Details for: DNAJC15

Gene ID: 29103

Symbol: DNAJC15

Ensembl ID: ENSG00000120675

Description: DnaJ heat shock protein family (Hsp40) member C15

Associated with

  • Atpase activator activity
    (GO:0001671)
  • Cellular response to starvation
    (GO:0009267)
  • Intracellular protein transport
    (GO:0006886)
  • Mitochondrial electron transport, nadh to ubiquinone
    (GO:0006120)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of mitochondrial electron transport, nadh to ubiquinone
    (GO:1902957)
  • Negative regulation of protein-containing complex assembly
    (GO:0031333)
  • Pam complex, tim23 associated import motor
    (GO:0001405)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein import into mitochondrial matrix
    (GO:0030150)
  • Regulation of lipid metabolic process
    (GO:0019216)
  • Tim23 mitochondrial import inner membrane translocase complex
    (GO:0005744)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 249.8309
    Cell Significance Index: -38.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.0205
    Cell Significance Index: -42.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 137.7845
    Cell Significance Index: -56.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.1494
    Cell Significance Index: -53.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.7488
    Cell Significance Index: -54.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 81.0033
    Cell Significance Index: -54.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.8530
    Cell Significance Index: -50.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.9937
    Cell Significance Index: -42.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.6580
    Cell Significance Index: -41.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3678
    Cell Significance Index: -52.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8511
    Cell Significance Index: -21.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.5642
    Cell Significance Index: 648.4400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.5723
    Cell Significance Index: 27.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8711
    Cell Significance Index: 220.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5702
    Cell Significance Index: 73.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2895
    Cell Significance Index: 209.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2613
    Cell Significance Index: 18.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2582
    Cell Significance Index: 687.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1932
    Cell Significance Index: 88.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1315
    Cell Significance Index: 33.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1249
    Cell Significance Index: 144.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0214
    Cell Significance Index: 21.3800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0115
    Cell Significance Index: 7.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9938
    Cell Significance Index: 21.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9295
    Cell Significance Index: 65.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8858
    Cell Significance Index: 175.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8838
    Cell Significance Index: 23.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8265
    Cell Significance Index: 81.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8236
    Cell Significance Index: 364.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8006
    Cell Significance Index: 160.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7656
    Cell Significance Index: 35.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7545
    Cell Significance Index: 57.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6302
    Cell Significance Index: 226.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5935
    Cell Significance Index: 10.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5839
    Cell Significance Index: 20.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5255
    Cell Significance Index: 12.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4516
    Cell Significance Index: 25.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3764
    Cell Significance Index: 48.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3468
    Cell Significance Index: 15.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3411
    Cell Significance Index: 58.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3391
    Cell Significance Index: 21.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2903
    Cell Significance Index: 262.1100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2833
    Cell Significance Index: 1.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1775
    Cell Significance Index: 3.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1773
    Cell Significance Index: 31.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1665
    Cell Significance Index: 1.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1545
    Cell Significance Index: 29.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0884
    Cell Significance Index: 66.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0740
    Cell Significance Index: 1.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0267
    Cell Significance Index: 19.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0215
    Cell Significance Index: 0.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0170
    Cell Significance Index: 2.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0115
    Cell Significance Index: 21.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0084
    Cell Significance Index: 15.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0075
    Cell Significance Index: 0.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0138
    Cell Significance Index: -0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0185
    Cell Significance Index: -13.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0201
    Cell Significance Index: -2.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0247
    Cell Significance Index: -1.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0315
    Cell Significance Index: -14.2900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0317
    Cell Significance Index: -0.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0329
    Cell Significance Index: -18.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0342
    Cell Significance Index: -21.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0351
    Cell Significance Index: -1.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0395
    Cell Significance Index: -53.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0475
    Cell Significance Index: -0.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0598
    Cell Significance Index: -1.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1129
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1179
    Cell Significance Index: -13.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1200
    Cell Significance Index: -25.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1508
    Cell Significance Index: -43.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2148
    Cell Significance Index: -13.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2166
    Cell Significance Index: -23.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2195
    Cell Significance Index: -3.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2250
    Cell Significance Index: -32.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2369
    Cell Significance Index: -6.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2390
    Cell Significance Index: -10.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3053
    Cell Significance Index: -11.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3053
    Cell Significance Index: -8.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3352
    Cell Significance Index: -38.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3811
    Cell Significance Index: -5.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3911
    Cell Significance Index: -26.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4063
    Cell Significance Index: -10.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4322
    Cell Significance Index: -11.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4346
    Cell Significance Index: -13.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4602
    Cell Significance Index: -47.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4774
    Cell Significance Index: -24.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5656
    Cell Significance Index: -44.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6779
    Cell Significance Index: -11.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7698
    Cell Significance Index: -22.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7856
    Cell Significance Index: -4.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7941
    Cell Significance Index: -8.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8060
    Cell Significance Index: -4.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8183
    Cell Significance Index: -15.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8362
    Cell Significance Index: -24.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8780
    Cell Significance Index: -53.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9154
    Cell Significance Index: -26.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9371
    Cell Significance Index: -47.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNAJC15 is characterized by its unique ability to interact with various mitochondrial proteins, including Tim23, a mitochondrial import motor complex. This interaction enables DNAJC15 to regulate the assembly and disassembly of protein-containing complexes, as well as the transport of proteins into the mitochondrial matrix. Additionally, DNAJC15 has been implicated in the regulation of mitochondrial electron transport, lipid metabolic processes, and the negative regulation of protein-containing complex assembly. **Pathways and Functions:** The DNAJC15 gene is involved in several critical cellular pathways, including: 1. **Mitochondrial Electron Transport**: DNAJC15 regulates the electron transport chain by interacting with Tim23, a mitochondrial import motor complex, to facilitate the transport of proteins into the mitochondrial matrix. 2. **Intracellular Protein Transport**: DNAJC15 interacts with various proteins to regulate the transport of proteins into the mitochondrial matrix, ensuring proper protein function and cellular homeostasis. 3. **Lipid Metabolic Process**: DNAJC15 is involved in the regulation of lipid synthesis and degradation, which is crucial for maintaining cellular energy homeostasis. 4. **Negative Regulation of Mitochondrial Electron Transport**: DNAJC15 has been shown to negatively regulate mitochondrial electron transport, which helps to prevent excessive energy production and maintain cellular homeostasis. 5. **Protein Binding and Protein Import into Mitochondrial Matrix**: DNAJC15 interacts with various proteins to facilitate the transport of proteins into the mitochondrial matrix, ensuring proper protein function and cellular homeostasis. **Clinical Significance:** Dysregulation of DNAJC15 has been implicated in various diseases, including: 1. **Mitochondrial Diseases**: Mutations in DNAJC15 have been associated with mitochondrial diseases, such as MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes) syndrome. 2. **Erythropoietic Disorders**: DNAJC15 has been implicated in the regulation of erythropoiesis, and dysregulation of this gene has been associated with anemia and other erythropoietic disorders. 3. **Cancer**: DNAJC15 has been shown to have anti-tumor properties, and its dysregulation has been implicated in various types of cancer, including breast and lung cancer. In conclusion, DNAJC15 is a crucial regulator of mitochondrial function and lipid metabolism, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of DNAJC15 in maintaining cellular homeostasis and developing therapeutic strategies for diseases associated with its dysregulation.

Genular Protein ID: 4965932

Symbol: DJC15_HUMAN

Name: DnaJ homolog subfamily C member 15

UniProtKB Accession Codes:

Q9Y5T4 B2R4L0 Q5T219 Q6X963

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11358853

Title: Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer.

PubMed ID: 11358853

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23263864

Title: Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria.

PubMed ID: 23263864

DOI: 10.1093/hmg/dds541

PubMed ID: 23530063

Title: MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations.

PubMed ID: 23530063

DOI: 10.1128/mcb.00189-13

Sequence Information:

  • Length: 150
  • Mass: 16383
  • Checksum: 988059B686D39967
  • Sequence:
    • MAARGVIAPV GESLRYAEYL QPSAKRPDAD VDQQRLVRSL IAVGLGVAAL AFAGRYAFRI 
WKPLEQVITE TAKKISTPSF SSYYKGGFEQ KMSRREAGLI LGVSPSAGKA KIRTAHRRVM 
ILNHPDKGGS PYVAAKINEA KDLLETTTKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.