Details for: TMOD3

Gene ID: 29766

Symbol: TMOD3

Ensembl ID: ENSG00000138594

Description: tropomodulin 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.45
    Marker Score: 2,580
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.36
    Marker Score: 1,608
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.19
    Marker Score: 2,642
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.15
    Marker Score: 18,509
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.11
    Marker Score: 1,259
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.04
    Marker Score: 23,697
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.01
    Marker Score: 2,921
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2
    Marker Score: 2,209
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.99
    Marker Score: 1,165
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.96
    Marker Score: 1,544
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.89
    Marker Score: 3,345
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.87
    Marker Score: 2,151
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.81
    Marker Score: 2,663
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.81
    Marker Score: 2,331
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.79
    Marker Score: 1,041
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.75
    Marker Score: 5,497
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.74
    Marker Score: 606
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.74
    Marker Score: 3,032
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.73
    Marker Score: 1,549
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.72
    Marker Score: 27,587
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.72
    Marker Score: 635
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.72
    Marker Score: 740
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.7
    Marker Score: 13,312
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.69
    Marker Score: 1,524
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.68
    Marker Score: 1,125
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.68
    Marker Score: 1,401
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.68
    Marker Score: 3,350
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.67
    Marker Score: 1,215
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.65
    Marker Score: 12,316
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.65
    Marker Score: 92,507
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.62
    Marker Score: 1,742
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.62
    Marker Score: 392
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.6
    Marker Score: 1,385
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.6
    Marker Score: 1,867
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.59
    Marker Score: 907
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.59
    Marker Score: 459
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.57
    Marker Score: 3,065
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.56
    Marker Score: 883
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.56
    Marker Score: 3,426
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.56
    Marker Score: 672
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.55
    Marker Score: 329
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.55
    Marker Score: 3,851
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.53
    Marker Score: 13,169
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.53
    Marker Score: 368
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.53
    Marker Score: 94,023
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.53
    Marker Score: 440
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.52
    Marker Score: 752
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.52
    Marker Score: 52,494
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.51
    Marker Score: 361
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.5
    Marker Score: 873
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.5
    Marker Score: 700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.48
    Marker Score: 1,164
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.48
    Marker Score: 50,380
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.48
    Marker Score: 1,392
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.47
    Marker Score: 1,005
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.47
    Marker Score: 37,656
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.47
    Marker Score: 725
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.46
    Marker Score: 2,120
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.46
    Marker Score: 606
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.46
    Marker Score: 1,555
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.45
    Marker Score: 1,403
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.43
    Marker Score: 1,546
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.43
    Marker Score: 1,439
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.43
    Marker Score: 1,678
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.43
    Marker Score: 581
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.42
    Marker Score: 3,240
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.41
    Marker Score: 15,887
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.41
    Marker Score: 9,161
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.41
    Marker Score: 2,704
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.4
    Marker Score: 545
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.4
    Marker Score: 779
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.4
    Marker Score: 567
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.4
    Marker Score: 13,297
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.4
    Marker Score: 1,922
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,154
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.39
    Marker Score: 1,281
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.39
    Marker Score: 3,542
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.39
    Marker Score: 447
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.39
    Marker Score: 14,367
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.39
    Marker Score: 2,537
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.38
    Marker Score: 1,186
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.37
    Marker Score: 8,752
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.37
    Marker Score: 613
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.36
    Marker Score: 1,541
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.36
    Marker Score: 849
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.36
    Marker Score: 1,369
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.35
    Marker Score: 1,306
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.35
    Marker Score: 310
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.34
    Marker Score: 707
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.34
    Marker Score: 1,460
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.34
    Marker Score: 384
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.33
    Marker Score: 12,532
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.32
    Marker Score: 1,598
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.31
    Marker Score: 5,350
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.31
    Marker Score: 3,209
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.31
    Marker Score: 2,572
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.31
    Marker Score: 753
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.31
    Marker Score: 818
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.31
    Marker Score: 4,506
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.31
    Marker Score: 1,742

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMOD3 is a highly conserved protein, with high sequence identity across different species. It is characterized by its ability to bind to actin filaments, tropomyosin, and other proteins, thereby regulating actin filament dynamics and organization. TMOD3 is predominantly expressed in epithelial cells, endothelial cells, and muscle cells, where it plays a crucial role in maintaining cellular homeostasis and function. **Pathways and Functions:** TMOD3 is involved in various signaling pathways, including: 1. **Actin binding and filament organization:** TMOD3 regulates actin filament dynamics by binding to actin and tropomyosin, thereby modulating the organization of actin filaments. 2. **Cell-cell adhesion:** TMOD3 interacts with cadherins and other adhesion molecules, facilitating cell-cell adhesion and maintaining tissue integrity. 3. **Muscle contraction:** TMOD3 is essential for striated muscle contraction, as it regulates the organization of actin filaments and tropomyosin. 4. **Cytoskeleton organization:** TMOD3 contributes to the organization of the cytoskeleton, which is crucial for maintaining cellular shape and function. 5. **Signaling by Rho GTPases:** TMOD3 interacts with Rho GTPases, which are key regulators of cell migration, proliferation, and differentiation. **Clinical Significance:** TMOD3's involvement in various cellular processes makes it an attractive target for therapeutic interventions. Abnormalities in TMOD3 expression or function have been linked to various diseases, including: 1. **Muscular dystrophy:** TMOD3 mutations have been identified in patients with muscular dystrophy, highlighting its crucial role in muscle function. 2. **Cancer:** TMOD3 is often downregulated in cancer cells, suggesting its role in maintaining cellular homeostasis and preventing tumorigenesis. 3. **Neurological disorders:** TMOD3's involvement in neuronal function and signaling pathways makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TMOD3 is a multifunctional protein that plays a critical role in maintaining cellular homeostasis and function. Its involvement in various signaling pathways and its expression in different cell types make it an attractive target for therapeutic interventions. Further research is necessary to fully elucidate the mechanisms of TMOD3 and its clinical significance. **References:** * [Insert references here] **Author's Note:** As an expert immunologist, I would like to emphasize the importance of TMOD3 in maintaining cellular homeostasis and function. Further research is necessary to fully elucidate the mechanisms of TMOD3 and its clinical significance.

Genular Protein ID: 3086384547

Symbol: TMOD3_HUMAN

Name: Tropomodulin-3

UniProtKB Accession Codes:

Q9NYL9 B2R6G7 Q9NT43 Q9NZR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10662549

Title: Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.

PubMed ID: 10662549

DOI: 10.1006/geno.1999.6061

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 352
  • Mass: 39595
  • Checksum: 8B7F2122C1BE9855
  • Sequence:
    • MALPFRKDLE KYKDLDEDEL LGNLSETELK QLETVLDDLD PENALLPAGF RQKNQTSKST 
TGPFDREHLL SYLEKEALEH KDREDYVPYT GEKKGKIFIP KQKPVQTFTE EKVSLDPELE 
EALTSASDTE LCDLAAILGM HNLITNTKFC NIMGSSNGVD QEHFSNVVKG EKILPVFDEP 
PNPTNVEESL KRTKENDAHL VEVNLNNIKN IPIPTLKDFA KALETNTHVK CFSLAATRSN 
DPVATAFAEM LKVNKTLKSL NVESNFITGV GILALIDALR DNETLAELKI DNQRQQLGTA 
VELEMAKMLE ENTNILKFGY QFTQQGPRTR AANAITKNND LVRKRRVEGD HQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.