Details for: UBQLN2

Gene ID: 29978

Symbol: UBQLN2

Ensembl ID: ENSG00000188021

Description: ubiquilin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 160.4035
    Cell Significance Index: -24.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.1730
    Cell Significance Index: -24.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.5133
    Cell Significance Index: -27.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.5833
    Cell Significance Index: -25.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.7221
    Cell Significance Index: -21.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.0962
    Cell Significance Index: -24.7400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.4786
    Cell Significance Index: -25.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.9067
    Cell Significance Index: -21.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.1849
    Cell Significance Index: -26.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6231
    Cell Significance Index: -23.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6700
    Cell Significance Index: -26.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3903
    Cell Significance Index: -7.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9756
    Cell Significance Index: 136.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2384
    Cell Significance Index: 1118.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1521
    Cell Significance Index: 31.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8469
    Cell Significance Index: 137.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7761
    Cell Significance Index: 40.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5768
    Cell Significance Index: 15.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5593
    Cell Significance Index: 35.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5460
    Cell Significance Index: 109.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5459
    Cell Significance Index: 28.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4132
    Cell Significance Index: 14.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4039
    Cell Significance Index: 55.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3903
    Cell Significance Index: 11.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3683
    Cell Significance Index: 45.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3496
    Cell Significance Index: 66.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3120
    Cell Significance Index: 6.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2993
    Cell Significance Index: 53.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2757
    Cell Significance Index: 98.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2488
    Cell Significance Index: 16.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2444
    Cell Significance Index: 133.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2323
    Cell Significance Index: 29.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1925
    Cell Significance Index: 19.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1876
    Cell Significance Index: 13.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1819
    Cell Significance Index: 21.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1692
    Cell Significance Index: 74.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1624
    Cell Significance Index: 32.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1604
    Cell Significance Index: 7.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1453
    Cell Significance Index: 18.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1325
    Cell Significance Index: 6.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1279
    Cell Significance Index: 3.6500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1242
    Cell Significance Index: 1.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1154
    Cell Significance Index: 2.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0802
    Cell Significance Index: 5.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0777
    Cell Significance Index: 2.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0551
    Cell Significance Index: 1.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0412
    Cell Significance Index: 1.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0329
    Cell Significance Index: 0.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0302
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0286
    Cell Significance Index: 4.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0278
    Cell Significance Index: 1.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0089
    Cell Significance Index: 0.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -9.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0062
    Cell Significance Index: -3.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0100
    Cell Significance Index: -0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0112
    Cell Significance Index: -7.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0146
    Cell Significance Index: -10.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0171
    Cell Significance Index: -31.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0193
    Cell Significance Index: -0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0206
    Cell Significance Index: -31.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0219
    Cell Significance Index: -29.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0302
    Cell Significance Index: -3.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0318
    Cell Significance Index: -17.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0399
    Cell Significance Index: -1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0415
    Cell Significance Index: -18.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0495
    Cell Significance Index: -2.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0518
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0585
    Cell Significance Index: -12.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0588
    Cell Significance Index: -4.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0634
    Cell Significance Index: -18.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0812
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0890
    Cell Significance Index: -10.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0934
    Cell Significance Index: -10.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0936
    Cell Significance Index: -13.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0948
    Cell Significance Index: -1.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1756
    Cell Significance Index: -3.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1935
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2052
    Cell Significance Index: -23.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2094
    Cell Significance Index: -16.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2229
    Cell Significance Index: -3.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2496
    Cell Significance Index: -25.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2521
    Cell Significance Index: -11.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2687
    Cell Significance Index: -21.2800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2787
    Cell Significance Index: -1.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2882
    Cell Significance Index: -6.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3048
    Cell Significance Index: -7.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3054
    Cell Significance Index: -15.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3411
    Cell Significance Index: -20.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3570
    Cell Significance Index: -13.5200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3658
    Cell Significance Index: -3.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4142
    Cell Significance Index: -7.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4424
    Cell Significance Index: -10.2200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4580
    Cell Significance Index: -6.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5001
    Cell Significance Index: -4.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5004
    Cell Significance Index: -4.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5121
    Cell Significance Index: -3.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5215
    Cell Significance Index: -4.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UBQLN2 shares structural similarity with other ubiquilin proteins, which are characterized by their ability to bind to ubiquitin chains. The UBQLN2 protein is a tetramer, composed of four identical subunits, each consisting of a ubiquitin-like domain and a ubiquitin-binding domain. The protein is primarily localized to the cytoplasm and is involved in the regulation of autophagosome assembly and the erad pathway. **Pathways and Functions** UBQLN2 plays a crucial role in several cellular pathways, including: 1. **Autophagosome Assembly**: UBQLN2 is involved in the assembly of autophagosomes, which are double-membraned structures responsible for the degradation and recycling of cellular components. 2. **Cargo Recognition for Clathrin-Mediated Endocytosis**: UBQLN2 is involved in the recognition of cargo for clathrin-mediated endocytosis, a process by which cells internalize and degrade proteins and lipids. 3. **Erad Pathway**: UBQLN2 is involved in the regulation of the erad pathway, a process responsible for the degradation of damaged or dysfunctional cellular components. 4. **Regulation of Autophagosome Assembly**: UBQLN2 is involved in the regulation of autophagosome assembly, ensuring that autophagosomes are formed and functional. 5. **Regulation of Macroautophagy**: UBQLN2 is involved in the regulation of macroautophagy, a process by which cells degrade and recycle large cellular components. **Clinical Significance** Dysregulation of UBQLN2 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders**: UBQLN2 has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where autophagy is impaired. 2. **Cancer**: UBQLN2 has been implicated in cancer, where autophagy is often dysregulated, leading to cancer progression and metastasis. 3. **Immune Disorders**: UBQLN2 has been implicated in immune disorders, such as autoimmune diseases, where autophagy is impaired, leading to immune dysfunction. In conclusion, UBQLN2 is a critical gene involved in the regulation of autophagy and cellular homeostasis. Dysregulation of UBQLN2 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular health and overall well-being.

Genular Protein ID: 3255919259

Symbol: UBQL2_HUMAN

Name: Ubiquilin-2

UniProtKB Accession Codes:

Q9UHD9 O94798 Q5D027 Q9H3W6 Q9HAZ4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10675567

Title: A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.

PubMed ID: 10675567

DOI: 10.1016/s0014-5793(00)01135-2

PubMed ID: 10983987

Title: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.

PubMed ID: 10983987

DOI: 10.1016/s1097-2765(00)00040-x

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 9853615

Title: Selection system for genes encoding nuclear-targeted proteins.

PubMed ID: 9853615

DOI: 10.1038/4315

PubMed ID: 16813565

Title: Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.

PubMed ID: 16813565

DOI: 10.1042/bj20060441

PubMed ID: 17098253

Title: Ubiquitin receptor proteins hHR23a and hPLIC2 interact.

PubMed ID: 17098253

DOI: 10.1016/j.jmb.2006.10.056

PubMed ID: 18307982

Title: Herp enhances ER-associated protein degradation by recruiting ubiquilins.

PubMed ID: 18307982

DOI: 10.1016/j.bbrc.2008.02.086

PubMed ID: 18199683

Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.

PubMed ID: 18199683

DOI: 10.1091/mbc.e07-08-0775

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19148225

Title: PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.

PubMed ID: 19148225

DOI: 10.1038/embor.2008.238

PubMed ID: 20729634

Title: Ubiquilin at a crossroads in protein degradation pathways.

PubMed ID: 20729634

DOI: 10.4161/auto.6.7.13118

PubMed ID: 20529957

Title: Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.

PubMed ID: 20529957

DOI: 10.1093/hmg/ddq231

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22628307

Title: Ubiquilins in the crosstalk among proteolytic pathways.

PubMed ID: 22628307

DOI: 10.1515/hsz-2012-0120

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23541532

Title: Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.

PubMed ID: 23541532

DOI: 10.1016/j.bbapap.2013.03.020

PubMed ID: 23459205

Title: Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.

PubMed ID: 23459205

DOI: 10.1038/embor.2013.22

PubMed ID: 24674348

Title: The ubiquilin gene family: evolutionary patterns and functional insights.

PubMed ID: 24674348

DOI: 10.1186/1471-2148-14-63

PubMed ID: 24549040

Title: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

PubMed ID: 24549040

DOI: 10.1093/hmg/ddu068

PubMed ID: 24589709

Title: Ubiquilin 2: a component of the ubiquitin-proteasome system with an emerging role in neurodegeneration.

PubMed ID: 24589709

DOI: 10.1016/j.biocel.2014.02.018

PubMed ID: 24215460

Title: Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation.

PubMed ID: 24215460

DOI: 10.1111/jnc.12606

PubMed ID: 11827521

Title: Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.

PubMed ID: 11827521

DOI: 10.1021/bi011892y

PubMed ID: 21857683

Title: Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.

PubMed ID: 21857683

DOI: 10.1038/nature10353

PubMed ID: 22892309

Title: Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype.

PubMed ID: 22892309

DOI: 10.1016/j.neurobiolaging.2012.07.002

PubMed ID: 22717235

Title: UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis.

PubMed ID: 22717235

DOI: 10.1016/j.neurobiolaging.2012.05.008

PubMed ID: 22560112

Title: UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis.

PubMed ID: 22560112

DOI: 10.1016/j.neurobiolaging.2012.03.015

PubMed ID: 25616961

Title: ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1.

PubMed ID: 25616961

DOI: 10.1093/hmg/ddv020

Sequence Information:

  • Length: 624
  • Mass: 65696
  • Checksum: DF7DF8C4D7B71AC3
  • Sequence:
    • MAENGESSGP PRPSRGPAAA QGSAAAPAEP KIIKVTVKTP KEKEEFAVPE NSSVQQFKEA 
ISKRFKSQTD QLVLIFAGKI LKDQDTLIQH GIHDGLTVHL VIKSQNRPQG QSTQPSNAAG 
TNTTSASTPR SNSTPISTNS NPFGLGSLGG LAGLSSLGLS STNFSELQSQ MQQQLMASPE 
MMIQIMENPF VQSMLSNPDL MRQLIMANPQ MQQLIQRNPE ISHLLNNPDI MRQTLEIARN 
PAMMQEMMRN QDLALSNLES IPGGYNALRR MYTDIQEPML NAAQEQFGGN PFASVGSSSS 
SGEGTQPSRT ENRDPLPNPW APPPATQSSA TTSTTTSTGS GSGNSSSNAT GNTVAAANYV 
ASIFSTPGMQ SLLQQITENP QLIQNMLSAP YMRSMMQSLS QNPDLAAQMM LNSPLFTANP 
QLQEQMRPQL PAFLQQMQNP DTLSAMSNPR AMQALMQIQQ GLQTLATEAP GLIPSFTPGV 
GVGVLGTAIG PVGPVTPIGP IGPIVPFTPI GPIGPIGPTG PAAPPGSTGS GGPTGPTVSS 
AAPSETTSPT SESGPNQQFI QQMVQALAGA NAPQLPNPEV RFQQQLEQLN AMGFLNREAN 
LQALIATGGD INAAIERLLG SQPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.