Details for: H1 2

Gene ID: 3006

Symbol: H1 2

Ensembl ID: ENSG00000187837

Description: H1.2 linker histone, cluster member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 149.8439
    Cell Significance Index: -23.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.6455
    Cell Significance Index: -29.8400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 93.7983
    Cell Significance Index: -38.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.8053
    Cell Significance Index: -38.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.4104
    Cell Significance Index: -38.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.8444
    Cell Significance Index: -31.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3435
    Cell Significance Index: -36.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8702
    Cell Significance Index: -18.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.2503
    Cell Significance Index: 274.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2135
    Cell Significance Index: 60.2500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.0780
    Cell Significance Index: 17.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6751
    Cell Significance Index: 182.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3774
    Cell Significance Index: 82.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2772
    Cell Significance Index: 126.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1701
    Cell Significance Index: 190.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0372
    Cell Significance Index: 15.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0181
    Cell Significance Index: 15.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9972
    Cell Significance Index: 51.8000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.9402
    Cell Significance Index: 9.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9236
    Cell Significance Index: 63.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8163
    Cell Significance Index: 51.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7958
    Cell Significance Index: 17.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7923
    Cell Significance Index: 432.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7693
    Cell Significance Index: 90.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7669
    Cell Significance Index: 36.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7269
    Cell Significance Index: 32.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5925
    Cell Significance Index: 76.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5856
    Cell Significance Index: 67.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5722
    Cell Significance Index: 26.6800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4554
    Cell Significance Index: 3.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4290
    Cell Significance Index: 52.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4156
    Cell Significance Index: 11.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3734
    Cell Significance Index: 51.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3181
    Cell Significance Index: 23.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3098
    Cell Significance Index: 21.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3050
    Cell Significance Index: 54.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2988
    Cell Significance Index: 38.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2705
    Cell Significance Index: 53.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2445
    Cell Significance Index: 7.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2099
    Cell Significance Index: 92.8200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2060
    Cell Significance Index: 1.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1975
    Cell Significance Index: 6.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1796
    Cell Significance Index: 30.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1720
    Cell Significance Index: 9.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1558
    Cell Significance Index: 4.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1140
    Cell Significance Index: 1.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0791
    Cell Significance Index: 15.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0184
    Cell Significance Index: 0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0123
    Cell Significance Index: 9.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0031
    Cell Significance Index: 2.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0062
    Cell Significance Index: -11.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0194
    Cell Significance Index: -14.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0197
    Cell Significance Index: -1.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0221
    Cell Significance Index: -40.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0237
    Cell Significance Index: -36.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0244
    Cell Significance Index: -2.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0291
    Cell Significance Index: -0.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0296
    Cell Significance Index: -40.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0297
    Cell Significance Index: -1.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0348
    Cell Significance Index: -22.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0373
    Cell Significance Index: -1.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0506
    Cell Significance Index: -28.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0633
    Cell Significance Index: -0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0642
    Cell Significance Index: -29.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0690
    Cell Significance Index: -24.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0774
    Cell Significance Index: -5.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0911
    Cell Significance Index: -56.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0912
    Cell Significance Index: -2.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0926
    Cell Significance Index: -26.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1150
    Cell Significance Index: -1.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1214
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1548
    Cell Significance Index: -3.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1612
    Cell Significance Index: -3.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1628
    Cell Significance Index: -32.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1729
    Cell Significance Index: -25.1400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2176
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2259
    Cell Significance Index: -47.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2282
    Cell Significance Index: -5.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2685
    Cell Significance Index: -7.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2850
    Cell Significance Index: -22.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3140
    Cell Significance Index: -32.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3233
    Cell Significance Index: -8.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3706
    Cell Significance Index: -4.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3965
    Cell Significance Index: -4.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4924
    Cell Significance Index: -8.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5064
    Cell Significance Index: -13.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5176
    Cell Significance Index: -12.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5303
    Cell Significance Index: -15.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6082
    Cell Significance Index: -37.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7092
    Cell Significance Index: -18.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7173
    Cell Significance Index: -14.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7531
    Cell Significance Index: -13.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7718
    Cell Significance Index: -10.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.7734
    Cell Significance Index: -5.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7804
    Cell Significance Index: -27.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7948
    Cell Significance Index: -29.1800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.7968
    Cell Significance Index: -6.3400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.8491
    Cell Significance Index: -4.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8491
    Cell Significance Index: -5.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8614
    Cell Significance Index: -38.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Histone H1.2 is a highly conserved protein that belongs to the H1 family of histones. It is characterized by its ability to bind to DNA and nucleosomes, forming a scaffold that facilitates chromatin assembly and compaction. Histone H1.2 is also known for its involvement in the regulation of gene expression, particularly in the context of apoptosis and cellular stress responses. Its expression is dynamically regulated during various cellular processes, including cell proliferation, differentiation, and senescence. **Pathways and Functions** Histone H1.2 plays a critical role in several cellular pathways, including: 1. **Apoptosis**: Histone H1.2 is involved in the regulation of apoptosis, a process of programmed cell death. It interacts with other proteins to modulate the activity of caspases, enzymes that execute the apoptotic program. 2. **Chromatin remodeling**: Histone H1.2 is essential for the assembly and compaction of chromatin, a complex of DNA and histone proteins. It helps to regulate the structure and function of chromatin, influencing gene expression and cellular responses to stress. 3. **Cellular responses to stimuli**: Histone H1.2 is involved in the regulation of cellular responses to various stimuli, including DNA damage, telomere stress, and senescence. 4. **Cellular senescence**: Histone H1.2 is implicated in the regulation of cellular senescence, a state of permanent cell cycle arrest that occurs in response to DNA damage or telomere shortening. **Clinical Significance** The dysregulation of Histone H1.2 has been implicated in various diseases, including: 1. **Cancer**: Histone H1.2 is often overexpressed in cancer cells, where it contributes to the regulation of gene expression and chromatin remodeling. 2. **Autoimmune diseases**: Histone H1.2 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis. 3. **Neurological disorders**: Histone H1.2 has been implicated in the regulation of neuronal function and plasticity, and its dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, Histone H1.2 is a critical protein that plays a pivotal role in maintaining the structure and function of chromatin. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of Histone H1.2 regulation and its role in human disease.

Genular Protein ID: 2678407538

Symbol: H12_HUMAN

Name: Histone H1.2

UniProtKB Accession Codes:

P16403 A8K4I2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 2 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2759094

Title: Human H1 histones: conserved and varied sequence elements in two H1 subtype genes.

PubMed ID: 2759094

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2613692

Title: Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d.

PubMed ID: 2613692

DOI: 10.1093/oxfordjournals.jbchem.a122941

PubMed ID: 8003976

Title: A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences.

PubMed ID: 8003976

DOI: 10.1002/pro.5560030406

PubMed ID: 10997781

Title: The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.

PubMed ID: 10997781

DOI: 10.1023/a:1009262819961

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20334638

Title: Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D.

PubMed ID: 20334638

DOI: 10.1186/1756-8935-3-7

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

PubMed ID: 34681573

Title: Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry.

PubMed ID: 34681573

DOI: 10.3390/ijms222010913

Sequence Information:

  • Length: 213
  • Mass: 21365
  • Checksum: AA66EA1901D8D56B
  • Sequence:
    • MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA SKERSGVSLA 
ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKV 
KKAGGTKPKK PVGAAKKPKK AAGGATPKKS AKKTPKKAKK PAAATVTKKV AKSPKKAKVA 
KPKKAAKSAA KAVKPKAAKP KVVKPKKAAP KKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.