Details for: NR3C1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 470.4741
Cell Significance Index: -73.1800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 282.1875
Cell Significance Index: -71.5800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 168.4032
Cell Significance Index: -68.4200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 167.9966
Cell Significance Index: -79.3200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 151.5401
Cell Significance Index: -77.9500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 72.9254
Cell Significance Index: -69.6300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 61.9730
Cell Significance Index: -76.4100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 25.9289
Cell Significance Index: -69.4600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 24.8105
Cell Significance Index: -54.3000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 23.9610
Cell Significance Index: -73.6000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.7185
Cell Significance Index: -77.8100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 5.7491
Cell Significance Index: 147.7800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 5.0714
Cell Significance Index: 98.9800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.5414
Cell Significance Index: 228.4700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.5920
Cell Significance Index: 519.9600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.4957
Cell Significance Index: 60.8900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.1719
Cell Significance Index: 113.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.0892
Cell Significance Index: 160.3200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4968
Cell Significance Index: 176.5200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4694
Cell Significance Index: 238.9900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.3407
Cell Significance Index: 132.6300 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.3299
Cell Significance Index: 170.4800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2715
Cell Significance Index: 1148.0400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1759
Cell Significance Index: 233.3700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.1275
Cell Significance Index: 131.4000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0197
Cell Significance Index: 365.7600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.7883
Cell Significance Index: 16.8500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7576
Cell Significance Index: 334.9400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7389
Cell Significance Index: 511.0600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.6370
Cell Significance Index: 10.7300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.6362
Cell Significance Index: 28.1400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.5329
Cell Significance Index: 20.1800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.5304
Cell Significance Index: 9.0900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5017
Cell Significance Index: 54.5700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.4860
Cell Significance Index: 32.6800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3705
Cell Significance Index: 10.6200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.2840
Cell Significance Index: 4.2800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2553
Cell Significance Index: 46.0200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2460
Cell Significance Index: 156.2100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2423
Cell Significance Index: 11.3900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2023
Cell Significance Index: 27.7900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1781
Cell Significance Index: 10.6900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1762
Cell Significance Index: 21.6700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1662
Cell Significance Index: 226.0100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1571
Cell Significance Index: 85.8100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1435
Cell Significance Index: 270.2900 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.0985
Cell Significance Index: 1.5900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0543
Cell Significance Index: 9.2800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0325
Cell Significance Index: 50.0600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0270
Cell Significance Index: 49.7600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0235
Cell Significance Index: 0.5100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0224
Cell Significance Index: 1.5500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0166
Cell Significance Index: 7.5300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0111
Cell Significance Index: 2.1200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0004
Cell Significance Index: 0.0100 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0469
Cell Significance Index: -0.6800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0485
Cell Significance Index: -35.5300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0502
Cell Significance Index: -37.1800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0600
Cell Significance Index: -45.4200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0633
Cell Significance Index: -39.5200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0677
Cell Significance Index: -3.0700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0680
Cell Significance Index: -9.8800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0769
Cell Significance Index: -43.4000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0792
Cell Significance Index: -2.1200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1135
Cell Significance Index: -8.0300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1141
Cell Significance Index: -11.6600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1168
Cell Significance Index: -3.1800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2010
Cell Significance Index: -42.3400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2106
Cell Significance Index: -7.4000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2431
Cell Significance Index: -69.9400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2452
Cell Significance Index: -31.6800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4261
Cell Significance Index: -9.0700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4272
Cell Significance Index: -31.8400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4273
Cell Significance Index: -23.9800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4809
Cell Significance Index: -55.1000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4891
Cell Significance Index: -9.0400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5466
Cell Significance Index: -62.3900 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5557
Cell Significance Index: -7.9800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.5637
Cell Significance Index: -16.2400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5806
Cell Significance Index: -27.0700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6130
Cell Significance Index: -37.6800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6295
Cell Significance Index: -65.5500 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.6377
Cell Significance Index: -8.0300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6468
Cell Significance Index: -10.8300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6984
Cell Significance Index: -44.0200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.7455
Cell Significance Index: -37.6800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8608
Cell Significance Index: -45.2000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8612
Cell Significance Index: -68.2100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.9020
Cell Significance Index: -5.4500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.9898
Cell Significance Index: -14.6100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.0082
Cell Significance Index: -26.9700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.0086
Cell Significance Index: -14.8900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1246
Cell Significance Index: -68.9500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.1616
Cell Significance Index: -60.3400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.3442
Cell Significance Index: -38.3600 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -1.3460
Cell Significance Index: -9.1200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.3737
Cell Significance Index: -43.7500 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -1.4011
Cell Significance Index: -18.6900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.4509
Cell Significance Index: -30.3700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.4963
Cell Significance Index: -30.0400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 650395134
Symbol: GCR_HUMAN
Name: Glucocorticoid receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2867473
Title: Primary structure and expression of a functional human glucocorticoid receptor cDNA.
PubMed ID: 2867473
DOI: 10.1038/318635a0
PubMed ID: 1707881
Title: The genomic structure of the human glucocorticoid receptor.
PubMed ID: 1707881
PubMed ID: 20843780
Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.
PubMed ID: 20843780
DOI: 10.1093/nar/gkq750
PubMed ID: 17404046
Title: A new transcript splice variant of the human glucocorticoid receptor: identification and tissue distribution of hGR Delta 313-338, an alternative exon 2 transactivation domain isoform.
PubMed ID: 17404046
PubMed ID: 21701417
Title: Novel hyperactive glucocorticoid receptor isoform identified within a human population.
PubMed ID: 21701417
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2026589
Title: Purification of a human glucocorticoid receptor gene promoter-binding protein. Production of polyclonal antibodies against the purified factor.
PubMed ID: 2026589
PubMed ID: 1958537
Title: Human glucocorticoid receptor gene promotor-homologous down regulation.
PubMed ID: 1958537
PubMed ID: 3841189
Title: Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product.
PubMed ID: 3841189
DOI: 10.1038/318670a0
PubMed ID: 8358712
Title: Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells.
PubMed ID: 8358712
PubMed ID: 7769088
Title: Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.
PubMed ID: 7769088
DOI: 10.1172/jci117943
PubMed ID: 8621628
Title: The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function.
PubMed ID: 8621628
PubMed ID: 9353307
Title: The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U.
PubMed ID: 9353307
PubMed ID: 9154805
Title: Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor.
PubMed ID: 9154805
PubMed ID: 9590696
Title: Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.
PubMed ID: 9590696
DOI: 10.1038/30032
PubMed ID: 10477749
Title: A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.
PubMed ID: 10477749
PubMed ID: 10566686
Title: Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing.
PubMed ID: 10566686
PubMed ID: 10902803
Title: Steroidogenic enzyme gene expression in the human heart.
PubMed ID: 10902803
PubMed ID: 10866662
Title: A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.
PubMed ID: 10866662
PubMed ID: 10639135
Title: Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor.
PubMed ID: 10639135
PubMed ID: 11358809
Title: Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells.
PubMed ID: 11358809
PubMed ID: 11555652
Title: Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.
PubMed ID: 11555652
PubMed ID: 11238589
Title: High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids.
PubMed ID: 11238589
PubMed ID: 11435610
Title: Molecular identification and characterization of A and B forms of the glucocorticoid receptor.
PubMed ID: 11435610
PubMed ID: 11381138
Title: Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance.
PubMed ID: 11381138
PubMed ID: 12144530
Title: Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.
PubMed ID: 12144530
DOI: 10.1042/bj20021085
PubMed ID: 12000743
Title: Deciphering the phosphorylation 'code' of the glucocorticoid receptor in vivo.
PubMed ID: 12000743
PubMed ID: 12415108
Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
PubMed ID: 12415108
PubMed ID: 19666546
PubMed ID: 15265776
Title: The origin and functions of multiple human glucocorticoid receptor isoforms.
PubMed ID: 15265776
PubMed ID: 15211577
Title: Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation.
PubMed ID: 15211577
DOI: 10.1002/jcb.20109
PubMed ID: 15866175
Title: Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.
PubMed ID: 15866175
PubMed ID: 15591535
Title: Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor.
PubMed ID: 15591535
DOI: 10.1210/me.2004-0333
PubMed ID: 15941832
Title: HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.
PubMed ID: 15941832
PubMed ID: 16914116
Title: Functional interaction between the glucocorticoid receptor and GANP/MCM3AP.
PubMed ID: 16914116
PubMed ID: 16478993
Title: GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.
PubMed ID: 16478993
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18838540
Title: Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles.
PubMed ID: 18838540
DOI: 10.1128/mcb.00808-08
PubMed ID: 18483179
Title: Glucocorticoid receptor phosphorylation differentially affects target gene expression.
PubMed ID: 18483179
DOI: 10.1210/me.2007-0219
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19248771
Title: Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity.
PubMed ID: 19248771
PubMed ID: 19141540
Title: Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.
PubMed ID: 19141540
DOI: 10.1096/fj.08-117697
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20078863
Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.
PubMed ID: 20078863
PubMed ID: 20484466
Title: Glucocorticoid receptor-beta and receptor-gamma exert dominant negative effect on gene repression but not on gene induction.
PubMed ID: 20484466
DOI: 10.1210/en.2009-1254
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21664385
Title: Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor.
PubMed ID: 21664385
PubMed ID: 21730050
Title: The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.
PubMed ID: 21730050
PubMed ID: 22170608
Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
PubMed ID: 22170608
DOI: 10.1038/nature10700
PubMed ID: 21980503
Title: Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man.
PubMed ID: 21980503
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23303127
Title: Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes.
PubMed ID: 23303127
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23508108
Title: RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity.
PubMed ID: 23508108
DOI: 10.1128/mcb.01470-12
PubMed ID: 23820903
Title: Determinants of the heightened activity of glucocorticoid receptor translational isoforms.
PubMed ID: 23820903
DOI: 10.1210/me.2013-1009
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 26711253
Title: Human Glucocorticoid Receptor beta (hGRbeta) Regulates Gluconeogenesis and Inflammation in Mouse Liver.
PubMed ID: 26711253
DOI: 10.1128/mcb.00908-15
PubMed ID: 25775514
Title: Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.
PubMed ID: 25775514
PubMed ID: 25847991
Title: Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
PubMed ID: 25847991
PubMed ID: 27353360
Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
PubMed ID: 27353360
DOI: 10.1038/ncomms12037
PubMed ID: 29127155
Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
PubMed ID: 29127155
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28139699
Title: Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor.
PubMed ID: 28139699
DOI: 10.1038/srep41598
PubMed ID: 37478846
Title: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
PubMed ID: 37478846
PubMed ID: 12151000
Title: Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.
PubMed ID: 12151000
PubMed ID: 12686538
Title: The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism.
PubMed ID: 12686538
PubMed ID: 1704018
Title: Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance.
PubMed ID: 1704018
DOI: 10.1172/jci115046
PubMed ID: 8358735
Title: Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells.
PubMed ID: 8358735
PubMed ID: 8445027
Title: Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene.
PubMed ID: 8445027
PubMed ID: 7683692
Title: A mutation of the glucocorticoid receptor in primary cortisol resistance.
PubMed ID: 7683692
DOI: 10.1172/jci116410
PubMed ID: 8316249
Title: Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes.
PubMed ID: 8316249
PubMed ID: 9150737
Title: Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance.
PubMed ID: 9150737
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
PubMed ID: 10898924
Title: Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophrenia.
PubMed ID: 10898924
DOI: 10.1002/1096-8628(20000612)96:3<412::aid-ajmg33>3.0.co;2-c
PubMed ID: 11589680
Title: Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance.
PubMed ID: 11589680
PubMed ID: 11344238
Title: The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus.
PubMed ID: 11344238
PubMed ID: 11701741
Title: Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking.
PubMed ID: 11701741
PubMed ID: 12351458
Title: A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.
PubMed ID: 12351458
PubMed ID: 11932321
Title: Female pseudohermaphroditism caused by a novel homozygous missense mutation of the GR gene.
PubMed ID: 11932321
PubMed ID: 12050230
Title: A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators.
PubMed ID: 12050230
PubMed ID: 15276593
Title: Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.
PubMed ID: 15276593
PubMed ID: 15292341
Title: The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults.
PubMed ID: 15292341
PubMed ID: 15769988
Title: A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity.
PubMed ID: 15769988
DOI: 10.1210/jc.2004-1920
PubMed ID: 16030164
Title: Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.
PubMed ID: 16030164
DOI: 10.1210/jc.2005-0646
PubMed ID: 17635946
Title: A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance.
PubMed ID: 17635946
DOI: 10.1210/jc.2006-2830
PubMed ID: 20335448
Title: A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.
PubMed ID: 20335448
DOI: 10.1210/jc.2009-2463
PubMed ID: 21362280
Title: Generalized glucocorticoid resistance accompanied with an adrenocortical adenoma and caused by a novel point mutation of human glucocorticoid receptor gene.
PubMed ID: 21362280
PubMed ID: 23426617
Title: A novel point mutation in the DNA-binding domain (DBD) of the human glucocorticoid receptor causes primary generalized glucocorticoid resistance by disrupting the hydrophobic structure of its DBD.
PubMed ID: 23426617
DOI: 10.1210/jc.2012-3549
PubMed ID: 24483153
Title: A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities.
PubMed ID: 24483153
DOI: 10.1210/jc.2013-3005
PubMed ID: 26031419
Title: A novel mutation of the hGR gene causing Chrousos syndrome.
PubMed ID: 26031419
DOI: 10.1111/eci.12470
PubMed ID: 26541474
Title: Functional characterization of the hGRalphaT556I causing Chrousos syndrome.
PubMed ID: 26541474
DOI: 10.1111/eci.12563
PubMed ID: 27120390
Title: Three novel heterozygous point mutations of NR3C1 causing glucocorticoid resistance.
PubMed ID: 27120390
DOI: 10.1002/humu.23008
Sequence Information:
- Length: 777
- Mass: 85659
- Checksum: C5C90C9A5DD16AAB
- Sequence:
MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GQHNYLCAGR NDCIIDKIRR KNCPACRYRK CLQAGMNLEA RKTKKKIKGI QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE PEVLYAGYDS SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS SELHRLQVSY EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA IVKREGNSSQ NWQRFYQLTK LLDSMHEVVE NLLNYCFQTF LDKTMSIEFP EMLAEIITNQ IPKYSNGNIK KLLFHQK
Genular Protein ID: 145446138
Symbol: E5KQF5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 20843780
Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.
PubMed ID: 20843780
DOI: 10.1093/nar/gkq750
Sequence Information:
- Length: 742
- Mass: 81509
- Checksum: E2D1F6EA0EE14704
- Sequence:
MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GQHNYLCAGR NDCIIDKIRR KNCPACRYRK CLQAGMNLEA RKTKKKIKGI QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE PEVLYAGYDS SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS SELHRLQVSY EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA IVKREGNSSQ NWQRFYQLTK LLDSMHENVM WLKPESTSHT LI
Genular Protein ID: 490365256
Symbol: E5KQF6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 20843780
Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.
PubMed ID: 20843780
DOI: 10.1093/nar/gkq750
Sequence Information:
- Length: 778
- Mass: 85815
- Checksum: 23048D99B60B169C
- Sequence:
MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GRQHNYLCAG RNDCIIDKIR RKNCPACRYR KCLQAGMNLE ARKTKKKIKG IQQATTGVSQ ETSENPGNKT IVPATLPQLT PTLVSLLEVI EPEVLYAGYD SSVPDSTWRI MTTLNMLGGR QVIAAVKWAK AIPGFRNLHL DDQMTLLQYS WMFLMAFALG WRSYRQSSAN LLCFAPDLII NEQRMTLPCM YDQCKHMLYV SSELHRLQVS YEEYLCMKTL LLLSSVPKDG LKSQELFDEI RMTYIKELGK AIVKREGNSS QNWQRFYQLT KLLDSMHEVV ENLLNYCFQT FLDKTMSIEF PEMLAEIITN QIPKYSNGNI KKLLFHQK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.