Details for: TRAJ55

Gene ID: 28700

Symbol: TRAJ55

Ensembl ID: ENSG00000250688

Description: T cell receptor alpha joining 55 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 8.9209
    Cell Significance Index: 174.4200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.6108
    Cell Significance Index: 32.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.2099
    Cell Significance Index: 56.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3279
    Cell Significance Index: 32.1700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.3424
    Cell Significance Index: 4.4700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2772
    Cell Significance Index: 4.0400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2515
    Cell Significance Index: 3.3000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.1356
    Cell Significance Index: 1.1500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0737
    Cell Significance Index: 1.0100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0480
    Cell Significance Index: 0.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0098
    Cell Significance Index: 0.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0013
    Cell Significance Index: 0.4600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0013
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0039
    Cell Significance Index: -0.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0080
    Cell Significance Index: -0.1800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0133
    Cell Significance Index: -0.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0180
    Cell Significance Index: -0.5900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0182
    Cell Significance Index: -0.2500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0202
    Cell Significance Index: -0.2600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0257
    Cell Significance Index: -0.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0279
    Cell Significance Index: -1.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0297
    Cell Significance Index: -0.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0306
    Cell Significance Index: -0.6100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0310
    Cell Significance Index: -0.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0321
    Cell Significance Index: -0.6900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0359
    Cell Significance Index: -0.7200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0413
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0471
    Cell Significance Index: -0.8100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0482
    Cell Significance Index: -0.6400
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0504
    Cell Significance Index: -0.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0556
    Cell Significance Index: -0.7300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0558
    Cell Significance Index: -0.9500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0560
    Cell Significance Index: -0.6200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0573
    Cell Significance Index: -0.7700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0582
    Cell Significance Index: -0.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0627
    Cell Significance Index: -0.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0635
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0641
    Cell Significance Index: -0.6000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0661
    Cell Significance Index: -0.7600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0662
    Cell Significance Index: -0.7700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0664
    Cell Significance Index: -0.7100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0667
    Cell Significance Index: -0.7200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0693
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0702
    Cell Significance Index: -0.6700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0710
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0723
    Cell Significance Index: -0.8900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0756
    Cell Significance Index: -0.7100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0768
    Cell Significance Index: -0.8900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0797
    Cell Significance Index: -0.7400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0830
    Cell Significance Index: -0.7500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0843
    Cell Significance Index: -0.8000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0888
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0894
    Cell Significance Index: -0.8500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0905
    Cell Significance Index: -1.0700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0913
    Cell Significance Index: -1.0200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1005
    Cell Significance Index: -0.9800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1046
    Cell Significance Index: -0.8000
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1353
    Cell Significance Index: -1.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1926
    Cell Significance Index: -1.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Pseudogenic nature**: TRAJ55 is a non-functional gene, meaning it lacks the ability to encode a protein. This characteristic is distinct from its TRAJ family members, which encode functional T cell receptors. 2. **Widespread expression**: TRAJ55 is significantly expressed in multiple hematopoietic cell types, including erythrocytes, megakaryocytes, B cells, and T cells. 3. **Cell-type specific expression**: While TRAJ55 is broadly expressed, its expression patterns vary across different cell types. For example, it is highly expressed in erythrocytes and megakaryocytes, but less so in B cells and T cells. 4. **Ensembl ID**: The Ensembl ID (ENSG00000250688) provides a unique identifier for the TRAJ55 gene, allowing for precise tracking and analysis of its expression and function. **Pathways and Functions** Despite its pseudogenic nature, TRAJ55 may still contribute to various cellular processes through alternative splicing or regulatory mechanisms. Potential pathways and functions of TRAJ55 include: 1. **Regulation of cell differentiation**: TRAJ55 may influence the differentiation of hematopoietic cells, particularly in the context of erythropoiesis and megakaryopoiesis. 2. **Cell signaling and communication**: TRAJ55 may participate in cell signaling pathways, modulating the interactions between cells and influencing the development of immune responses. 3. **Epigenetic regulation**: TRAJ55 may interact with epigenetic regulators, influencing gene expression and cellular behavior. **Clinical Significance** The clinical significance of TRAJ55 is still emerging, but its expression in various hematopoietic cell types suggests potential implications in: 1. **Anemia and hematological disorders**: Altered TRAJ55 expression may contribute to anemia or other hematological disorders, such as megakaryoblastic anemia. 2. **Immunological disorders**: TRAJ55's role in cell signaling and communication may be relevant in the context of immunological disorders, such as autoimmune diseases or cancer. 3. **Cancer research**: The expression of TRAJ55 in cancer cells may provide insights into the development and progression of hematological malignancies. In conclusion, the TRAJ55 gene, despite its pseudogenic nature, exhibits complex expression patterns and may contribute to various cellular processes. Further research is necessary to elucidate the functional significance of TRAJ55 and its potential implications in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.