Details for: NOB1

Gene ID: 28987

Symbol: NOB1

Ensembl ID: ENSG00000141101

Description: NIN1 (RPN12) binding protein 1 homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.5671
    Cell Significance Index: -23.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.5744
    Cell Significance Index: -23.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.8592
    Cell Significance Index: -27.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.2193
    Cell Significance Index: -10.4600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.8332
    Cell Significance Index: -27.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.8130
    Cell Significance Index: -23.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.8686
    Cell Significance Index: -25.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8499
    Cell Significance Index: -18.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7232
    Cell Significance Index: -26.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1214
    Cell Significance Index: -15.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2855
    Cell Significance Index: 266.3600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2720
    Cell Significance Index: 24.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.7005
    Cell Significance Index: 28.4600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.6306
    Cell Significance Index: 9.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5664
    Cell Significance Index: 20.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3145
    Cell Significance Index: 35.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3107
    Cell Significance Index: 10.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2544
    Cell Significance Index: 162.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2034
    Cell Significance Index: 21.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1867
    Cell Significance Index: 162.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1713
    Cell Significance Index: 82.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1662
    Cell Significance Index: 189.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1624
    Cell Significance Index: 30.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1308
    Cell Significance Index: 33.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0217
    Cell Significance Index: 13.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0023
    Cell Significance Index: 64.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9581
    Cell Significance Index: 20.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9446
    Cell Significance Index: 65.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9350
    Cell Significance Index: 510.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8266
    Cell Significance Index: 9.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7982
    Cell Significance Index: 136.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7879
    Cell Significance Index: 27.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7858
    Cell Significance Index: 40.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7818
    Cell Significance Index: 36.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7693
    Cell Significance Index: 340.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6242
    Cell Significance Index: 76.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5859
    Cell Significance Index: 69.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5205
    Cell Significance Index: 93.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5183
    Cell Significance Index: 467.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5119
    Cell Significance Index: 38.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4937
    Cell Significance Index: 14.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4503
    Cell Significance Index: 12.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4208
    Cell Significance Index: 83.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4090
    Cell Significance Index: 8.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3867
    Cell Significance Index: 11.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3605
    Cell Significance Index: 16.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3240
    Cell Significance Index: 41.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2673
    Cell Significance Index: 2.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2312
    Cell Significance Index: 10.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2130
    Cell Significance Index: 4.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2059
    Cell Significance Index: 39.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2043
    Cell Significance Index: 40.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1974
    Cell Significance Index: 5.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1271
    Cell Significance Index: 1.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0553
    Cell Significance Index: 5.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0511
    Cell Significance Index: 18.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0477
    Cell Significance Index: 33.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0471
    Cell Significance Index: 1.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0428
    Cell Significance Index: 1.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0069
    Cell Significance Index: 5.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0097
    Cell Significance Index: -14.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0125
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0163
    Cell Significance Index: -0.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0163
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0179
    Cell Significance Index: -11.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0211
    Cell Significance Index: -11.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0225
    Cell Significance Index: -30.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0324
    Cell Significance Index: -20.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0419
    Cell Significance Index: -1.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0481
    Cell Significance Index: -0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0505
    Cell Significance Index: -22.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0563
    Cell Significance Index: -0.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0658
    Cell Significance Index: -18.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0764
    Cell Significance Index: -16.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1192
    Cell Significance Index: -13.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1241
    Cell Significance Index: -18.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1255
    Cell Significance Index: -7.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1981
    Cell Significance Index: -10.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2161
    Cell Significance Index: -24.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2416
    Cell Significance Index: -10.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2432
    Cell Significance Index: -2.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2494
    Cell Significance Index: -25.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2540
    Cell Significance Index: -6.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2732
    Cell Significance Index: -20.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2827
    Cell Significance Index: -10.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2919
    Cell Significance Index: -17.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2962
    Cell Significance Index: -23.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3125
    Cell Significance Index: -21.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3226
    Cell Significance Index: -18.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3236
    Cell Significance Index: -2.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3271
    Cell Significance Index: -9.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3290
    Cell Significance Index: -20.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3747
    Cell Significance Index: -18.9400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3898
    Cell Significance Index: -2.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4335
    Cell Significance Index: -17.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4630
    Cell Significance Index: -12.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **RNA-binding protein**: NOB1 is a RNA-binding protein that interacts with various RNAs, including ssu-rrna, to regulate their processing and stability. 2. **Ribosome biogenesis**: NOB1 is involved in the maturation of ssu-rrna, a crucial step in ribosome biogenesis. 3. **RNA metabolism**: NOB1 regulates the metabolism of RNAs, including the control of ribonuclease activity. 4. **Cell type specificity**: NOB1 is expressed in various cell types, including pro-T cells, decidual cells, and erythroid progenitor cells, highlighting its importance in different cellular contexts. 5. **Tissue-specific expression**: NOB1 is highly expressed in tissues involved in immune responses, development, and tissue homeostasis. **Pathways and Functions** NOB1 is involved in several key pathways, including: 1. **RNA processing**: NOB1 regulates the maturation of ssu-rrna and the processing of other RNAs in the nucleus and cytosol. 2. **Ribosome biogenesis**: NOB1 is essential for the biogenesis of ribosomes, which are critical for protein synthesis. 3. **RNA metabolism**: NOB1 regulates the metabolism of RNAs, including the control of ribonuclease activity. 4. **Cell signaling**: NOB1 may interact with other proteins to regulate cell signaling pathways involved in immune responses and development. **Clinical Significance** Dysregulation of NOB1 has been implicated in several diseases, including: 1. **Cancer**: NOB1 is often overexpressed in cancer cells, where it may contribute to tumorigenesis. 2. **Autoimmune disorders**: NOB1 has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Neurological conditions**: NOB1 may be involved in the pathogenesis of neurological conditions, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive disorders**: NOB1 is highly expressed in placental villous trophoblasts, where it may play a role in the development of reproductive disorders, such as gestational diabetes. In conclusion, NOB1 is a critical regulator of RNA processing and metabolism, with implications for various diseases. Further research is needed to fully understand the functions of NOB1 and its role in human disease.

Genular Protein ID: 2693032315

Symbol: NOB1_HUMAN

Name: RNA-binding protein NOB1

UniProtKB Accession Codes:

Q9ULX3 Q7L6B7 Q7M4M4 Q7Z4B5 Q9NWB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 9 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16172919

Title: Cloning, expression and characterization of the human NOB1 gene.

PubMed ID: 16172919

DOI: 10.1007/s11033-005-3141-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1791827

Title: Cloning and expression of a new human polypeptide which regulates protein phosphorylation in Escherichia coli.

PubMed ID: 1791827

DOI: 10.1007/bf00225511

PubMed ID: 15231747

Title: A protein interaction framework for human mRNA degradation.

PubMed ID: 15231747

DOI: 10.1101/gr.2122004

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29875412

Title: Visualizing late states of human 40S ribosomal subunit maturation.

PubMed ID: 29875412

DOI: 10.1038/s41586-018-0193-0

Sequence Information:

  • Length: 412
  • Mass: 46675
  • Checksum: 369680A6DCFC7CB0
  • Sequence:
    • MAPVEHVVAD AGAFLRHAAL QDIGKNIYTI REVVTEIRDK ATRRRLAVLP YELRFKEPLP 
EYVRLVTEFS KKTGDYPSLS ATDIQVLALT YQLEAEFVGV SHLKQEPQKV KVSSSIQHPE 
TPLHISGFHL PYKPKPPQET EKGHSACEPE NLEFSSFMFW RNPLPNIDHE LQELLIDRGE 
DVPSEEEEEE ENGFEDRKDD SDDDGGGWIT PSNIKQIQQE LEQCDVPEDV RVGCLTTDFA 
MQNVLLQMGL HVLAVNGMLI REARSYILRC HGCFKTTSDM SRVFCSHCGN KTLKKVSVTV 
SDDGTLHMHF SRNPKVLNPR GLRYSLPTPK GGKYAINPHL TEDQRFPQLR LSQKARQKTN 
VFAPDYIAGV SPFVENDISS RSATLQVRDS TLGAGRRRLN PNASRKKFVK KR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.