Details for: SULT1C4

Gene ID: 27233

Symbol: SULT1C4

Ensembl ID: ENSG00000198075

Description: sulfotransferase family 1C member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 65.5758
    Cell Significance Index: -10.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.0278
    Cell Significance Index: -7.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 27.0423
    Cell Significance Index: -11.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.4396
    Cell Significance Index: -9.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2728
    Cell Significance Index: -10.2000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.3879
    Cell Significance Index: 20.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2435
    Cell Significance Index: -4.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.4817
    Cell Significance Index: 11.8300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.3116
    Cell Significance Index: 4.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2003
    Cell Significance Index: 29.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7640
    Cell Significance Index: 42.8700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6336
    Cell Significance Index: 5.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5942
    Cell Significance Index: 7.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.5812
    Cell Significance Index: 17.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4445
    Cell Significance Index: 88.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3476
    Cell Significance Index: 12.0800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3121
    Cell Significance Index: 5.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2538
    Cell Significance Index: 34.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2495
    Cell Significance Index: 31.9900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2126
    Cell Significance Index: 2.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1825
    Cell Significance Index: 4.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1682
    Cell Significance Index: 3.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1490
    Cell Significance Index: 1.6200
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.1433
    Cell Significance Index: 0.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1400
    Cell Significance Index: 16.3100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0812
    Cell Significance Index: 1.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0783
    Cell Significance Index: 0.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0558
    Cell Significance Index: 30.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0450
    Cell Significance Index: 84.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0449
    Cell Significance Index: 1.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0385
    Cell Significance Index: 24.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0344
    Cell Significance Index: 0.5800
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.0327
    Cell Significance Index: 0.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0265
    Cell Significance Index: 0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0031
    Cell Significance Index: 4.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0027
    Cell Significance Index: 2.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0029
    Cell Significance Index: -0.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0112
    Cell Significance Index: -1.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0115
    Cell Significance Index: -0.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0125
    Cell Significance Index: -0.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0128
    Cell Significance Index: -5.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0137
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0150
    Cell Significance Index: -11.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0165
    Cell Significance Index: -10.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0170
    Cell Significance Index: -9.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0225
    Cell Significance Index: -8.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0286
    Cell Significance Index: -0.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0293
    Cell Significance Index: -8.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0388
    Cell Significance Index: -3.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0417
    Cell Significance Index: -7.5200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0447
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0489
    Cell Significance Index: -8.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0500
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0520
    Cell Significance Index: -10.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0563
    Cell Significance Index: -6.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0566
    Cell Significance Index: -7.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0644
    Cell Significance Index: -7.9200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0756
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0919
    Cell Significance Index: -9.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0957
    Cell Significance Index: -2.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0966
    Cell Significance Index: -6.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0993
    Cell Significance Index: -6.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1032
    Cell Significance Index: -8.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1147
    Cell Significance Index: -8.8000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1217
    Cell Significance Index: -0.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1242
    Cell Significance Index: -6.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1264
    Cell Significance Index: -9.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1321
    Cell Significance Index: -8.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1481
    Cell Significance Index: -9.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1493
    Cell Significance Index: -6.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1532
    Cell Significance Index: -4.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1563
    Cell Significance Index: -7.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1687
    Cell Significance Index: -10.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1819
    Cell Significance Index: -9.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1929
    Cell Significance Index: -5.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1968
    Cell Significance Index: -5.5000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1981
    Cell Significance Index: -1.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2091
    Cell Significance Index: -9.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2129
    Cell Significance Index: -11.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2363
    Cell Significance Index: -10.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2491
    Cell Significance Index: -10.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2495
    Cell Significance Index: -8.7400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2542
    Cell Significance Index: -8.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2661
    Cell Significance Index: -6.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2725
    Cell Significance Index: -11.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2751
    Cell Significance Index: -6.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2781
    Cell Significance Index: -10.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2860
    Cell Significance Index: -7.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2880
    Cell Significance Index: -9.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2881
    Cell Significance Index: -6.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3005
    Cell Significance Index: -9.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3011
    Cell Significance Index: -4.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3108
    Cell Significance Index: -11.4100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3111
    Cell Significance Index: -4.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3144
    Cell Significance Index: -3.2600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3158
    Cell Significance Index: -2.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Sulfotransferase activity**: SULT1C4 exhibits sulfotransferase activity, which involves the transfer of a sulfur-containing group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to various substrates. 2. **Substrate specificity**: The enzyme has been shown to sulfonate a range of compounds, including flavonoids, doxorubicin, and paracetamol. 3. **Tissue distribution**: SULT1C4 is highly expressed in endothelial cells, which line blood vessels and lymphatic vessels, as well as in gut, lung, thymus, and kidney tissues. 4. **Cellular localization**: The enzyme is primarily localized to the cytosol of cells, where it can interact with various substrates and cofactors. **Pathways and Functions:** SULT1C4 is involved in multiple metabolic pathways, including: 1. **Xenobiotic metabolism**: The enzyme plays a crucial role in the metabolism and detoxification of xenobiotics, such as environmental pollutants and pharmaceuticals. 2. **Endogenous metabolism**: SULT1C4 is involved in the sulfonation of endogenous compounds, including flavonoids and other small molecules. 3. **Aryl sulfotransferase activity**: The enzyme exhibits aryl sulfotransferase activity, which involves the sulfonation of aromatic compounds. 4. **3'-phosphoadenosine 5'-phosphosulfate metabolic process**: SULT1C4 is involved in the metabolism of 3'-phosphoadenosine 5'-phosphosulfate, a key sulfur-containing compound in the sulfonation process. **Clinical Significance:** The clinical significance of SULT1C4 is multifaceted: 1. **Detoxification of xenobiotics**: The enzyme plays a crucial role in the metabolism and detoxification of xenobiotics, which can help protect against environmental pollutants and pharmaceuticals. 2. **Metabolism of endogenous compounds**: SULT1C4 is involved in the sulfonation of endogenous compounds, which can affect various physiological processes, including inflammation and immune response. 3. **Pharmacokinetics and pharmacodynamics**: The enzyme can influence the pharmacokinetics and pharmacodynamics of drugs, particularly those that are substrates for SULT1C4. 4. **Cancer and disease**: Alterations in SULT1C4 expression or activity have been linked to various diseases, including cancer, inflammation, and metabolic disorders. In conclusion, SULT1C4 is a crucial sulfotransferase enzyme that plays a vital role in the metabolism and detoxification of various compounds in the body. Its clinical significance is multifaceted, and further research is needed to fully elucidate its role in human health and disease.

Genular Protein ID: 2232243190

Symbol: ST1C4_HUMAN

Name: Sulfotransferase 1C4

UniProtKB Accession Codes:

O75897 Q069I8 Q08AS5 Q53S63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 21 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9852044

Title: Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene.

PubMed ID: 9852044

DOI: 10.1074/jbc.273.51.33929

PubMed ID: 10783263

Title: Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization.

PubMed ID: 10783263

DOI: 10.1006/geno.2000.6150

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17425406

Title: Structural and chemical profiling of the human cytosolic sulfotransferases.

PubMed ID: 17425406

DOI: 10.1371/journal.pbio.0050097

PubMed ID: 26948952

Title: Human cytosolic sulfotransferase SULT1C4 mediates the sulfation of doxorubicin and epirubicin.

PubMed ID: 26948952

DOI: 10.1016/j.dmpk.2016.01.003

PubMed ID: 28222028

Title: Expression, purification and characterization of human cytosolic sulfotransferase (SULT) 1C4.

PubMed ID: 28222028

DOI: 10.1515/hmbci-2016-0053

Sequence Information:

  • Length: 302
  • Mass: 35520
  • Checksum: 905E1820A6E222F3
  • Sequence:
    • MALHDMEDFT FDGTKRLSVN YVKGILQPTD TCDIWDKIWN FQAKPDDLLI STYPKAGTTW 
TQEIVELIQN EGDVEKSKRA PTHQRFPFLE MKIPSLGSGL EQAHAMPSPR ILKTHLPFHL 
LPPSLLEKNC KIIYVARNPK DNMVSYYHFQ RMNKALPAPG TWEEYFETFL AGKVCWGSWH 
EHVKGWWEAK DKHRILYLFY EDMKKNPKHE IQKLAEFIGK KLDDKVLDKI VHYTSFDVMK 
QNPMANYSSI PAEIMDHSIS PFMRKGAVGD WKKHFTVAQN ERFDEDYKKK MTDTRLTFHF 
QF

Genular Protein ID: 701657658

Symbol: Q6PD90_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PD90

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 3 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 102
  • Mass: 11766
  • Checksum: 9AF28A3F07FA6384
  • Sequence:
    • MALHDMEDFT FDGTKRLSVN YVKGILQPTD TCDIWDKIWN FQAKPDDLLI STYPKAGTTW 
TQEIVELIQN EGDVEKSKRA PTHQRFPFLE MKIPSLGSGE YK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.