Details for: CFAP20

Gene ID: 29105

Symbol: CFAP20

Ensembl ID: ENSG00000070761

Description: cilia and flagella associated protein 20

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.69
    Marker Score: 2,404
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.46
    Marker Score: 2,762
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.35
    Marker Score: 1,252
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.9
    Marker Score: 2,027
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.83
    Marker Score: 616
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.83
    Marker Score: 1,151
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.83
    Marker Score: 1,720
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.76
    Marker Score: 1,176
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.71
    Marker Score: 806
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.69
    Marker Score: 1,006
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.65
    Marker Score: 6,502
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.57
    Marker Score: 13,640
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.5
    Marker Score: 3,134
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4
    Marker Score: 2,660
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.35
    Marker Score: 1,272
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.33
    Marker Score: 2,267
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.31
    Marker Score: 5,354
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.28
    Marker Score: 473
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.27
    Marker Score: 3,465
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.26
    Marker Score: 2,514
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.26
    Marker Score: 839
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.21
    Marker Score: 2,449
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.2
    Marker Score: 1,209
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.19
    Marker Score: 2,268
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.18
    Marker Score: 538
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.17
    Marker Score: 1,419
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.17
    Marker Score: 838
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.17
    Marker Score: 4,322
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17,853
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.13
    Marker Score: 1,191
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.11
    Marker Score: 1,044
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.08
    Marker Score: 919
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.07
    Marker Score: 1,139
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.06
    Marker Score: 586
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.06
    Marker Score: 503
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.04
    Marker Score: 243
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.03
    Marker Score: 1,076
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.03
    Marker Score: 13,582
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.02
    Marker Score: 680
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.02
    Marker Score: 1,414
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.01
    Marker Score: 685
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.01
    Marker Score: 257
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 919
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.99
    Marker Score: 9,968
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,387
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.98
    Marker Score: 291
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.98
    Marker Score: 33,818
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.97
    Marker Score: 2,777
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.96
    Marker Score: 388
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.96
    Marker Score: 698
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.95
    Marker Score: 576
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 297
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.94
    Marker Score: 1,451
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.94
    Marker Score: 4,051
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,387
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.92
    Marker Score: 483
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.92
    Marker Score: 717
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.91
    Marker Score: 5,943
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.9
    Marker Score: 2,462
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.9
    Marker Score: 883
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,681
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.88
    Marker Score: 950
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.88
    Marker Score: 258
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.88
    Marker Score: 1,442
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.88
    Marker Score: 307
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.86
    Marker Score: 1,251
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,208
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.86
    Marker Score: 227
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.86
    Marker Score: 922
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.85
    Marker Score: 1,068
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.85
    Marker Score: 475
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.84
    Marker Score: 1,192
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.84
    Marker Score: 9,431
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.83
    Marker Score: 402
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.83
    Marker Score: 1,227
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.83
    Marker Score: 867
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.82
    Marker Score: 585
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.82
    Marker Score: 616
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1,331
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.82
    Marker Score: 592
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.81
    Marker Score: 327
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4,643
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.81
    Marker Score: 892
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.81
    Marker Score: 532
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.81
    Marker Score: 200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.81
    Marker Score: 731
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.81
    Marker Score: 300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.79
    Marker Score: 448
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.79
    Marker Score: 455
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.79
    Marker Score: 1,875
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.79
    Marker Score: 362
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.79
    Marker Score: 26,758
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.78
    Marker Score: 158
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.78
    Marker Score: 809
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.77
    Marker Score: 1,825
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.77
    Marker Score: 1,306

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CFAP20 is a member of the CFA family of proteins, which are evolutionarily conserved and essential for ciliary and flagellar assembly and function. The protein contains multiple domains, including a polyglutamylation site, which is involved in protein modification and regulation. CFAP20's unique structure and localization to ciliary and flagellar bases suggest its role in maintaining microtubule dynamics and regulating cilium beat frequency. Furthermore, its association with extracellular exosomes and RNA binding capabilities imply its involvement in intercellular communication and gene regulation. **Pathways and Functions:** CFAP20 is implicated in various cellular processes, including: 1. **Ciliary Motility**: CFAP20 regulates cilium beat frequency, which is essential for sensing and responding to environmental cues, such as touch, temperature, and light. 2. **Cell Signaling**: CFAP20 interacts with RNA and extracellular exosomes, which enables it to modulate gene expression and intercellular communication. 3. **Protein Binding**: CFAP20's polyglutamylation site facilitates protein-protein interactions, which are crucial for maintaining cilia structure and function. 4. **Regulation of Cell Motility**: CFAP20's involvement in positive regulation of cell motility and feeding behavior highlights its role in controlling cellular movement and behavior. **Clinical Significance:** Dysregulation of CFAP20 has been implicated in various diseases, including: 1. **Primary Ciliary Dyskinesia (PCD)**: A genetic disorder characterized by defective ciliary function, leading to respiratory and reproductive complications. 2. **Neurological Disorders**: CFAP20's role in regulating cilia beat frequency and cell signaling suggests its involvement in neurological diseases, such as Parkinson's disease and autism spectrum disorder. 3. **Cancer**: CFAP20's expression in various cancer types, including neural crest-derived tumors, implies its potential role in tumorigenesis and cancer progression. In conclusion, CFAP20 is a multifunctional protein that plays a critical role in maintaining ciliary and flagellar function, regulating cell signaling, and controlling cellular behavior. Further research on CFAP20's functions and dysregulation in disease will provide valuable insights into the molecular mechanisms underlying various human diseases.

Genular Protein ID: 799332960

Symbol: CFA20_HUMAN

Name: Cilia- and flagella-associated protein 20

UniProtKB Accession Codes:

Q9Y6A4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20118210

Title: Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium.

PubMed ID: 20118210

DOI: 10.1128/ec.00368-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24414207

Title: Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules.

PubMed ID: 24414207

DOI: 10.1242/bio.20146577

PubMed ID: 36191189

Title: SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.

PubMed ID: 36191189

DOI: 10.1073/pnas.2207605119

Sequence Information:

  • Length: 193
  • Mass: 22774
  • Checksum: 82ECDB0D2515BF77
  • Sequence:
    • MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT 
CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR RRFRASNYQS TTRVKPFICT 
MPMRLDDGWN QIQFNLLDFT RRAYGTNYIE TLRVQIHANC RIRRVYFSDR LYSEDELPAE 
FKLYLPVQNK AKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.