Gene GTF3A - ENSG00000122034 | NCBI Gene ID: 2971

Details for: GTF3A

Gene ID: 2971

Symbol: GTF3A

Ensembl ID: ENSG00000122034

Description: general transcription factor IIIA

Associated with

Gene expression (transcription)
(R-HSA-74160)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
5s rrna binding
(GO:0008097)
Dna binding
(GO:0003677)
Metal ion binding
(GO:0046872)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ribosomal large subunit biogenesis
(GO:0042273)
Rrna transcription
(GO:0009303)
Transcription by rna polymerase iii
(GO:0006383)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pro-T cell (CL0000827)
Fold Change: 2.73
Marker Score: 11190
Cell Name: mature T cell (CL0002419)
Fold Change: 2.72
Marker Score: 26935
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.69
Marker Score: 2802
Cell Name: blood cell (CL0000081)
Fold Change: 2.64
Marker Score: 30669
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.64
Marker Score: 11307
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.58
Marker Score: 7139
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.56
Marker Score: 1277
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.55
Marker Score: 3607
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.5
Marker Score: 1963.5
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.49
Marker Score: 7853
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.46
Marker Score: 24891.5
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.46
Marker Score: 5990
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.46
Marker Score: 4386.5
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.45
Marker Score: 2416
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.44
Marker Score: 2288
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.44
Marker Score: 1469
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.44
Marker Score: 2928.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.42
Marker Score: 4216.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.37
Marker Score: 6930
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.37
Marker Score: 1022
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.35
Marker Score: 124019
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.34
Marker Score: 2265
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.33
Marker Score: 2188
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.28
Marker Score: 1337
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.26
Marker Score: 745
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.26
Marker Score: 2278
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.25
Marker Score: 6325.5
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.25
Marker Score: 1997
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.23
Marker Score: 788
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.2
Marker Score: 681
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.2
Marker Score: 1848.5
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.2
Marker Score: 766
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.18
Marker Score: 4270
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.18
Marker Score: 4960
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 2.1
Marker Score: 1583.5
Cell Name: Unknown (CL0000548)
Fold Change: 2.1
Marker Score: 1528
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.09
Marker Score: 1838.5
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 2.06
Marker Score: 1138
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.05
Marker Score: 1488
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.05
Marker Score: 3019
Cell Name: naive B cell (CL0000788)
Fold Change: 2.04
Marker Score: 1824
Cell Name: immature B cell (CL0000816)
Fold Change: 2.03
Marker Score: 1346
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.01
Marker Score: 2166
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2
Marker Score: 1055
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2
Marker Score: 12792
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.99
Marker Score: 50840.5
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.96
Marker Score: 4106
Cell Name: memory B cell (CL0000787)
Fold Change: 1.95
Marker Score: 1477
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.95
Marker Score: 2685
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.92
Marker Score: 1169
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.92
Marker Score: 938.5
Cell Name: plasmablast (CL0000980)
Fold Change: 1.9
Marker Score: 2523
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.9
Marker Score: 1553
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.89
Marker Score: 1614
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.88
Marker Score: 618
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.88
Marker Score: 1099
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.86
Marker Score: 14487.5
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.85
Marker Score: 1355
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.84
Marker Score: 1238
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.82
Marker Score: 7009
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.81
Marker Score: 1748
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.81
Marker Score: 1970
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 1.81
Marker Score: 3107
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.8
Marker Score: 429
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.79
Marker Score: 623
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.79
Marker Score: 3768
Cell Name: naive T cell (CL0000898)
Fold Change: 1.78
Marker Score: 1148
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.78
Marker Score: 1778.5
Cell Name: decidual cell (CL2000002)
Fold Change: 1.77
Marker Score: 7627
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.76
Marker Score: 616
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.76
Marker Score: 98166
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.74
Marker Score: 1987
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.74
Marker Score: 2048
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.73
Marker Score: 953
Cell Name: malignant cell (CL0001064)
Fold Change: 1.73
Marker Score: 23215
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.73
Marker Score: 524
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.72
Marker Score: 1243
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.72
Marker Score: 2071.5
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.71
Marker Score: 748
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.71
Marker Score: 4656.5
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.71
Marker Score: 835
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.7
Marker Score: 3317
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.7
Marker Score: 587
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.7
Marker Score: 2441.5
Cell Name: male germ cell (CL0000015)
Fold Change: 1.69
Marker Score: 487
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.69
Marker Score: 369.5
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.69
Marker Score: 1144.5
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.69
Marker Score: 541
Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.69
Marker Score: 673
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.68
Marker Score: 2105.5
Cell Name: osteoclast (CL0000092)
Fold Change: 1.67
Marker Score: 832.5
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.67
Marker Score: 1137
Cell Name: peptic cell (CL0000155)
Fold Change: 1.66
Marker Score: 696
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.65
Marker Score: 4893
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.65
Marker Score: 4267
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.64
Marker Score: 330
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.63
Marker Score: 807
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 1.63
Marker Score: 1437
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.62
Marker Score: 663
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.62
Marker Score: 660.5

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**Key characteristics:** - GTF3A is a member of the GATA family of transcription factors. - It is a key regulator of T cell development and function. - It is involved in the regulation of cell cycle progression, differentiation, and apoptosis. - It is also involved in the regulation of inflammation and immune responses. **Pathways and functions:** - GTF3A is a key regulator of T cell development. It is expressed in high levels in pro-T cells and is essential for their survival and proliferation. - It is also expressed in mature T cells, where it plays a role in regulating cell cycle progression and differentiation. - In erythroid progenitor cells, GTF3A is essential for the development of normal blood cells. - It is also expressed in blood cells, where it plays a role in regulating cell cycle progression and differentiation. - In T-helper 22 cells, GTF3A is involved in the regulation of immune responses to allergens and parasites. - In decidual natural killer cells, GTF3A is expressed in high levels and is essential for the development and function of these cells. - In human, GTF3A is expressed in various immune cells, including pro-T cells, mature T cells, and DN3 thymocytes. **Clinical significance:** GTF3A is a potential therapeutic target for a variety of diseases. For example, mutations in GTF3A have been linked to several human cancers, including leukemia and lymphoma. Inhibition of GTF3A has been shown to be effective in inhibiting cancer cell growth and metastasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor IIIA

Genular Protein ID: 1107011793

Symbol: TF3A_HUMAN

Name: Transcription factor IIIA

UniProtKB Accession Codes:

Q92664 B7ZBK5 Q12963 Q13097

Database IDs:

Citations:

PubMed ID: 7789179

Title: Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA.

PubMed ID: 7789179

DOI: 10.1159/000134041

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 7622052

Title: Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA.

PubMed ID: 7622052

DOI: 10.1016/0378-1119(95)00145-v

PubMed ID: 8063702

Title: Purification and characterization of human transcription factor IIIA.

PubMed ID: 8063702

DOI: 10.1016/s0021-9258(17)31901-4

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 24120868

Title: The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

PubMed ID: 24120868

DOI: 10.1016/j.celrep.2013.08.049

Sequence Information:

Length: 365
Mass: 41515
Checksum: 261EBDCC550130B9
Sequence:

MDPPAVVAES VSSLTIADAF IAAGESSAPT PPRPALPRRF ICSFPDCSAN YSKAWKLDAH 
LCKHTGERPF VCDYEGCGKA FIRDYHLSRH ILTHTGEKPF VCAANGCDQK FNTKSNLKKH 
FERKHENQQK QYICSFEDCK KTFKKHQQLK IHQCQHTNEP LFKCTQEGCG KHFASPSKLK 
RHAKAHEGYV CQKGCSFVAK TWTELLKHVR ETHKEEILCE VCRKTFKRKD YLKQHMKTHA 
PERDVCRCPR EGCGRTYTTV FNLQSHILSF HEESRPFVCE HAGCGKTFAM KQSLTRHAVV 
HDPDKKKMKL KVKKSREKRS LASHLSGYIP PKRKQGQGLS LCQNGESPNC VEDKMLSTVA 
VLTLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GTF3A

Associated with

Cells (max top 100)

Other Information

Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA. PubMed ID: 7789179

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA. PubMed ID: 7622052

Purification and characterization of human transcription factor IIIA. PubMed ID: 8063702

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330