Details for: OR6C74

Gene ID: 254783

Symbol: OR6C74

Ensembl ID: ENSG00000197706

Description: olfactory receptor family 6 subfamily C member 74

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.1812
    Cell Significance Index: 2.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1179
    Cell Significance Index: 1.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1101
    Cell Significance Index: 2.9500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0629
    Cell Significance Index: 0.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0444
    Cell Significance Index: 5.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0112
    Cell Significance Index: 0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0067
    Cell Significance Index: 1.3400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0060
    Cell Significance Index: -0.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0061
    Cell Significance Index: -0.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0064
    Cell Significance Index: -0.2100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0070
    Cell Significance Index: -0.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0071
    Cell Significance Index: -0.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0074
    Cell Significance Index: -0.1600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0075
    Cell Significance Index: -0.1500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0077
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0087
    Cell Significance Index: -0.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0090
    Cell Significance Index: -0.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0105
    Cell Significance Index: -0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0107
    Cell Significance Index: -0.2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0107
    Cell Significance Index: -0.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0158
    Cell Significance Index: -0.2300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0162
    Cell Significance Index: -0.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0162
    Cell Significance Index: -0.2100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0167
    Cell Significance Index: -0.2200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0176
    Cell Significance Index: -0.2300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0187
    Cell Significance Index: -0.2300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0196
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0197
    Cell Significance Index: -0.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0201
    Cell Significance Index: -0.4200
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0204
    Cell Significance Index: -0.2500
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0207
    Cell Significance Index: -0.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0213
    Cell Significance Index: -0.2500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0220
    Cell Significance Index: -0.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0223
    Cell Significance Index: -0.3700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0225
    Cell Significance Index: -0.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0227
    Cell Significance Index: -0.2100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0228
    Cell Significance Index: -0.1800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0233
    Cell Significance Index: -0.2500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0243
    Cell Significance Index: -0.2600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0247
    Cell Significance Index: -0.2200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0250
    Cell Significance Index: -0.3000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0273
    Cell Significance Index: -0.3200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0276
    Cell Significance Index: -0.4000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0284
    Cell Significance Index: -0.1800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0286
    Cell Significance Index: -0.2500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0328
    Cell Significance Index: -0.2200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0330
    Cell Significance Index: -0.1900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0421
    Cell Significance Index: -0.2500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0438
    Cell Significance Index: -0.4000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0488
    Cell Significance Index: -0.4100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0556
    Cell Significance Index: -0.7000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0692
    Cell Significance Index: -0.6100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0721
    Cell Significance Index: -0.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR6C74 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family. It is expressed in a wide range of cell types, including neuronal receptor cells, smooth muscle cells, and immune cells like T cells and neutrophils. The receptor is characterized by its unique ligand-binding domain, which allows it to detect specific chemical stimuli in the air we breathe. OR6C74 is also notable for its high degree of polymorphism, with multiple variants identified in the human population. **Pathways and Functions:** OR6C74 plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. When bound to its ligand, the receptor activates a G protein-coupled signaling pathway, which ultimately triggers a response in the olfactory system. This process is essential for our ability to perceive odors and differentiate between various scents. Beyond its sensory functions, OR6C74 has been implicated in various cellular processes. For example, it has been shown to regulate the expression and translocation of other olfactory receptors, which is essential for the development and maintenance of the olfactory system. OR6C74 has also been linked to immune response, with studies suggesting that it plays a role in the regulation of immune cell function and the production of cytokines. In addition to its sensory and immune functions, OR6C74 has been implicated in hematopoiesis, the process by which blood cells are produced. Research has shown that OR6C74 is expressed in megakaryocytes, the cells responsible for producing platelets, and that it plays a role in regulating platelet production. **Clinical Significance:** OR6C74 has significant clinical implications, particularly in the context of olfactory disorders. Individuals with impaired olfactory function, such as those with anosmia or hyposmia, may have altered OR6C74 expression or function. Furthermore, polymorphisms in the OR6C74 gene have been associated with various diseases, including asthma, allergies, and autoimmune disorders. In addition to its clinical significance, OR6C74 has potential applications in the development of novel therapeutic strategies. For example, targeting OR6C74 with specific ligands or antagonists may provide a new approach to treating olfactory disorders or modulating immune responses. In conclusion, OR6C74 is a fascinating gene that has shed light on the complex relationships between the olfactory system, immune response, and hematopoiesis. Further research is needed to fully elucidate the functions and clinical significance of OR6C74, but its discovery has undoubtedly opened up new avenues for investigation and potential therapeutic intervention.

Genular Protein ID: 2464553133

Symbol: O6C74_HUMAN

Name: Olfactory receptor 6C74

UniProtKB Accession Codes:

A6NCV1 B9EIN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 312
  • Mass: 35253
  • Checksum: 90C62992CA8844AA
  • Sequence:
    • MRNHTTVANF ILLGLTDDPQ LQVIIFLLLF FTYMLSITGN LTIITLTLLD LHLKTPMYFF 
LRNFSFLEVS FTTVYIPKFL VSMATGDKTI SYNDCAAQLF FTILLGATEF FLLAAMSYER 
YVAICKPLHY TTIMSSRVCS LLVFASWMAG FLIIFPPLLM GLQLDFCAAN TVDHFFCDVS 
PILQLSCTDT DIIELMMLLS AILTLLVTLV LVILSYTNII RTILKIPSSQ QRKKAFSTCS 
SHMVVVSISY GSCIFMYVKP SAKERVSLNK GIALLSTSVA PMLNPFIYTL RNKQVKDVFK 
HTVKKIELFS MK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.