Details for: PHPT1

Gene ID: 29085

Symbol: PHPT1

Ensembl ID: ENSG00000054148

Description: phosphohistidine phosphatase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 457.1018
    Cell Significance Index: -71.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 279.8417
    Cell Significance Index: -70.9800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 229.1311
    Cell Significance Index: -94.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 168.7909
    Cell Significance Index: -79.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 167.8248
    Cell Significance Index: -68.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 149.6058
    Cell Significance Index: -76.9600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 119.8768
    Cell Significance Index: -80.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.6164
    Cell Significance Index: -69.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 66.1013
    Cell Significance Index: -81.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.3302
    Cell Significance Index: -84.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.7594
    Cell Significance Index: -60.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.1308
    Cell Significance Index: -48.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.0320
    Cell Significance Index: 281.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.3362
    Cell Significance Index: 100.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.9446
    Cell Significance Index: 31.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.6600
    Cell Significance Index: 76.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.6269
    Cell Significance Index: 95.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2211
    Cell Significance Index: 1759.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.9759
    Cell Significance Index: 79.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7502
    Cell Significance Index: 338.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2624
    Cell Significance Index: 407.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1308
    Cell Significance Index: 96.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0594
    Cell Significance Index: 282.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9866
    Cell Significance Index: 93.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.9177
    Cell Significance Index: 24.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8848
    Cell Significance Index: 133.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7688
    Cell Significance Index: 131.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7413
    Cell Significance Index: 769.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6868
    Cell Significance Index: 88.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5448
    Cell Significance Index: 17.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3873
    Cell Significance Index: 37.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3441
    Cell Significance Index: 173.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2287
    Cell Significance Index: 11.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1394
    Cell Significance Index: 146.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0081
    Cell Significance Index: 60.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8518
    Cell Significance Index: 29.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7974
    Cell Significance Index: 41.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7879
    Cell Significance Index: 41.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7589
    Cell Significance Index: 20.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7494
    Cell Significance Index: 22.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6319
    Cell Significance Index: 6.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5448
    Cell Significance Index: 108.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5137
    Cell Significance Index: 60.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4781
    Cell Significance Index: 12.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4471
    Cell Significance Index: 6.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3895
    Cell Significance Index: 74.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3859
    Cell Significance Index: 62.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3151
    Cell Significance Index: 31.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3098
    Cell Significance Index: 234.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2698
    Cell Significance Index: 197.8000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1991
    Cell Significance Index: 1.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1297
    Cell Significance Index: 8.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1027
    Cell Significance Index: 17.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0965
    Cell Significance Index: 1.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0809
    Cell Significance Index: 16.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0257
    Cell Significance Index: 1.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0299
    Cell Significance Index: -56.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0366
    Cell Significance Index: -25.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0389
    Cell Significance Index: -3.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0418
    Cell Significance Index: -77.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0439
    Cell Significance Index: -15.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0475
    Cell Significance Index: -73.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0726
    Cell Significance Index: -98.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0803
    Cell Significance Index: -59.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0899
    Cell Significance Index: -3.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0960
    Cell Significance Index: -7.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0967
    Cell Significance Index: -61.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0982
    Cell Significance Index: -6.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1222
    Cell Significance Index: -68.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1397
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1504
    Cell Significance Index: -93.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1558
    Cell Significance Index: -70.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2025
    Cell Significance Index: -58.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3543
    Cell Significance Index: -40.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3613
    Cell Significance Index: -22.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3639
    Cell Significance Index: -42.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3650
    Cell Significance Index: -28.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4412
    Cell Significance Index: -92.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4871
    Cell Significance Index: -70.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5071
    Cell Significance Index: -12.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5706
    Cell Significance Index: -18.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5969
    Cell Significance Index: -17.1100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.6309
    Cell Significance Index: -3.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6950
    Cell Significance Index: -7.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7740
    Cell Significance Index: -10.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7753
    Cell Significance Index: -14.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8158
    Cell Significance Index: -84.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9459
    Cell Significance Index: -16.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0623
    Cell Significance Index: -71.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0972
    Cell Significance Index: -61.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1156
    Cell Significance Index: -24.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.1479
    Cell Significance Index: -79.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1772
    Cell Significance Index: -17.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.1836
    Cell Significance Index: -41.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2810
    Cell Significance Index: -10.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2942
    Cell Significance Index: -79.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4270
    Cell Significance Index: -42.0300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.7559
    Cell Significance Index: -36.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8021
    Cell Significance Index: -79.7100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -1.8184
    Cell Significance Index: -11.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein dephosphorylation activity**: PHPT1 is a protein phosphatase that specifically dephosphorylates histidine residues, playing a critical role in regulating protein function and cellular signaling pathways. 2. **Regulation of cell motility**: PHPT1 is involved in regulating cell motility, particularly at the leading edge of lamellipodia, which is essential for cell migration and tissue repair. 3. **Calcium channel inhibition**: PHPT1 inhibits calcium channels, which helps regulate calcium influx into cells, maintaining proper calcium homeostasis and preventing excessive calcium-mediated signaling. 4. **Negative regulation of signaling pathways**: PHPT1 negatively regulates various signaling pathways, including the T-cell receptor signaling pathway and the regulation of ATP citrate synthase activity, which is essential for energy metabolism. **Pathways and Functions:** PHPT1 is involved in various cellular pathways, including: 1. **Actin cytoskeleton organization**: PHPT1 regulates the organization and dynamics of the actin cytoskeleton, which is essential for cell motility and shape determination. 2. **Lamellipodium organization**: PHPT1 plays a critical role in regulating the organization and dynamics of lamellipodia, which is essential for cell migration and tissue repair. 3. **Calcium signaling**: PHPT1 inhibits calcium channels, regulating calcium influx into cells and maintaining proper calcium homeostasis. 4. **Protein dephosphorylation**: PHPT1 specifically dephosphorylates histidine residues, regulating protein function and cellular signaling pathways. **Clinical Significance:** Dysregulation of PHPT1 has been implicated in various diseases, including: 1. **Pancreatic diseases**: PHPT1 is significantly expressed in pancreatic A cells, and dysregulation of PHPT1 has been linked to pancreatic diseases, such as diabetes and pancreatitis. 2. **Kidney diseases**: PHPT1 is also expressed in kidney cells, and dysregulation of PHPT1 has been linked to kidney diseases, such as chronic kidney disease and kidney failure. 3. **Cancer**: PHPT1 has been implicated in the regulation of cell motility and signaling pathways, which are essential for cancer progression and metastasis. In summary, PHPT1 is a critical regulator of various cellular processes, including protein dephosphorylation, cell motility, and calcium channel inhibition. Dysregulation of PHPT1 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3120220284

Symbol: PHP14_HUMAN

Name: Protein janus-A homolog

UniProtKB Accession Codes:

Q9NRX4 B1AMX0 B1AMX1 Q9H0Y3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12383260

Title: Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase.

PubMed ID: 12383260

DOI: 10.1046/j.1432-1033.2002.03206.x

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11342225

Title: Identification of the human crooked neck gene by comparative gene identification.

PubMed ID: 11342225

DOI: 10.1016/s0167-4781(00)00295-5

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16219293

Title: Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity.

PubMed ID: 16219293

DOI: 10.1016/j.bbrc.2005.09.134

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19836471

Title: Chemical phosphorylation of histidine-containing peptides based on the sequence of histone H4 and their dephosphorylation by protein histidine phosphatase.

PubMed ID: 19836471

DOI: 10.1016/j.bbapap.2009.10.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25574816

Title: Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine.

PubMed ID: 25574816

DOI: 10.3109/03009734.2014.996720

PubMed ID: 16990267

Title: First structure of a eukaryotic phosphohistidine phosphatase.

PubMed ID: 16990267

DOI: 10.1074/jbc.c600231200

PubMed ID: 18991813

Title: Solution structure and catalytic mechanism of human protein histidine phosphatase 1.

PubMed ID: 18991813

DOI: 10.1042/bj20081571

Sequence Information:

  • Length: 125
  • Mass: 13833
  • Checksum: 24F0CA2BADB78478
  • Sequence:
    • MAVADLALIP DVDIDSDGVF KYVLIRVHSA PRSGAPAAES KEIVRGYKWA EYHADIYDKV 
SGDMQKQGCD CECLGGGRIS HQSQDKKIHV YGYSMAYGPA QHAISTEKIK AKYPDYEVTW 
ANDGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.