Details for: IGKJ4

Gene ID: 28947

Symbol: IGKJ4

Ensembl ID: ENSG00000211594

Description: immunoglobulin kappa joining 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.9096
    Cell Significance Index: 30.9300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.7795
    Cell Significance Index: 10.6900
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.6324
    Cell Significance Index: 8.3200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4108
    Cell Significance Index: 5.3100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.3213
    Cell Significance Index: 3.4100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.1215
    Cell Significance Index: 1.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0149
    Cell Significance Index: -0.2000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0158
    Cell Significance Index: -0.2700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0283
    Cell Significance Index: -0.3700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0340
    Cell Significance Index: -0.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0389
    Cell Significance Index: -0.9900
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: -0.0473
    Cell Significance Index: -0.2700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0602
    Cell Significance Index: -0.5700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0651
    Cell Significance Index: -0.7700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0703
    Cell Significance Index: -0.8300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0755
    Cell Significance Index: -0.9400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0765
    Cell Significance Index: -0.9700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0824
    Cell Significance Index: -1.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0910
    Cell Significance Index: -2.2700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1071
    Cell Significance Index: -1.4100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1089
    Cell Significance Index: -0.9700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1092
    Cell Significance Index: -1.2200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1092
    Cell Significance Index: -0.6800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1120
    Cell Significance Index: -1.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1181
    Cell Significance Index: -1.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1309
    Cell Significance Index: -2.5600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1312
    Cell Significance Index: -1.5500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1478
    Cell Significance Index: -1.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1482
    Cell Significance Index: -2.7400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1483
    Cell Significance Index: -0.9200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1548
    Cell Significance Index: -1.6300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1575
    Cell Significance Index: -1.3000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1582
    Cell Significance Index: -1.9500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1704
    Cell Significance Index: -1.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1749
    Cell Significance Index: -1.7800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1768
    Cell Significance Index: -2.1000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1855
    Cell Significance Index: -2.0200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1905
    Cell Significance Index: -1.9500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1966
    Cell Significance Index: -1.5800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1992
    Cell Significance Index: -2.6000
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.2106
    Cell Significance Index: -1.9900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2239
    Cell Significance Index: -2.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2299
    Cell Significance Index: -2.7400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2310
    Cell Significance Index: -2.6800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2311
    Cell Significance Index: -2.1700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2323
    Cell Significance Index: -2.4500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2366
    Cell Significance Index: -2.6200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2378
    Cell Significance Index: -2.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2381
    Cell Significance Index: -2.7400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.2411
    Cell Significance Index: -2.4800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2452
    Cell Significance Index: -2.6000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2566
    Cell Significance Index: -2.7300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2675
    Cell Significance Index: -2.2600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2688
    Cell Significance Index: -2.7200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2774
    Cell Significance Index: -1.4900
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.2781
    Cell Significance Index: -2.7300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2837
    Cell Significance Index: -2.6900
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2931
    Cell Significance Index: -2.6800
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.3141
    Cell Significance Index: -2.5600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3288
    Cell Significance Index: -2.7200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3951
    Cell Significance Index: -2.7400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.4009
    Cell Significance Index: -2.6700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4260
    Cell Significance Index: -5.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.5007
    Cell Significance Index: -2.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKJ4 is a gene that is part of the immunoglobulin kappa locus, which is responsible for the development of B cells and the production of antibodies. The IgK locus consists of a series of gene segments that are joined together to form the kappa light chain of the IgK antibody. IGKJ4 is specifically involved in the joining of kappa gene segments, which is a critical step in the assembly of the IgK antibody. The gene is highly expressed in a range of immune cells, including those that are involved in the humoral immune response. **Pathways and Functions:** The IGKJ4 gene is involved in the following pathways and functions: 1. **B cell development:** IGKJ4 is essential for the development of B cells, which are the cells responsible for the production of antibodies. 2. **Antibody production:** The joining of kappa gene segments by IGKJ4 is critical for the assembly of the IgK antibody, which is produced by B cells. 3. **Immune cell activation:** IGKJ4 is involved in the activation of immune cells, including mast cells and plasma cells, which are critical for the humoral immune response. 4. **Cell signaling:** IGKJ4 may also be involved in cell signaling pathways that regulate the development and function of immune cells. **Clinical Significance:** The IGKJ4 gene has significant clinical implications for the understanding and treatment of immune-related disorders. Abnormalities in the IGKJ4 gene have been associated with various immunodeficiency disorders, including X-linked agammaglobulinemia (XLA) and Bruton's agammaglobulinemia (BA). These disorders are characterized by impaired B cell development and function, leading to increased susceptibility to infections. Additionally, IGKJ4 may also be involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of the immune system leads to inflammation and tissue damage. In conclusion, the IGKJ4 gene plays a critical role in the development and function of immune cells, particularly those involved in the humoral immune response. Further research is needed to fully understand the mechanisms by which IGKJ4 regulates immune cell development and function, as well as its clinical significance in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.