Details for: BRD7

Gene ID: 29117

Symbol: BRD7

Ensembl ID: ENSG00000166164

Description: bromodomain containing 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.75
    Marker Score: 60,759
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.75
    Marker Score: 505
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.75
    Marker Score: 2,509
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.73
    Marker Score: 1,825
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.59
    Marker Score: 1,996
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.58
    Marker Score: 16,008
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.58
    Marker Score: 680
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.52
    Marker Score: 5,635
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5
    Marker Score: 2,211
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.44
    Marker Score: 721
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.4
    Marker Score: 488
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.4
    Marker Score: 2,475
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.39
    Marker Score: 948
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.39
    Marker Score: 5,450
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.38
    Marker Score: 1,429
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.36
    Marker Score: 3,713
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.36
    Marker Score: 3,100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.35
    Marker Score: 1,128
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.34
    Marker Score: 1,732
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.34
    Marker Score: 677
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.33
    Marker Score: 1,431
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.32
    Marker Score: 1,459
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.32
    Marker Score: 1,410
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.31
    Marker Score: 11,515
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.31
    Marker Score: 1,204
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.31
    Marker Score: 1,586
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.29
    Marker Score: 752
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.29
    Marker Score: 383
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.27
    Marker Score: 7,515
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.25
    Marker Score: 467
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.25
    Marker Score: 1,172
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.25
    Marker Score: 411
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.24
    Marker Score: 1,315
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.23
    Marker Score: 12,423
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.23
    Marker Score: 381
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.23
    Marker Score: 1,649
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.21
    Marker Score: 350
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.21
    Marker Score: 1,290
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.21
    Marker Score: 2,837
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2
    Marker Score: 13,502
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.19
    Marker Score: 804
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.19
    Marker Score: 1,115
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.18
    Marker Score: 4,579
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.17
    Marker Score: 1,419
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.17
    Marker Score: 1,154
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.16
    Marker Score: 3,253
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.15
    Marker Score: 398
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.15
    Marker Score: 1,293
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.15
    Marker Score: 407
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.15
    Marker Score: 258
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.14
    Marker Score: 688
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.14
    Marker Score: 9,799
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.12
    Marker Score: 630
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.11
    Marker Score: 935
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.11
    Marker Score: 265
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.1
    Marker Score: 444
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.1
    Marker Score: 687
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.1
    Marker Score: 1,107
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.1
    Marker Score: 801
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.09
    Marker Score: 861
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.09
    Marker Score: 262
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.09
    Marker Score: 509
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.08
    Marker Score: 2,931
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.08
    Marker Score: 375
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.07
    Marker Score: 6,967
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.07
    Marker Score: 14,073
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.07
    Marker Score: 4,337
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.06
    Marker Score: 2,240
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.06
    Marker Score: 433
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.06
    Marker Score: 1,242
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.06
    Marker Score: 5,204
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.06
    Marker Score: 1,063
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.06
    Marker Score: 664
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.06
    Marker Score: 581
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.05
    Marker Score: 35,730
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.05
    Marker Score: 823
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.05
    Marker Score: 9,952
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.05
    Marker Score: 546
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.04
    Marker Score: 476
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.04
    Marker Score: 596
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.04
    Marker Score: 690
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.04
    Marker Score: 1,127
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.04
    Marker Score: 63,652
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.03
    Marker Score: 8,895
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.03
    Marker Score: 2,059
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16,103
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.03
    Marker Score: 8,913
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.03
    Marker Score: 506
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.02
    Marker Score: 492
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.02
    Marker Score: 696
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.01
    Marker Score: 384
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.01
    Marker Score: 690
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.01
    Marker Score: 976
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.01
    Marker Score: 2,703
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,575
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.99
    Marker Score: 302
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,799
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.99
    Marker Score: 1,531
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.99
    Marker Score: 934
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.99
    Marker Score: 1,002

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bromodomain structure:** The BRD7 protein contains a highly conserved bromodomain, which is responsible for its interaction with acetylated histones and other transcriptional regulators. 2. **Histone binding:** BRD7 binds to acetylated histones, particularly H3K27ac, and recruits other transcriptional regulators to specific genomic regions. 3. **Transcriptional regulation:** BRD7 acts as a transcriptional coactivator or corepressor, depending on the context, and regulates the expression of target genes involved in cell differentiation, proliferation, and survival. 4. **Cell-type specificity:** BRD7 is expressed in various cell types, including immune cells, germ cells, and epithelial cells, suggesting its involvement in multiple cellular processes. 5. **Disease association:** BRD7 dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological disorders. **Pathways and Functions:** 1. **Cell cycle regulation:** BRD7 regulates the G1/S transition of the cell cycle by interacting with p53 and other transcriptional regulators. 2. **Gene expression:** BRD7 regulates the expression of target genes involved in cell differentiation, proliferation, and survival by interacting with RNA polymerase II and other transcriptional regulators. 3. **Chromatin remodeling:** BRD7 interacts with chromatin remodeling complexes, such as RSC, to regulate chromatin structure and transcriptional access. 4. **DNA damage response:** BRD7 regulates the response to DNA damage by interacting with p53 and other transcriptional regulators involved in double-strand break repair. 5. **Immune cell development:** BRD7 is essential for the development and function of immune cells, including T cells and B cells. **Clinical Significance:** 1. **Cancer:** BRD7 dysregulation has been implicated in various cancers, including lymphoma, leukemia, and breast cancer. 2. **Autoimmune disorders:** BRD7 dysregulation has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Neurological disorders:** BRD7 dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immunotherapy:** BRD7 is a potential target for immunotherapy, given its role in immune cell development and function. 5. **Cancer therapy:** BRD7 inhibition has been explored as a potential therapeutic strategy for cancer treatment. In conclusion, the BRD7 gene plays a critical role in regulating transcriptional activities and cell differentiation. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological disorders. Further research is needed to fully understand the mechanisms of BRD7 regulation and its clinical significance.

Genular Protein ID: 2593632114

Symbol: BRD7_HUMAN

Name: Bromodomain-containing protein 7

UniProtKB Accession Codes:

Q9NPI1 Q4VC09 Q8N2L9 Q96KA4 Q9BV48 Q9UH59

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 2 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 11 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11025449

Title: Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2.

PubMed ID: 11025449

DOI: 10.1002/1097-4652(200011)185:2<269::aid-jcp12>3.0.co;2-l

PubMed ID: 12489984

Title: Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7.

PubMed ID: 12489984

DOI: 10.1042/bj20021281

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16265664

Title: The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain.

PubMed ID: 16265664

DOI: 10.1002/jcb.20645

PubMed ID: 16475162

Title: Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression.

PubMed ID: 16475162

DOI: 10.1002/jcb.20788

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 20215511

Title: BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription.

PubMed ID: 20215511

DOI: 10.1158/0008-5472.can-09-2089

PubMed ID: 20228809

Title: BRD7 is a candidate tumour suppressor gene required for p53 function.

PubMed ID: 20228809

DOI: 10.1038/ncb2038

PubMed ID: 20660729

Title: Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.

PubMed ID: 20660729

DOI: 10.1073/pnas.1009559107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17498659

Title: Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4.

PubMed ID: 17498659

DOI: 10.1016/j.bbrc.2007.04.139

Sequence Information:

  • Length: 651
  • Mass: 74139
  • Checksum: 29B7947644C215E7
  • Sequence:
    • MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD 
RKRKKRKKGE KQIPGEEKGR KRRRVKEDKK KRDRDRVENE AEKDLQCHAP VRLDLPPEKP 
LTSSLAKQEE VEQTPLQEAL NQLMRQLQRK DPSAFFSFPV TDFIAPGYSM IIKHPMDFST 
MKEKIKNNDY QSIEELKDNF KLMCTNAMIY NKPETIYYKA AKKLLHSGMK ILSQERIQSL 
KQSIDFMADL QKTRKQKDGT DTSQSGEDGG CWQREREDSG DAEAHAFKSP SKENKKKDKD 
MLEDKFKSNN LEREQEQLDR IVKESGGKLT RRLVNSQCEF ERRKPDGTTT LGLLHPVDPI 
VGEPGYCPVR LGMTTGRLQS GVNTLQGFKE DKRNKVTPVL YLNYGPYSSY APHYDSTFAN 
ISKDDSDLIY STYGEDSDLP SDFSIHEFLA TCQDYPYVMA DSLLDVLTKG GHSRTLQEME 
MSLPEDEGHT RTLDTAKEME ITEVEPPGRL DSSTQDRLIA LKAVTNFGVP VEVFDSEEAE 
IFQKKLDETT RLLRELQEAQ NERLSTRPPP NMICLLGPSY REMHLAEQVT NNLKELAQQV 
TPGDIVSTYG VRKAMGISIP SPVMENNFVD LTEDTEEPKK TDVAECGPGG S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.