Details for: GSTM5

Gene ID: 2949

Symbol: GSTM5

Ensembl ID: ENSG00000134201

Description: glutathione S-transferase mu 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 57.3467
    Cell Significance Index: -8.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.6446
    Cell Significance Index: -5.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 17.9634
    Cell Significance Index: -7.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 17.4319
    Cell Significance Index: -8.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.2509
    Cell Significance Index: -8.9400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.0641
    Cell Significance Index: 31.3300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.8893
    Cell Significance Index: 22.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.5065
    Cell Significance Index: 32.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.2706
    Cell Significance Index: -8.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.0837
    Cell Significance Index: 43.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5077
    Cell Significance Index: 36.5200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.0150
    Cell Significance Index: 5.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5096
    Cell Significance Index: 65.3300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.4884
    Cell Significance Index: 2.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4839
    Cell Significance Index: 66.4500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.4531
    Cell Significance Index: 2.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3661
    Cell Significance Index: 3.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3592
    Cell Significance Index: 7.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3466
    Cell Significance Index: 9.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3119
    Cell Significance Index: 2.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2078
    Cell Significance Index: 10.5000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1638
    Cell Significance Index: 2.2900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1352
    Cell Significance Index: 1.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0712
    Cell Significance Index: 1.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0523
    Cell Significance Index: 1.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0409
    Cell Significance Index: 7.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0179
    Cell Significance Index: 0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0141
    Cell Significance Index: 21.7500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.0130
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0127
    Cell Significance Index: 4.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0107
    Cell Significance Index: 20.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0067
    Cell Significance Index: 0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -6.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0119
    Cell Significance Index: -5.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -9.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0138
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0150
    Cell Significance Index: -9.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0164
    Cell Significance Index: -8.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0183
    Cell Significance Index: -10.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0200
    Cell Significance Index: -2.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0366
    Cell Significance Index: -4.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0391
    Cell Significance Index: -2.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0403
    Cell Significance Index: -8.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0426
    Cell Significance Index: -0.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0446
    Cell Significance Index: -8.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0491
    Cell Significance Index: -10.3500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0493
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0577
    Cell Significance Index: -9.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0581
    Cell Significance Index: -7.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0694
    Cell Significance Index: -8.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0701
    Cell Significance Index: -8.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0721
    Cell Significance Index: -7.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0787
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0800
    Cell Significance Index: -9.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0834
    Cell Significance Index: -8.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0871
    Cell Significance Index: -4.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0932
    Cell Significance Index: -7.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0953
    Cell Significance Index: -5.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0977
    Cell Significance Index: -7.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0997
    Cell Significance Index: -6.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1053
    Cell Significance Index: -5.4700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1062
    Cell Significance Index: -0.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1199
    Cell Significance Index: -9.2000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1218
    Cell Significance Index: -0.7700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1220
    Cell Significance Index: -2.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1240
    Cell Significance Index: -4.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1274
    Cell Significance Index: -6.6900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1298
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1307
    Cell Significance Index: -8.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1349
    Cell Significance Index: -3.7700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1351
    Cell Significance Index: -1.5700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.1606
    Cell Significance Index: -1.4900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1610
    Cell Significance Index: -2.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1709
    Cell Significance Index: -7.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1728
    Cell Significance Index: -5.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1794
    Cell Significance Index: -8.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1889
    Cell Significance Index: -1.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1907
    Cell Significance Index: -8.2900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1927
    Cell Significance Index: -2.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1969
    Cell Significance Index: -4.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2031
    Cell Significance Index: -5.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2101
    Cell Significance Index: -9.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2282
    Cell Significance Index: -6.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2386
    Cell Significance Index: -8.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2386
    Cell Significance Index: -3.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2455
    Cell Significance Index: -8.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2496
    Cell Significance Index: -9.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2554
    Cell Significance Index: -7.5000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2584
    Cell Significance Index: -1.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2634
    Cell Significance Index: -6.5800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2652
    Cell Significance Index: -3.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2706
    Cell Significance Index: -8.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2729
    Cell Significance Index: -8.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2823
    Cell Significance Index: -9.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2827
    Cell Significance Index: -6.1900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2831
    Cell Significance Index: -3.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GSTM5 is a member of the GST family, which consists of multiple isoforms, each with distinct substrate specificities and tissue distributions. GSTM5 is characterized by its ability to catalyze the conjugation of glutathione with a wide range of electrophilic compounds, including environmental toxins, reactive oxygen species, and endogenous metabolites. The enzyme is also known for its ability to interact with various cellular proteins, including transcription factors and signaling molecules. **Pathways and Functions:** GSTM5 is involved in several key cellular processes, including: 1. **Glutathione conjugation:** GSTM5 catalyzes the conjugation of glutathione with electrophilic compounds, resulting in the formation of a water-soluble conjugate that can be easily excreted from the cell. 2. **Detoxification:** GSTM5 plays a role in the detoxification of environmental toxins, including pesticides, heavy metals, and industrial chemicals. 3. **Oxidative stress response:** GSTM5 helps to mitigate oxidative stress by conjugating glutathione with reactive oxygen species, thereby neutralizing their toxic effects. 4. **Protein binding:** GSTM5 interacts with various cellular proteins, including transcription factors and signaling molecules, influencing gene expression and cellular signaling pathways. **Clinical Significance:** The clinical significance of GSTM5 is multifaceted: 1. **Cancer susceptibility:** Polymorphisms in the GSTM5 gene have been associated with an increased risk of certain cancers, including lung, breast, and prostate cancer. 2. **Neurodegenerative diseases:** GSTM5 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Environmental toxicity:** GSTM5 plays a crucial role in detoxifying environmental toxins, and its deficiency may contribute to the development of environmental-related diseases. 4. **Immunological disorders:** GSTM5 is expressed in immune cells, and its dysfunction may contribute to the development of immunological disorders, such as autoimmune diseases. In conclusion, GSTM5 is a multifaceted enzyme that plays a critical role in cellular defense mechanisms, detoxification, and oxidative stress response. Further studies are needed to fully elucidate the functional significance of GSTM5 and its clinical implications.

Genular Protein ID: 1987780560

Symbol: GSTM5_HUMAN

Name: Glutathione S-transferase Mu 5

UniProtKB Accession Codes:

P46439 A8K0V8 Q6PD78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 9 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 2 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8473333

Title: A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5.

PubMed ID: 8473333

DOI: 10.1016/s0021-9258(18)52957-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10587441

Title: An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.

PubMed ID: 10587441

DOI: 10.1021/bi991714t

Sequence Information:

  • Length: 218
  • Mass: 25675
  • Checksum: 62B03FCD960FB4AB
  • Sequence:
    • MPMTLGYWDI RGLAHAIRLL LEYTDSSYVE KKYTLGDAPD YDRSQWLNEK FKLGLDFPNL 
PYLIDGAHKI TQSNAILRYI ARKHNLCGET EEEKIRVDIL ENQVMDNHME LVRLCYDPDF 
EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG DKITFVDFLA YDVLDMKRIF EPKCLDAFLN 
LKDFISRFEG LKKISAYMKS SQFLRGLLFG KSATWNSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.