Details for: GTF3A

Gene ID: 2971

Symbol: GTF3A

Ensembl ID: ENSG00000122034

Description: general transcription factor IIIA

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 247.3236
    Cell Significance Index: -38.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 142.2025
    Cell Significance Index: -58.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 133.6838
    Cell Significance Index: -54.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.6209
    Cell Significance Index: -57.4200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.0694
    Cell Significance Index: -59.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.5847
    Cell Significance Index: -28.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.8243
    Cell Significance Index: -57.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.9214
    Cell Significance Index: -55.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.6641
    Cell Significance Index: -51.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4271
    Cell Significance Index: -56.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9836
    Cell Significance Index: -42.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6044
    Cell Significance Index: -23.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.1707
    Cell Significance Index: 204.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0712
    Cell Significance Index: 60.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6188
    Cell Significance Index: 76.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5340
    Cell Significance Index: 71.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4473
    Cell Significance Index: 1306.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3097
    Cell Significance Index: 154.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2839
    Cell Significance Index: 95.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2392
    Cell Significance Index: 87.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0436
    Cell Significance Index: 569.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0148
    Cell Significance Index: 23.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9422
    Cell Significance Index: 160.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9104
    Cell Significance Index: 182.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8897
    Cell Significance Index: 393.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8014
    Cell Significance Index: 98.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7615
    Cell Significance Index: 104.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7291
    Cell Significance Index: 94.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7258
    Cell Significance Index: 130.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7174
    Cell Significance Index: 116.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4228
    Cell Significance Index: 22.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3054
    Cell Significance Index: 60.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3041
    Cell Significance Index: 5.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2797
    Cell Significance Index: 100.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2494
    Cell Significance Index: 24.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2324
    Cell Significance Index: 29.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1194
    Cell Significance Index: 0.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1136
    Cell Significance Index: 1.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0923
    Cell Significance Index: 4.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0786
    Cell Significance Index: 59.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0576
    Cell Significance Index: 2.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0269
    Cell Significance Index: 5.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0035
    Cell Significance Index: 6.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0133
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0139
    Cell Significance Index: -10.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0236
    Cell Significance Index: -0.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0280
    Cell Significance Index: -38.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0326
    Cell Significance Index: -22.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0340
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0461
    Cell Significance Index: -28.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0598
    Cell Significance Index: -37.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0671
    Cell Significance Index: -37.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0944
    Cell Significance Index: -42.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0975
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1264
    Cell Significance Index: -26.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1440
    Cell Significance Index: -41.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1470
    Cell Significance Index: -3.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1557
    Cell Significance Index: -2.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1687
    Cell Significance Index: -19.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1870
    Cell Significance Index: -21.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2193
    Cell Significance Index: -4.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2468
    Cell Significance Index: -15.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2846
    Cell Significance Index: -10.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3067
    Cell Significance Index: -44.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3114
    Cell Significance Index: -2.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3322
    Cell Significance Index: -20.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3817
    Cell Significance Index: -29.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4026
    Cell Significance Index: -45.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4095
    Cell Significance Index: -18.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4110
    Cell Significance Index: -3.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4239
    Cell Significance Index: -28.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4369
    Cell Significance Index: -4.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4510
    Cell Significance Index: -13.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4691
    Cell Significance Index: -16.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4891
    Cell Significance Index: -14.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5035
    Cell Significance Index: -8.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5341
    Cell Significance Index: -42.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5366
    Cell Significance Index: -55.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5465
    Cell Significance Index: -17.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6581
    Cell Significance Index: -17.6100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6646
    Cell Significance Index: -11.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6813
    Cell Significance Index: -38.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6946
    Cell Significance Index: -41.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7396
    Cell Significance Index: -20.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7510
    Cell Significance Index: -33.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8062
    Cell Significance Index: -11.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8649
    Cell Significance Index: -10.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9361
    Cell Significance Index: -57.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9755
    Cell Significance Index: -36.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0579
    Cell Significance Index: -18.1300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0607
    Cell Significance Index: -25.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1255
    Cell Significance Index: -6.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1513
    Cell Significance Index: -30.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1564
    Cell Significance Index: -33.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1982
    Cell Significance Index: -30.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GTF3A, also known as Transcription factor IIIA, is a multifunctional protein that belongs to the general transcription factor IIIA family. This protein is characterized by its ability to bind to DNA, RNA polymerase III, and other transcription factors, facilitating the regulation of gene expression. GTF3A is predominantly expressed in pro-T cells, mature T cells, erythroid progenitor cells, and various other cell types, including blood cells, T-helper 22 cells, and decidual natural killer cells. **Pathways and Functions:** GTF3A plays a crucial role in various transcriptional pathways, including: 1. **RNA Polymerase III Transcription**: GTF3A binds to RNA polymerase III, facilitating the transcription of genes involved in ribosomal large subunit biogenesis, 5S rRNA transcription, and other RNA polymerase III-dependent processes. 2. **Gene Expression (Transcription)**: GTF3A interacts with other transcription factors, such as NF-κB and NFAT, to regulate the expression of genes involved in immune responses, cell proliferation, and differentiation. 3. **Metal Ion Binding**: GTF3A exhibits metal ion binding activity, which is essential for its function in transcriptional regulation. **Clinical Significance:** Dysregulation of GTF3A has been implicated in various diseases, including: 1. **Immunodeficiency Disorders**: Mutations in the GTF3A gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID) and T-cell lymphoma. 2. **Cancer**: Aberrant expression of GTF3A has been observed in various types of cancer, including T-cell lymphoma, leukemia, and solid tumors. 3. **Autoimmune Diseases**: GTF3A dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, GTF3A is a multifunctional protein that plays a critical role in regulating gene expression in various cell types, including immune cells. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying GTF3A's function and its clinical significance. **Recommendations for Future Research:** 1. Investigate the molecular mechanisms underlying GTF3A's interaction with RNA polymerase III and other transcription factors. 2. Explore the role of GTF3A in the development and function of immune cells, including T cells and natural killer cells. 3. Investigate the potential therapeutic applications of GTF3A as a target for cancer and autoimmune disease treatment. By continuing to unravel the complexities of GTF3A, we can gain a deeper understanding of its role in human health and disease, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 1107011793

Symbol: TF3A_HUMAN

Name: Transcription factor IIIA

UniProtKB Accession Codes:

Q92664 B7ZBK5 Q12963 Q13097

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7789179

Title: Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA.

PubMed ID: 7789179

DOI: 10.1159/000134041

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 7622052

Title: Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA.

PubMed ID: 7622052

DOI: 10.1016/0378-1119(95)00145-v

PubMed ID: 8063702

Title: Purification and characterization of human transcription factor IIIA.

PubMed ID: 8063702

DOI: 10.1016/s0021-9258(17)31901-4

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 24120868

Title: The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

PubMed ID: 24120868

DOI: 10.1016/j.celrep.2013.08.049

Sequence Information:

  • Length: 365
  • Mass: 41515
  • Checksum: 261EBDCC550130B9
  • Sequence:
    • MDPPAVVAES VSSLTIADAF IAAGESSAPT PPRPALPRRF ICSFPDCSAN YSKAWKLDAH 
LCKHTGERPF VCDYEGCGKA FIRDYHLSRH ILTHTGEKPF VCAANGCDQK FNTKSNLKKH 
FERKHENQQK QYICSFEDCK KTFKKHQQLK IHQCQHTNEP LFKCTQEGCG KHFASPSKLK 
RHAKAHEGYV CQKGCSFVAK TWTELLKHVR ETHKEEILCE VCRKTFKRKD YLKQHMKTHA 
PERDVCRCPR EGCGRTYTTV FNLQSHILSF HEESRPFVCE HAGCGKTFAM KQSLTRHAVV 
HDPDKKKMKL KVKKSREKRS LASHLSGYIP PKRKQGQGLS LCQNGESPNC VEDKMLSTVA 
VLTLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.