Details for: H1 1

Gene ID: 3024

Symbol: H1 1

Ensembl ID: ENSG00000124610

Description: H1.1 linker histone, cluster member

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 3.24
    Marker Score: 1260
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.29
    Marker Score: 4006
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.66
    Marker Score: 2387
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.44
    Marker Score: 2067
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.28
    Marker Score: 772
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.04
    Marker Score: 256
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2525
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.87
    Marker Score: 1481
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.86
    Marker Score: 1083
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.72
    Marker Score: 2665
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.65
    Marker Score: 680
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.65
    Marker Score: 610
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.6
    Marker Score: 216
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.57
    Marker Score: 189
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.54
    Marker Score: 186
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.53
    Marker Score: 386
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.51
    Marker Score: 148
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.51
    Marker Score: 407
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.47
    Marker Score: 294
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.46
    Marker Score: 221
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 272
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.45
    Marker Score: 220
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.44
    Marker Score: 474
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.44
    Marker Score: 924
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.44
    Marker Score: 1196.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.44
    Marker Score: 241
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.43
    Marker Score: 294
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.43
    Marker Score: 1214
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.42
    Marker Score: 206
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.42
    Marker Score: 192
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.42
    Marker Score: 278
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.38
    Marker Score: 320
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.38
    Marker Score: 2269
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.38
    Marker Score: 282
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.37
    Marker Score: 391.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.35
    Marker Score: 963
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.35
    Marker Score: 255
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.34
    Marker Score: 96
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.34
    Marker Score: 696
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.33
    Marker Score: 2153
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.31
    Marker Score: 78
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.3
    Marker Score: 4004
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.3
    Marker Score: 119
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.28
    Marker Score: 269
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.27
    Marker Score: 72
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.27
    Marker Score: 271
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.27
    Marker Score: 790
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.26
    Marker Score: 622
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.26
    Marker Score: 138
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.26
    Marker Score: 60
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.25
    Marker Score: 227
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.23
    Marker Score: 68
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.23
    Marker Score: 174
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.22
    Marker Score: 80
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.21
    Marker Score: 201
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.21
    Marker Score: 125
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2
    Marker Score: 133
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.2
    Marker Score: 99
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.2
    Marker Score: 211
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.2
    Marker Score: 98
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.19
    Marker Score: 1929.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.19
    Marker Score: 1411
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.18
    Marker Score: 296
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.18
    Marker Score: 109
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.18
    Marker Score: 94
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.17
    Marker Score: 113
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.16
    Marker Score: 440
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.16
    Marker Score: 163
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.16
    Marker Score: 49
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.15
    Marker Score: 75
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.15
    Marker Score: 101
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.15
    Marker Score: 166
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.15
    Marker Score: 110
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.15
    Marker Score: 150
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.15
    Marker Score: 215
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.14
    Marker Score: 150
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 72

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Other Information

**Key characteristics:** - H1.1 is a globular protein with a molecular weight of approximately 120 kDa. - It is a member of the H1 family of histone proteins, which are characterized by their ability to bind to DNA and regulate gene expression. - H1.1 is found in a variety of cell types, including neuroendocrine cells, germ cells, and immune cells. **Pathways and functions:** - H1.1 is involved in apoptosis through various mechanisms, including DNA fragmentation, chromatin remodeling, and activation of pro-apoptotic signaling pathways. - It is a key regulator of cellular senescence, promoting cell cycle arrest and differentiation into a resting or senescent state. - H1.1 also plays a role in the regulation of fertility by controlling the expression of genes involved in spermatogenesis. - It is involved in the regulation of immune responses, where it helps to control the activation of immune cells and maintain immune homeostasis. **Clinical significance:** - Mutations in the H1.1 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. - H1.1 inhibitors are being investigated as potential therapeutic agents for cancer and other diseases that are characterized by abnormal cell growth and survival.

Genular Protein ID: 3529078836

Symbol: H11_HUMAN

Name: Histone H1.1

UniProtKB Accession Codes:

Q02539 Q3MJ34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2759094

Title: Human H1 histones: conserved and varied sequence elements in two H1 subtype genes.

PubMed ID: 2759094

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8003976

Title: A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences.

PubMed ID: 8003976

DOI: 10.1002/pro.5560030406

PubMed ID: 14985337

Title: The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo.

PubMed ID: 14985337

DOI: 10.1074/jbc.m400070200

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 19882353

Title: Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells.

PubMed ID: 19882353

DOI: 10.1007/s10495-009-0418-7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 215
  • Mass: 21842
  • Checksum: 854B03622D78774A
  • Sequence:
    • MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA ASSSKERGGV 
SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK GTGASGSFKL NKKASSVETK 
PGASKVATKT KATGASKKLK KATGASKKSV KTPKKAKKPA ATRKSSKNPK KPKTVKPKKV 
AKSPAKAKAV KPKAAKARVT KPKTAKPKKA APKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.