Details for: TMOD3

Gene ID: 29766

Symbol: TMOD3

Ensembl ID: ENSG00000138594

Description: tropomodulin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 371.7247
    Cell Significance Index: -57.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.2121
    Cell Significance Index: -59.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 137.6125
    Cell Significance Index: -64.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 134.7546
    Cell Significance Index: -54.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 120.5517
    Cell Significance Index: -62.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 97.3142
    Cell Significance Index: -65.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.8742
    Cell Significance Index: -55.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.2938
    Cell Significance Index: -62.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.7406
    Cell Significance Index: -58.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.1441
    Cell Significance Index: -39.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.9045
    Cell Significance Index: -62.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.7617
    Cell Significance Index: -45.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.4137
    Cell Significance Index: 64.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9443
    Cell Significance Index: 44.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8807
    Cell Significance Index: 204.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5770
    Cell Significance Index: 42.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3444
    Cell Significance Index: 266.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3054
    Cell Significance Index: 261.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2658
    Cell Significance Index: 155.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2524
    Cell Significance Index: 225.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1451
    Cell Significance Index: 10.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0796
    Cell Significance Index: 21.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9813
    Cell Significance Index: 97.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9265
    Cell Significance Index: 505.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8434
    Cell Significance Index: 23.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7839
    Cell Significance Index: 22.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7438
    Cell Significance Index: 102.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7213
    Cell Significance Index: 37.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7213
    Cell Significance Index: 37.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6905
    Cell Significance Index: 112.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6169
    Cell Significance Index: 29.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5693
    Cell Significance Index: 204.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5448
    Cell Significance Index: 35.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5429
    Cell Significance Index: 24.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4946
    Cell Significance Index: 23.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4498
    Cell Significance Index: 5.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4335
    Cell Significance Index: 191.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3913
    Cell Significance Index: 30.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3221
    Cell Significance Index: 14.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3041
    Cell Significance Index: 210.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2895
    Cell Significance Index: 5.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2229
    Cell Significance Index: 12.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2176
    Cell Significance Index: 3.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1970
    Cell Significance Index: 7.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1953
    Cell Significance Index: 1.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1340
    Cell Significance Index: 182.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1197
    Cell Significance Index: 22.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0593
    Cell Significance Index: 111.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0518
    Cell Significance Index: 1.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0514
    Cell Significance Index: 23.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0442
    Cell Significance Index: 5.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0348
    Cell Significance Index: 4.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0345
    Cell Significance Index: 5.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0275
    Cell Significance Index: 0.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0137
    Cell Significance Index: 21.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0090
    Cell Significance Index: 0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0071
    Cell Significance Index: 13.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0056
    Cell Significance Index: 0.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0178
    Cell Significance Index: -11.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0195
    Cell Significance Index: -17.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0234
    Cell Significance Index: -14.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0319
    Cell Significance Index: -23.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0360
    Cell Significance Index: -4.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0455
    Cell Significance Index: -34.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0813
    Cell Significance Index: -45.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0826
    Cell Significance Index: -8.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1214
    Cell Significance Index: -3.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1412
    Cell Significance Index: -2.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1793
    Cell Significance Index: -51.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1841
    Cell Significance Index: -13.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1850
    Cell Significance Index: -21.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1987
    Cell Significance Index: -41.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2104
    Cell Significance Index: -2.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2640
    Cell Significance Index: -38.3800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3219
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3358
    Cell Significance Index: -38.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4849
    Cell Significance Index: -55.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5225
    Cell Significance Index: -13.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5347
    Cell Significance Index: -55.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5349
    Cell Significance Index: -32.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5962
    Cell Significance Index: -40.0900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6256
    Cell Significance Index: -8.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6400
    Cell Significance Index: -50.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7127
    Cell Significance Index: -44.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7294
    Cell Significance Index: -12.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7540
    Cell Significance Index: -24.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7545
    Cell Significance Index: -19.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7707
    Cell Significance Index: -20.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8944
    Cell Significance Index: -46.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9062
    Cell Significance Index: -31.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9253
    Cell Significance Index: -56.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9292
    Cell Significance Index: -19.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9843
    Cell Significance Index: -26.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0869
    Cell Significance Index: -29.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1598
    Cell Significance Index: -24.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2387
    Cell Significance Index: -35.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2801
    Cell Significance Index: -46.9900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.2934
    Cell Significance Index: -19.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMOD3 is a highly conserved protein, with high sequence identity across different species. It is characterized by its ability to bind to actin filaments, tropomyosin, and other proteins, thereby regulating actin filament dynamics and organization. TMOD3 is predominantly expressed in epithelial cells, endothelial cells, and muscle cells, where it plays a crucial role in maintaining cellular homeostasis and function. **Pathways and Functions:** TMOD3 is involved in various signaling pathways, including: 1. **Actin binding and filament organization:** TMOD3 regulates actin filament dynamics by binding to actin and tropomyosin, thereby modulating the organization of actin filaments. 2. **Cell-cell adhesion:** TMOD3 interacts with cadherins and other adhesion molecules, facilitating cell-cell adhesion and maintaining tissue integrity. 3. **Muscle contraction:** TMOD3 is essential for striated muscle contraction, as it regulates the organization of actin filaments and tropomyosin. 4. **Cytoskeleton organization:** TMOD3 contributes to the organization of the cytoskeleton, which is crucial for maintaining cellular shape and function. 5. **Signaling by Rho GTPases:** TMOD3 interacts with Rho GTPases, which are key regulators of cell migration, proliferation, and differentiation. **Clinical Significance:** TMOD3's involvement in various cellular processes makes it an attractive target for therapeutic interventions. Abnormalities in TMOD3 expression or function have been linked to various diseases, including: 1. **Muscular dystrophy:** TMOD3 mutations have been identified in patients with muscular dystrophy, highlighting its crucial role in muscle function. 2. **Cancer:** TMOD3 is often downregulated in cancer cells, suggesting its role in maintaining cellular homeostasis and preventing tumorigenesis. 3. **Neurological disorders:** TMOD3's involvement in neuronal function and signaling pathways makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TMOD3 is a multifunctional protein that plays a critical role in maintaining cellular homeostasis and function. Its involvement in various signaling pathways and its expression in different cell types make it an attractive target for therapeutic interventions. Further research is necessary to fully elucidate the mechanisms of TMOD3 and its clinical significance. **References:** * [Insert references here] **Author's Note:** As an expert immunologist, I would like to emphasize the importance of TMOD3 in maintaining cellular homeostasis and function. Further research is necessary to fully elucidate the mechanisms of TMOD3 and its clinical significance.

Genular Protein ID: 3086384547

Symbol: TMOD3_HUMAN

Name: Tropomodulin-3

UniProtKB Accession Codes:

Q9NYL9 B2R6G7 Q9NT43 Q9NZR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10662549

Title: Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.

PubMed ID: 10662549

DOI: 10.1006/geno.1999.6061

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 37126682

Title: A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy.

PubMed ID: 37126682

DOI: 10.1073/pnas.2213696120

Sequence Information:

  • Length: 352
  • Mass: 39595
  • Checksum: 8B7F2122C1BE9855
  • Sequence:
    • MALPFRKDLE KYKDLDEDEL LGNLSETELK QLETVLDDLD PENALLPAGF RQKNQTSKST 
TGPFDREHLL SYLEKEALEH KDREDYVPYT GEKKGKIFIP KQKPVQTFTE EKVSLDPELE 
EALTSASDTE LCDLAAILGM HNLITNTKFC NIMGSSNGVD QEHFSNVVKG EKILPVFDEP 
PNPTNVEESL KRTKENDAHL VEVNLNNIKN IPIPTLKDFA KALETNTHVK CFSLAATRSN 
DPVATAFAEM LKVNKTLKSL NVESNFITGV GILALIDALR DNETLAELKI DNQRQQLGTA 
VELEMAKMLE ENTNILKFGY QFTQQGPRTR AANAITKNND LVRKRRVEGD HQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.