Details for: C19orf53

Gene ID: 28974

Symbol: C19orf53

Ensembl ID: ENSG00000104979

Description: chromosome 19 open reading frame 53

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 467.9025
    Cell Significance Index: -72.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 292.9310
    Cell Significance Index: -74.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 225.2471
    Cell Significance Index: -92.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 188.7751
    Cell Significance Index: -89.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 171.4863
    Cell Significance Index: -88.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 133.6320
    Cell Significance Index: -89.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.1461
    Cell Significance Index: -87.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.6870
    Cell Significance Index: -93.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.4082
    Cell Significance Index: -56.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.3820
    Cell Significance Index: -43.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.7635
    Cell Significance Index: 175.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.3882
    Cell Significance Index: 465.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2285
    Cell Significance Index: 151.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9956
    Cell Significance Index: 1635.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7130
    Cell Significance Index: 73.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.5572
    Cell Significance Index: 59.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4291
    Cell Significance Index: 437.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4133
    Cell Significance Index: 179.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3482
    Cell Significance Index: 288.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3309
    Cell Significance Index: 48.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.3142
    Cell Significance Index: 26.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2419
    Cell Significance Index: 20.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1412
    Cell Significance Index: 252.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1264
    Cell Significance Index: 16.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1134
    Cell Significance Index: 149.4700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.0514
    Cell Significance Index: 12.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0179
    Cell Significance Index: 892.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.9892
    Cell Significance Index: 58.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9795
    Cell Significance Index: 21.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9243
    Cell Significance Index: 209.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7271
    Cell Significance Index: 223.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5475
    Cell Significance Index: 99.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4872
    Cell Significance Index: 190.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4702
    Cell Significance Index: 76.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3548
    Cell Significance Index: 38.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3389
    Cell Significance Index: 35.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2639
    Cell Significance Index: 66.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0724
    Cell Significance Index: 48.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6969
    Cell Significance Index: 12.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6952
    Cell Significance Index: 12.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5889
    Cell Significance Index: 100.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5564
    Cell Significance Index: 160.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4169
    Cell Significance Index: 41.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3715
    Cell Significance Index: 73.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3344
    Cell Significance Index: 11.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2581
    Cell Significance Index: 195.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2557
    Cell Significance Index: 41.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2093
    Cell Significance Index: 39.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1531
    Cell Significance Index: 138.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1142
    Cell Significance Index: 83.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1069
    Cell Significance Index: 21.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0786
    Cell Significance Index: 1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0569
    Cell Significance Index: 1.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0314
    Cell Significance Index: -3.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0348
    Cell Significance Index: -65.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0574
    Cell Significance Index: -105.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0680
    Cell Significance Index: -104.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0788
    Cell Significance Index: -49.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0800
    Cell Significance Index: -108.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0850
    Cell Significance Index: -5.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1064
    Cell Significance Index: -60.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1159
    Cell Significance Index: -73.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1243
    Cell Significance Index: -44.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1802
    Cell Significance Index: -81.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2038
    Cell Significance Index: -42.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3340
    Cell Significance Index: -38.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3875
    Cell Significance Index: -10.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4357
    Cell Significance Index: -11.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4810
    Cell Significance Index: -56.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5539
    Cell Significance Index: -80.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5614
    Cell Significance Index: -44.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7387
    Cell Significance Index: -23.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7610
    Cell Significance Index: -86.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8722
    Cell Significance Index: -11.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8989
    Cell Significance Index: -93.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9261
    Cell Significance Index: -11.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9881
    Cell Significance Index: -60.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.0359
    Cell Significance Index: -71.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0684
    Cell Significance Index: -31.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1132
    Cell Significance Index: -16.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1476
    Cell Significance Index: -13.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1591
    Cell Significance Index: -77.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1625
    Cell Significance Index: -89.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1693
    Cell Significance Index: -71.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1921
    Cell Significance Index: -20.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2529
    Cell Significance Index: -33.5200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2664
    Cell Significance Index: -13.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3082
    Cell Significance Index: -73.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3211
    Cell Significance Index: -35.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.3917
    Cell Significance Index: -11.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4327
    Cell Significance Index: -31.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.5244
    Cell Significance Index: -9.2100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.6134
    Cell Significance Index: -10.1000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.8050
    Cell Significance Index: -25.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9976
    Cell Significance Index: -73.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.0638
    Cell Significance Index: -53.0500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -2.0842
    Cell Significance Index: -28.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.1200
    Cell Significance Index: -11.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.1294
    Cell Significance Index: -94.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** C19orf53 is significantly expressed in mature T cells, epithelial cells, and hematopoietic progenitor cells, suggesting a role in cell development and maintenance. 2. **Protein Homology:** The encoded protein, L10K_HUMAN, shares homology with the Leydig cell tumor 10 kDa protein, a protein involved in steroidogenesis. 3. **Cell Type-Specific Expression:** C19orf53 is expressed in various cell types, including CD8-alpha-alpha-positive and alpha-beta intraepithelial T cells, indicating a potential role in T cell development and function. **Pathways and Functions:** 1. **T Cell Development and Function:** C19orf53 may play a role in T cell development, particularly in the context of alpha-beta T cell differentiation. The gene's expression in mature T cells and CD8-alpha-alpha-positive and alpha-beta intraepithelial T cells suggests a functional role in T cell development and maintenance. 2. **Epithelial Cell Regulation:** C19orf53 may also regulate epithelial cell function, particularly in the context of ciliated epithelial cells and stratified epithelial cells. 3. **Immune Regulation:** The gene's expression in blood cells and erythroid progenitor cells suggests a broader role in immune regulation, potentially influencing the development and function of various immune cells. **Clinical Significance:** 1. **Immune-Related Disorders:** Aberrant expression of C19orf53 has been linked to immune-related disorders, such as autoimmune diseases and cancer. Further investigation is needed to elucidate the mechanisms underlying these associations. 2. **Cancer Research:** The gene's expression in fibroblasts of mammary glands and its homology to the Leydig cell tumor 10 kDa protein suggest potential roles in cancer development and progression. 3. **Therapeutic Targeting:** C19orf53 may serve as a potential therapeutic target for the treatment of immune-related disorders and cancer. Further research is needed to elucidate the gene's role in disease pathogenesis and to identify potential therapeutic strategies. In conclusion, C19orf53 is a gene of significant immunological relevance, with a complex expression pattern and potential roles in T cell development, epithelial cell regulation, and immune regulation. Further investigation is needed to elucidate the gene's mechanisms of action and to explore its potential as a therapeutic target for immune-related disorders and cancer.

Genular Protein ID: 1790461082

Symbol: L10K_HUMAN

Name: Leydig cell tumor 10 kDa protein homolog

UniProtKB Accession Codes:

Q9UNZ5 B2R4J9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 EMBL 4 EMDB 7 Ensembl 1 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 99
  • Mass: 10577
  • Checksum: A5FDF26764BED659
  • Sequence:
    • MAQGQRKFQA HKPAKSKTAA AASEKNRGPR KGGRVIAPKK ARVVQQQKLK KNLEVGIRKK 
IEHDVVMKAS SSLPKKLALL KAPAKKKGAA AATSSKTPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.