Details for: GALNS

Gene ID: 2588

Symbol: GALNS

Ensembl ID: ENSG00000141012

Description: galactosamine (N-acetyl)-6-sulfatase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.1199
    Cell Significance Index: -13.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.6366
    Cell Significance Index: -12.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.2672
    Cell Significance Index: -11.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.8953
    Cell Significance Index: -13.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.4641
    Cell Significance Index: -11.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.8844
    Cell Significance Index: -13.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8565
    Cell Significance Index: -13.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4490
    Cell Significance Index: -13.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.6592
    Cell Significance Index: 43.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6495
    Cell Significance Index: 163.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9757
    Cell Significance Index: 26.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8722
    Cell Significance Index: 11.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7523
    Cell Significance Index: 21.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5287
    Cell Significance Index: 31.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5258
    Cell Significance Index: 57.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4908
    Cell Significance Index: 79.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4750
    Cell Significance Index: 21.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4048
    Cell Significance Index: 8.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3805
    Cell Significance Index: 76.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3643
    Cell Significance Index: 5.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3224
    Cell Significance Index: 61.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2907
    Cell Significance Index: 20.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2824
    Cell Significance Index: 14.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2798
    Cell Significance Index: 152.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2644
    Cell Significance Index: 52.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2444
    Cell Significance Index: 6.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2299
    Cell Significance Index: 82.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1612
    Cell Significance Index: 4.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1442
    Cell Significance Index: 9.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1428
    Cell Significance Index: 7.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1365
    Cell Significance Index: 2.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1264
    Cell Significance Index: 22.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1227
    Cell Significance Index: 15.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1224
    Cell Significance Index: 16.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1089
    Cell Significance Index: 2.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0908
    Cell Significance Index: 3.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0646
    Cell Significance Index: 8.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0635
    Cell Significance Index: 2.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0617
    Cell Significance Index: 27.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0567
    Cell Significance Index: 4.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0466
    Cell Significance Index: 2.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0445
    Cell Significance Index: 1.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0395
    Cell Significance Index: 1.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0158
    Cell Significance Index: 29.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0090
    Cell Significance Index: 0.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0074
    Cell Significance Index: 13.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0070
    Cell Significance Index: 4.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0068
    Cell Significance Index: 0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0045
    Cell Significance Index: 6.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0015
    Cell Significance Index: 0.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0006
    Cell Significance Index: -0.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -4.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0052
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0078
    Cell Significance Index: -0.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0108
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0152
    Cell Significance Index: -1.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0156
    Cell Significance Index: -2.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0175
    Cell Significance Index: -0.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0193
    Cell Significance Index: -1.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0200
    Cell Significance Index: -11.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0209
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0226
    Cell Significance Index: -14.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0267
    Cell Significance Index: -1.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0404
    Cell Significance Index: -11.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0407
    Cell Significance Index: -6.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0497
    Cell Significance Index: -5.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0540
    Cell Significance Index: -2.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0560
    Cell Significance Index: -4.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0593
    Cell Significance Index: -1.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0630
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0666
    Cell Significance Index: -14.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0691
    Cell Significance Index: -2.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0707
    Cell Significance Index: -1.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0834
    Cell Significance Index: -5.9000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0862
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0882
    Cell Significance Index: -10.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0918
    Cell Significance Index: -6.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1190
    Cell Significance Index: -12.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1201
    Cell Significance Index: -1.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1263
    Cell Significance Index: -4.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1417
    Cell Significance Index: -7.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1421
    Cell Significance Index: -8.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1482
    Cell Significance Index: -4.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1561
    Cell Significance Index: -12.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1710
    Cell Significance Index: -3.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1757
    Cell Significance Index: -4.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2010
    Cell Significance Index: -4.8200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2013
    Cell Significance Index: -2.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2023
    Cell Significance Index: -1.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2034
    Cell Significance Index: -5.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2279
    Cell Significance Index: -4.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2317
    Cell Significance Index: -5.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2350
    Cell Significance Index: -5.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2449
    Cell Significance Index: -2.5400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2600
    Cell Significance Index: -3.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic function:** GALNS is a sulfatase enzyme that specifically hydrolyzes N-acetylglucosamine-6-sulfate, a key intermediate in keratan sulfate biosynthesis. 2. **Tissue expression:** GALNS is widely expressed in various tissues, including the tracheobronchial tree, germ cells, cardiac endothelial cells, and neurons. 3. **Cellular localization:** GALNS is primarily localized in the lysosomal lumen, where it regulates keratan sulfate degradation. 4. **Substrate specificity:** GALNS has a high specificity for N-acetylglucosamine-6-sulfate, allowing for precise regulation of keratan sulfate levels. **Pathways and Functions:** 1. **Glycosaminoglycan metabolism:** GALNS is a key enzyme in the degradation pathway of keratan sulfate, a GAG that plays a crucial role in maintaining the integrity of the extracellular matrix and cartilage. 2. **Immune system regulation:** GALNS is involved in regulating the immune response by modulating the levels of keratan sulfate, which affects the function of neutrophils and other immune cells. 3. **Neurodevelopmental processes:** GALNS is expressed in neurons and plays a role in regulating the development and maintenance of the nervous system. 4. **Metabolic regulation:** GALNS is part of a larger metabolic network that regulates the degradation of various GAGs, including chondroitin sulfate and dermatan sulfate. **Clinical Significance:** 1. **Mucopolysaccharidoses:** Mutations in the GALNS gene have been identified as a cause of Morquio syndrome A, a type of mucopolysaccharidosis characterized by the accumulation of keratan sulfate. 2. **Neurodegenerative diseases:** Dysregulation of GALNS has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where keratan sulfate accumulation may contribute to disease progression. 3. **Cancer:** GALNS expression has been detected in various types of cancer, including lung and breast cancer, suggesting a potential role in tumor progression and metastasis. 4. **Immunological disorders:** GALNS is involved in regulating the immune response, and dysregulation of this enzyme may contribute to the development of immunological disorders, such as atherosclerosis and autoimmune diseases. In conclusion, GALNS is a crucial enzyme involved in glycosaminoglycan metabolism and immune system regulation. Dysregulation of this enzyme has been implicated in various diseases, highlighting the importance of GALNS in maintaining tissue homeostasis and immune system function. Further research is needed to fully understand the mechanisms by which GALNS regulates keratan sulfate levels and to develop therapeutic strategies for treating diseases associated with GALNS dysfunction.

Genular Protein ID: 3608982954

Symbol: GALNS_HUMAN

Name: N-acetylgalactosamine-6-sulfatase

UniProtKB Accession Codes:

P34059 Q86VK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1755850

Title: Morquio disease: isolation, characterization and expression of full-length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase.

PubMed ID: 1755850

DOI: 10.1016/0006-291x(91)91244-7

PubMed ID: 8001980

Title: Morquio A syndrome: cloning, sequence, and structure of the human N-acetylgalactosamine 6-sulfatase (GALNS) gene.

PubMed ID: 8001980

DOI: 10.1006/geno.1994.1443

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 22940367

Title: The structure of human GALNS reveals the molecular basis for mucopolysaccharidosis IV A.

PubMed ID: 22940367

DOI: 10.1016/j.jmb.2012.08.020

PubMed ID: 1522213

Title: Mucopolysaccharidosis type IVA. N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.

PubMed ID: 1522213

DOI: 10.1172/jci115919

PubMed ID: 7668283

Title: Mucopolysaccharidosis IVA: identification of a common missense mutation I113F in the N-Acetylgalactosamine-6-sulfate sulfatase gene.

PubMed ID: 7668283

PubMed ID: 7795586

Title: Mucopolysaccharidosis IVA: screening and identification of mutations of the N-acetylgalactosamine-6-sulfate sulfatase gene.

PubMed ID: 7795586

DOI: 10.1093/hmg/4.3.341

PubMed ID: 7633425

Title: Mucopolysaccharidosis type IVA: identification of six novel mutations among non-Japanese patients.

PubMed ID: 7633425

DOI: 10.1093/hmg/4.4.741

PubMed ID: 7581409

Title: Two new mutations, Q473X and N487S, in a Caucasian patient with mucopolysaccharidosis IVA (Morquio disease).

PubMed ID: 7581409

DOI: 10.1002/humu.1380060218

PubMed ID: 8651279

Title: Mucopolysaccharidosis IVA: four new exonic mutations in patients with N-acetylgalactosamine-6-sulfate sulfatase deficiency.

PubMed ID: 8651279

PubMed ID: 8826435

Title: Heteroallelic missense mutations of the galactosamine-6-sulfate sulfatase (GALNS) gene in a mild form of Morquio disease (MPS IVA).

PubMed ID: 8826435

DOI: 10.1002/(sici)1096-8628(19960628)63:4<558::aid-ajmg9>3.0.co;2-k

PubMed ID: 9298823

Title: Identification of 31 novel mutations in the N-acetylgalactosamine-6-sulfatase gene reveals excessive allelic heterogeneity among patients with Morquio A syndrome.

PubMed ID: 9298823

DOI: 10.1002/(sici)1098-1004(1997)10:3<223::aid-humu8>3.0.co;2-j

PubMed ID: 9375852

Title: Fourteen novel mucopolysaccharidosis IVA producing mutations in GALNS gene.

PubMed ID: 9375852

DOI: 10.1002/(sici)1098-1004(1997)10:5<368::aid-humu6>3.0.co;2-b

PubMed ID: 9521421

Title: Molecular heterogeneity in mucopolysaccharidosis IVA in Australia and Northern Ireland: nine novel mutations including T312S, a common allele that confers a mild phenotype.

PubMed ID: 9521421

DOI: 10.1002/(sici)1098-1004(1998)11:3<202::aid-humu4>3.0.co;2-j

PubMed ID: 9452036

Title: Fifteen polymorphisms in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene: diagnostic implications in Morquio disease.

PubMed ID: 9452036

DOI: 10.1002/humu.1380110115

PubMed ID: 16287098

Title: Mutation and polymorphism spectrum of the GALNS gene in mucopolysaccharidosis IVA (Morquio A).

PubMed ID: 16287098

DOI: 10.1002/humu.20257

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 24726177

Title: Molecular testing of 163 patients with Morquio A (Mucopolysaccharidosis IVA) identifies 39 novel GALNS mutations.

PubMed ID: 24726177

DOI: 10.1016/j.ymgme.2014.03.004

Sequence Information:

  • Length: 522
  • Mass: 58026
  • Checksum: 1D086E528AAAE949
  • Sequence:
    • MAAVVAATRW WQLLLVLSAA GMGASGAPQP PNILLLLMDD MGWGDLGVYG EPSRETPNLD 
RMAAEGLLFP NFYSANPLCS PSRAALLTGR LPIRNGFYTT NAHARNAYTP QEIVGGIPDS 
EQLLPELLKK AGYVSKIVGK WHLGHRPQFH PLKHGFDEWF GSPNCHFGPY DNKARPNIPV 
YRDWEMVGRY YEEFPINLKT GEANLTQIYL QEALDFIKRQ ARHHPFFLYW AVDATHAPVY 
ASKPFLGTSQ RGRYGDAVRE IDDSIGKILE LLQDLHVADN TFVFFTSDNG AALISAPEQG 
GSNGPFLCGK QTTFEGGMRE PALAWWPGHV TAGQVSHQLG SIMDLFTTSL ALAGLTPPSD 
RAIDGLNLLP TLLQGRLMDR PIFYYRGDTL MAATLGQHKA HFWTWTNSWE NFRQGIDFCP 
GQNVSGVTTH NLEDHTKLPL IFHLGRDPGE RFPLSFASAE YQEALSRITS VVQQHQEALV 
PAQPQLNVCN WAVMNWAPPG CEKLGKCLTP PESIPKKCLW SH

Genular Protein ID: 3250203457

Symbol: Q96I49_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96I49

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 238
  • Mass: 26148
  • Checksum: BC4810E73D89D5ED
  • Sequence:
    • FTSDNGAALI SAPEQGGSNG PFLCGKQTTF EGGMREPALA WWPGHVTAGQ VSHQLGSIMD 
LFTTSLALAG LTPPSDRAID GLNLLPTLLQ GRLMDRPIFY YRGDTLMAAT LGQHKAHFWT 
WTNSWENFRQ GIDFCPGQNV SGVTTHNLED HTKLPLIFHL GRDPGERFPL SFASAEYQEA 
LSRITSVVQQ HQEALVPAQP QLNVCNWAVM NWAPPGCEKL GKCLTPPESI PKKCLWSH

Genular Protein ID: 1926451998

Symbol: Q6YL38_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6YL38

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 2 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 337
  • Mass: 37579
  • Checksum: 7D6A6DBF166CE355
  • Sequence:
    • MVGRYYEEFP INLKTGEANL TQIYLQEALD FIKRQARHHP FFLYWAVDAT HAPVYASKPF 
LGTSQRGRYG DAVREIDDSI GKILELLQDL HVADNTFVFF TSDNGAALIS APEQGGSNGP 
FLCGKQTTFE GGMREPALAW WPGHVTAGQV SHQLGSIMDL FTTSLALAGL TPPSDRAIDG 
LNLLPTLLQG RLMDRPIFYY RGDTLMAATL GQHKAHFWTW TNSWENFRQG IDFCPGQNVS 
GVTTHNLEDH TKLPLIFHLG RDPGERFPLS FASAEYQEAL SRITSVVQQH QEALVPAQPQ 
LNVCNWAVMN WAPPGCEKLG KCLTPPESIP KKCLWSH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.