Details for: TIMM13

Gene ID: 26517

Symbol: TIMM13

Ensembl ID: ENSG00000099800

Description: translocase of inner mitochondrial membrane 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 275.0325
    Cell Significance Index: -42.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 148.3927
    Cell Significance Index: -61.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 128.1658
    Cell Significance Index: -60.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 127.9750
    Cell Significance Index: -32.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 117.2079
    Cell Significance Index: -60.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 90.0566
    Cell Significance Index: -60.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.6918
    Cell Significance Index: -53.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.3731
    Cell Significance Index: -46.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8883
    Cell Significance Index: -58.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9869
    Cell Significance Index: -42.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.8605
    Cell Significance Index: 62.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0776
    Cell Significance Index: -15.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.0610
    Cell Significance Index: 55.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.0103
    Cell Significance Index: 105.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.9777
    Cell Significance Index: 83.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.9659
    Cell Significance Index: 50.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.8020
    Cell Significance Index: 101.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3273
    Cell Significance Index: 30.6400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.6629
    Cell Significance Index: 22.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4475
    Cell Significance Index: 336.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3621
    Cell Significance Index: 110.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3357
    Cell Significance Index: 1275.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.2609
    Cell Significance Index: 106.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.2518
    Cell Significance Index: 78.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1964
    Cell Significance Index: 155.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1358
    Cell Significance Index: 275.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9827
    Cell Significance Index: 357.4200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.9775
    Cell Significance Index: 12.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9725
    Cell Significance Index: 242.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9084
    Cell Significance Index: 142.2400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.8896
    Cell Significance Index: 4.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6161
    Cell Significance Index: 714.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4880
    Cell Significance Index: 77.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4873
    Cell Significance Index: 95.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4314
    Cell Significance Index: 33.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3406
    Cell Significance Index: 36.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3361
    Cell Significance Index: 38.5000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.2902
    Cell Significance Index: 7.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1625
    Cell Significance Index: 137.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0808
    Cell Significance Index: 48.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9701
    Cell Significance Index: 58.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9600
    Cell Significance Index: 190.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9519
    Cell Significance Index: 94.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9043
    Cell Significance Index: 26.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8908
    Cell Significance Index: 46.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8699
    Cell Significance Index: 111.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7940
    Cell Significance Index: 9.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5910
    Cell Significance Index: 15.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5846
    Cell Significance Index: 8.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5325
    Cell Significance Index: 153.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5049
    Cell Significance Index: 82.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4816
    Cell Significance Index: 12.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3368
    Cell Significance Index: 64.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3103
    Cell Significance Index: 280.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2313
    Cell Significance Index: 175.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1317
    Cell Significance Index: 26.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1095
    Cell Significance Index: 3.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0989
    Cell Significance Index: 1.6600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0942
    Cell Significance Index: 1.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0941
    Cell Significance Index: 3.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0921
    Cell Significance Index: 15.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0860
    Cell Significance Index: 63.0300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0495
    Cell Significance Index: 0.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0185
    Cell Significance Index: 6.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0219
    Cell Significance Index: -41.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0279
    Cell Significance Index: -2.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0339
    Cell Significance Index: -62.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0419
    Cell Significance Index: -64.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0494
    Cell Significance Index: -67.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0553
    Cell Significance Index: -40.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0558
    Cell Significance Index: -1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0739
    Cell Significance Index: -46.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0897
    Cell Significance Index: -50.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1104
    Cell Significance Index: -68.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1182
    Cell Significance Index: -53.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1429
    Cell Significance Index: -16.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1488
    Cell Significance Index: -2.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1591
    Cell Significance Index: -4.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2420
    Cell Significance Index: -15.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2733
    Cell Significance Index: -5.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3081
    Cell Significance Index: -64.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3239
    Cell Significance Index: -25.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3509
    Cell Significance Index: -2.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3590
    Cell Significance Index: -52.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3628
    Cell Significance Index: -41.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3780
    Cell Significance Index: -8.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3951
    Cell Significance Index: -4.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4255
    Cell Significance Index: -5.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4435
    Cell Significance Index: -27.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5684
    Cell Significance Index: -59.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5812
    Cell Significance Index: -17.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6112
    Cell Significance Index: -21.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6277
    Cell Significance Index: -48.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7050
    Cell Significance Index: -39.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7116
    Cell Significance Index: -47.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7774
    Cell Significance Index: -47.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0410
    Cell Significance Index: -17.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1988
    Cell Significance Index: -14.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3691
    Cell Significance Index: -60.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3836
    Cell Significance Index: -50.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: TIMM13 is specifically localized to the inner mitochondrial membrane, where it interacts with other mitochondrial proteins to facilitate protein import. 2. **Subunit of mitochondrial import inner membrane translocase**: TIMM13 is a subunit of the mitochondrial import inner membrane translocase, which is responsible for the translocation of proteins across the inner mitochondrial membrane. 3. **Zinc ion binding**: TIMM13 has been shown to bind zinc ions, which is essential for its function and stability. 4. **Expression in various cell types**: TIMM13 is expressed in a wide range of cell types, including pancreatic A cells, erythroid progenitor cells, and interstitial cells of the ovary. **Pathways and Functions:** TIMM13 is involved in the following pathways and functions: 1. **Mitochondrial protein import**: TIMM13 facilitates the import of essential mitochondrial proteins, including those involved in energy metabolism, oxidative stress response, and mitochondrial biogenesis. 2. **Protein insertion into mitochondrial inner membrane**: TIMM13 helps to insert proteins into the inner mitochondrial membrane, where they can perform their functions. 3. **Protein targeting to mitochondrion**: TIMM13 is involved in the targeting of proteins to the mitochondrion, ensuring that only essential proteins are imported. 4. **Sensory perception of sound**: TIMM13 has been implicated in the sensory perception of sound, particularly in the context of ototoxicity. **Clinical Significance:** Dysregulation of TIMM13 has been implicated in various disease states, including: 1. **Mitochondrial disorders**: Mutations in TIMM13 have been associated with mitochondrial disorders, such as MERRF (myoclonic epilepsy with ragged-red fibers) and MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). 2. **Neurodegenerative diseases**: TIMM13 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction plays a key role. 3. **Cancer**: TIMM13 has been shown to be overexpressed in certain types of cancer, including pancreatic cancer, where it may contribute to tumorigenesis. 4. **Ototoxicity**: TIMM13 has been implicated in ototoxicity, particularly in the context of sound exposure, where it may contribute to hearing loss. In conclusion, TIMM13 is a critical component of mitochondrial protein import, and its dysregulation has been implicated in various disease states. Further research is needed to fully understand the functions and significance of TIMM13 and its role in human disease.

Genular Protein ID: 3361659600

Symbol: TIM13_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim13

UniProtKB Accession Codes:

Q9Y5L4 P62206 Q9UHL8 Q9WTL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10611480

Title: The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

PubMed ID: 10611480

DOI: 10.1016/s0014-5793(99)01665-8

PubMed ID: 10552927

Title: The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins.

PubMed ID: 10552927

DOI: 10.1006/geno.1999.5966

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11489896

Title: Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria.

PubMed ID: 11489896

DOI: 10.1074/jbc.m105313200

PubMed ID: 15254020

Title: The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex.

PubMed ID: 15254020

DOI: 10.1093/hmg/ddh217

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 95
  • Mass: 10500
  • Checksum: E40E742C7CA55834
  • Sequence:
    • MEGGFGSDFG GSGSGKLDPG LIMEQVKVQI AVANAQELLQ RMTDKCFRKC IGKPGGSLDN 
SEQKCIAMCM DRYMDAWNTV SRAYNSRLQR ERANM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.