Details for: PACSIN3

Gene ID: 29763

Symbol: PACSIN3

Ensembl ID: ENSG00000165912

Description: protein kinase C and casein kinase substrate in neurons 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 3
    Marker Score: 4,627
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,155
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,040
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.24
    Marker Score: 10,486
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18,711
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.19
    Marker Score: 10,279
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.08
    Marker Score: 592
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.06
    Marker Score: 8,278
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 784
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.01
    Marker Score: 424
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,023
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1
    Marker Score: 2,269
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.98
    Marker Score: 3,640
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.95
    Marker Score: 338
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.92
    Marker Score: 1,017
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,195
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.91
    Marker Score: 1,611
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.9
    Marker Score: 934
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.87
    Marker Score: 728
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,277
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.84
    Marker Score: 1,768
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.83
    Marker Score: 264
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.82
    Marker Score: 6,088
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.8
    Marker Score: 1,678
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1,498
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.79
    Marker Score: 827
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.77
    Marker Score: 244
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1,562
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.76
    Marker Score: 2,993
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.75
    Marker Score: 1,698
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.73
    Marker Score: 773
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.73
    Marker Score: 1,774
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.72
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,978
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 440
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.69
    Marker Score: 15,357
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.68
    Marker Score: 723
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.67
    Marker Score: 161
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.66
    Marker Score: 919
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 310
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.65
    Marker Score: 1,520
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.64
    Marker Score: 301
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.64
    Marker Score: 1,084
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.63
    Marker Score: 2,421
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.63
    Marker Score: 588
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.62
    Marker Score: 178
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.61
    Marker Score: 8,220
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.61
    Marker Score: 733
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.61
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.61
    Marker Score: 182
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.59
    Marker Score: 1,390
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.59
    Marker Score: 2,097
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.57
    Marker Score: 403
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.57
    Marker Score: 908
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.56
    Marker Score: 7,421
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.56
    Marker Score: 277
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.56
    Marker Score: 258
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.56
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.55
    Marker Score: 891
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 333
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.55
    Marker Score: 141
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.55
    Marker Score: 266
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.55
    Marker Score: 1,026
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.54
    Marker Score: 3,503
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.52
    Marker Score: 5,856
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.51
    Marker Score: 153
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5
    Marker Score: 293
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.5
    Marker Score: 335
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.49
    Marker Score: 2,594
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.49
    Marker Score: 160
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.48
    Marker Score: 330
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.48
    Marker Score: 164
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.48
    Marker Score: 316
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.48
    Marker Score: 299
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.47
    Marker Score: 776
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.47
    Marker Score: 420
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.47
    Marker Score: 856
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.47
    Marker Score: 442
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.46
    Marker Score: 605
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.46
    Marker Score: 677
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.46
    Marker Score: 552
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.45
    Marker Score: 1,398
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.45
    Marker Score: 2,940
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.45
    Marker Score: 579

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate for PKC and CK:** PACSIN3 is a substrate for both PKC and CK, which are key enzymes involved in signal transduction pathways. 2. **Involvement in Endocytosis:** PACSIN3 is involved in the regulation of endocytosis, a process by which cells internalize molecules from the extracellular environment. 3. **Cytoskeleton Organization:** PACSIN3 is also involved in the organization of the cytoskeleton, which is essential for maintaining cell shape and providing mechanical support. 4. **Regulation of Calcium Ion Transport:** PACSIN3 plays a role in regulating calcium ion transport, which is critical for various cellular processes, including muscle contraction and neuronal signaling. **Pathways and Functions:** 1. **Clathrin-Mediated Endocytosis:** PACSIN3 is involved in the regulation of clathrin-mediated endocytosis, a process by which cells internalize molecules from the extracellular environment. 2. **Cytoskeletal Protein Binding:** PACSIN3 interacts with various cytoskeletal proteins, including actin and tubulin, to regulate cytoskeleton organization. 3. **Negative Regulation of Endocytosis:** PACSIN3 acts as a negative regulator of endocytosis, preventing excessive internalization of molecules. 4. **Regulation of Membrane Trafficking:** PACSIN3 is involved in the regulation of membrane trafficking, including the transport of vesicles and proteins between the plasma membrane and endosomes. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in PACSIN3 expression have been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 2. **Cancer:** PACSIN3 is overexpressed in certain types of cancer, including colon cancer, and may play a role in tumor progression and metastasis. 3. **Cardiac Disease:** PACSIN3 is involved in the regulation of calcium ion transport, which is critical for cardiac function. Alterations in PACSIN3 expression may contribute to cardiac dysfunction and disease. 4. **Immunological Disorders:** PACSIN3 is expressed in immune cells, including T lymphocytes, and may play a role in immune regulation and autoimmune diseases. In conclusion, PACSIN3 is a multifunctional protein that plays a critical role in various cellular processes, including endocytosis, cytoskeleton organization, and regulation of calcium ion transport. Its involvement in neurological disorders, cancer, cardiac disease, and immunological disorders highlights its importance in human health and disease. Further research is needed to fully understand the complex roles of PACSIN3 and its implications for human disease.

Genular Protein ID: 2343175138

Symbol: PACN3_HUMAN

Name: Protein kinase C and casein kinase substrate in neurons protein 3

UniProtKB Accession Codes:

Q9UKS6 A6NH84 Q9H331 Q9NWV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10531379

Title: Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.

PubMed ID: 10531379

DOI: 10.1074/jbc.274.44.31693

PubMed ID: 11082044

Title: All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.

PubMed ID: 11082044

DOI: 10.1242/jcs.113.24.4511

PubMed ID: 11179684

Title: PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.

PubMed ID: 11179684

DOI: 10.1016/s0378-1119(00)00531-x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23236520

Title: Versatile membrane deformation potential of activated pacsin.

PubMed ID: 23236520

DOI: 10.1371/journal.pone.0051628

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 424
  • Mass: 48487
  • Checksum: 6DBD940AE6D1F352
  • Sequence:
    • MAPEEDAGGE ALGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW 
ARKWRGTVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE KLQGQDSERV RAWQRGAFHR 
PVLGGFRESR AAEDGFRKAQ KPWLKRLKEV EASKKSYHAA RKDEKTAQTR ESHAKADSAV 
SQEQLRKLQE RVERCAKEAE KTKAQYEQTL AELHRYTPRY MEDMEQAFET CQAAERQRLL 
FFKDMLLTLH QHLDLSSSEK FHELHRDLHQ GIEAASDEED LRWWRSTHGP GMAMNWPQFE 
EWSLDTQRTI SRKEKGGRSP DEVTLTSIVP TRDGTAPPPQ SPGSPGTGQD EEWSDEESPR 
KAATGVRVRA LYDYAGQEAD ELSFRAGEEL LKMSEEDEQG WCQGQLQSGR IGLYPANYVE 
CVGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.