Details for: TIMM10

Gene ID: 26519

Symbol: TIMM10

Ensembl ID: ENSG00000134809

Description: translocase of inner mitochondrial membrane 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.8886
    Cell Significance Index: -23.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.4664
    Cell Significance Index: -28.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.4862
    Cell Significance Index: -33.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.9350
    Cell Significance Index: -33.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 63.9404
    Cell Significance Index: -32.8900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 49.9984
    Cell Significance Index: -33.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.9620
    Cell Significance Index: -32.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3417
    Cell Significance Index: -25.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7936
    Cell Significance Index: -34.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.6902
    Cell Significance Index: -23.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7836
    Cell Significance Index: 47.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6746
    Cell Significance Index: 1512.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3735
    Cell Significance Index: 18.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3495
    Cell Significance Index: 8.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2570
    Cell Significance Index: 65.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1706
    Cell Significance Index: 55.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0634
    Cell Significance Index: 125.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0205
    Cell Significance Index: 72.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0072
    Cell Significance Index: 69.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9800
    Cell Significance Index: 44.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9661
    Cell Significance Index: 72.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9513
    Cell Significance Index: 420.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9300
    Cell Significance Index: 10.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9238
    Cell Significance Index: 113.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9111
    Cell Significance Index: 10.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9023
    Cell Significance Index: 42.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8924
    Cell Significance Index: 160.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8347
    Cell Significance Index: 107.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7764
    Cell Significance Index: 7.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7094
    Cell Significance Index: 19.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6848
    Cell Significance Index: 94.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6709
    Cell Significance Index: 366.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6297
    Cell Significance Index: 13.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6172
    Cell Significance Index: 14.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5663
    Cell Significance Index: 16.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5188
    Cell Significance Index: 11.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4872
    Cell Significance Index: 7.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4408
    Cell Significance Index: 12.6400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4196
    Cell Significance Index: 3.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3840
    Cell Significance Index: 24.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3430
    Cell Significance Index: 43.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3381
    Cell Significance Index: 8.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2904
    Cell Significance Index: 8.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2736
    Cell Significance Index: 4.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2037
    Cell Significance Index: 38.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1583
    Cell Significance Index: 5.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1263
    Cell Significance Index: 20.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1221
    Cell Significance Index: 3.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0947
    Cell Significance Index: 71.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0516
    Cell Significance Index: 10.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0432
    Cell Significance Index: 2.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0409
    Cell Significance Index: 8.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0379
    Cell Significance Index: 1.3300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0372
    Cell Significance Index: 0.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0269
    Cell Significance Index: 0.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0233
    Cell Significance Index: 17.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0105
    Cell Significance Index: -1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0140
    Cell Significance Index: -26.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0233
    Cell Significance Index: -2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0236
    Cell Significance Index: -43.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0245
    Cell Significance Index: -16.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0289
    Cell Significance Index: -44.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0295
    Cell Significance Index: -10.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0317
    Cell Significance Index: -5.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0330
    Cell Significance Index: -44.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0333
    Cell Significance Index: -24.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0394
    Cell Significance Index: -2.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0428
    Cell Significance Index: -27.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0490
    Cell Significance Index: -27.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0610
    Cell Significance Index: -38.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0696
    Cell Significance Index: -31.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0816
    Cell Significance Index: -23.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0974
    Cell Significance Index: -11.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1033
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1428
    Cell Significance Index: -16.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1839
    Cell Significance Index: -38.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1986
    Cell Significance Index: -3.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2025
    Cell Significance Index: -29.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2053
    Cell Significance Index: -16.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2358
    Cell Significance Index: -6.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3288
    Cell Significance Index: -8.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3320
    Cell Significance Index: -34.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3324
    Cell Significance Index: -20.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3502
    Cell Significance Index: -12.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4080
    Cell Significance Index: -2.4700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4119
    Cell Significance Index: -5.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4520
    Cell Significance Index: -30.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4605
    Cell Significance Index: -35.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4873
    Cell Significance Index: -5.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5225
    Cell Significance Index: -29.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5485
    Cell Significance Index: -33.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5731
    Cell Significance Index: -16.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6417
    Cell Significance Index: -5.3900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6438
    Cell Significance Index: -6.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7163
    Cell Significance Index: -19.1900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.7204
    Cell Significance Index: -4.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7257
    Cell Significance Index: -32.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7341
    Cell Significance Index: -26.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7843
    Cell Significance Index: -20.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TIMM10 is a mitochondrial inner membrane translocase that belongs to the TIM family of proteins. It is a heterodimeric complex composed of two subunits, Tim10 and Tim23, which work together to facilitate the import of mitochondrial proteins into the inner mitochondrial membrane. TIMM10 has been shown to possess a unique structure, featuring a conserved zinc-binding motif and a protein-folding chaperone-binding domain. This structure allows the protein to interact with various mitochondrial proteins, including those involved in energy production, antioxidant defense, and cell signaling. **Pathways and Functions:** The primary function of TIMM10 is to facilitate the import of mitochondrial proteins into the inner mitochondrial membrane. This process involves the recognition and binding of mitochondrial proteins to the Tim10-Tim23 complex, followed by their translocation across the inner mitochondrial membrane. TIMM10 plays a critical role in various cellular processes, including: 1. **Mitochondrial protein degradation:** TIMM10 is involved in the recognition and targeting of damaged or misfolded mitochondrial proteins for degradation. 2. **Energy production:** TIMM10 facilitates the import of proteins involved in energy production, such as those involved in the electron transport chain and oxidative phosphorylation. 3. **Antioxidant defense:** TIMM10 helps to import proteins involved in antioxidant defense, including those involved in the regulation of reactive oxygen species (ROS) production. 4. **Cell signaling:** TIMM10 is involved in the import of proteins involved in cell signaling, including those involved in the regulation of apoptosis, autophagy, and immune responses. **Clinical Significance:** Dysregulation of TIMM10 has been implicated in various diseases, including: 1. **Mitochondrial disorders:** Mutations in the TIMM10 gene have been associated with mitochondrial disorders, such as MELAS syndrome and Kearns-Sayre syndrome. 2. **Cancer:** TIMM10 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 3. **Neurodegenerative diseases:** TIMM10 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, TIMM10 is a critical component of mitochondrial protein import, playing a vital role in maintaining mitochondrial function and overall cellular health. Further research is needed to fully understand the mechanisms of TIMM10 and its role in various diseases.

Genular Protein ID: 4202842210

Symbol: TIM10_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim10

UniProtKB Accession Codes:

P62072 A8K136 Q9WV99 Q9WVA0 Q9Y5J8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 Ensembl 3 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10611480

Title: The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

PubMed ID: 10611480

DOI: 10.1016/s0014-5793(99)01665-8

PubMed ID: 10552927

Title: The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins.

PubMed ID: 10552927

DOI: 10.1006/geno.1999.5966

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11489896

Title: Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria.

PubMed ID: 11489896

DOI: 10.1074/jbc.m105313200

PubMed ID: 14726512

Title: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.

PubMed ID: 14726512

DOI: 10.1074/jbc.m312485200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16387659

Title: Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller.

PubMed ID: 16387659

DOI: 10.1016/j.molcel.2005.11.010

Sequence Information:

  • Length: 90
  • Mass: 10333
  • Checksum: D20EFAE694D14BAB
  • Sequence:
    • MDPLRAQQLA AELEVEMMAD MYNRMTSACH RKCVPPHYKE AELSKGESVC LDRCVSKYLD 
IHERMGKKLT ELSMQDEELM KRVQQSSGPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.