Details for: TRBJ2 2P

Gene ID: 28627

Symbol: TRBJ2 2P

Ensembl ID: ENSG00000211766

Description: T cell receptor beta joining 2-2P (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 10.2003
    Cell Significance Index: 199.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.2164
    Cell Significance Index: 77.9100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.6329
    Cell Significance Index: 8.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5557
    Cell Significance Index: 8.1000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0479
    Cell Significance Index: 0.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0174
    Cell Significance Index: 0.1000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0018
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0076
    Cell Significance Index: -0.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0080
    Cell Significance Index: -0.0900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0085
    Cell Significance Index: -0.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0115
    Cell Significance Index: -0.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0147
    Cell Significance Index: -0.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0167
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0179
    Cell Significance Index: -0.3300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0185
    Cell Significance Index: -0.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0192
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0194
    Cell Significance Index: -0.1800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0210
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0210
    Cell Significance Index: -0.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0217
    Cell Significance Index: -0.2400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0217
    Cell Significance Index: -0.1900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0220
    Cell Significance Index: -0.2200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0232
    Cell Significance Index: -0.2700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0241
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0247
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0268
    Cell Significance Index: -0.2700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0269
    Cell Significance Index: -0.3100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0272
    Cell Significance Index: -0.3300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0277
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0280
    Cell Significance Index: -0.3000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0282
    Cell Significance Index: -0.3000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0283
    Cell Significance Index: -0.3700
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0288
    Cell Significance Index: -0.2900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0289
    Cell Significance Index: -0.3100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0298
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0299
    Cell Significance Index: -0.2800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0302
    Cell Significance Index: -0.3500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0304
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0306
    Cell Significance Index: -0.3100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0311
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0330
    Cell Significance Index: -0.3200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0339
    Cell Significance Index: -0.3700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0339
    Cell Significance Index: -0.3700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0340
    Cell Significance Index: -0.3800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0344
    Cell Significance Index: -0.3100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0357
    Cell Significance Index: -0.3700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0368
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0390
    Cell Significance Index: -0.3600
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0390
    Cell Significance Index: -0.2900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0410
    Cell Significance Index: -0.3600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0469
    Cell Significance Index: -0.5400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0519
    Cell Significance Index: -0.3400
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0553
    Cell Significance Index: -0.3600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0625
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional T cell receptor beta joining chain:** The TRBJ2 2P gene encodes for a non-functional T cell receptor beta joining chain, which is essential for the proper assembly and function of the T cell receptor complex. 2. **Significant expression in immune cells:** The TRBJ2 2P gene is significantly expressed in various immune cells, including plasma cells, B cells, T cells, natural killer cells, and megakaryocytes. 3. **Cell type-specific expression:** The TRBJ2 2P gene is expressed in specific cell types, such as decidual natural killer cells, CD8-positive, alpha-beta T cells, and unswitched memory B cells. 4. **Evolutionary conservation:** The TRBJ2 2P gene is conserved across multiple species, suggesting its importance in immune function. **Pathways and Functions:** 1. **T cell receptor signaling:** The TRBJ2 2P gene plays a crucial role in the development and function of T cells, which are essential for adaptive immune responses. 2. **Immune cell development:** The TRBJ2 2P gene is involved in the development of various immune cells, including plasma cells, B cells, and natural killer cells. 3. **Cytokine production:** The TRBJ2 2P gene is involved in the production of cytokines, which are essential for immune responses and inflammation. 4. **Immune tolerance:** The TRBJ2 2P gene may play a role in immune tolerance, as it is expressed in cells that are involved in immune regulation, such as decidual natural killer cells. **Clinical Significance:** 1. **Autoimmune diseases:** The TRBJ2 2P gene may be involved in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, due to its role in immune regulation. 2. **Cancer:** The TRBJ2 2P gene may be involved in cancer development and progression, as it is expressed in cells that are involved in immune evasion and tumor growth. 3. **Infectious diseases:** The TRBJ2 2P gene may be involved in the development of infectious diseases, such as HIV and tuberculosis, due to its role in immune regulation and response. 4. **Immunodeficiency disorders:** The TRBJ2 2P gene may be involved in immunodeficiency disorders, such as severe combined immunodeficiency (SCID), due to its role in immune cell development and function. In conclusion, the TRBJ2 2P gene is a non-functional T cell receptor beta joining chain that plays a crucial role in immune regulation and disease. Its significant expression in various immune cells and its involvement in immune cell development, cytokine production, and immune tolerance make it an important gene for understanding immune function and disease. Further research is needed to fully elucidate the role of the TRBJ2 2P gene in immune regulation and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.