Details for: CACYBP

Gene ID: 27101

Symbol: CACYBP

Ensembl ID: ENSG00000116161

Description: calcyclin binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 323.3786
    Cell Significance Index: -50.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 202.2525
    Cell Significance Index: -51.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 162.1808
    Cell Significance Index: -66.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 138.2268
    Cell Significance Index: -65.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 137.1053
    Cell Significance Index: -55.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 126.4422
    Cell Significance Index: -65.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 97.6719
    Cell Significance Index: -65.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.9847
    Cell Significance Index: -57.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.9507
    Cell Significance Index: -62.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.8954
    Cell Significance Index: -66.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.7978
    Cell Significance Index: -42.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9738
    Cell Significance Index: -42.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0737
    Cell Significance Index: -17.6700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 6.1072
    Cell Significance Index: 35.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.0608
    Cell Significance Index: 31.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.6786
    Cell Significance Index: 20.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4315
    Cell Significance Index: 63.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2605
    Cell Significance Index: 24.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.2306
    Cell Significance Index: 641.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.2248
    Cell Significance Index: 77.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1768
    Cell Significance Index: 17.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9504
    Cell Significance Index: 102.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9471
    Cell Significance Index: 229.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8460
    Cell Significance Index: 38.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6790
    Cell Significance Index: 49.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3196
    Cell Significance Index: 62.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2895
    Cell Significance Index: 704.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2563
    Cell Significance Index: 65.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1652
    Cell Significance Index: 160.0100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0627
    Cell Significance Index: 13.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9933
    Cell Significance Index: 197.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9019
    Cell Significance Index: 115.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8641
    Cell Significance Index: 382.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8629
    Cell Significance Index: 106.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8325
    Cell Significance Index: 166.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8162
    Cell Significance Index: 52.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8128
    Cell Significance Index: 23.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8042
    Cell Significance Index: 144.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7903
    Cell Significance Index: 54.6600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7661
    Cell Significance Index: 8.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6729
    Cell Significance Index: 47.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6038
    Cell Significance Index: 28.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5899
    Cell Significance Index: 15.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5806
    Cell Significance Index: 110.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5746
    Cell Significance Index: 6.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5256
    Cell Significance Index: 85.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4168
    Cell Significance Index: 11.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3988
    Cell Significance Index: 8.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2508
    Cell Significance Index: 89.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2127
    Cell Significance Index: 5.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1925
    Cell Significance Index: 10.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1631
    Cell Significance Index: 16.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1558
    Cell Significance Index: 26.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0850
    Cell Significance Index: 10.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0743
    Cell Significance Index: 4.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0439
    Cell Significance Index: 2.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0280
    Cell Significance Index: 21.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0012
    Cell Significance Index: 0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0013
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0154
    Cell Significance Index: -9.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0186
    Cell Significance Index: -35.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0258
    Cell Significance Index: -19.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0329
    Cell Significance Index: -60.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0354
    Cell Significance Index: -54.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0409
    Cell Significance Index: -55.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0447
    Cell Significance Index: -4.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0576
    Cell Significance Index: -2.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0605
    Cell Significance Index: -34.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0794
    Cell Significance Index: -50.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1268
    Cell Significance Index: -57.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1276
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1308
    Cell Significance Index: -27.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1629
    Cell Significance Index: -1.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1650
    Cell Significance Index: -3.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1676
    Cell Significance Index: -12.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1696
    Cell Significance Index: -19.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2237
    Cell Significance Index: -25.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2998
    Cell Significance Index: -7.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3214
    Cell Significance Index: -21.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3302
    Cell Significance Index: -48.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3306
    Cell Significance Index: -10.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4922
    Cell Significance Index: -56.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4988
    Cell Significance Index: -13.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5250
    Cell Significance Index: -29.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5698
    Cell Significance Index: -9.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5932
    Cell Significance Index: -46.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6316
    Cell Significance Index: -65.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6504
    Cell Significance Index: -49.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8562
    Cell Significance Index: -51.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8789
    Cell Significance Index: -30.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9004
    Cell Significance Index: -5.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9207
    Cell Significance Index: -56.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9242
    Cell Significance Index: -12.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9366
    Cell Significance Index: -17.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1279
    Cell Significance Index: -49.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1462
    Cell Significance Index: -24.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1474
    Cell Significance Index: -30.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1843
    Cell Significance Index: -33.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.2164
    Cell Significance Index: -18.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CACYBP exhibits several key characteristics that distinguish it from other proteins in the S100 family. Its ability to bind calcyclin is a notable feature, as this interaction is crucial for its function. Additionally, CACYBP has been shown to interact with various proteins, including scf ubiquitin ligase complex, tubulin, and ubiquitin protein ligase, suggesting its involvement in multiple cellular pathways. Its expression is also notable for its widespread distribution across different cell types, highlighting its potential role in diverse cellular processes. **Pathways and Functions** CACYBP is involved in several key pathways, including: 1. **Beta-catenin destruction complex**: CACYBP has been shown to interact with the beta-catenin destruction complex, a critical regulator of Wnt signaling. This interaction suggests that CACYBP may play a role in regulating cell growth and differentiation. 2. **Cellular response to leukemia inhibitory factor**: CACYBP has been implicated in the cellular response to leukemia inhibitory factor (LIF), a cytokine involved in hematopoiesis and immune regulation. 3. **Protein binding and homodimerization**: CACYBP's ability to bind various proteins and form homodimers suggests its role in protein-protein interactions, which are crucial for regulating cellular processes. **Functions** CACYBP's functions are multifaceted, with implications in: 1. **Immune regulation**: CACYBP's expression in myeloid leukocytes and B-1 B cells suggests its role in immune regulation, potentially influencing the development and function of these cells. 2. **Cell differentiation**: CACYBP's interaction with calcyclin and its involvement in the beta-catenin destruction complex suggest its role in cell differentiation, particularly in hematopoietic cells. 3. **Development**: CACYBP's expression in oogonial cells and its involvement in heart development suggest its role in embryonic development and tissue formation. **Clinical Significance** CACYBP's involvement in various cellular processes and its expression in multiple cell types make it a potential target for therapeutic interventions. Its role in immune regulation and cell differentiation suggests its potential involvement in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Additionally, its expression in oogonial cells and its involvement in heart development suggest its potential role in congenital heart defects and other developmental disorders. In conclusion, CACYBP is a complex protein with significant implications in various cellular processes. Its widespread expression and involvement in multiple pathways make it a promising target for therapeutic interventions. Further research is needed to fully elucidate its role in immune regulation, cell differentiation, and development, and to explore its potential clinical significance.

Genular Protein ID: 4081805195

Symbol: CYBP_HUMAN

Name: Calcyclin-binding protein

UniProtKB Accession Codes:

Q9HB71 B2ZWH2 B3KSF1 O60666 Q5R370 Q5R371

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12006993

Title: Cloning and expression of human calcyclin binding protein (hCacyBP) gene.

PubMed ID: 12006993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11389839

Title: Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.

PubMed ID: 11389839

DOI: 10.1016/s1097-2765(01)00242-8

PubMed ID: 12895292

Title: Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells.

PubMed ID: 12895292

DOI: 10.5483/bmbrep.2003.36.4.354

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16085652

Title: Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.

PubMed ID: 16085652

DOI: 10.1074/jbc.m506707200

Sequence Information:

  • Length: 228
  • Mass: 26210
  • Checksum: 88C822FB14A7EF89
  • Sequence:
    • MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK KAELLDNEKP 
AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP TENVQVHFTE RSFDLLVKNL 
NGKSYSMIVN NLLKPISVEG SSKKVKTDTV LILCRKKVEN TRWDYLTQVE KECKEKEKPS 
YDTETDPSEG LMNVLKKIYE DGDDDMKRTI NKAWVESREK QAKGDTEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.