Details for: GSTM5

Gene ID: 2949

Symbol: GSTM5

Ensembl ID: ENSG00000134201

Description: glutathione S-transferase mu 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 4.35
    Marker Score: 4559
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.3
    Marker Score: 17143
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.29
    Marker Score: 8374
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.25
    Marker Score: 287
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.21
    Marker Score: 3158
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.2
    Marker Score: 1026
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.1
    Marker Score: 1573
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15849
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1
    Marker Score: 318
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.98
    Marker Score: 1356.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.95
    Marker Score: 499
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.9
    Marker Score: 1382
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.88
    Marker Score: 628
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.83
    Marker Score: 1681
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.81
    Marker Score: 976
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.72
    Marker Score: 1367
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.7
    Marker Score: 242
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.69
    Marker Score: 2994
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.64
    Marker Score: 158
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.63
    Marker Score: 229
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.62
    Marker Score: 259
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.6
    Marker Score: 258
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.6
    Marker Score: 12762
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.59
    Marker Score: 1392.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.58
    Marker Score: 186
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.57
    Marker Score: 708
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.56
    Marker Score: 6296
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.55
    Marker Score: 769
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.54
    Marker Score: 169
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.54
    Marker Score: 521
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1242
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.52
    Marker Score: 148
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.51
    Marker Score: 267
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.5
    Marker Score: 186
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.5
    Marker Score: 317
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.5
    Marker Score: 98
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.47
    Marker Score: 339
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.46
    Marker Score: 249
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.45
    Marker Score: 15161
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 245
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.41
    Marker Score: 429
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4
    Marker Score: 2419
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.4
    Marker Score: 100
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.4
    Marker Score: 100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 250
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.36
    Marker Score: 492
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.35
    Marker Score: 82
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.35
    Marker Score: 221
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.35
    Marker Score: 681
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.34
    Marker Score: 77
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.34
    Marker Score: 297
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.34
    Marker Score: 366
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.34
    Marker Score: 1306
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.33
    Marker Score: 107
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.33
    Marker Score: 216
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.32
    Marker Score: 313
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.32
    Marker Score: 392
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.29
    Marker Score: 161
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.29
    Marker Score: 101
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.29
    Marker Score: 188
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 125
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.27
    Marker Score: 469
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.27
    Marker Score: 282
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.25
    Marker Score: 95
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.25
    Marker Score: 323
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.25
    Marker Score: 215
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.25
    Marker Score: 167
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.24
    Marker Score: 1014.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.24
    Marker Score: 86
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.23
    Marker Score: 241
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.22
    Marker Score: 254
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.21
    Marker Score: 150
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.21
    Marker Score: 143
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.21
    Marker Score: 3115
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.21
    Marker Score: 51
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.21
    Marker Score: 58
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.2
    Marker Score: 96
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.2
    Marker Score: 97
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 51

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GSTM5 is a large protein (1100 amino acids) that belongs to the glutathione S-transferase family of enzymes. * It is expressed in both soluble and membrane-bound forms. * The soluble form of GSTM5 is responsible for the majority of its enzymatic activity. * GSTM5 is a multi-functional enzyme that can perform both glutathione conjugation and transfer reactions. * It is involved in various cellular processes, including antioxidant defense, detoxification, and immune regulation. **Pathways and functions:** * GSTM5 is involved in the biological oxidation of various substrates, including hydrogen peroxide, alkylating agents, and electrophilic compounds. * It acts as a key regulator of cellular redox balance by maintaining the intracellular glutathione (GSH) pool. * GSH is a powerful antioxidant that protects cells from damage caused by ROS generated during oxidative stress. * GSTM5 helps to detoxify electrophilic compounds and protect cells from oxidative damage. * It also plays a role in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the GSTM5 gene have been linked to several human diseases, including: * Liver diseases: GSTM5 deficiency is associated with liver damage and cirrhosis. * Cancer: GSTM5 mutations have been found in a significant proportion of human cancers, suggesting that it may play a role in tumor growth and proliferation. * Neurological disorders: GSTM5 mutations have been linked to neurological disorders such as Alzheimer's disease and Parkinson's disease. * GSTM5 is a promising target for the development of novel therapeutic strategies for diseases that are characterized by oxidative stress and inflammation.

Genular Protein ID: 1987780560

Symbol: GSTM5_HUMAN

Name: Glutathione S-transferase Mu 5

UniProtKB Accession Codes:

P46439 A8K0V8 Q6PD78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 9 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8473333

Title: A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5.

PubMed ID: 8473333

DOI: 10.1016/s0021-9258(18)52957-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10587441

Title: An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.

PubMed ID: 10587441

DOI: 10.1021/bi991714t

Sequence Information:

  • Length: 218
  • Mass: 25675
  • Checksum: 62B03FCD960FB4AB
  • Sequence:
    • MPMTLGYWDI RGLAHAIRLL LEYTDSSYVE KKYTLGDAPD YDRSQWLNEK FKLGLDFPNL 
PYLIDGAHKI TQSNAILRYI ARKHNLCGET EEEKIRVDIL ENQVMDNHME LVRLCYDPDF 
EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG DKITFVDFLA YDVLDMKRIF EPKCLDAFLN 
LKDFISRFEG LKKISAYMKS SQFLRGLLFG KSATWNSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.