Details for: NR3C1

Gene ID: 2908

Symbol: NR3C1

Ensembl ID: ENSG00000113580

Description: nuclear receptor subfamily 3 group C member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.72
    Marker Score: 2592
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.63
    Marker Score: 3023
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.55
    Marker Score: 4911
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.52
    Marker Score: 25537
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.48
    Marker Score: 6204
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.37
    Marker Score: 1176
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.33
    Marker Score: 88447
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.33
    Marker Score: 841
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.24
    Marker Score: 2390
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.21
    Marker Score: 2751
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.17
    Marker Score: 1298
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.16
    Marker Score: 18972.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.11
    Marker Score: 8752.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.1
    Marker Score: 41781
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.07
    Marker Score: 46234
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.05
    Marker Score: 1554
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.05
    Marker Score: 994
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.04
    Marker Score: 3561
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 2.03
    Marker Score: 398
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.03
    Marker Score: 1186
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.01
    Marker Score: 1669
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2
    Marker Score: 73918
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.97
    Marker Score: 1299
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.97
    Marker Score: 1102
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.96
    Marker Score: 120679
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.95
    Marker Score: 18385
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.95
    Marker Score: 1144
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.94
    Marker Score: 2395
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.93
    Marker Score: 4621.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.93
    Marker Score: 65537
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.91
    Marker Score: 8836
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.91
    Marker Score: 1033
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.9
    Marker Score: 2295
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.9
    Marker Score: 3974
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.89
    Marker Score: 2612
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.89
    Marker Score: 30387
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.87
    Marker Score: 5560
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.87
    Marker Score: 547
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.87
    Marker Score: 580
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.86
    Marker Score: 427
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.86
    Marker Score: 27846
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.86
    Marker Score: 1742
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17521
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.84
    Marker Score: 689
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.83
    Marker Score: 399
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15478
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.8
    Marker Score: 7490
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.79
    Marker Score: 1643
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.78
    Marker Score: 723
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.77
    Marker Score: 7203.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.76
    Marker Score: 5555
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.75
    Marker Score: 92272
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.74
    Marker Score: 416
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.73
    Marker Score: 1887
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.72
    Marker Score: 634
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.71
    Marker Score: 7317
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.69
    Marker Score: 868
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.68
    Marker Score: 35867
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.65
    Marker Score: 814
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.64
    Marker Score: 669
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.64
    Marker Score: 4594.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.64
    Marker Score: 1578
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.64
    Marker Score: 1417
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.63
    Marker Score: 1020
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.63
    Marker Score: 1458
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.62
    Marker Score: 1961
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.62
    Marker Score: 1752
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.62
    Marker Score: 944
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.61
    Marker Score: 1589
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.61
    Marker Score: 426
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.6
    Marker Score: 15876
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.6
    Marker Score: 691
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.6
    Marker Score: 1607.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.6
    Marker Score: 1359
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.6
    Marker Score: 828
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.6
    Marker Score: 799
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.58
    Marker Score: 552
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.58
    Marker Score: 12112.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.58
    Marker Score: 370
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.58
    Marker Score: 5833
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.57
    Marker Score: 1118
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.57
    Marker Score: 772
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.56
    Marker Score: 412.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.56
    Marker Score: 540
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.55
    Marker Score: 1919
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.55
    Marker Score: 2665
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.55
    Marker Score: 457
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.54
    Marker Score: 1119
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.54
    Marker Score: 380.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.54
    Marker Score: 9900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.54
    Marker Score: 1652
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.53
    Marker Score: 1160
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.53
    Marker Score: 434
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.53
    Marker Score: 381
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.53
    Marker Score: 85361
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2355
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.52
    Marker Score: 637
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.52
    Marker Score: 554
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.51
    Marker Score: 690.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.51
    Marker Score: 522

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Other Information

**Key characteristics:** * NR3C1 is a key regulator of cellular responses to stress, inflammation, and apoptosis. * It is highly expressed in various cell types, including immune cells, cancer cells, and endothelial cells. * NR3C1 is a key regulator of inflammation, as it promotes the production of inflammatory cytokines and chemokines. * It is also a key regulator of cell growth, differentiation, and apoptosis. **Pathways and functions:** * NR3C1 is a key regulator of the cellular stress response. * It is activated by a variety of stress signals, including cytokines, reactive oxygen species, and heat shock proteins. * Upon activation, NR3C1 translocates to the nucleus and forms a complex with other transcription factors, such as STAT3 and NF-κB. * This complex binds to DNA and promotes the transcription of target genes involved in stress response, inflammation, and cell survival. **Clinical significance:** * NR3C1 mutations are associated with a number of human diseases, including asthma, chronic pain, and cancer. * Targeting NR3C1 has been explored as a therapeutic strategy for these diseases. **Additional information:** * NR3C1 is also a key regulator of the circadian clock. * It is expressed in the brain and other tissues, where it plays a role in regulating sleep-wake cycles. * NR3C1 is a potent activator of the p53 tumor suppressor protein. * It is a key regulator of the expression of inflammatory cytokines and chemokines.

Genular Protein ID: 650395134

Symbol: GCR_HUMAN

Name: Glucocorticoid receptor

UniProtKB Accession Codes:

P04150 A0ZXF9 B0LPG8 D3DQF4 F5ATB7 P04151 Q53EP5 Q6N0A4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 69 DrugCentral 1 ELM 1 EMBL 60 EMDB 3 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 61 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 63 PDBsum 55 PIR 2 PRINTS 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 9 RefSeq 20 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

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PubMed ID: 2867473

DOI: 10.1038/318635a0

PubMed ID: 1707881

Title: The genomic structure of the human glucocorticoid receptor.

PubMed ID: 1707881

DOI: 10.1016/s0021-9258(20)89627-6

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

PubMed ID: 17404046

Title: A new transcript splice variant of the human glucocorticoid receptor: identification and tissue distribution of hGR Delta 313-338, an alternative exon 2 transactivation domain isoform.

PubMed ID: 17404046

DOI: 10.1196/annals.1397.037

PubMed ID: 21701417

Title: Novel hyperactive glucocorticoid receptor isoform identified within a human population.

PubMed ID: 21701417

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PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2026589

Title: Purification of a human glucocorticoid receptor gene promoter-binding protein. Production of polyclonal antibodies against the purified factor.

PubMed ID: 2026589

DOI: 10.1016/s0021-9258(18)31504-7

PubMed ID: 1958537

Title: Human glucocorticoid receptor gene promotor-homologous down regulation.

PubMed ID: 1958537

DOI: 10.1016/0960-0760(91)90197-d

PubMed ID: 3841189

Title: Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product.

PubMed ID: 3841189

DOI: 10.1038/318670a0

PubMed ID: 8358712

Title: Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells.

PubMed ID: 8358712

PubMed ID: 7769088

Title: Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.

PubMed ID: 7769088

DOI: 10.1172/jci117943

PubMed ID: 8621628

Title: The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function.

PubMed ID: 8621628

DOI: 10.1074/jbc.271.16.9550

PubMed ID: 9353307

Title: The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U.

PubMed ID: 9353307

DOI: 10.1074/jbc.272.45.28471

PubMed ID: 9154805

Title: Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor.

PubMed ID: 9154805

DOI: 10.1128/mcb.17.6.3065

PubMed ID: 9590696

Title: Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.

PubMed ID: 9590696

DOI: 10.1038/30032

PubMed ID: 10477749

Title: A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.

PubMed ID: 10477749

DOI: 10.1083/jcb.146.5.929

PubMed ID: 10566686

Title: Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing.

PubMed ID: 10566686

DOI: 10.1210/jcem.84.11.6235

PubMed ID: 10902803

Title: Steroidogenic enzyme gene expression in the human heart.

PubMed ID: 10902803

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PubMed ID: 10866662

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PubMed ID: 10866662

DOI: 10.1128/mcb.20.14.5048-5063.2000

PubMed ID: 10639135

Title: Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor.

PubMed ID: 10639135

DOI: 10.1073/pnas.97.2.657

PubMed ID: 11358809

Title: Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells.

PubMed ID: 11358809

PubMed ID: 11555652

Title: Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.

PubMed ID: 11555652

DOI: 10.1074/jbc.m106033200

PubMed ID: 11238589

Title: High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids.

PubMed ID: 11238589

DOI: 10.1084/jem.193.5.585

PubMed ID: 11435610

Title: Molecular identification and characterization of A and B forms of the glucocorticoid receptor.

PubMed ID: 11435610

DOI: 10.1210/mend.15.7.0667

PubMed ID: 11381138

Title: Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance.

PubMed ID: 11381138

DOI: 10.1073/pnas.121455098

PubMed ID: 12144530

Title: Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.

PubMed ID: 12144530

DOI: 10.1042/bj20021085

PubMed ID: 12000743

Title: Deciphering the phosphorylation 'code' of the glucocorticoid receptor in vivo.

PubMed ID: 12000743

DOI: 10.1074/jbc.m110530200

PubMed ID: 12415108

Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.

PubMed ID: 12415108

DOI: 10.1073/pnas.192569699

PubMed ID: 19666546

Title:

PubMed ID: 19666546

DOI: 10.1073/pnas.0908685106

PubMed ID: 15265776

Title: The origin and functions of multiple human glucocorticoid receptor isoforms.

PubMed ID: 15265776

DOI: 10.1196/annals.1321.008

PubMed ID: 15211577

Title: Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation.

PubMed ID: 15211577

DOI: 10.1002/jcb.20109

PubMed ID: 15866175

Title: Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.

PubMed ID: 15866175

DOI: 10.1016/j.molcel.2005.03.025

PubMed ID: 15591535

Title: Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor.

PubMed ID: 15591535

DOI: 10.1210/me.2004-0333

PubMed ID: 15941832

Title: HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.

PubMed ID: 15941832

DOI: 10.1073/pnas.0409863102

PubMed ID: 16914116

Title: Functional interaction between the glucocorticoid receptor and GANP/MCM3AP.

PubMed ID: 16914116

DOI: 10.1016/j.bbrc.2006.07.182

PubMed ID: 16478993

Title: GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.

PubMed ID: 16478993

DOI: 10.1128/mcb.26.5.1722-1730.2006

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18838540

Title: Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles.

PubMed ID: 18838540

DOI: 10.1128/mcb.00808-08

PubMed ID: 18483179

Title: Glucocorticoid receptor phosphorylation differentially affects target gene expression.

PubMed ID: 18483179

DOI: 10.1210/me.2007-0219

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19248771

Title: Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity.

PubMed ID: 19248771

DOI: 10.1016/j.bbrc.2009.02.110

PubMed ID: 19141540

Title: Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.

PubMed ID: 19141540

DOI: 10.1096/fj.08-117697

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

PubMed ID: 20484466

Title: Glucocorticoid receptor-beta and receptor-gamma exert dominant negative effect on gene repression but not on gene induction.

PubMed ID: 20484466

DOI: 10.1210/en.2009-1254

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21664385

Title: Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor.

PubMed ID: 21664385

DOI: 10.1016/j.bbamcr.2011.05.014

PubMed ID: 21730050

Title: The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.

PubMed ID: 21730050

DOI: 10.1074/jbc.m111.256610

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 21980503

Title: Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man.

PubMed ID: 21980503

DOI: 10.1371/journal.pone.0025612

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23303127

Title: Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes.

PubMed ID: 23303127

DOI: 10.1038/cddis.2012.193

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23508108

Title: RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity.

PubMed ID: 23508108

DOI: 10.1128/mcb.01470-12

PubMed ID: 23820903

Title: Determinants of the heightened activity of glucocorticoid receptor translational isoforms.

PubMed ID: 23820903

DOI: 10.1210/me.2013-1009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26711253

Title: Human Glucocorticoid Receptor beta (hGRbeta) Regulates Gluconeogenesis and Inflammation in Mouse Liver.

PubMed ID: 26711253

DOI: 10.1128/mcb.00908-15

PubMed ID: 25775514

Title: Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.

PubMed ID: 25775514

DOI: 10.1073/pnas.1409612112

PubMed ID: 25847991

Title: Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

PubMed ID: 25847991

DOI: 10.1073/pnas.1411356112

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 29127155

Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

PubMed ID: 29127155

DOI: 10.15252/embj.201796700

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28139699

Title: Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor.

PubMed ID: 28139699

DOI: 10.1038/srep41598

PubMed ID: 12151000

Title: Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.

PubMed ID: 12151000

DOI: 10.1016/s0092-8674(02)00817-6

PubMed ID: 12686538

Title: The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism.

PubMed ID: 12686538

DOI: 10.1074/jbc.m212711200

PubMed ID: 1704018

Title: Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance.

PubMed ID: 1704018

DOI: 10.1172/jci115046

PubMed ID: 8358735

Title: Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells.

PubMed ID: 8358735

PubMed ID: 8445027

Title: Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene.

PubMed ID: 8445027

DOI: 10.1210/jcem.76.3.8445027

PubMed ID: 7683692

Title: A mutation of the glucocorticoid receptor in primary cortisol resistance.

PubMed ID: 7683692

DOI: 10.1172/jci116410

PubMed ID: 8316249

Title: Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes.

PubMed ID: 8316249

DOI: 10.1210/mend.7.5.8316249

PubMed ID: 9150737

Title: Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance.

PubMed ID: 9150737

DOI: 10.1007/s004390050425

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10898924

Title: Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophrenia.

PubMed ID: 10898924

DOI: 10.1002/1096-8628(20000612)96:3<412::aid-ajmg33>3.0.co;2-c

PubMed ID: 11589680

Title: Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance.

PubMed ID: 11589680

DOI: 10.1046/j.1365-2265.2001.01323.x

PubMed ID: 11344238

Title: The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus.

PubMed ID: 11344238

DOI: 10.1210/jcem.86.5.7465

PubMed ID: 11701741

Title: Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking.

PubMed ID: 11701741

DOI: 10.1210/jcem.86.11.8017

PubMed ID: 12351458

Title: A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.

PubMed ID: 12351458

DOI: 10.2337/diabetes.51.10.3128

PubMed ID: 11932321

Title: Female pseudohermaphroditism caused by a novel homozygous missense mutation of the GR gene.

PubMed ID: 11932321

DOI: 10.1210/jcem.87.4.8379

PubMed ID: 12050230

Title: A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators.

PubMed ID: 12050230

DOI: 10.1210/jcem.87.6.8520

PubMed ID: 15276593

Title: Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.

PubMed ID: 15276593

DOI: 10.1016/j.amjmed.2004.01.027

PubMed ID: 15292341

Title: The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults.

PubMed ID: 15292341

DOI: 10.1210/jc.2003-031422

PubMed ID: 15769988

Title: A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity.

PubMed ID: 15769988

DOI: 10.1210/jc.2004-1920

PubMed ID: 16030164

Title: Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.

PubMed ID: 16030164

DOI: 10.1210/jc.2005-0646

PubMed ID: 17635946

Title: A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance.

PubMed ID: 17635946

DOI: 10.1210/jc.2006-2830

PubMed ID: 20335448

Title: A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.

PubMed ID: 20335448

DOI: 10.1210/jc.2009-2463

PubMed ID: 21362280

Title: Generalized glucocorticoid resistance accompanied with an adrenocortical adenoma and caused by a novel point mutation of human glucocorticoid receptor gene.

PubMed ID: 21362280

PubMed ID: 23426617

Title: A novel point mutation in the DNA-binding domain (DBD) of the human glucocorticoid receptor causes primary generalized glucocorticoid resistance by disrupting the hydrophobic structure of its DBD.

PubMed ID: 23426617

DOI: 10.1210/jc.2012-3549

PubMed ID: 24483153

Title: A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities.

PubMed ID: 24483153

DOI: 10.1210/jc.2013-3005

PubMed ID: 26031419

Title: A novel mutation of the hGR gene causing Chrousos syndrome.

PubMed ID: 26031419

DOI: 10.1111/eci.12470

PubMed ID: 26541474

Title: Functional characterization of the hGRalphaT556I causing Chrousos syndrome.

PubMed ID: 26541474

DOI: 10.1111/eci.12563

PubMed ID: 27120390

Title: Three novel heterozygous point mutations of NR3C1 causing glucocorticoid resistance.

PubMed ID: 27120390

DOI: 10.1002/humu.23008

Sequence Information:

  • Length: 777
  • Mass: 85659
  • Checksum: C5C90C9A5DD16AAB
  • Sequence:
    • MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR 
LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK 
LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN 
VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN 
SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV 
YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG 
SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL 
CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GQHNYLCAGR NDCIIDKIRR KNCPACRYRK 
CLQAGMNLEA RKTKKKIKGI QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE 
PEVLYAGYDS SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW 
MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS SELHRLQVSY 
EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA IVKREGNSSQ NWQRFYQLTK 
LLDSMHEVVE NLLNYCFQTF LDKTMSIEFP EMLAEIITNQ IPKYSNGNIK KLLFHQK

Genular Protein ID: 490365256

Symbol: E5KQF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KQF6

Database IDs:

ARBA 19 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 43 ExpressionAtlas 1 GO 11 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 3 RefSeq 5 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 778
  • Mass: 85815
  • Checksum: 23048D99B60B169C
  • Sequence:
    • MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR 
LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK 
LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN 
VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN 
SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV 
YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG 
SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL 
CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GRQHNYLCAG RNDCIIDKIR RKNCPACRYR 
KCLQAGMNLE ARKTKKKIKG IQQATTGVSQ ETSENPGNKT IVPATLPQLT PTLVSLLEVI 
EPEVLYAGYD SSVPDSTWRI MTTLNMLGGR QVIAAVKWAK AIPGFRNLHL DDQMTLLQYS 
WMFLMAFALG WRSYRQSSAN LLCFAPDLII NEQRMTLPCM YDQCKHMLYV SSELHRLQVS 
YEEYLCMKTL LLLSSVPKDG LKSQELFDEI RMTYIKELGK AIVKREGNSS QNWQRFYQLT 
KLLDSMHEVV ENLLNYCFQT FLDKTMSIEF PEMLAEIITN QIPKYSNGNI KKLLFHQK

Genular Protein ID: 145446138

Symbol: E5KQF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KQF5

Database IDs:

ARBA 19 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 43 ExpressionAtlas 1 GO 11 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 3 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 742
  • Mass: 81509
  • Checksum: E2D1F6EA0EE14704
  • Sequence:
    • MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR 
LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK 
LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN 
VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN 
SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV 
YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG 
SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL 
CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GQHNYLCAGR NDCIIDKIRR KNCPACRYRK 
CLQAGMNLEA RKTKKKIKGI QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE 
PEVLYAGYDS SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW 
MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS SELHRLQVSY 
EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA IVKREGNSSQ NWQRFYQLTK 
LLDSMHENVM WLKPESTSHT LI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.