Details for: PCLO

Gene ID: 27445

Symbol: PCLO

Ensembl ID: ENSG00000186472

Description: piccolo presynaptic cytomatrix protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 258.9462
    Cell Significance Index: -65.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.5972
    Cell Significance Index: -62.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.0311
    Cell Significance Index: -54.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.5705
    Cell Significance Index: -66.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7357
    Cell Significance Index: -66.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.7176
    Cell Significance Index: -25.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 8.5271
    Cell Significance Index: 146.1300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.8304
    Cell Significance Index: 44.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.6366
    Cell Significance Index: 379.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.6256
    Cell Significance Index: 2017.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 5.1659
    Cell Significance Index: 147.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.8012
    Cell Significance Index: 212.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.7022
    Cell Significance Index: 178.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.4658
    Cell Significance Index: 97.7900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 3.3103
    Cell Significance Index: 42.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2429
    Cell Significance Index: 650.5200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 3.0787
    Cell Significance Index: 32.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.0237
    Cell Significance Index: 2091.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.6644
    Cell Significance Index: 149.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.5949
    Cell Significance Index: 136.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5565
    Cell Significance Index: 34.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.5156
    Cell Significance Index: 154.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1707
    Cell Significance Index: 214.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1696
    Cell Significance Index: 62.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.1564
    Cell Significance Index: 135.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7836
    Cell Significance Index: 80.8500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.4176
    Cell Significance Index: 18.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4027
    Cell Significance Index: 33.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3849
    Cell Significance Index: 95.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1904
    Cell Significance Index: 14.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1535
    Cell Significance Index: 24.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0723
    Cell Significance Index: 174.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7973
    Cell Significance Index: 61.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4650
    Cell Significance Index: 50.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4520
    Cell Significance Index: 850.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3559
    Cell Significance Index: 70.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3471
    Cell Significance Index: 12.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3327
    Cell Significance Index: 59.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2785
    Cell Significance Index: 378.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2357
    Cell Significance Index: 212.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1889
    Cell Significance Index: 120.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1787
    Cell Significance Index: 10.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1634
    Cell Significance Index: 3.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1510
    Cell Significance Index: 4.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1124
    Cell Significance Index: 173.0200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.1034
    Cell Significance Index: 0.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0838
    Cell Significance Index: 10.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0558
    Cell Significance Index: 10.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0541
    Cell Significance Index: 99.8000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0413
    Cell Significance Index: 0.4500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0158
    Cell Significance Index: 0.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0127
    Cell Significance Index: 5.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0034
    Cell Significance Index: -2.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0181
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0293
    Cell Significance Index: -13.3000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0417
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0429
    Cell Significance Index: -26.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0553
    Cell Significance Index: -0.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0676
    Cell Significance Index: -38.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0689
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0702
    Cell Significance Index: -11.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0754
    Cell Significance Index: -41.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0761
    Cell Significance Index: -3.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0766
    Cell Significance Index: -57.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1074
    Cell Significance Index: -22.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1947
    Cell Significance Index: -56.0200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2423
    Cell Significance Index: -2.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3021
    Cell Significance Index: -9.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3336
    Cell Significance Index: -7.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3407
    Cell Significance Index: -10.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3505
    Cell Significance Index: -5.0200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3744
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3801
    Cell Significance Index: -43.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3938
    Cell Significance Index: -54.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4022
    Cell Significance Index: -46.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4239
    Cell Significance Index: -54.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4240
    Cell Significance Index: -44.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4406
    Cell Significance Index: -45.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4986
    Cell Significance Index: -58.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5051
    Cell Significance Index: -10.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5331
    Cell Significance Index: -62.8700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6575
    Cell Significance Index: -8.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6834
    Cell Significance Index: -50.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6890
    Cell Significance Index: -48.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7348
    Cell Significance Index: -58.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7433
    Cell Significance Index: -9.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7453
    Cell Significance Index: -15.4600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.7523
    Cell Significance Index: -8.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7849
    Cell Significance Index: -36.8900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.8171
    Cell Significance Index: -13.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8706
    Cell Significance Index: -18.6100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.9528
    Cell Significance Index: -11.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9939
    Cell Significance Index: -60.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9950
    Cell Significance Index: -64.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.0030
    Cell Significance Index: -12.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0081
    Cell Significance Index: -21.7800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.0200
    Cell Significance Index: -11.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0428
    Cell Significance Index: -54.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** One of the key characteristics of the PCLO gene is its widespread expression in the nervous system. The protein is predominantly found in Purkinje cells, granule cells, stellate neurons, and other types of neurons, as well as in macroglial cells and chromaffin cells. This widespread expression suggests that Piccolo plays a critical role in the development and function of the nervous system. Another characteristic of the PCLO gene is its involvement in various signaling pathways. Piccolo interacts with multiple proteins and pathways, including the calcium-dependent phospholipid binding pathway, the cytoskeleton organization pathway, and the regulation of exocytosis pathway. These interactions suggest that Piccolo plays a key role in the regulation of neurotransmitter release and synaptic plasticity. **Pathways and Functions** The PCLO gene is involved in several key pathways, including: 1. **Cytoskeleton organization**: Piccolo interacts with profilin and other proteins to regulate the organization of the cytoskeleton in the presynaptic active zone. 2. **Presynaptic active zone assembly**: Piccolo plays a critical role in the assembly and maintenance of the presynaptic active zone structure. 3. **Regulation of exocytosis**: Piccolo interacts with other proteins to regulate the process of exocytosis, which is critical for neurotransmitter release. 4. **Synaptic plasticity**: Piccolo is involved in the regulation of synaptic plasticity, which is the ability of synapses to change in response to experience. **Clinical Significance** Dysregulation of the PCLO gene has been implicated in several neurological disorders, including autism spectrum disorder, schizophrenia, and bipolar disorder. Mutations in the PCLO gene have been associated with impaired synaptic plasticity and altered neurotransmitter release, which may contribute to the development of these disorders. In addition, the PCLO gene has been implicated in the development of hearing loss and tinnitus. Mutations in the PCLO gene have been associated with impaired sensory processing and altered neurotransmitter release in the inner hair cells of the cochlea. In conclusion, the PCLO gene plays a critical role in the structure and function of the presynaptic active zone, and its dysregulation has been implicated in several neurological disorders. Further research is needed to fully understand the mechanisms by which the PCLO gene regulates synaptic plasticity and neurotransmitter release, and to develop therapeutic strategies for the treatment of disorders associated with PCLO dysfunction.

Genular Protein ID: 3850164895

Symbol: PCLO_HUMAN

Name: Protein piccolo

UniProtKB Accession Codes:

Q9Y6V0 A4D1A7 A6NNX9 O43373 O60305 Q08E72 Q9BVC8 Q9UIV2 Q9Y6U9

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508862

Title: Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin.

PubMed ID: 10508862

DOI: 10.1083/jcb.147.1.151

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 25832664

Title: Loss of PCLO function underlies pontocerebellar hypoplasia type III.

PubMed ID: 25832664

DOI: 10.1212/wnl.0000000000001523

Sequence Information:

  • Length: 5142
  • Mass: 560699
  • Checksum: 18F145349952C935
  • Sequence:
    • MGNEASLEGE GLPEGLAAAA AAGGGASGAG SPSHTAIPAG MEADLSQLSE EERRQIAAVM 
SRAQGLPKGS VPPAAAESPS MHRKQELDSS HPPKQSGRPP DPGRPAQPGL SKSRTTDTFR 
SEQKLPGRSP STISLKESKS RTDLKEEHKS SMMPGFLSEV NALSAVSSVV NKFNPFDLIS 
DSEASQEETT KKQKVVQKEQ GKPEGIIKPP LQQQPPKPIP KQQGPGRDPL QQDGTPKSIS 
SQQPEKIKSQ PPGTGKPIQG PTQTPQTDHA KLPLQRDASR PQTKQADIVR GESVKPSLPS 
PSKPPIQQPT PGKPPAQQPG HEKSQPGPAK PPAQPSGLTK PLAQQPGTVK PPVQPPGTTK 
PPAQPLGPAK PPAQQTGSEK PSSEQPGPKA LAQPPGVGKT PAQQPGPAKP PTQQVGTPKP 
LAQQPGLQSP AKAPGPTKTP VQQPGPGKIP AQQAGPGKTS AQQTGPTKPP SQLPGPAKPP 
PQQPGPAKPP PQQPGSAKPP SQQPGSTKPP PQQPGPAKPS PQQPGSTKPP SQQPGSAKPS 
AQQPSPAKPS AQQSTKPVSQ TGSGKPLQPP TVSPSAKQPP SQGLPKTICP LCNTTELLLH 
VPEKANFNTC TECQTTVCSL CGFNPNPHLT EVKEWLCLNC QMKRALGGDL APVPSSPQPK 
LKTAPVTTTS AVSKSSPQPQ QTSPKKDAAP KQDLSKAPEP KKPPPLVKQP TLHGSPSAKA 
KQPPEADSLS KPAPPKEPSV PSEQDKAPVA DDKPKQPKMV KPTTDLVSSS SATTKPDIPS 
SKVQSQAEEK TTPPLKTDSA KPSQSFPPTG EKVSPFDSKA IPRPASDSKI ISHPGPSSES 
KGQKQVDPVQ KKEEPKKAQT KMSPKPDAKP MPKGSPTPPG PRPTAGQTVP TPQQSPKPQE 
QSRRFSLNLG SITDAPKSQP TTPQETVTGK LFGFGASIFS QASNLISTAG QPGPHSQSGP 
GAPMKQAPAP SQPPTSQGPP KSTGQAPPAP AKSIPVKKET KAPAAEKLEP KAEQAPTVKR 
TETEKKPPPI KDSKSLTAEP QKAVLPTKLE KSPKPESTCP LCKTELNIGS KDPPNFNTCT 
ECKNQVCNLC GFNPTPHLTE IQEWLCLNCQ TQRAISGQLG DIRKMPPAPS GPKASPMPVP 
TESSSQKTAV PPQVKLVKKQ EQEVKTEAEK VILEKVKETL SMEKIPPMVT TDQKQEESKL 
EKDKASALQE KKPLPEEKKL IPEEEKIRSE EKKPLLEEKK PTPEDKKLLP EAKTSAPEEQ 
KHDLLKSQVQ IAEEKLEGRV APKTVQEGKQ PQTKMEGLPS GTPQSLPKED DKTTKTIKEQ 
PQPPCTAKPD QVEPGKEKTE KEDDKSDTSS SQQPKSPQGL SDTGYSSDGI SSSLGEIPSL 
IPTDEKDILK GLKKDSFSQE SSPSSPSDLA KLESTVLSIL EAQASTLADE KSEKKTQPHE 
VSPEQPKDQE KTQSLSETLE ITISEEEIKE SQEERKDTFK KDSQQDIPSS KDHKEKSEFV 
DDITTRREPY DSVEESSESE NSPVPQRKRR TSVGSSSSDE YKQEDSQGSG EEEDFIRKQI 
IEMSADEDAS GSEDDEFIRN QLKEISSSTE SQKKEETKGK GKITAGKHRR LTRKSSTSID 
EDAGRRHSWH DEDDEAFDES PELKYRETKS QESEELVVTG GGGLRRFKTI ELNSTIADKY 
SAESSQKKTS LYFDEEPELE MESLTDSPED RSRGEGSSSL HASSFTPGTS PTSVSSLDED 
SDSSPSHKKG ESKQQRKARH RPHGPLLPTI EDSSEEEELR EEEELLKEQE KQREIEQQQR 
KSSSKKSKKD KDELRAQRRR ERPKTPPSNL SPIEDASPTE ELRQAAEMEE LHRSSCSEYS 
PSIESDPEGF EISPEKIIEV QKVYKLPTAV SLYSPTDEQS IMQKEGSQKA LKSAEEMYEE 
MMHKTHKYKA FPAANERDEV FEKEPLYGGM LIEDYIYESL VEDTYNGSVD GSLLTRQEEE 
NGFMQQKGRE QKIRLSEQIY EDPMQKITDL QKEFYELESL HSVVPQEDIV SSSFIIPESH 
EIVDLGTMVT STEEERKLLD ADAAYEELMK RQQMQLTPGS SPTQAPIGED MTESTMDFDR 
MPDASLTSSV LSGASLTDST SSATLSIPDV KITQHFSTEE IEDEYVTDYT REIQEIIAHE 
SLILTYSEPS ESATSVPPSD TPSLTSSVSS VCTTDSSSPI TTLDSITTVY TEPVDMITKF 
EDSEEISSST YFPGSIIDYP EEISVSLDRT APPDGRASAD HIVISLSDMA SSIIESVVPK 
PEGPVADTVS TDLLISEKDP VKKAKKETGN GIILEVLEAY RDKKELEAER TKSSLSETVF 
DHPPSSVIAL PMKEQLSTTY FTSGETFGQE KPASQLPSGS PSVSSLPAKP RPFFRSSSLD 
ISAQPPPPPP PPPPPPPPPP PPPPPPLPPP TSPKPTILPK KKLTVASPVT TATPLFDAVT 
TLETTAVLRS NGLPVTRICT TAPPPVPPKP SSIPSGLVFT HRPEPSKPPI APKPVIPQLP 
TTTQKPTDIH PKPTGLSLTS SMTLNLVTSA DYKLPSPTSP LSPHSNKSSP RFSKSLTETY 
VVITLPSEPG TPTDSSASQA ITSWPLGSPS KDLVSVEPVF SVVPPVTAVE IPISSEQTFY 
ISGALQTFSA TPVTAPSSFQ AAPTSVTQFL TTEVSKTEVS ATRSTAPSVG LSSISITIPP 
EPLALDNIHL EKPQYKEDGK LQLVGDVIDL RTVPKVEVKT TDKCIDLSAS TMDVKRQITA 
NEVYGKQISA VQPSIINLSV TSSIVTPVSL ATETVTFVTC TASASYTTGT ESLVGAEHAM 
TTPLQLTTSK HAEPPYRIPS DQVFPIAREE APINLSLGTP AHAVTLAITK PVTVPPVGVT 
NGWTDSTVSQ GITDGEVVDL STTKSHRTVV TMDESTSSVM TKIIEDEKPV DLTAGRRAVC 
CDVVYKLPFG RSCTAQQPAT TLPEDRFGYR DDHYQYDRSG PYGYRGIGGM KPSMSDTNLA 
EAGHFFYKSK NAFDYSEGTD TAVDLTSGRV TTGEVMDYSS KTTGPYPETR QVISGAGIST 
PQYSTARMTP PPGPQYCVGS VLRSSNGVVY SSVATPTPST FAITTQPGSI FSTTVRDLSG 
IHTADAVTSL PAMHHSQPMP RSYFITTGAS ETDIAVTGID ISASLQTITM ESLTAETIDS 
VPTLTTASEV FPEVVGDESA LLIVPEEDKQ QQQLDLEREL LELEKIKQQR FAEELEWERQ 
EIQRFREQEK IMVQKKLEEL QSMKQHLLFQ QEEERQAQFM MRQETLAQQQ LQLEQIQQLQ 
QQLHQQLEEQ KIRQIYQYNY DPSGTASPQT TTEQAILEGQ YAALEGSQFW ATEDATTTAS 
AVVAIEIPQS QGWYTVQSDG VTQYIAPPGI LSTVSEIPLT DVVVKEEKQP KKRSSGAKVR 
GQYDDMGENM TDDPRSFKKI VDSGVQTDDE DATDRSYVSR RRRTKKSVDT SVQTDDEDQD 
EWDMPTRSRR KARVGKYGDS MTEADKTKPL SKVSSIAVQT VAEISVQTEP VGTIRTPSIR 
ARVDAKVEII KHISAPEKTY KGGSLGCQTE ADSDTQSPQY LSATSPPKDK KRPTPLEIGY 
SSHLRADSTV QLAPSPPKSP KVLYSPISPL SPGKALESAF VPYEKPLPDD ISPQKVLHPD 
MAKVPPASPK TAKMMQRSMS DPKPLSPTAD ESSRAPFQYT EGYTTKGSQT MTSSGAQKKV 
KRTLPNPPPE EISTGTQSTF STMGTVSRRR ICRTNTMARA KILQDIDREL DLVERESAKL 
RKKQAELDEE EKEIDAKLRY LEMGINRRKE ALLKEREKRE RAYLQGVAED RDYMSDSEVS 
STRPTRIESQ HGIERPRTAP QTEFSQFIPP QTQTESQLVP PTSPYTQYQY SSPALPTQAP 
TSYTQQSHFE QQTLYHQQVS PYQTQPTFQA VATMSFTPQV QPTPTPQPSY QLPSQMMVIQ 
QKPRQTTLYL EPKITSNYEV IRNQPLMIAP VSTDNTFAVS HLGSKYNSLD LRIGLEERSS 
MASSPISSIS ADSFYADIDH HTPRNYVLID DIGEITKGTA ALSTAFSLHE KDLSKTDRLL 
RTTETRRSQE VTDFLAPLQS SSRLHSYVKA EEDPMEDPYE LKLLKHQIKQ EFRRGTESLD 
HLAGLSHYYH ADTSYRHFPK SEKYSISRLT LEKQAAKQLP AAILYQKQSK HKKSLIDPKM 
SKFSPIQESR DLEPDYSSYM TSSTSSIGGI SSRARLLQDD ITFGLRKNIT DQQKFMGSSL 
GTGLGTLGNT IRSALQDEAD KPYSSGSRSR PSSRPSSVYG LDLSIKRDSS SSSLRLKAQE 
AEALDVSFSH ASSSARTKPT SLPISQSRGR IPIVAQNSEE ESPLSPVGQP MGMARAAAGP 
LPPISADTRD QFGSSHSLPE VQQHMREESR TRGYDRDIAF IMDDFQHAMS DSEAYHLRRE 
ETDWFDKPRE SRLENGHGLD RKLPERLVHS RPLSQHQEQI IQMNGKTMHY IFPHARIKIT 
RDSKDHTVSG NGLGIRIVGG KEIPGHSGEI GAYIAKILPG GSAEQTGKLM EGMQVLEWNG 
IPLTSKTYEE VQSIISQQSG EAEICVRLDL NMLSDSENSQ HLELHEPPKA VDKAKSPGVD 
PKQLAAELQK VSLQQSPLVL SSVVEKGSHV HSGPTSAGSS SVPSPGQPGS PSVSKKKHGS 
SKPTDGTKVV SHPITGEIQL QINYDLGNLI IHILQARNLV PRDNNGYSDP FVKVYLLPGR 
GQVMVVQNAS AEYKRRTKHV QKSLNPEWNQ TVIYKSISME QLKKKTLEVT VWDYDRFSSN 
DFLGEVLIDL SSTSHLDNTP RWYPLKEQTE SIDHGKSHSS QSSQQSPKPS VIKSRSHGIF 
PDPSKDMQVP TIEKSHSSPG SSKSSSEGHL RSHGPSRSQS KTSVTQTHLE DAGAAIAAAE 
AAVQQLRIQP TKPPNHRPAE SSVSTGSSGS SFGSGYSVDS EGSSSTAGET NLFPIPRIGK 
MGQNGQEPVK QPGVGVGLAD TEAKTQVMGE IKIALKKEMK TDGEQLIVEI LQCRNITYKF 
KSPDHLPDLY VKIYVMNIST QKKVIKKKTR VCRHDREPSF NETFRFSLSP AGHSLQILLF 
SNGGKFMKKT LIGEACIWLD KVDLRKRIVN WHKLLVSPTQ TH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.