Details for: HTATSF1

Gene ID: 27336

Symbol: HTATSF1

Ensembl ID: ENSG00000102241

Description: HIV-1 Tat specific factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.8904
    Cell Significance Index: -27.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.5165
    Cell Significance Index: -29.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 95.2791
    Cell Significance Index: -39.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.2726
    Cell Significance Index: -36.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.2418
    Cell Significance Index: -29.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.0509
    Cell Significance Index: -34.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.6644
    Cell Significance Index: -36.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.5739
    Cell Significance Index: -30.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.3181
    Cell Significance Index: -34.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4190
    Cell Significance Index: -30.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2067
    Cell Significance Index: -36.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1460
    Cell Significance Index: -25.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1502
    Cell Significance Index: 217.8600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.8237
    Cell Significance Index: 13.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6998
    Cell Significance Index: 184.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2901
    Cell Significance Index: 44.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1820
    Cell Significance Index: 34.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1029
    Cell Significance Index: 69.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0813
    Cell Significance Index: 132.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0625
    Cell Significance Index: 22.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0192
    Cell Significance Index: 11.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9037
    Cell Significance Index: 115.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8486
    Cell Significance Index: 152.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8251
    Cell Significance Index: 42.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8047
    Cell Significance Index: 41.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8002
    Cell Significance Index: 21.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7587
    Cell Significance Index: 104.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7141
    Cell Significance Index: 46.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6876
    Cell Significance Index: 18.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6251
    Cell Significance Index: 32.8200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5060
    Cell Significance Index: 3.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4977
    Cell Significance Index: 13.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4700
    Cell Significance Index: 256.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4280
    Cell Significance Index: 189.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4220
    Cell Significance Index: 80.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4152
    Cell Significance Index: 48.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4021
    Cell Significance Index: 28.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3764
    Cell Significance Index: 75.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3509
    Cell Significance Index: 16.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2834
    Cell Significance Index: 2.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2797
    Cell Significance Index: 8.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2588
    Cell Significance Index: 3.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2435
    Cell Significance Index: 24.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1742
    Cell Significance Index: 10.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1692
    Cell Significance Index: 7.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1689
    Cell Significance Index: 33.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1660
    Cell Significance Index: 28.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1476
    Cell Significance Index: 1.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1463
    Cell Significance Index: 6.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1404
    Cell Significance Index: 50.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1377
    Cell Significance Index: 17.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1324
    Cell Significance Index: 3.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1203
    Cell Significance Index: 8.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0548
    Cell Significance Index: 8.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0276
    Cell Significance Index: 20.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0095
    Cell Significance Index: 6.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0036
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0051
    Cell Significance Index: -9.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0091
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0188
    Cell Significance Index: -14.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0206
    Cell Significance Index: -38.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0242
    Cell Significance Index: -37.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0280
    Cell Significance Index: -38.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0310
    Cell Significance Index: -19.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0317
    Cell Significance Index: -17.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0354
    Cell Significance Index: -7.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0388
    Cell Significance Index: -3.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0662
    Cell Significance Index: -30.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0812
    Cell Significance Index: -23.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0903
    Cell Significance Index: -13.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1074
    Cell Significance Index: -12.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1093
    Cell Significance Index: -12.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1344
    Cell Significance Index: -4.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1426
    Cell Significance Index: -5.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1505
    Cell Significance Index: -1.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1838
    Cell Significance Index: -3.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1868
    Cell Significance Index: -12.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2030
    Cell Significance Index: -2.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2100
    Cell Significance Index: -4.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2149
    Cell Significance Index: -5.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2291
    Cell Significance Index: -26.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2446
    Cell Significance Index: -5.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2754
    Cell Significance Index: -21.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2859
    Cell Significance Index: -2.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2988
    Cell Significance Index: -5.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3485
    Cell Significance Index: -36.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3574
    Cell Significance Index: -27.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4026
    Cell Significance Index: -11.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4471
    Cell Significance Index: -6.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4777
    Cell Significance Index: -29.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5304
    Cell Significance Index: -4.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5450
    Cell Significance Index: -13.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5528
    Cell Significance Index: -24.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5725
    Cell Significance Index: -15.3200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5841
    Cell Significance Index: -3.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5843
    Cell Significance Index: -16.7500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5846
    Cell Significance Index: -8.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6993
    Cell Significance Index: -26.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7272
    Cell Significance Index: -19.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HTATSF1 is a non-coding gene, meaning it does not encode a protein. However, it is highly expressed in specific cell types, including oogonial cells, sympathetic neurons, placental villous trophoblasts, and various immune cells such as CD4-positive T cells and alpha-beta memory T cells. This unique expression pattern suggests that HTATSF1 may play a regulatory role in the development and function of these cells. **Pathways and Functions:** HTATSF1 is involved in several cellular pathways, including: 1. **Chromatin organization and remodeling**: HTATSF1 interacts with chromatin-associated proteins, influencing chromatin structure and gene expression. 2. **RNA processing and splicing**: HTATSF1 is involved in the regulation of RNA splicing, a critical process in gene expression. 3. **Double-strand break repair**: HTATSF1 plays a role in the repair of double-strand breaks in DNA, ensuring genome stability. 4. **Metabolism of RNA**: HTATSF1 is involved in the regulation of RNA metabolism, including transcriptional regulation and RNA degradation. 5. **Protein binding and localization**: HTATSF1 interacts with various proteins, influencing their localization and function within the cell. **Clinical Significance:** The dysregulation of HTATSF1 has been implicated in various human diseases, including: 1. **HIV-1 infection**: HTATSF1 is specifically expressed in HIV-1 infected cells, suggesting its involvement in the regulation of HIV-1 gene expression. 2. **Cancer**: HTATSF1 expression is altered in various types of cancer, including breast and ovarian cancer, suggesting its role in tumorigenesis. 3. **Neurological disorders**: HTATSF1 expression is altered in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, suggesting its involvement in neuronal function and survival. 4. **Immune system dysfunction**: HTATSF1 expression is altered in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, suggesting its role in immune system regulation. In conclusion, HTATSF1 is a multifunctional gene that plays a critical role in regulating gene expression, DNA repair, and RNA processing. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the mechanisms of HTATSF1 and its potential therapeutic applications.

Genular Protein ID: 2309701176

Symbol: HTSF1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O43719 D3DWG9 Q59G06 Q99730

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8849451

Title: Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.

PubMed ID: 8849451

DOI: 10.1126/science.274.5287.605

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9649438

Title: Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages.

PubMed ID: 9649438

DOI: 10.1093/emboj/17.13.3681

PubMed ID: 9765201

Title: The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.

PubMed ID: 9765201

DOI: 10.1101/gad.12.19.2992

PubMed ID: 9710584

Title: CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif.

PubMed ID: 9710584

DOI: 10.1128/mcb.18.9.5000

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10454543

Title: Tat-SF1 protein associates with RAP30 and human SPT5 proteins.

PubMed ID: 10454543

DOI: 10.1128/mcb.19.9.5960

PubMed ID: 10913173

Title: Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.

PubMed ID: 10913173

DOI: 10.1128/mcb.20.16.5897-5907.2000

PubMed ID: 11420046

Title: Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.

PubMed ID: 11420046

DOI: 10.1016/s1074-7613(01)00158-3

PubMed ID: 11780068

Title: Stimulatory effect of splicing factors on transcriptional elongation.

PubMed ID: 11780068

DOI: 10.1038/414929a

PubMed ID: 15485897

Title: FF domains of CA150 bind transcription and splicing factors through multiple weak interactions.

PubMed ID: 15485897

DOI: 10.1128/mcb.24.21.9274-9285.2004

PubMed ID: 15905670

Title: Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression.

PubMed ID: 15905670

DOI: 10.1097/01.aids.0000171403.07995.92

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35597237

Title: A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.

PubMed ID: 35597237

DOI: 10.1016/j.molcel.2022.04.031

PubMed ID: 30567737

Title: The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.

PubMed ID: 30567737

DOI: 10.1074/jbc.ra118.006764

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 34822310

Title: Structural basis of branch site recognition by the human spliceosome.

PubMed ID: 34822310

DOI: 10.1126/science.abm4245

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 755
  • Mass: 85853
  • Checksum: C9CA6C89E4F2A319
  • Sequence:
    • MSGTNLDGND EFDEQLRMQE LYGDGKDGDT QTDAGGEPDS LGQQPTDTPY EWDLDKKAWF 
PKITEDFIAT YQANYGFSND GASSSTANVE DVHARTAEEP PQEKAPEPTD ARKKGEKRKA 
ESGWFHVEED RNTNVYVSGL PPDITVDEFI QLMSKFGIIM RDPQTEEFKV KLYKDNQGNL 
KGDGLCCYLK RESVELALKL LDEDEIRGYK LHVEVAKFQL KGEYDASKKK KKCKDYKKKL 
SMQQKQLDWR PERRAGPSRM RHERVVIIKN MFHPMDFEDD PLVLNEIRED LRVECSKFGQ 
IRKLLLFDRH PDGVASVSFR DPEEADYCIQ TLDGRWFGGR QITAQAWDGT TDYQVEETSR 
EREERLRGWE AFLNAPEANR GLRRSDSVSA SERAGPSRAR HFSEHPSTSK MNAQETATGM 
AFEEPIDEKK FEKTEDGGEF EEGASENNAK ESSPEKEAEE GCPEKESEEG CPKRGFEGSC 
SQKESEEGNP VRGSEEDSPK KESKKKTLKN DCEENGLAKE SEDDLNKESE EEVGPTKESE 
EDDSEKESDE DCSEKQSEDG SEREFEENGL EKDLDEEGSE KELHENVLDK ELEENDSENS 
EFEDDGSEKV LDEEGSEREF DEDSDEKEEE EDTYEKVFDD ESDEKEDEEY ADEKGLEAAD 
KKAEEGDADE KLFEESDDKE DEDADGKEVE DADEKLFEDD DSNEKLFDEE EDSSEKLFDD 
SDERGTLGGF GSVEEGPLST GSSFILSSDD DDDDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.