Gene H1 2 - ENSG00000187837 | NCBI Gene ID: 3006

Details for: H1 2

Gene ID: 3006

Symbol: H1 2

Ensembl ID: ENSG00000187837

Description: H1.2 linker histone, cluster member

Associated with

Apoptosis
(R-HSA-109581)
Apoptosis induced dna fragmentation
(R-HSA-140342)
Apoptotic execution phase
(R-HSA-75153)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Formation of senescence-associated heterochromatin foci (sahf)
(R-HSA-2559584)
Programmed cell death
(R-HSA-5357801)
Chromatin dna binding
(GO:0031490)
Chromosome condensation
(GO:0030261)
Double-stranded dna binding
(GO:0003690)
Euchromatin
(GO:0000791)
Negative regulation of dna recombination
(GO:0045910)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleosomal dna binding
(GO:0031492)
Nucleosome
(GO:0000786)
Nucleosome assembly
(GO:0006334)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.5
Marker Score: 9489.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 3.61
Marker Score: 3536.5
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 3.02
Marker Score: 3624
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.79
Marker Score: 2047
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.62
Marker Score: 1536
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.57
Marker Score: 12646
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.56
Marker Score: 1745
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.52
Marker Score: 1086
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.47
Marker Score: 24998
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.37
Marker Score: 2111
Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.29
Marker Score: 2705
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.29
Marker Score: 5620
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.1
Marker Score: 5123
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.05
Marker Score: 708
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.02
Marker Score: 718
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2
Marker Score: 5616
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.92
Marker Score: 3401
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.89
Marker Score: 5126
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.87
Marker Score: 1470
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.84
Marker Score: 1452
Cell Name: malignant cell (CL0001064)
Fold Change: 1.82
Marker Score: 24471
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.81
Marker Score: 1053
Cell Name: enterocyte (CL0000584)
Fold Change: 1.79
Marker Score: 8586
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.75
Marker Score: 5500
Cell Name: blood cell (CL0000081)
Fold Change: 1.73
Marker Score: 20165
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.73
Marker Score: 442
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.72
Marker Score: 859
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.66
Marker Score: 3485.5
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.65
Marker Score: 456
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.62
Marker Score: 2380
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.59
Marker Score: 8382
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.53
Marker Score: 13271.5
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.49
Marker Score: 443
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.47
Marker Score: 699
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166853
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.44
Marker Score: 1565
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.43
Marker Score: 1445
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.43
Marker Score: 1216
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.4
Marker Score: 930
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.4
Marker Score: 433
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.39
Marker Score: 1339.5
Cell Name: thymocyte (CL0000893)
Fold Change: 1.36
Marker Score: 1426.5
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.34
Marker Score: 583
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.32
Marker Score: 885
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.31
Marker Score: 1882
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.29
Marker Score: 11111
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.27
Marker Score: 766
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.27
Marker Score: 918
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.27
Marker Score: 531
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.27
Marker Score: 620
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.27
Marker Score: 4702
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.27
Marker Score: 1316
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.26
Marker Score: 1948
Cell Name: Unknown (CL0000548)
Fold Change: 1.26
Marker Score: 919
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 1.25
Marker Score: 487
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.25
Marker Score: 410
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.23
Marker Score: 2339
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.22
Marker Score: 420
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.21
Marker Score: 2756
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.21
Marker Score: 9412
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.2
Marker Score: 663
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.19
Marker Score: 1682
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.18
Marker Score: 623
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.17
Marker Score: 15577
Cell Name: secretory cell (CL0000151)
Fold Change: 1.17
Marker Score: 2127
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 1.15
Marker Score: 346
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.15
Marker Score: 302
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.14
Marker Score: 1875.5
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.14
Marker Score: 3909
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.14
Marker Score: 1808
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.13
Marker Score: 1978
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.13
Marker Score: 858
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.13
Marker Score: 1419
Cell Name: mature B cell (CL0000785)
Fold Change: 1.12
Marker Score: 822
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 1.12
Marker Score: 733
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.12
Marker Score: 456
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.12
Marker Score: 389
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 1.11
Marker Score: 466
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.11
Marker Score: 1333
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.11
Marker Score: 3156.5
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.11
Marker Score: 505
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.1
Marker Score: 289
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.1
Marker Score: 443
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.1
Marker Score: 917.5
Cell Name: keratocyte (CL0002363)
Fold Change: 1.1
Marker Score: 252
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.09
Marker Score: 37854
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 1.09
Marker Score: 240
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.08
Marker Score: 533
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.08
Marker Score: 556
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.08
Marker Score: 6887.5
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.07
Marker Score: 678
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.07
Marker Score: 1036
Cell Name: osteoblast (CL0000062)
Fold Change: 1.07
Marker Score: 575
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.07
Marker Score: 2094
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.05
Marker Score: 711
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.04
Marker Score: 249.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.04
Marker Score: 1033
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.04
Marker Score: 235
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.03
Marker Score: 806
Cell Name: plasmablast (CL0000980)
Fold Change: 1.02
Marker Score: 1361

Hover over a box to see details here...

**Key characteristics:** - H1.2 is a basic histone that is found in all eukaryotic cells. - It is a linker histone, which means that it helps to connect DNA molecules together. - H1.2 is a highly conserved protein, with a sequence that is found in organisms from yeast to humans. - It is known to be a key regulator of cell death and differentiation. **Pathways and functions:** - H1.2 is involved in the regulation of apoptosis, the programmed cell death process. - It is also involved in the regulation of cell differentiation and tissue homeostasis. - H1.2 is expressed in cells that are in the process of differentiating into an apoptotic cell. - It is also expressed in cells that are in the process of dying. **Clinical significance:** H1.2 is a potential therapeutic target for cancer. Inhibition of H1.2 has been shown to inhibit apoptosis in cancer cells, leading to the growth of tumors. This suggests that H1.2 is a potential target for the treatment of cancer. **Additional information:** - H1.2 is a highly conserved protein, with a sequence that is found in organisms from yeast to humans. - It is known to be a key regulator of cell death and differentiation. - H1.2 is a potential therapeutic target for cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H1.2

Genular Protein ID: 2678407538

Symbol: H12_HUMAN

Name: Histone H1.2

UniProtKB Accession Codes:

P16403 A8K4I2

Database IDs:

Citations:

PubMed ID: 2759094

Title: Human H1 histones: conserved and varied sequence elements in two H1 subtype genes.

PubMed ID: 2759094

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2613692

Title: Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d.

PubMed ID: 2613692

DOI: 10.1093/oxfordjournals.jbchem.a122941

PubMed ID: 8003976

Title: A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences.

PubMed ID: 8003976

DOI: 10.1002/pro.5560030406

PubMed ID: 10997781

Title: The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.

PubMed ID: 10997781

DOI: 10.1023/a:1009262819961

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20334638

Title: Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D.

PubMed ID: 20334638

DOI: 10.1186/1756-8935-3-7

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

PubMed ID: 34681573

Title: Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry.

PubMed ID: 34681573

DOI: 10.3390/ijms222010913

Sequence Information:

Length: 213
Mass: 21365
Checksum: AA66EA1901D8D56B
Sequence:

MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA SKERSGVSLA 
ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKV 
KKAGGTKPKK PVGAAKKPKK AAGGATPKKS AKKTPKKAKK PAAATVTKKV AKSPKKAKVA 
KPKKAAKSAA KAVKPKAAKP KVVKPKKAAP KKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: H1 2

Associated with

Cells (max top 100)

Other Information

Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. PubMed ID: 2759094

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d. PubMed ID: 2613692

A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences. PubMed ID: 8003976

The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. PubMed ID: 10997781

H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain. PubMed ID: 15911621

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D. PubMed ID: 20334638

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Serine is a new target residue for endogenous ADP-ribosylation on histones. PubMed ID: 27723750

Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry. PubMed ID: 34681573