Details for: NTMT1

Gene ID: 28989

Symbol: NTMT1

Ensembl ID: ENSG00000148335

Description: N-terminal Xaa-Pro-Lys N-methyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.1183
    Cell Significance Index: -26.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.2265
    Cell Significance Index: -26.6900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 77.6555
    Cell Significance Index: -31.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.1782
    Cell Significance Index: -30.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.3958
    Cell Significance Index: -25.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.9332
    Cell Significance Index: -29.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.2891
    Cell Significance Index: -30.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.3320
    Cell Significance Index: -26.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9181
    Cell Significance Index: -29.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0449
    Cell Significance Index: -24.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7242
    Cell Significance Index: -30.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9760
    Cell Significance Index: -18.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2121
    Cell Significance Index: -7.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4076
    Cell Significance Index: 166.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7756
    Cell Significance Index: 47.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6951
    Cell Significance Index: 46.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0235
    Cell Significance Index: 29.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0043
    Cell Significance Index: 163.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9859
    Cell Significance Index: 538.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7457
    Cell Significance Index: 34.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6648
    Cell Significance Index: 49.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6605
    Cell Significance Index: 31.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6432
    Cell Significance Index: 63.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6155
    Cell Significance Index: 5.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5550
    Cell Significance Index: 71.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5437
    Cell Significance Index: 74.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4884
    Cell Significance Index: 5.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4843
    Cell Significance Index: 96.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4783
    Cell Significance Index: 58.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4434
    Cell Significance Index: 23.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4399
    Cell Significance Index: 12.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4281
    Cell Significance Index: 77.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4099
    Cell Significance Index: 8.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3941
    Cell Significance Index: 20.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3757
    Cell Significance Index: 26.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3631
    Cell Significance Index: 160.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3583
    Cell Significance Index: 16.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3444
    Cell Significance Index: 40.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3390
    Cell Significance Index: 43.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3163
    Cell Significance Index: 16.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2810
    Cell Significance Index: 4.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2743
    Cell Significance Index: 189.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2181
    Cell Significance Index: 196.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2034
    Cell Significance Index: 40.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1358
    Cell Significance Index: 4.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1338
    Cell Significance Index: 25.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0880
    Cell Significance Index: 1.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0862
    Cell Significance Index: 2.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0804
    Cell Significance Index: 28.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0633
    Cell Significance Index: 1.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0572
    Cell Significance Index: 2.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0507
    Cell Significance Index: 3.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0297
    Cell Significance Index: 0.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0211
    Cell Significance Index: 1.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0146
    Cell Significance Index: 9.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0073
    Cell Significance Index: 5.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0064
    Cell Significance Index: 12.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0049
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0027
    Cell Significance Index: 2.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0015
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0165
    Cell Significance Index: -1.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0173
    Cell Significance Index: -26.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0180
    Cell Significance Index: -33.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0212
    Cell Significance Index: -28.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0251
    Cell Significance Index: -0.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0299
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0316
    Cell Significance Index: -23.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0453
    Cell Significance Index: -20.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0494
    Cell Significance Index: -27.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0532
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0546
    Cell Significance Index: -34.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0675
    Cell Significance Index: -5.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0750
    Cell Significance Index: -8.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0791
    Cell Significance Index: -22.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0920
    Cell Significance Index: -1.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1034
    Cell Significance Index: -15.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1213
    Cell Significance Index: -3.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1407
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1475
    Cell Significance Index: -16.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1626
    Cell Significance Index: -34.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1898
    Cell Significance Index: -10.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2368
    Cell Significance Index: -14.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2438
    Cell Significance Index: -14.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2592
    Cell Significance Index: -20.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2828
    Cell Significance Index: -29.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2876
    Cell Significance Index: -7.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2904
    Cell Significance Index: -9.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2991
    Cell Significance Index: -6.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3144
    Cell Significance Index: -4.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3574
    Cell Significance Index: -6.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3676
    Cell Significance Index: -24.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3991
    Cell Significance Index: -9.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3993
    Cell Significance Index: -10.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4169
    Cell Significance Index: -12.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4183
    Cell Significance Index: -3.3400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4656
    Cell Significance Index: -2.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4901
    Cell Significance Index: -21.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5284
    Cell Significance Index: -3.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5859
    Cell Significance Index: -15.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5981
    Cell Significance Index: -22.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NTMT1 is a member of the N-terminal protein N-methyltransferase family, which is responsible for the methylation of N-terminal peptides. The protein has a specific substrate specificity, targeting peptides with the Xaa-Pro-Lys motif. This motif is conserved in various proteins, including histones, which are essential for chromatin structure and gene expression. NTMT1 has also been shown to interact with other proteins, including histones and transcription factors, suggesting its role in regulating chromatin dynamics and gene transcription. **Pathways and Functions** NTMT1 is involved in several cellular pathways, including: 1. **Chromatin remodeling**: NTMT1 contributes to the regulation of chromatin structure by methylating histones, which in turn affects gene expression and transcriptional regulation. 2. **Cell cycle progression**: NTMT1 is required for the proper progression of the cell cycle, particularly during mitosis, by regulating the methylation of N-terminal peptides on key proteins involved in cell cycle control. 3. **Protein-protein interactions**: NTMT1 modulates protein-protein interactions by methylating N-terminal peptides, which can affect the binding affinity of proteins and their interactions with other molecules. 4. **Histone modification**: NTMT1 is involved in the methylation of histones, which is crucial for the regulation of gene expression and chromatin structure. **Clinical Significance** Dysregulation of NTMT1 has been implicated in various diseases, including: 1. **Cancer**: Aberrant methylation of N-terminal peptides by NTMT1 has been observed in several types of cancer, including pancreatic cancer, prostate cancer, and breast cancer. 2. **Neurodegenerative diseases**: NTMT1 has been implicated in the regulation of protein-protein interactions and histone modification, which are critical for the development and progression of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 3. **Atherosclerosis**: NTMT1 has been shown to regulate the methylation of N-terminal peptides on proteins involved in inflammation and atherosclerosis, suggesting its role in the development of cardiovascular disease. In conclusion, NTMT1 is a critical gene involved in the regulation of various cellular functions, including chromatin remodeling, cell cycle progression, and protein-protein interactions. Its dysregulation has been implicated in several diseases, highlighting the importance of NTMT1 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the role of NTMT1 in human health and disease.

Genular Protein ID: 2364961951

Symbol: NTM1A_HUMAN

Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1

UniProtKB Accession Codes:

Q9BV86 A8K4J2 A8K8G7 Q5SZB9 Q9UI28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 7 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 18 PDBsum 18 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 9 Rhea 9 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20481588

Title: Identification of protein N-terminal methyltransferases in yeast and humans.

PubMed ID: 20481588

DOI: 10.1021/bi100428x

PubMed ID: 20668449

Title: NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.

PubMed ID: 20668449

DOI: 10.1038/nature09343

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24090352

Title: NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.

PubMed ID: 24090352

DOI: 10.1042/bj20131163

PubMed ID: 26543159

Title: Molecular basis for histone N-terminal methylation by NRMT1.

PubMed ID: 26543159

DOI: 10.1101/gad.270926.115

PubMed ID: 26543161

Title: Structural basis for substrate recognition by the human N-terminal methyltransferase 1.

PubMed ID: 26543161

DOI: 10.1101/gad.270611.115

Sequence Information:

  • Length: 223
  • Mass: 25387
  • Checksum: 4A0EC492D9B52C49
  • Sequence:
    • MTSEVIEDEK QFYSKAKTYW KQIPPTVDGM LGGYGHISSI DINSSRKFLQ RFLREGPNKT 
GTSCALDCGA GIGRITKRLL LPLFREVDMV DITEDFLVQA KTYLGEEGKR VRNYFCCGLQ 
DFTPEPDSYD VIWIQWVIGH LTDQHLAEFL RRCKGSLRPN GIIVIKDNMA QEGVILDDVD 
SSVCRDLDVV RRIICSAGLS LLAEERQENL PDEIYHVYSF ALR

Genular Protein ID: 3571574712

Symbol: S4R338_HUMAN

Name: N/A

UniProtKB Accession Codes:

S4R338

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 3 EMBL 2 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 4 Rhea 9 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 135
  • Mass: 15523
  • Checksum: BE4AF973EBC311C5
  • Sequence:
    • MVDITEDFLV QAKTYLGEEG KRVRNYFCCG LQDFTPEPDS YDVIWIQWVI GHLTDQHLAE 
FLRRCKGSLR PNGIIVIKDN MAQEGVILDD VDSSVCRDLD VVRRIICSAG LSLLAEERQE 
NLPDEIYHVY SFALR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.