Details for: NR3C1

Gene ID: 2908

Symbol: NR3C1

Ensembl ID: ENSG00000113580

Description: nuclear receptor subfamily 3 group C member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 470.4741
    Cell Significance Index: -73.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 282.1875
    Cell Significance Index: -71.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 168.4032
    Cell Significance Index: -68.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 167.9966
    Cell Significance Index: -79.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 151.5401
    Cell Significance Index: -77.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.9254
    Cell Significance Index: -69.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.9730
    Cell Significance Index: -76.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.9289
    Cell Significance Index: -69.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.8105
    Cell Significance Index: -54.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.9610
    Cell Significance Index: -73.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.7185
    Cell Significance Index: -77.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.7491
    Cell Significance Index: 147.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.0714
    Cell Significance Index: 98.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5414
    Cell Significance Index: 228.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5920
    Cell Significance Index: 519.9600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.4957
    Cell Significance Index: 60.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.1719
    Cell Significance Index: 113.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.0892
    Cell Significance Index: 160.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4968
    Cell Significance Index: 176.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4694
    Cell Significance Index: 238.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3407
    Cell Significance Index: 132.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3299
    Cell Significance Index: 170.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2715
    Cell Significance Index: 1148.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1759
    Cell Significance Index: 233.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1275
    Cell Significance Index: 131.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0197
    Cell Significance Index: 365.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7883
    Cell Significance Index: 16.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7576
    Cell Significance Index: 334.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7389
    Cell Significance Index: 511.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6370
    Cell Significance Index: 10.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6362
    Cell Significance Index: 28.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5329
    Cell Significance Index: 20.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5304
    Cell Significance Index: 9.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5017
    Cell Significance Index: 54.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4860
    Cell Significance Index: 32.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3705
    Cell Significance Index: 10.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2840
    Cell Significance Index: 4.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2553
    Cell Significance Index: 46.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2460
    Cell Significance Index: 156.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2423
    Cell Significance Index: 11.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2023
    Cell Significance Index: 27.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1781
    Cell Significance Index: 10.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1762
    Cell Significance Index: 21.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1662
    Cell Significance Index: 226.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1571
    Cell Significance Index: 85.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1435
    Cell Significance Index: 270.2900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0985
    Cell Significance Index: 1.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0543
    Cell Significance Index: 9.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0325
    Cell Significance Index: 50.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0270
    Cell Significance Index: 49.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0235
    Cell Significance Index: 0.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0224
    Cell Significance Index: 1.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0166
    Cell Significance Index: 7.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0111
    Cell Significance Index: 2.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0469
    Cell Significance Index: -0.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0485
    Cell Significance Index: -35.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0502
    Cell Significance Index: -37.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0600
    Cell Significance Index: -45.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0633
    Cell Significance Index: -39.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0677
    Cell Significance Index: -3.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0680
    Cell Significance Index: -9.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0769
    Cell Significance Index: -43.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0792
    Cell Significance Index: -2.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1135
    Cell Significance Index: -8.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1141
    Cell Significance Index: -11.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1168
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2010
    Cell Significance Index: -42.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2106
    Cell Significance Index: -7.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2431
    Cell Significance Index: -69.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2452
    Cell Significance Index: -31.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4261
    Cell Significance Index: -9.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4272
    Cell Significance Index: -31.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4273
    Cell Significance Index: -23.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4809
    Cell Significance Index: -55.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4891
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5466
    Cell Significance Index: -62.3900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5557
    Cell Significance Index: -7.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5637
    Cell Significance Index: -16.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5806
    Cell Significance Index: -27.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6130
    Cell Significance Index: -37.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6295
    Cell Significance Index: -65.5500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.6377
    Cell Significance Index: -8.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6468
    Cell Significance Index: -10.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6984
    Cell Significance Index: -44.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7455
    Cell Significance Index: -37.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8608
    Cell Significance Index: -45.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8612
    Cell Significance Index: -68.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9020
    Cell Significance Index: -5.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9898
    Cell Significance Index: -14.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0082
    Cell Significance Index: -26.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.0086
    Cell Significance Index: -14.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1246
    Cell Significance Index: -68.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1616
    Cell Significance Index: -60.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.3442
    Cell Significance Index: -38.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.3460
    Cell Significance Index: -9.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3737
    Cell Significance Index: -43.7500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.4011
    Cell Significance Index: -18.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.4509
    Cell Significance Index: -30.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.4963
    Cell Significance Index: -30.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NR3C1 is a member of the nuclear receptor subfamily 3 group C and exhibits characteristics typical of this class of receptors. Some key features of NR3C1 include: 1. **Ligand-binding domain**: NR3C1 contains a ligand-binding domain that allows it to bind to glucocorticoid hormones. 2. **DNA-binding domain**: The receptor also possesses a DNA-binding domain, which enables it to interact with specific DNA sequences and regulate gene expression. 3. **Transcriptional regulation**: NR3C1 acts as a transcriptional regulator by binding to specific DNA sequences and recruiting transcriptional machinery to activate or repress gene expression. 4. **Cellular localization**: The receptor is primarily found in the nucleus, where it regulates gene expression. **Pathways and Functions** NR3C1 is involved in various biological pathways, including: 1. **Stress response**: NR3C1 regulates the expression of genes involved in the stress response, including those involved in inflammation, immune response, and metabolism. 2. **Metabolism**: The receptor modulates the expression of genes involved in glucose and lipid metabolism, as well as energy homeostasis. 3. **Development**: NR3C1 plays a role in the development of various tissues, including the adrenal glands, immune cells, and neurons. 4. **Neuroinflammation**: The receptor is involved in the regulation of neuroinflammatory responses, including those mediated by microglia and astrocytes. **Clinical Significance** Dysregulation of NR3C1 has been implicated in various diseases, including: 1. **Glucocorticoid resistance**: Abnormalities in the NR3C1 gene have been linked to glucocorticoid resistance, a condition characterized by impaired glucocorticoid action. 2. **Metabolic disorders**: NR3C1 dysregulation has been implicated in metabolic disorders, such as obesity and type 2 diabetes. 3. **Neurological disorders**: The receptor's role in neuroinflammation and neurodevelopment suggests its involvement in neurological disorders, such as multiple sclerosis and schizophrenia. 4. **Infectious diseases**: NR3C1 has been shown to play a role in the regulation of immune responses to viral infections, including SARS-CoV. In conclusion, NR3C1 is a crucial regulator of various physiological processes, including stress response, metabolism, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms and therapeutic potential of this gene.

Genular Protein ID: 650395134

Symbol: GCR_HUMAN

Name: Glucocorticoid receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2867473

Title: Primary structure and expression of a functional human glucocorticoid receptor cDNA.

PubMed ID: 2867473

DOI: 10.1038/318635a0

PubMed ID: 1707881

Title: The genomic structure of the human glucocorticoid receptor.

PubMed ID: 1707881

DOI: 10.1016/s0021-9258(20)89627-6

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

PubMed ID: 17404046

Title: A new transcript splice variant of the human glucocorticoid receptor: identification and tissue distribution of hGR Delta 313-338, an alternative exon 2 transactivation domain isoform.

PubMed ID: 17404046

DOI: 10.1196/annals.1397.037

PubMed ID: 21701417

Title: Novel hyperactive glucocorticoid receptor isoform identified within a human population.

PubMed ID: 21701417

DOI: 10.1097/shk.0b013e318228eca7

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2026589

Title: Purification of a human glucocorticoid receptor gene promoter-binding protein. Production of polyclonal antibodies against the purified factor.

PubMed ID: 2026589

DOI: 10.1016/s0021-9258(18)31504-7

PubMed ID: 1958537

Title: Human glucocorticoid receptor gene promotor-homologous down regulation.

PubMed ID: 1958537

DOI: 10.1016/0960-0760(91)90197-d

PubMed ID: 3841189

Title: Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product.

PubMed ID: 3841189

DOI: 10.1038/318670a0

PubMed ID: 8358712

Title: Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells.

PubMed ID: 8358712

PubMed ID: 7769088

Title: Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.

PubMed ID: 7769088

DOI: 10.1172/jci117943

PubMed ID: 8621628

Title: The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function.

PubMed ID: 8621628

DOI: 10.1074/jbc.271.16.9550

PubMed ID: 9353307

Title: The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U.

PubMed ID: 9353307

DOI: 10.1074/jbc.272.45.28471

PubMed ID: 9154805

Title: Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor.

PubMed ID: 9154805

DOI: 10.1128/mcb.17.6.3065

PubMed ID: 9590696

Title: Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.

PubMed ID: 9590696

DOI: 10.1038/30032

PubMed ID: 10477749

Title: A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.

PubMed ID: 10477749

DOI: 10.1083/jcb.146.5.929

PubMed ID: 10566686

Title: Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing.

PubMed ID: 10566686

DOI: 10.1210/jcem.84.11.6235

PubMed ID: 10902803

Title: Steroidogenic enzyme gene expression in the human heart.

PubMed ID: 10902803

DOI: 10.1210/jcem.85.7.6663

PubMed ID: 10866662

Title: A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.

PubMed ID: 10866662

DOI: 10.1128/mcb.20.14.5048-5063.2000

PubMed ID: 10639135

Title: Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor.

PubMed ID: 10639135

DOI: 10.1073/pnas.97.2.657

PubMed ID: 11358809

Title: Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells.

PubMed ID: 11358809

PubMed ID: 11555652

Title: Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.

PubMed ID: 11555652

DOI: 10.1074/jbc.m106033200

PubMed ID: 11238589

Title: High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids.

PubMed ID: 11238589

DOI: 10.1084/jem.193.5.585

PubMed ID: 11435610

Title: Molecular identification and characterization of A and B forms of the glucocorticoid receptor.

PubMed ID: 11435610

DOI: 10.1210/mend.15.7.0667

PubMed ID: 11381138

Title: Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance.

PubMed ID: 11381138

DOI: 10.1073/pnas.121455098

PubMed ID: 12144530

Title: Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.

PubMed ID: 12144530

DOI: 10.1042/bj20021085

PubMed ID: 12000743

Title: Deciphering the phosphorylation 'code' of the glucocorticoid receptor in vivo.

PubMed ID: 12000743

DOI: 10.1074/jbc.m110530200

PubMed ID: 12415108

Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.

PubMed ID: 12415108

DOI: 10.1073/pnas.192569699

PubMed ID: 19666546

Title:

PubMed ID: 19666546

DOI: 10.1073/pnas.0908685106

PubMed ID: 15265776

Title: The origin and functions of multiple human glucocorticoid receptor isoforms.

PubMed ID: 15265776

DOI: 10.1196/annals.1321.008

PubMed ID: 15211577

Title: Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation.

PubMed ID: 15211577

DOI: 10.1002/jcb.20109

PubMed ID: 15866175

Title: Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.

PubMed ID: 15866175

DOI: 10.1016/j.molcel.2005.03.025

PubMed ID: 15591535

Title: Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor.

PubMed ID: 15591535

DOI: 10.1210/me.2004-0333

PubMed ID: 15941832

Title: HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.

PubMed ID: 15941832

DOI: 10.1073/pnas.0409863102

PubMed ID: 16914116

Title: Functional interaction between the glucocorticoid receptor and GANP/MCM3AP.

PubMed ID: 16914116

DOI: 10.1016/j.bbrc.2006.07.182

PubMed ID: 16478993

Title: GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.

PubMed ID: 16478993

DOI: 10.1128/mcb.26.5.1722-1730.2006

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18838540

Title: Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles.

PubMed ID: 18838540

DOI: 10.1128/mcb.00808-08

PubMed ID: 18483179

Title: Glucocorticoid receptor phosphorylation differentially affects target gene expression.

PubMed ID: 18483179

DOI: 10.1210/me.2007-0219

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19248771

Title: Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity.

PubMed ID: 19248771

DOI: 10.1016/j.bbrc.2009.02.110

PubMed ID: 19141540

Title: Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.

PubMed ID: 19141540

DOI: 10.1096/fj.08-117697

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

PubMed ID: 20484466

Title: Glucocorticoid receptor-beta and receptor-gamma exert dominant negative effect on gene repression but not on gene induction.

PubMed ID: 20484466

DOI: 10.1210/en.2009-1254

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21664385

Title: Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor.

PubMed ID: 21664385

DOI: 10.1016/j.bbamcr.2011.05.014

PubMed ID: 21730050

Title: The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.

PubMed ID: 21730050

DOI: 10.1074/jbc.m111.256610

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 21980503

Title: Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man.

PubMed ID: 21980503

DOI: 10.1371/journal.pone.0025612

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23303127

Title: Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes.

PubMed ID: 23303127

DOI: 10.1038/cddis.2012.193

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23508108

Title: RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity.

PubMed ID: 23508108

DOI: 10.1128/mcb.01470-12

PubMed ID: 23820903

Title: Determinants of the heightened activity of glucocorticoid receptor translational isoforms.

PubMed ID: 23820903

DOI: 10.1210/me.2013-1009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26711253

Title: Human Glucocorticoid Receptor beta (hGRbeta) Regulates Gluconeogenesis and Inflammation in Mouse Liver.

PubMed ID: 26711253

DOI: 10.1128/mcb.00908-15

PubMed ID: 25775514

Title: Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.

PubMed ID: 25775514

DOI: 10.1073/pnas.1409612112

PubMed ID: 25847991

Title: Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

PubMed ID: 25847991

DOI: 10.1073/pnas.1411356112

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 29127155

Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

PubMed ID: 29127155

DOI: 10.15252/embj.201796700

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28139699

Title: Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor.

PubMed ID: 28139699

DOI: 10.1038/srep41598

PubMed ID: 37478846

Title: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

PubMed ID: 37478846

DOI: 10.1016/j.molcel.2023.06.028

PubMed ID: 12151000

Title: Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.

PubMed ID: 12151000

DOI: 10.1016/s0092-8674(02)00817-6

PubMed ID: 12686538

Title: The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism.

PubMed ID: 12686538

DOI: 10.1074/jbc.m212711200

PubMed ID: 1704018

Title: Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance.

PubMed ID: 1704018

DOI: 10.1172/jci115046

PubMed ID: 8358735

Title: Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells.

PubMed ID: 8358735

PubMed ID: 8445027

Title: Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene.

PubMed ID: 8445027

DOI: 10.1210/jcem.76.3.8445027

PubMed ID: 7683692

Title: A mutation of the glucocorticoid receptor in primary cortisol resistance.

PubMed ID: 7683692

DOI: 10.1172/jci116410

PubMed ID: 8316249

Title: Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes.

PubMed ID: 8316249

DOI: 10.1210/mend.7.5.8316249

PubMed ID: 9150737

Title: Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance.

PubMed ID: 9150737

DOI: 10.1007/s004390050425

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10898924

Title: Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophrenia.

PubMed ID: 10898924

DOI: 10.1002/1096-8628(20000612)96:3<412::aid-ajmg33>3.0.co;2-c

PubMed ID: 11589680

Title: Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance.

PubMed ID: 11589680

DOI: 10.1046/j.1365-2265.2001.01323.x

PubMed ID: 11344238

Title: The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus.

PubMed ID: 11344238

DOI: 10.1210/jcem.86.5.7465

PubMed ID: 11701741

Title: Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking.

PubMed ID: 11701741

DOI: 10.1210/jcem.86.11.8017

PubMed ID: 12351458

Title: A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.

PubMed ID: 12351458

DOI: 10.2337/diabetes.51.10.3128

PubMed ID: 11932321

Title: Female pseudohermaphroditism caused by a novel homozygous missense mutation of the GR gene.

PubMed ID: 11932321

DOI: 10.1210/jcem.87.4.8379

PubMed ID: 12050230

Title: A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators.

PubMed ID: 12050230

DOI: 10.1210/jcem.87.6.8520

PubMed ID: 15276593

Title: Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.

PubMed ID: 15276593

DOI: 10.1016/j.amjmed.2004.01.027

PubMed ID: 15292341

Title: The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults.

PubMed ID: 15292341

DOI: 10.1210/jc.2003-031422

PubMed ID: 15769988

Title: A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity.

PubMed ID: 15769988

DOI: 10.1210/jc.2004-1920

PubMed ID: 16030164

Title: Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.

PubMed ID: 16030164

DOI: 10.1210/jc.2005-0646

PubMed ID: 17635946

Title: A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance.

PubMed ID: 17635946

DOI: 10.1210/jc.2006-2830

PubMed ID: 20335448

Title: A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.

PubMed ID: 20335448

DOI: 10.1210/jc.2009-2463

PubMed ID: 21362280

Title: Generalized glucocorticoid resistance accompanied with an adrenocortical adenoma and caused by a novel point mutation of human glucocorticoid receptor gene.

PubMed ID: 21362280

PubMed ID: 23426617

Title: A novel point mutation in the DNA-binding domain (DBD) of the human glucocorticoid receptor causes primary generalized glucocorticoid resistance by disrupting the hydrophobic structure of its DBD.

PubMed ID: 23426617

DOI: 10.1210/jc.2012-3549

PubMed ID: 24483153

Title: A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities.

PubMed ID: 24483153

DOI: 10.1210/jc.2013-3005

PubMed ID: 26031419

Title: A novel mutation of the hGR gene causing Chrousos syndrome.

PubMed ID: 26031419

DOI: 10.1111/eci.12470

PubMed ID: 26541474

Title: Functional characterization of the hGRalphaT556I causing Chrousos syndrome.

PubMed ID: 26541474

DOI: 10.1111/eci.12563

PubMed ID: 27120390

Title: Three novel heterozygous point mutations of NR3C1 causing glucocorticoid resistance.

PubMed ID: 27120390

DOI: 10.1002/humu.23008

Sequence Information:

  • Length: 777
  • Mass: 85659
  • Checksum: C5C90C9A5DD16AAB
  • Sequence:
  • MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR 
    LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK 
    LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN 
    VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN 
    SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV 
    YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG 
    SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL 
    CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GQHNYLCAGR NDCIIDKIRR KNCPACRYRK 
    CLQAGMNLEA RKTKKKIKGI QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE 
    PEVLYAGYDS SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW 
    MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS SELHRLQVSY 
    EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA IVKREGNSSQ NWQRFYQLTK 
    LLDSMHEVVE NLLNYCFQTF LDKTMSIEFP EMLAEIITNQ IPKYSNGNIK KLLFHQK

Genular Protein ID: 145446138

Symbol: E5KQF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 742
  • Mass: 81509
  • Checksum: E2D1F6EA0EE14704
  • Sequence:
  • MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR 
    LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK 
    LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN 
    VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN 
    SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV 
    YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG 
    SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL 
    CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GQHNYLCAGR NDCIIDKIRR KNCPACRYRK 
    CLQAGMNLEA RKTKKKIKGI QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE 
    PEVLYAGYDS SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW 
    MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS SELHRLQVSY 
    EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA IVKREGNSSQ NWQRFYQLTK 
    LLDSMHENVM WLKPESTSHT LI

Genular Protein ID: 490365256

Symbol: E5KQF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 778
  • Mass: 85815
  • Checksum: 23048D99B60B169C
  • Sequence:
  • MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR 
    LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK 
    LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN 
    VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN 
    SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV 
    YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG 
    SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL 
    CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GRQHNYLCAG RNDCIIDKIR RKNCPACRYR 
    KCLQAGMNLE ARKTKKKIKG IQQATTGVSQ ETSENPGNKT IVPATLPQLT PTLVSLLEVI 
    EPEVLYAGYD SSVPDSTWRI MTTLNMLGGR QVIAAVKWAK AIPGFRNLHL DDQMTLLQYS 
    WMFLMAFALG WRSYRQSSAN LLCFAPDLII NEQRMTLPCM YDQCKHMLYV SSELHRLQVS 
    YEEYLCMKTL LLLSSVPKDG LKSQELFDEI RMTYIKELGK AIVKREGNSS QNWQRFYQLT 
    KLLDSMHEVV ENLLNYCFQT FLDKTMSIEF PEMLAEIITN QIPKYSNGNI KKLLFHQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.