Details for: PACSIN3

Gene ID: 29763

Symbol: PACSIN3

Ensembl ID: ENSG00000165912

Description: protein kinase C and casein kinase substrate in neurons 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.7360
    Cell Significance Index: -17.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.4820
    Cell Significance Index: -17.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0881
    Cell Significance Index: -17.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.8781
    Cell Significance Index: -13.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3993
    Cell Significance Index: -17.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.9266
    Cell Significance Index: 39.9300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2778
    Cell Significance Index: 20.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2709
    Cell Significance Index: 10.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.0033
    Cell Significance Index: 24.4800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.9659
    Cell Significance Index: 15.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8764
    Cell Significance Index: 166.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8193
    Cell Significance Index: 38.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6725
    Cell Significance Index: 18.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6384
    Cell Significance Index: 63.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6210
    Cell Significance Index: 16.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5890
    Cell Significance Index: 76.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4672
    Cell Significance Index: 9.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3850
    Cell Significance Index: 347.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3813
    Cell Significance Index: 52.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3573
    Cell Significance Index: 25.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3386
    Cell Significance Index: 15.9200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3282
    Cell Significance Index: 0.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3240
    Cell Significance Index: 24.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3238
    Cell Significance Index: 52.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3233
    Cell Significance Index: 142.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3210
    Cell Significance Index: 16.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3194
    Cell Significance Index: 34.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3073
    Cell Significance Index: 18.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3021
    Cell Significance Index: 38.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2987
    Cell Significance Index: 22.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2387
    Cell Significance Index: 47.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2086
    Cell Significance Index: 10.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1864
    Cell Significance Index: 5.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1591
    Cell Significance Index: 1.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1472
    Cell Significance Index: 3.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1446
    Cell Significance Index: 78.9500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1272
    Cell Significance Index: 1.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1263
    Cell Significance Index: 8.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1179
    Cell Significance Index: 21.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1101
    Cell Significance Index: 1.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1070
    Cell Significance Index: 13.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0929
    Cell Significance Index: 1.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0928
    Cell Significance Index: 1.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0868
    Cell Significance Index: 2.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0734
    Cell Significance Index: 1.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0368
    Cell Significance Index: 1.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0333
    Cell Significance Index: 0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0311
    Cell Significance Index: 5.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0124
    Cell Significance Index: 1.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0041
    Cell Significance Index: 7.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0039
    Cell Significance Index: 0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0034
    Cell Significance Index: 2.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0007
    Cell Significance Index: 1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0092
    Cell Significance Index: -6.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0100
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0150
    Cell Significance Index: -9.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0253
    Cell Significance Index: -11.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0253
    Cell Significance Index: -18.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0263
    Cell Significance Index: -1.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0280
    Cell Significance Index: -15.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0414
    Cell Significance Index: -4.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0440
    Cell Significance Index: -2.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0456
    Cell Significance Index: -16.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0568
    Cell Significance Index: -16.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0598
    Cell Significance Index: -8.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0612
    Cell Significance Index: -12.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0700
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0902
    Cell Significance Index: -19.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1097
    Cell Significance Index: -11.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1117
    Cell Significance Index: -6.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1181
    Cell Significance Index: -2.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1378
    Cell Significance Index: -16.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1620
    Cell Significance Index: -16.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1635
    Cell Significance Index: -12.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1766
    Cell Significance Index: -8.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1788
    Cell Significance Index: -7.3300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1807
    Cell Significance Index: -1.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1985
    Cell Significance Index: -12.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2162
    Cell Significance Index: -13.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2294
    Cell Significance Index: -14.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2533
    Cell Significance Index: -7.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2626
    Cell Significance Index: -17.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2873
    Cell Significance Index: -16.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2910
    Cell Significance Index: -9.3200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2983
    Cell Significance Index: -1.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3181
    Cell Significance Index: -9.3700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3328
    Cell Significance Index: -2.8600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3355
    Cell Significance Index: -2.0700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3411
    Cell Significance Index: -5.1400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3677
    Cell Significance Index: -5.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3731
    Cell Significance Index: -13.7000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3732
    Cell Significance Index: -3.8500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.3918
    Cell Significance Index: -3.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3970
    Cell Significance Index: -17.5600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4107
    Cell Significance Index: -3.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4232
    Cell Significance Index: -5.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate for PKC and CK:** PACSIN3 is a substrate for both PKC and CK, which are key enzymes involved in signal transduction pathways. 2. **Involvement in Endocytosis:** PACSIN3 is involved in the regulation of endocytosis, a process by which cells internalize molecules from the extracellular environment. 3. **Cytoskeleton Organization:** PACSIN3 is also involved in the organization of the cytoskeleton, which is essential for maintaining cell shape and providing mechanical support. 4. **Regulation of Calcium Ion Transport:** PACSIN3 plays a role in regulating calcium ion transport, which is critical for various cellular processes, including muscle contraction and neuronal signaling. **Pathways and Functions:** 1. **Clathrin-Mediated Endocytosis:** PACSIN3 is involved in the regulation of clathrin-mediated endocytosis, a process by which cells internalize molecules from the extracellular environment. 2. **Cytoskeletal Protein Binding:** PACSIN3 interacts with various cytoskeletal proteins, including actin and tubulin, to regulate cytoskeleton organization. 3. **Negative Regulation of Endocytosis:** PACSIN3 acts as a negative regulator of endocytosis, preventing excessive internalization of molecules. 4. **Regulation of Membrane Trafficking:** PACSIN3 is involved in the regulation of membrane trafficking, including the transport of vesicles and proteins between the plasma membrane and endosomes. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in PACSIN3 expression have been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 2. **Cancer:** PACSIN3 is overexpressed in certain types of cancer, including colon cancer, and may play a role in tumor progression and metastasis. 3. **Cardiac Disease:** PACSIN3 is involved in the regulation of calcium ion transport, which is critical for cardiac function. Alterations in PACSIN3 expression may contribute to cardiac dysfunction and disease. 4. **Immunological Disorders:** PACSIN3 is expressed in immune cells, including T lymphocytes, and may play a role in immune regulation and autoimmune diseases. In conclusion, PACSIN3 is a multifunctional protein that plays a critical role in various cellular processes, including endocytosis, cytoskeleton organization, and regulation of calcium ion transport. Its involvement in neurological disorders, cancer, cardiac disease, and immunological disorders highlights its importance in human health and disease. Further research is needed to fully understand the complex roles of PACSIN3 and its implications for human disease.

Genular Protein ID: 2343175138

Symbol: PACN3_HUMAN

Name: Protein kinase C and casein kinase substrate in neurons protein 3

UniProtKB Accession Codes:

Q9UKS6 A6NH84 Q9H331 Q9NWV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10531379

Title: Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.

PubMed ID: 10531379

DOI: 10.1074/jbc.274.44.31693

PubMed ID: 11082044

Title: All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.

PubMed ID: 11082044

DOI: 10.1242/jcs.113.24.4511

PubMed ID: 11179684

Title: PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.

PubMed ID: 11179684

DOI: 10.1016/s0378-1119(00)00531-x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23236520

Title: Versatile membrane deformation potential of activated pacsin.

PubMed ID: 23236520

DOI: 10.1371/journal.pone.0051628

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 424
  • Mass: 48487
  • Checksum: 6DBD940AE6D1F352
  • Sequence:
    • MAPEEDAGGE ALGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW 
ARKWRGTVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE KLQGQDSERV RAWQRGAFHR 
PVLGGFRESR AAEDGFRKAQ KPWLKRLKEV EASKKSYHAA RKDEKTAQTR ESHAKADSAV 
SQEQLRKLQE RVERCAKEAE KTKAQYEQTL AELHRYTPRY MEDMEQAFET CQAAERQRLL 
FFKDMLLTLH QHLDLSSSEK FHELHRDLHQ GIEAASDEED LRWWRSTHGP GMAMNWPQFE 
EWSLDTQRTI SRKEKGGRSP DEVTLTSIVP TRDGTAPPPQ SPGSPGTGQD EEWSDEESPR 
KAATGVRVRA LYDYAGQEAD ELSFRAGEEL LKMSEEDEQG WCQGQLQSGR IGLYPANYVE 
CVGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.