Details for: GNL3

Gene ID: 26354

Symbol: GNL3

Ensembl ID: ENSG00000163938

Description: G protein nucleolar 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 257.8028
    Cell Significance Index: -40.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 132.6666
    Cell Significance Index: -33.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 105.8873
    Cell Significance Index: -43.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.2067
    Cell Significance Index: -44.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.8538
    Cell Significance Index: -36.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 85.1939
    Cell Significance Index: -43.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.1728
    Cell Significance Index: -37.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.7677
    Cell Significance Index: -44.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8940
    Cell Significance Index: -37.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4950
    Cell Significance Index: -45.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9399
    Cell Significance Index: -30.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9640
    Cell Significance Index: -17.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6809
    Cell Significance Index: 191.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3979
    Cell Significance Index: 31.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9400
    Cell Significance Index: 21.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8904
    Cell Significance Index: 88.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8888
    Cell Significance Index: 54.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8106
    Cell Significance Index: 134.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7914
    Cell Significance Index: 231.4400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.6444
    Cell Significance Index: 10.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6407
    Cell Significance Index: 295.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5529
    Cell Significance Index: 1402.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4637
    Cell Significance Index: 179.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4474
    Cell Significance Index: 287.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3206
    Cell Significance Index: 93.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2979
    Cell Significance Index: 37.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0923
    Cell Significance Index: 150.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0916
    Cell Significance Index: 19.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0883
    Cell Significance Index: 50.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0331
    Cell Significance Index: 28.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9981
    Cell Significance Index: 26.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9708
    Cell Significance Index: 429.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8670
    Cell Significance Index: 59.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8499
    Cell Significance Index: 17.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8395
    Cell Significance Index: 458.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6788
    Cell Significance Index: 30.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6416
    Cell Significance Index: 13.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5185
    Cell Significance Index: 14.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4986
    Cell Significance Index: 32.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4386
    Cell Significance Index: 83.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4376
    Cell Significance Index: 15.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4050
    Cell Significance Index: 10.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3776
    Cell Significance Index: 64.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3763
    Cell Significance Index: 75.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2996
    Cell Significance Index: 48.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2717
    Cell Significance Index: 16.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2554
    Cell Significance Index: 32.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2234
    Cell Significance Index: 26.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2167
    Cell Significance Index: 6.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1889
    Cell Significance Index: 10.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1824
    Cell Significance Index: 6.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1562
    Cell Significance Index: 56.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1096
    Cell Significance Index: 2.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0498
    Cell Significance Index: 4.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0225
    Cell Significance Index: 17.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0138
    Cell Significance Index: 25.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0115
    Cell Significance Index: 17.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0114
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0073
    Cell Significance Index: 13.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0135
    Cell Significance Index: -8.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0163
    Cell Significance Index: -12.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0224
    Cell Significance Index: -14.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0238
    Cell Significance Index: -1.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0384
    Cell Significance Index: -28.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0558
    Cell Significance Index: -31.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0568
    Cell Significance Index: -25.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0740
    Cell Significance Index: -7.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0809
    Cell Significance Index: -1.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0810
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0840
    Cell Significance Index: -17.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1049
    Cell Significance Index: -15.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1186
    Cell Significance Index: -13.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1240
    Cell Significance Index: -14.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1283
    Cell Significance Index: -36.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1665
    Cell Significance Index: -12.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1768
    Cell Significance Index: -4.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1854
    Cell Significance Index: -1.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2039
    Cell Significance Index: -5.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2316
    Cell Significance Index: -3.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2394
    Cell Significance Index: -12.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2880
    Cell Significance Index: -32.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3329
    Cell Significance Index: -7.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3379
    Cell Significance Index: -5.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3854
    Cell Significance Index: -24.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3859
    Cell Significance Index: -25.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4142
    Cell Significance Index: -43.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4949
    Cell Significance Index: -39.2000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5183
    Cell Significance Index: -8.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6339
    Cell Significance Index: -16.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6441
    Cell Significance Index: -39.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6521
    Cell Significance Index: -19.1500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.6844
    Cell Significance Index: -3.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7126
    Cell Significance Index: -31.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7188
    Cell Significance Index: -10.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7276
    Cell Significance Index: -21.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7590
    Cell Significance Index: -19.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7839
    Cell Significance Index: -8.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7889
    Cell Significance Index: -18.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8129
    Cell Significance Index: -10.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GNL3 is a member of the G protein nucleolar family, which is involved in the regulation of rRNA processing and protein localization. The gene encodes a protein that binds to guanine nucleotides, suggesting its involvement in signal transduction pathways. The expression of GNL3 is restricted to specific cell types, including stem cells, immune cells, and epithelial cells, indicating its specialized function in these cells. **Pathways and Functions:** GNL3 is involved in various cellular pathways, including: 1. **rRNA processing:** GNL3 plays a crucial role in the processing of rRNA, which is essential for the synthesis of ribosomes. The gene is involved in the regulation of rRNA processing in the nucleolus and cytosol. 2. **Protein localization:** GNL3 regulates the localization of proteins to specific cellular compartments, including the nucleus and cytosol. The gene is involved in the positive regulation of protein localization to chromosome, telomeric region, and sumoylation sites. 3. **Telomere maintenance:** GNL3 is involved in the maintenance of telomeres, which are essential for the regulation of cell proliferation and aging. 4. **Positive regulation of miRNA transcription:** GNL3 regulates the transcription of microRNAs, which are small non-coding RNAs that play a crucial role in the regulation of gene expression. **Clinical Significance:** The involvement of GNL3 in the regulation of cell population proliferation and stem cell maintenance highlights its potential as a therapeutic target in diseases characterized by uncontrolled cell growth, such as cancer. The expression of GNL3 in various cell types suggests its potential as a biomarker for disease diagnosis and prognosis. Furthermore, the regulation of GNL3 by microRNAs suggests its potential as a target for microRNA-based therapies. In conclusion, GNL3 is a gene that plays a crucial role in the regulation of RNA processing, protein localization, and telomere maintenance. The involvement of GNL3 in the regulation of cell population proliferation and stem cell maintenance highlights its potential as a therapeutic target in diseases characterized by uncontrolled cell growth. Further research is necessary to fully elucidate the function of GNL3 and its clinical significance. **Implications for Immunology:** The expression of GNL3 in immune cells, such as IgG plasmablasts, highlights its potential as a biomarker for immune-related diseases. The regulation of GNL3 by microRNAs suggests its potential as a target for microRNA-based therapies in immunological disorders. Furthermore, the involvement of GNL3 in the regulation of cell population proliferation and stem cell maintenance highlights its potential as a therapeutic target in immunological diseases, such as autoimmune disorders and cancer. **Future Directions:** Further research is necessary to fully elucidate the function of GNL3 and its clinical significance. The use of gene editing technologies, such as CRISPR/Cas9, to study the function of GNL3 in human cells is an exciting area of research. Additionally, the development of microRNA-based therapies targeting GNL3 has the potential to revolutionize the treatment of immunological disorders and cancer.

Genular Protein ID: 731080928

Symbol: GNL3_HUMAN

Name: Guanine nucleotide-binding protein-like 3

UniProtKB Accession Codes:

Q9BVP2 B2RDC1 Q5PU80 Q96SV6 Q96SV7 Q9UJY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 19 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 19 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11085516

Title: Effects of estrogen on global gene expression: identification of novel targets of estrogen action.

PubMed ID: 11085516

PubMed ID: 16012751

Title: Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells.

PubMed ID: 16012751

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11790298

Title: Directed proteomic analysis of the human nucleolus.

PubMed ID: 11790298

DOI: 10.1016/s0960-9822(01)00650-9

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 12464630

Title: A nucleolar mechanism controlling cell proliferation in stem and cancer cells.

PubMed ID: 12464630

DOI: 10.1101/gad.55671

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34681573

Title: Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry.

PubMed ID: 34681573

DOI: 10.3390/ijms222010913

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 549
  • Mass: 61993
  • Checksum: F3928FE1C77C77F4
  • Sequence:
    • MKRPKLKKAS KRMTCHKRYK IQKKVREHHR KLRKEAKKRG HKKPRKDPGV PNSAPFKEAL 
LREAELRKQR LEELKQQQKL DRQKELEKKR KLETNPDIKP SNVEPMEKEF GLCKTENKAK 
SGKQNSKKLY CQELKKVIEA SDVVLEVLDA RDPLGCRCPQ VEEAIVQSGQ KKLVLILNKS 
DLVPKENLES WLNYLKKELP TVVFRASTKP KDKGKITKRV KAKKNAAPFR SEVCFGKEGL 
WKLLGGFQET CSKAIRVGVI GFPNVGKSSI INSLKQEQMC NVGVSMGLTR SMQVVPLDKQ 
ITIIDSPSFI VSPLNSSSAL ALRSPASIEV VKPMEAASAI LSQADARQVV LKYTVPGYRN 
SLEFFTVLAQ RRGMHQKGGI PNVEGAAKLL WSEWTGASLA YYCHPPTSWT PPPYFNESIV 
VDMKSGFNLE ELEKNNAQSI RAIKGPHLAN SILFQSSGLT NGIIEEKDIH EELPKRKERK 
QEEREDDKDS DQETVDEEVD ENSSGMFAAE ETGEALSEET TAGEQSTRSF ILDKIIEEDD 
AYDFSTDYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.