Details for: TIMM21

Gene ID: 29090

Symbol: TIMM21

Ensembl ID: ENSG00000075336

Description: translocase of inner mitochondrial membrane 21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 115.2719
    Cell Significance Index: -17.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.2451
    Cell Significance Index: -20.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.0407
    Cell Significance Index: -21.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.2319
    Cell Significance Index: -21.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.2454
    Cell Significance Index: -17.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.8097
    Cell Significance Index: -21.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.8218
    Cell Significance Index: -17.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.0647
    Cell Significance Index: -21.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9545
    Cell Significance Index: -18.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4789
    Cell Significance Index: -21.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.1775
    Cell Significance Index: 52.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3985
    Cell Significance Index: 138.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9808
    Cell Significance Index: 58.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8636
    Cell Significance Index: 93.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7892
    Cell Significance Index: 35.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7444
    Cell Significance Index: 121.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6194
    Cell Significance Index: 39.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5927
    Cell Significance Index: 69.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5277
    Cell Significance Index: 7.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4564
    Cell Significance Index: 13.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3834
    Cell Significance Index: 76.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2952
    Cell Significance Index: 6.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2741
    Cell Significance Index: 14.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2638
    Cell Significance Index: 7.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2562
    Cell Significance Index: 5.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2501
    Cell Significance Index: 19.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2453
    Cell Significance Index: 44.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2428
    Cell Significance Index: 2.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2318
    Cell Significance Index: 27.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2242
    Cell Significance Index: 99.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2229
    Cell Significance Index: 201.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2202
    Cell Significance Index: 15.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2199
    Cell Significance Index: 78.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2150
    Cell Significance Index: 42.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1882
    Cell Significance Index: 13.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1870
    Cell Significance Index: 25.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1828
    Cell Significance Index: 4.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1809
    Cell Significance Index: 22.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1714
    Cell Significance Index: 32.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1630
    Cell Significance Index: 5.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1545
    Cell Significance Index: 106.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1484
    Cell Significance Index: 81.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1460
    Cell Significance Index: 4.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1218
    Cell Significance Index: 15.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1160
    Cell Significance Index: 5.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0926
    Cell Significance Index: 4.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0814
    Cell Significance Index: 2.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0344
    Cell Significance Index: 1.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0257
    Cell Significance Index: 1.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0044
    Cell Significance Index: 8.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0027
    Cell Significance Index: 5.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0021
    Cell Significance Index: 3.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0017
    Cell Significance Index: 1.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0053
    Cell Significance Index: -0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0125
    Cell Significance Index: -9.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0190
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0234
    Cell Significance Index: -10.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0265
    Cell Significance Index: -2.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0355
    Cell Significance Index: -20.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0414
    Cell Significance Index: -25.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0502
    Cell Significance Index: -6.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0517
    Cell Significance Index: -14.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0541
    Cell Significance Index: -9.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0611
    Cell Significance Index: -8.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0721
    Cell Significance Index: -3.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0738
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0793
    Cell Significance Index: -9.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0858
    Cell Significance Index: -2.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1007
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1064
    Cell Significance Index: -22.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1246
    Cell Significance Index: -9.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1285
    Cell Significance Index: -3.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1303
    Cell Significance Index: -8.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1323
    Cell Significance Index: -5.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1349
    Cell Significance Index: -9.0700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1704
    Cell Significance Index: -1.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1849
    Cell Significance Index: -2.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1918
    Cell Significance Index: -11.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1962
    Cell Significance Index: -20.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2085
    Cell Significance Index: -16.5100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2107
    Cell Significance Index: -3.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2153
    Cell Significance Index: -3.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2313
    Cell Significance Index: -10.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2477
    Cell Significance Index: -12.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2639
    Cell Significance Index: -3.3800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2757
    Cell Significance Index: -1.8300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2815
    Cell Significance Index: -2.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3077
    Cell Significance Index: -7.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3284
    Cell Significance Index: -6.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3362
    Cell Significance Index: -8.5900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3452
    Cell Significance Index: -4.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3452
    Cell Significance Index: -7.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4120
    Cell Significance Index: -9.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4250
    Cell Significance Index: -3.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4420
    Cell Significance Index: -12.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TIMM21 is a transmembrane protein that belongs to the inner mitochondrial membrane. It is a subunit of the Tim23 mitochondrial import inner membrane translocase complex, which is responsible for importing proteins into the mitochondrial matrix. TIMM21 has a specific binding site for the mitochondrial import signal sequence (MIS) of the imported protein, allowing it to facilitate the translocation of these proteins across the inner mitochondrial membrane. The protein is highly conserved across species, suggesting its essential role in maintaining mitochondrial function. **Pathways and Functions:** TIMM21 is involved in several critical pathways that regulate mitochondrial function and protein import. These include: 1. **Intracellular protein transport:** TIMM21 facilitates the transport of proteins into the mitochondrial matrix, which is essential for the assembly and function of the respiratory chain complex I. 2. **Mitochondrial cytochrome c oxidase assembly:** TIMM21 plays a role in the assembly of cytochrome c oxidase, a key enzyme in the mitochondrial respiratory chain. 3. **Mitochondrial protein import:** TIMM21 is involved in the import of proteins into the mitochondrial matrix, which is essential for maintaining mitochondrial function and regulating cellular metabolism. 4. **Protein localization:** TIMM21 regulates the localization of proteins within the mitochondria, ensuring that they are correctly targeted to their specific subcellular compartments. **Clinical Significance:** Dysregulation of TIMM21 has been implicated in several diseases, including: 1. **Neurodegenerative disorders:** Mutations in TIMM21 have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cardiovascular diseases:** TIMM21 dysfunction has been linked to cardiovascular diseases, including coronary artery disease and cardiac arrhythmias. 3. **Metabolic disorders:** TIMM21 has been implicated in metabolic disorders, such as diabetes and obesity, due to its role in regulating mitochondrial function and energy metabolism. In conclusion, TIMM21 is a critical component of the mitochondrial inner membrane that plays a vital role in regulating mitochondrial function and protein import. Its dysregulation has significant implications for human health, and further research is needed to understand the mechanisms underlying TIMM21-related diseases.

Genular Protein ID: 363866768

Symbol: TIM21_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim21

UniProtKB Accession Codes:

Q9BVV7 Q9P010

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23260140

Title: MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation.

PubMed ID: 23260140

DOI: 10.1016/j.cell.2012.11.053

PubMed ID: 26321642

Title: MITRAC7 acts as a COX1-specific chaperone and reveals a checkpoint during cytochrome c oxidase assembly.

PubMed ID: 26321642

DOI: 10.1016/j.celrep.2015.08.009

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 248
  • Mass: 28202
  • Checksum: 7BA2694A9DCD9024
  • Sequence:
    • MICTFLRAVQ YTEKLHRSSA KRLLLPYIVL NKACLKTEPS LRCGLQYQKK TLRPRCILGV 
TQKTIWTQGP SPRKAKEDGS KQVSVHRSQR GGTAVPTSQK VKEAGRDFTY LIVVLFGISI 
TGGLFYTIFK ELFSSSSPSK IYGRALEKCR SHPEVIGVFG ESVKGYGEVT RRGRRQHVRF 
TEYVKDGLKH TCVKFYIEGS EPGKQGTVYA QVKENPGSGE YDFRYIFVEI ESYPRRTIII 
EDNRSQDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.