Index: -0.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0624
    Cell Significance Index: -0.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0625
    Cell Significance Index: -4.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0649
    Cell Significance Index: -0.9000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0709
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0720
    Cell Significance Index: -0.7600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0751
    Cell Significance Index: -0.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0820
    Cell Significance Index: -2.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0824
    Cell Significance Index: -1.1800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0839
    Cell Significance Index: -0.9200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0886
    Cell Significance Index: -1.0300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0896
    Cell Significance Index: -1.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0903
    Cell Significance Index: -2.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0995
    Cell Significance Index: -1.7000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1004
    Cell Significance Index: -1.1800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1013
    Cell Significance Index: -1.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1121
    Cell Significance Index: -2.7200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1165
    Cell Significance Index: -2.4300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1226
    Cell Significance Index: -1.6800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1232
    Cell Significance Index: -0.7600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1425
    Cell Significance Index: -1.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1479
    Cell Significance Index: -5.4300
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: -0.1541
    Cell Significance Index: -1.3500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1647
    Cell Significance Index: -1.7500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1661
    Cell Significance Index: -2.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1678
    Cell Significance Index: -4.8100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1679
    Cell Significance Index: -1.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1686
    Cell Significance Index: -1.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1709
    Cell Significance Index: -3.3800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1788
    Cell Significance Index: -2.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1816
    Cell Significance Index: -1.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1823
    Cell Significance Index: -3.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1824
    Cell Significance Index: -4.8000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1837
    Cell Significance Index: -1.9000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1846
    Cell Significance Index: -2.6900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2010
    Cell Significance Index: -2.0800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2048
    Cell Significance Index: -2.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2055
    Cell Significance Index: -3.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2073
    Cell Significance Index: -4.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2158
    Cell Significance Index: -4.2200
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.2185
    Cell Significance Index: -2.3100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2231
    Cell Significance Index: -2.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2240
    Cell Significance Index: -4.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2243
    Cell Significance Index: -4.7600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2248
    Cell Significance Index: -2.3500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2261
    Cell Significance Index: -2.3700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2270
    Cell Significance Index: -1.4800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.2341
    Cell Significance Index: -2.9700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2360
    Cell Significance Index: -2.7200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2363
    Cell Significance Index: -1.8800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2368
    Cell Significance Index: -2.5900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2380
    Cell Significance Index: -3.0700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2416
    Cell Significance Index: -2.8800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2427
    Cell Significance Index: -2.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOXI1 is a member of the forkhead box (FOX) family of transcription factors, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is a transcriptional activator, meaning it promotes the transcription of target genes. FOXI1 is highly expressed in various cell types, including glutamatergic neurons, erythrocytes, oligodendrocyte precursor cells, and hematopoietic stem cells. Its expression is also detected in megakaryocytes, microglial cells, and blood vessel endothelial cells, highlighting its widespread role in different tissues. **Pathways and Functions:** FOXI1 is involved in several key pathways, including: 1. **Anatomical structure morphogenesis**: FOXI1 regulates the development of various tissues and organs, including the inner ear and kidney collecting ducts. 2. **Cell differentiation**: FOXI1 promotes the differentiation of hematopoietic stem cells into various blood cell types, including erythrocytes and megakaryocytes. 3. **Chromatin remodeling**: FOXI1 interacts with chromatin-remodeling complexes to regulate gene expression and maintain genome stability. 4. **DNA binding and bending**: FOXI1 binds to specific DNA sequences, inducing chromatin bending and facilitating the recruitment of co-regulatory proteins. FOXI1's functions are diverse, including: 1. **Positive regulation of transcription**: FOXI1 activates the transcription of target genes by binding to specific DNA sequences and recruiting RNA polymerase II. 2. **Regulation of transcription by RNA polymerase II**: FOXI1 interacts with RNA polymerase II to modulate gene expression in response to various signals. 3. **DNA binding, bending, and sequence-specific binding**: FOXI1's ability to bind to specific DNA sequences and induce chromatin bending enables it to regulate gene expression and maintain genome stability. **Clinical Significance:** FOXI1's dysregulation has been implicated in various diseases, including: 1. **Immune disorders**: FOXI1's role in hematopoiesis and immune cell development makes it a potential target for the treatment of immune-related disorders, such as leukemia and lymphoma. 2. **Neurological disorders**: FOXI1's involvement in neuronal development and function suggests its potential role in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: FOXI1's ability to regulate gene expression and maintain genome stability makes it a potential target for cancer therapy. In conclusion, FOXI1 is a critical transcription factor that plays a regulatory role in various cellular processes, including development, differentiation, and gene expression. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of immune-related disorders, neurological disorders, and cancer. Further research is needed to fully elucidate the mechanisms of FOXI1's actions and its implications in human disease.

Genular Protein ID: 663657551

Symbol: FOXI1_HUMAN

Name: Forkhead box protein I1

UniProtKB Accession Codes:

Q12951 Q14518 Q66SR7 Q8N6L8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9153225

Title: The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney.

PubMed ID: 9153225

DOI: 10.1074/jbc.272.21.13725

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 378
  • Mass: 40973
  • Checksum: D99835F8A296F11C
  • Sequence:
    • MSSFDLPAPS PPRCSPQFPS IGQEPPEMNL YYENFFHPQG VPSPQRPSFE GGGEYGATPN 
PYLWFNGPTM TPPPYLPGPN ASPFLPQAYG VQRPLLPSVS GLGGSDLGWL PIPSQEELMK 
LVRPPYSYSA LIAMAIHGAP DKRLTLSQIY QYVADNFPFY NKSKAGWQNS IRHNLSLNDC 
FKKVPRDEDD PGKGNYWTLD PNCEKMFDNG NFRRKRKRKS DVSSSTASLA LEKTESSLPV 
DSPKTTEPQD ILDGASPGGT TSSPEKRPSP PPSGAPCLNS FLSSMTAYVS GGSPTSHPLV 
TPGLSPEPSD KTGQNSLTFN SFSPLTNLSN HSGGGDWANP MPTNMLSYGG SVLSQFSPHF 
YNSVNTSGVL YPREGTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.