Details for: CFAP20

Gene ID: 29105

Symbol: CFAP20

Ensembl ID: ENSG00000070761

Description: cilia and flagella associated protein 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 78.1410
    Cell Significance Index: -32.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.9545
    Cell Significance Index: -32.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.9896
    Cell Significance Index: -27.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.6360
    Cell Significance Index: -27.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0561
    Cell Significance Index: -24.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8962
    Cell Significance Index: -18.1100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.0681
    Cell Significance Index: 12.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6334
    Cell Significance Index: 56.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2249
    Cell Significance Index: 25.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1001
    Cell Significance Index: 11.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0376
    Cell Significance Index: 62.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9784
    Cell Significance Index: 106.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9513
    Cell Significance Index: 59.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9388
    Cell Significance Index: 24.6900
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.9123
    Cell Significance Index: 3.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7696
    Cell Significance Index: 40.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6952
    Cell Significance Index: 113.0700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6813
    Cell Significance Index: 5.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6813
    Cell Significance Index: 87.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6545
    Cell Significance Index: 64.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6058
    Cell Significance Index: 83.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6050
    Cell Significance Index: 330.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5726
    Cell Significance Index: 15.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4717
    Cell Significance Index: 32.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4441
    Cell Significance Index: 20.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4364
    Cell Significance Index: 192.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3805
    Cell Significance Index: 24.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3304
    Cell Significance Index: 40.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3257
    Cell Significance Index: 3.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3223
    Cell Significance Index: 61.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3210
    Cell Significance Index: 57.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3106
    Cell Significance Index: 36.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3078
    Cell Significance Index: 61.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3044
    Cell Significance Index: 5.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2880
    Cell Significance Index: 6.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2529
    Cell Significance Index: 50.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2455
    Cell Significance Index: 17.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2410
    Cell Significance Index: 31.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2302
    Cell Significance Index: 11.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1290
    Cell Significance Index: 46.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1050
    Cell Significance Index: 5.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1017
    Cell Significance Index: 1.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0833
    Cell Significance Index: 57.6400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0461
    Cell Significance Index: 0.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0356
    Cell Significance Index: 1.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0136
    Cell Significance Index: 1.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0062
    Cell Significance Index: 11.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0050
    Cell Significance Index: 0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0090
    Cell Significance Index: -0.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0157
    Cell Significance Index: -29.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0177
    Cell Significance Index: -27.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0234
    Cell Significance Index: -31.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0236
    Cell Significance Index: -17.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0295
    Cell Significance Index: -0.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0311
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0315
    Cell Significance Index: -23.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0320
    Cell Significance Index: -20.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0328
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0528
    Cell Significance Index: -5.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0543
    Cell Significance Index: -33.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0551
    Cell Significance Index: -25.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0704
    Cell Significance Index: -1.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0827
    Cell Significance Index: -2.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0875
    Cell Significance Index: -25.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0880
    Cell Significance Index: -4.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0936
    Cell Significance Index: -10.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0982
    Cell Significance Index: -1.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1173
    Cell Significance Index: -7.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1273
    Cell Significance Index: -21.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1325
    Cell Significance Index: -15.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1408
    Cell Significance Index: -20.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1547
    Cell Significance Index: -6.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1550
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1596
    Cell Significance Index: -33.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2329
    Cell Significance Index: -17.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2607
    Cell Significance Index: -8.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2648
    Cell Significance Index: -17.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2783
    Cell Significance Index: -9.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2850
    Cell Significance Index: -29.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3322
    Cell Significance Index: -26.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3470
    Cell Significance Index: -10.1900
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.3620
    Cell Significance Index: -2.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3714
    Cell Significance Index: -9.9400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3988
    Cell Significance Index: -5.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4024
    Cell Significance Index: -24.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4428
    Cell Significance Index: -10.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4759
    Cell Significance Index: -6.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4834
    Cell Significance Index: -21.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5376
    Cell Significance Index: -5.5700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5685
    Cell Significance Index: -3.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5685
    Cell Significance Index: -14.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5933
    Cell Significance Index: -22.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6023
    Cell Significance Index: -22.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6145
    Cell Significance Index: -10.5300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6379
    Cell Significance Index: -4.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6424
    Cell Significance Index: -18.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6470
    Cell Significance Index: -16.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CFAP20 is a member of the CFA family of proteins, which are evolutionarily conserved and essential for ciliary and flagellar assembly and function. The protein contains multiple domains, including a polyglutamylation site, which is involved in protein modification and regulation. CFAP20's unique structure and localization to ciliary and flagellar bases suggest its role in maintaining microtubule dynamics and regulating cilium beat frequency. Furthermore, its association with extracellular exosomes and RNA binding capabilities imply its involvement in intercellular communication and gene regulation. **Pathways and Functions:** CFAP20 is implicated in various cellular processes, including: 1. **Ciliary Motility**: CFAP20 regulates cilium beat frequency, which is essential for sensing and responding to environmental cues, such as touch, temperature, and light. 2. **Cell Signaling**: CFAP20 interacts with RNA and extracellular exosomes, which enables it to modulate gene expression and intercellular communication. 3. **Protein Binding**: CFAP20's polyglutamylation site facilitates protein-protein interactions, which are crucial for maintaining cilia structure and function. 4. **Regulation of Cell Motility**: CFAP20's involvement in positive regulation of cell motility and feeding behavior highlights its role in controlling cellular movement and behavior. **Clinical Significance:** Dysregulation of CFAP20 has been implicated in various diseases, including: 1. **Primary Ciliary Dyskinesia (PCD)**: A genetic disorder characterized by defective ciliary function, leading to respiratory and reproductive complications. 2. **Neurological Disorders**: CFAP20's role in regulating cilia beat frequency and cell signaling suggests its involvement in neurological diseases, such as Parkinson's disease and autism spectrum disorder. 3. **Cancer**: CFAP20's expression in various cancer types, including neural crest-derived tumors, implies its potential role in tumorigenesis and cancer progression. In conclusion, CFAP20 is a multifunctional protein that plays a critical role in maintaining ciliary and flagellar function, regulating cell signaling, and controlling cellular behavior. Further research on CFAP20's functions and dysregulation in disease will provide valuable insights into the molecular mechanisms underlying various human diseases.

Genular Protein ID: 799332960

Symbol: CFA20_HUMAN

Name: Cilia- and flagella-associated protein 20

UniProtKB Accession Codes:

Q9Y6A4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20118210

Title: Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium.

PubMed ID: 20118210

DOI: 10.1128/ec.00368-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24414207

Title: Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules.

PubMed ID: 24414207

DOI: 10.1242/bio.20146577

PubMed ID: 36191189

Title: SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.

PubMed ID: 36191189

DOI: 10.1073/pnas.2207605119

Sequence Information:

  • Length: 193
  • Mass: 22774
  • Checksum: 82ECDB0D2515BF77
  • Sequence:
    • MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT 
CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR RRFRASNYQS TTRVKPFICT 
MPMRLDDGWN QIQFNLLDFT RRAYGTNYIE TLRVQIHANC RIRRVYFSDR LYSEDELPAE 
FKLYLPVQNK AKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.