Details for: FOXI1

Gene ID: 2299

Symbol: FOXI1

Ensembl ID: ENSG00000168269

Description: forkhead box I1

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding, bending
    (GO:0008301)
  • Embryo development ending in birth or egg hatching
    (GO:0009792)
  • Inner ear morphogenesis
    (GO:0042472)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Nucleolus
    (GO:0005730)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162084
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 10.86
    Marker Score: 6014
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8278
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.69
    Marker Score: 2666
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6844
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.49
    Marker Score: 1840
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.36
    Marker Score: 3909
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.28
    Marker Score: 2298
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.23
    Marker Score: 931
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2000
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.91
    Marker Score: 1016
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.58
    Marker Score: 1044
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.44
    Marker Score: 840
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.21
    Marker Score: 2299
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7688
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.13
    Marker Score: 597
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.12
    Marker Score: 2268
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.03
    Marker Score: 634
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1404
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13146
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 486
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.67
    Marker Score: 651
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 386
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.64
    Marker Score: 203
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 497
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3448
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.52
    Marker Score: 159
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.46
    Marker Score: 510
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 125.5
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 167
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 497
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.3
    Marker Score: 429
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3
    Marker Score: 228
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.29
    Marker Score: 276
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.28
    Marker Score: 348
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.27
    Marker Score: 672
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 116
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 206
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.21
    Marker Score: 122
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.11
    Marker Score: 729
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 109
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 29.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.09
    Marker Score: 316
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 139
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 52
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.07
    Marker Score: 13
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.06
    Marker Score: 124
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.06
    Marker Score: 108
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 68
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.06
    Marker Score: 129
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 72
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.05
    Marker Score: 137
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 49

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Other Information

**Key characteristics:** * 85% of the protein is encoded by the FOXI1 gene. * It is a member of the forkhead box (FOXO) family of transcription factors. * It is a key regulator of the expression of many genes involved in embryonic development, tissue differentiation, and inflammation. * It is also involved in the regulation of cell cycle progression and apoptosis. **Pathways and functions:** * **Embryo development:** FOXI1 is essential for the early stages of embryonic development, where it regulates the expression of genes involved in cell proliferation, migration, and differentiation. * **Cell differentiation:** FOXI1 is also essential for cell differentiation into various cell types. It is expressed in proliferating and differentiating cells and is required for the proper development of tissues and organs. * **Inflammation:** FOXI1 is a key regulator of inflammation. It is expressed in immune cells, where it promotes the production of inflammatory cytokines and chemokines. * **Tissue repair and regeneration:** FOXI1 is also involved in tissue repair and regeneration. It is expressed in cells that are responsible for wound healing and tissue regeneration. **Clinical significance:** * Mutations in the FOXI1 gene have been linked to several human diseases, including autism, developmental disorders, and cancer. * Overexpression of FOXI1 has been linked to some forms of cancer, such as breast cancer and leukemia. * Inhibition of FOXI1 has been shown to suppress tumor growth and metastasis. **Additional notes:** * FOXI1 is a highly conserved protein that is found in all vertebrates. * It is a ubiquitin-dependent protein, meaning that it is targeted for degradation by the proteasome when it is no longer needed. * It is a well-studied protein with a complex and multifaceted function.

Genular Protein ID: 663657551

Symbol: FOXI1_HUMAN

Name: Forkhead box protein I1

UniProtKB Accession Codes:

Q12951 Q14518 Q66SR7 Q8N6L8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9153225

Title: The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney.

PubMed ID: 9153225

DOI: 10.1074/jbc.272.21.13725

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 378
  • Mass: 40973
  • Checksum: D99835F8A296F11C
  • Sequence:
    • MSSFDLPAPS PPRCSPQFPS IGQEPPEMNL YYENFFHPQG VPSPQRPSFE GGGEYGATPN 
PYLWFNGPTM TPPPYLPGPN ASPFLPQAYG VQRPLLPSVS GLGGSDLGWL PIPSQEELMK 
LVRPPYSYSA LIAMAIHGAP DKRLTLSQIY QYVADNFPFY NKSKAGWQNS IRHNLSLNDC 
FKKVPRDEDD PGKGNYWTLD PNCEKMFDNG NFRRKRKRKS DVSSSTASLA LEKTESSLPV 
DSPKTTEPQD ILDGASPGGT TSSPEKRPSP PPSGAPCLNS FLSSMTAYVS GGSPTSHPLV 
TPGLSPEPSD KTGQNSLTFN SFSPLTNLSN HSGGGDWANP MPTNMLSYGG SVLSQFSPHF 
YNSVNTSGVL YPREGTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.