Details for: TRAJ45

Gene ID: 28710

Symbol: TRAJ45

Ensembl ID: ENSG00000211844

Description: T cell receptor alpha joining 45

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6121
    Cell Significance Index: 39.0500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.5194
    Cell Significance Index: 6.7800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0147
    Cell Significance Index: 0.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0031
    Cell Significance Index: -0.0600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0037
    Cell Significance Index: -0.0300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0052
    Cell Significance Index: -0.0900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0054
    Cell Significance Index: -0.0500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0072
    Cell Significance Index: -0.0700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0079
    Cell Significance Index: -0.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0083
    Cell Significance Index: -0.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0093
    Cell Significance Index: -0.2400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0126
    Cell Significance Index: -0.1700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0148
    Cell Significance Index: -0.2400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0160
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0163
    Cell Significance Index: -0.1700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0168
    Cell Significance Index: -0.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0168
    Cell Significance Index: -0.2000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0168
    Cell Significance Index: -0.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0188
    Cell Significance Index: -0.2100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0189
    Cell Significance Index: -0.2000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0192
    Cell Significance Index: -0.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0198
    Cell Significance Index: -0.2300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0198
    Cell Significance Index: -0.1800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0199
    Cell Significance Index: -0.2200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0199
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0202
    Cell Significance Index: -0.2300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0210
    Cell Significance Index: -0.2100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0212
    Cell Significance Index: -0.2600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0216
    Cell Significance Index: -0.2000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0218
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0220
    Cell Significance Index: -0.1900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0220
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0224
    Cell Significance Index: -0.2100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0225
    Cell Significance Index: -0.1600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0225
    Cell Significance Index: -0.2000
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0227
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0238
    Cell Significance Index: -0.2200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0240
    Cell Significance Index: -0.2100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0243
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0245
    Cell Significance Index: -0.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0251
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0259
    Cell Significance Index: -0.2100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0263
    Cell Significance Index: -0.2100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0275
    Cell Significance Index: -0.2800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0278
    Cell Significance Index: -0.3600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0281
    Cell Significance Index: -0.3000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0282
    Cell Significance Index: -0.2100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0282
    Cell Significance Index: -0.3300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0306
    Cell Significance Index: -0.2600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0320
    Cell Significance Index: -0.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0338
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0345
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0366
    Cell Significance Index: -0.3300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0378
    Cell Significance Index: -0.3300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0394
    Cell Significance Index: -0.2100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0456
    Cell Significance Index: -0.3500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0755
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression in Immune Cells**: TRAJ45 is significantly expressed in various immune cells, including mature gamma-delta T cells, T cells, innate lymphoid cells, B cells, and natural killer cells. 2. **T Cell Receptor Complex Formation**: TRAJ45 joins to different TCRα chains to form functional TCR complexes that recognize and bind to specific antigens. 3. **Diversity of TCR Combinations**: The TRAJ45 gene can combine with various TCRα chains, resulting in a diverse range of TCR combinations that can recognize different antigens. 4. **Role in Immune Cell Development**: TRAJ45 plays a crucial role in the development and maturation of immune cells, including T cells, B cells, and innate lymphoid cells. **Pathways and Functions** 1. **T Cell Receptor Signaling**: TRAJ45 is involved in T cell receptor signaling, which is a critical step in the activation of T cells in response to antigen presentation. 2. **Antigen Recognition**: TRAJ45 helps to recognize and bind to specific antigens, which is essential for the immune system's response to pathogens and foreign substances. 3. **Immune Cell Activation**: TRAJ45 is involved in the activation of immune cells, including T cells, B cells, and innate lymphoid cells, which is critical for the immune system's response to infection. 4. **Cytokine Production**: TRAJ45 can regulate the production of cytokines, which are signaling molecules that promote or inhibit immune responses. **Clinical Significance** 1. **Immunodeficiency Disorders**: Mutations in the TRAJ45 gene have been associated with immunodeficiency disorders, including severe combined immunodeficiency (SCID) and other T cell-related immunodeficiencies. 2. **Cancer Immune Evasion**: TRAJ45 can be involved in the immune evasion of cancer cells, which can lead to the development of immunotherapy-resistant tumors. 3. **Autoimmune Diseases**: TRAJ45 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, by promoting the activation of autoreactive T cells. 4. **Vaccine Development**: TRAJ45 can be used as a target for vaccine development, as it is involved in the recognition and binding to specific antigens, which is essential for the immune system's response to pathogens. In conclusion, the TRAJ45 gene plays a crucial role in the development and function of immune cells, including T cells, B cells, and innate lymphoid cells. Its involvement in T cell receptor signaling, antigen recognition, and immune cell activation makes it a critical gene in the immune system's response to pathogens and foreign substances. Further research is needed to fully understand the clinical significance of TRAJ45 and its potential applications in immunotherapy and vaccine development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.