Details for: RNU1 1

Gene ID: 26871

Symbol: RNU1 1

Ensembl ID: ENSG00000206652

Description: RNA, U1 small nuclear 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.4654
    Cell Significance Index: 5.8800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.1793
    Cell Significance Index: 1.5800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1059
    Cell Significance Index: 1.3300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0837
    Cell Significance Index: 1.0600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0131
    Cell Significance Index: 0.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0043
    Cell Significance Index: 0.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0078
    Cell Significance Index: -0.1300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0118
    Cell Significance Index: -0.1200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0232
    Cell Significance Index: -0.2800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0242
    Cell Significance Index: -0.2300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0255
    Cell Significance Index: -0.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0297
    Cell Significance Index: -0.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0336
    Cell Significance Index: -0.7400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0336
    Cell Significance Index: -0.1800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0355
    Cell Significance Index: -0.3100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0371
    Cell Significance Index: -0.4100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0386
    Cell Significance Index: -0.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0404
    Cell Significance Index: -0.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0406
    Cell Significance Index: -0.4500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0426
    Cell Significance Index: -0.4900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0442
    Cell Significance Index: -0.5100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0466
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0475
    Cell Significance Index: -0.4500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0475
    Cell Significance Index: -0.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0495
    Cell Significance Index: -1.2400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0523
    Cell Significance Index: -0.6600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0533
    Cell Significance Index: -0.6300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0551
    Cell Significance Index: -0.6700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0570
    Cell Significance Index: -0.5900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0596
    Cell Significance Index: -0.6600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0600
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0620
    Cell Significance Index: -0.5800
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0626
    Cell Significance Index: -0.6200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0634
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0638
    Cell Significance Index: -0.7100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0703
    Cell Significance Index: -0.9200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0711
    Cell Significance Index: -0.8400
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0721
    Cell Significance Index: -0.5000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0743
    Cell Significance Index: -0.9700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0762
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0773
    Cell Significance Index: -0.9400
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0777
    Cell Significance Index: -0.8000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0805
    Cell Significance Index: -0.8600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0821
    Cell Significance Index: -0.8900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0836
    Cell Significance Index: -1.0000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0843
    Cell Significance Index: -0.8600
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0843
    Cell Significance Index: -0.9000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0847
    Cell Significance Index: -0.9300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0851
    Cell Significance Index: -0.9300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0898
    Cell Significance Index: -1.0200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0907
    Cell Significance Index: -0.7500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0912
    Cell Significance Index: -0.9000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0926
    Cell Significance Index: -1.0600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0936
    Cell Significance Index: -0.8600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0972
    Cell Significance Index: -1.0800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0977
    Cell Significance Index: -1.1100
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0977
    Cell Significance Index: -1.0600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0995
    Cell Significance Index: -1.3100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1019
    Cell Significance Index: -1.1100
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.1030
    Cell Significance Index: -1.0900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1043
    Cell Significance Index: -0.7500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1160
    Cell Significance Index: -1.4100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1321
    Cell Significance Index: -1.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1329
    Cell Significance Index: -1.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The RNU1 gene is located on chromosome 1 and encodes a small nuclear ribonucleoprotein (snRNP) component. It is part of the U1 small nuclear ribonucleoprotein (U1 snRNP) complex, which plays a critical role in the splicing of pre-mRNA. 2. **Expression Patterns:** The RNU1 gene is widely expressed in various cell types, including hematopoietic cells (T cells, B cells), epithelial cells (goblet cells, plasma cells, intestinal epithelial cells), and stem cells (intestinal crypt stem cells, transit amplifying cells). 3. **Function:** The RNU1 gene is involved in the splicing and maturation of snRNAs, which are essential for the regulation of gene expression, immune response, and cellular differentiation. **Pathways and Functions:** 1. **RNA Splicing:** The RNU1 gene is a key component of the U1 snRNP complex, which recognizes and binds to the 5' splice site of pre-mRNA, facilitating the removal of introns and the joining of exons. 2. **Immune Response:** The RNU1 gene is significantly expressed in immune cells, including T cells and B cells, where it plays a crucial role in the regulation of immune response and the production of antibodies. 3. **Gene Expression Regulation:** The RNU1 gene is involved in the regulation of gene expression by controlling the splicing and maturation of snRNAs, which in turn affects the expression of target genes. 4. **Cellular Differentiation:** The RNU1 gene is expressed in stem cells and transit amplifying cells, where it plays a role in the regulation of cellular differentiation and the maintenance of tissue homeostasis. **Clinical Significance:** 1. **Immune System Disorders:** Dysregulation of the RNU1 gene has been implicated in various immune system disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** The RNU1 gene is overexpressed in certain types of cancer, including lymphoma and leukemia, where it may contribute to tumorigenesis and cancer progression. 3. **Genetic Disorders:** Mutations in the RNU1 gene have been associated with genetic disorders, such as immunodeficiency and developmental abnormalities. 4. **Disease Modeling:** The RNU1 gene has been used as a model for studying the regulation of gene expression and the immune response in various diseases. In conclusion, the RNA U1 Small Nuclear 1 gene plays a critical role in the regulation of gene expression, immune response, and cellular differentiation. Its dysregulation has been implicated in various diseases, including immune system disorders, cancer, and genetic disorders. Further research is needed to fully understand the function of the RNU1 gene and its role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.