Details for: TRAJ18

Gene ID: 28737

Symbol: TRAJ18

Ensembl ID: ENSG00000211871

Description: T cell receptor alpha joining 18

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 7.3929
    Cell Significance Index: 144.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3438
    Cell Significance Index: 32.5500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4007
    Cell Significance Index: 5.8400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3764
    Cell Significance Index: 4.9400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2423
    Cell Significance Index: 3.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0430
    Cell Significance Index: 0.9400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0426
    Cell Significance Index: 0.4800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0403
    Cell Significance Index: 0.2200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0097
    Cell Significance Index: 0.1200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0061
    Cell Significance Index: 0.0700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0023
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0002
    Cell Significance Index: -0.0700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0015
    Cell Significance Index: -0.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0069
    Cell Significance Index: -0.1400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0097
    Cell Significance Index: -0.0900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0123
    Cell Significance Index: -0.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0127
    Cell Significance Index: -0.2200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0141
    Cell Significance Index: -0.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0148
    Cell Significance Index: -0.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0157
    Cell Significance Index: -0.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0159
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0167
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0179
    Cell Significance Index: -0.1500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0197
    Cell Significance Index: -0.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0198
    Cell Significance Index: -0.1900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0214
    Cell Significance Index: -0.2700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0222
    Cell Significance Index: -0.3000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0225
    Cell Significance Index: -0.2800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0228
    Cell Significance Index: -0.3000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0245
    Cell Significance Index: -0.2600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0250
    Cell Significance Index: -0.2900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0261
    Cell Significance Index: -0.3000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0268
    Cell Significance Index: -0.2700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0270
    Cell Significance Index: -0.2500
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0270
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0273
    Cell Significance Index: -0.2600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0273
    Cell Significance Index: -0.2900
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0283
    Cell Significance Index: -0.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0286
    Cell Significance Index: -0.2900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0289
    Cell Significance Index: -0.3200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0291
    Cell Significance Index: -0.2600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0295
    Cell Significance Index: -0.3100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0298
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0302
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0307
    Cell Significance Index: -0.3100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0310
    Cell Significance Index: -0.2700
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0317
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0318
    Cell Significance Index: -0.3200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0320
    Cell Significance Index: -0.2800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0320
    Cell Significance Index: -0.2700
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0325
    Cell Significance Index: -0.2900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0334
    Cell Significance Index: -0.3200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0344
    Cell Significance Index: -0.2900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0353
    Cell Significance Index: -0.3100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0355
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0368
    Cell Significance Index: -0.2800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0373
    Cell Significance Index: -0.2900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0374
    Cell Significance Index: -0.4300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0390
    Cell Significance Index: -0.2900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0422
    Cell Significance Index: -0.2900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0540
    Cell Significance Index: -0.2900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0591
    Cell Significance Index: -0.5500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1378
    Cell Significance Index: -0.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ18 is a gene that encodes a protein involved in the assembly of TCRs. It is a member of the TRAJ family, which consists of four genes (TRAJ1-TRAJ4) that contribute to the diversity and specificity of TCRs. TRAJ18 is specifically expressed in various immune cells, including B cells, CD8-positive and CD4-positive T cells, natural killer T (NKT) cells, and alpha-beta T cells. Its expression is maintained throughout the development of T cells, from double-positive thymocytes to mature alpha-beta T cells. **Pathways and Functions:** The TRAJ18 gene is integral to the TCR assembly process, which involves the combination of TCR alpha (TCRA) and beta (TCRB) chains with other accessory molecules. The TRAJ18 protein interacts with other TRAJ family members to facilitate the assembly of functional TCRs. Once assembled, TCRs recognize and bind to specific antigens, triggering a signaling cascade that initiates an immune response. The signaling pathways activated by TRAJ18 involve the interaction of TCRs with the T cell receptor complex (TCR-CD3), which includes the CD3 chains and the zeta chains. This interaction triggers the activation of downstream signaling molecules, including the ZAP-70 kinase and the phosphatase PTPN11. The activation of these signaling molecules leads to the phosphorylation and activation of several transcription factors, including NF-AT and NF-κB, which regulate the expression of genes involved in the immune response. **Clinical Significance:** Dysregulation of TRAJ18 has been implicated in various immunological disorders, including autoimmune diseases and cancer. For instance, aberrant expression of TRAJ18 has been observed in patients with multiple sclerosis, where it contributes to the development of autoreactive T cells. Additionally, TRAJ18 has been linked to the progression of certain types of cancer, including leukemia and lymphoma, where it may contribute to the development of malignant T cells. Furthermore, TRAJ18 has been identified as a potential therapeutic target for the treatment of autoimmune diseases. Modulating the expression of TRAJ18 could potentially lead to the development of novel immunotherapies aimed at restoring immune homeostasis and preventing the development of autoimmunity. In conclusion, TRAJ18 is a critical component of the immune system, playing a pivotal role in the assembly and function of T cell receptors. Its dysregulation has been implicated in various immunological disorders, highlighting the need for further research into the mechanisms underlying TRAJ18-mediated immune responses. As our understanding of TRAJ18 continues to evolve, it is likely that this gene will emerge as a key target for the development of novel immunotherapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.