Details for: H1 1

Gene ID: 3024

Symbol: H1 1

Ensembl ID: ENSG00000124610

Description: H1.1 linker histone, cluster member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 40.8884
    Cell Significance Index: -6.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.8093
    Cell Significance Index: -6.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.5395
    Cell Significance Index: -6.8300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.6985
    Cell Significance Index: 12.8300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.6185
    Cell Significance Index: 9.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.0060
    Cell Significance Index: -3.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8555
    Cell Significance Index: 9.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7802
    Cell Significance Index: 22.9800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.6764
    Cell Significance Index: 4.4900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.6566
    Cell Significance Index: 9.2100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5949
    Cell Significance Index: 4.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4199
    Cell Significance Index: 8.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3865
    Cell Significance Index: 20.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2171
    Cell Significance Index: 2.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1771
    Cell Significance Index: 20.8900
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.1256
    Cell Significance Index: 0.3600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.0946
    Cell Significance Index: 0.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0903
    Cell Significance Index: 49.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0867
    Cell Significance Index: 38.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0624
    Cell Significance Index: 1.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0545
    Cell Significance Index: 9.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0515
    Cell Significance Index: 7.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0485
    Cell Significance Index: 0.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0393
    Cell Significance Index: 4.8300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0339
    Cell Significance Index: 0.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0219
    Cell Significance Index: 16.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0137
    Cell Significance Index: 1.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0053
    Cell Significance Index: -0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0072
    Cell Significance Index: -11.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0084
    Cell Significance Index: -11.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0090
    Cell Significance Index: -5.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0146
    Cell Significance Index: -0.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0149
    Cell Significance Index: -4.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0151
    Cell Significance Index: -5.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0164
    Cell Significance Index: -7.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0175
    Cell Significance Index: -3.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0180
    Cell Significance Index: -10.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0217
    Cell Significance Index: -0.6100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0227
    Cell Significance Index: -0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0253
    Cell Significance Index: -1.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0299
    Cell Significance Index: -0.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0331
    Cell Significance Index: -6.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0336
    Cell Significance Index: -0.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0343
    Cell Significance Index: -2.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0388
    Cell Significance Index: -5.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0420
    Cell Significance Index: -1.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0445
    Cell Significance Index: -0.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0457
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0504
    Cell Significance Index: -10.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0519
    Cell Significance Index: -5.3000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0549
    Cell Significance Index: -0.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0627
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0631
    Cell Significance Index: -10.7800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0656
    Cell Significance Index: -0.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0689
    Cell Significance Index: -5.2900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0728
    Cell Significance Index: -0.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0802
    Cell Significance Index: -10.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0863
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0909
    Cell Significance Index: -10.4100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0921
    Cell Significance Index: -0.9500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0932
    Cell Significance Index: -1.1800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0945
    Cell Significance Index: -1.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1057
    Cell Significance Index: -4.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1103
    Cell Significance Index: -2.9000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1273
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1319
    Cell Significance Index: -1.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1338
    Cell Significance Index: -3.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1348
    Cell Significance Index: -7.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1362
    Cell Significance Index: -3.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1402
    Cell Significance Index: -6.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1465
    Cell Significance Index: -10.9200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1476
    Cell Significance Index: -1.9300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1547
    Cell Significance Index: -0.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1630
    Cell Significance Index: -7.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1640
    Cell Significance Index: -3.7900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1772
    Cell Significance Index: -1.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1896
    Cell Significance Index: -7.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1977
    Cell Significance Index: -4.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1988
    Cell Significance Index: -6.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2011
    Cell Significance Index: -6.5900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2013
    Cell Significance Index: -1.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2028
    Cell Significance Index: -5.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2086
    Cell Significance Index: -7.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2126
    Cell Significance Index: -6.8100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2141
    Cell Significance Index: -1.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2145
    Cell Significance Index: -5.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2155
    Cell Significance Index: -7.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2157
    Cell Significance Index: -6.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2167
    Cell Significance Index: -1.8200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2199
    Cell Significance Index: -3.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2218
    Cell Significance Index: -5.5400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.2236
    Cell Significance Index: -1.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2355
    Cell Significance Index: -1.8800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2373
    Cell Significance Index: -3.4000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2393
    Cell Significance Index: -1.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The H1.1 linker histone is a type of histone protein, which is a fundamental component of chromatin. It is characterized by its ability to bind to DNA and its role in maintaining the structure of chromatin. The H1.1 linker histone is composed of a globular head domain and a long, unstructured tail domain. The head domain is responsible for DNA binding, while the tail domain interacts with other chromatin proteins and regulates chromatin structure. **Pathways and Functions:** The H1.1 linker histone is involved in various cellular pathways, including: 1. **Apoptosis**: The H1.1 linker histone regulates apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins, thereby modulating the cell death process. 2. **DNA Repair**: The H1.1 linker histone is involved in DNA repair mechanisms, including non-homologous end joining and homologous recombination. 3. **Cell Cycle Regulation**: The H1.1 linker histone regulates cell cycle progression by interacting with cyclin-dependent kinases and other cell cycle regulators. 4. **Chromatin Remodeling**: The H1.1 linker histone is involved in chromatin remodeling, which is essential for gene expression and transcriptional regulation. **Clinical Significance:** Dysregulation of the H1.1 linker histone has been implicated in various diseases, including: 1. **Cancer**: The H1.1 linker histone is frequently overexpressed in cancer cells, leading to chromatin instability and poor prognosis. 2. **Neurodegenerative Disorders**: The H1.1 linker histone has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where it plays a role in chromatin structure and function. 3. **Autoimmune Diseases**: The H1.1 linker histone is involved in autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates the immune response and chromatin structure. In conclusion, the H1.1 linker histone is a crucial component of chromatin structure and function, playing a vital role in various cellular processes, including apoptosis, DNA repair, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 3529078836

Symbol: H11_HUMAN

Name: Histone H1.1

UniProtKB Accession Codes:

Q02539 Q3MJ34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2759094

Title: Human H1 histones: conserved and varied sequence elements in two H1 subtype genes.

PubMed ID: 2759094

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8003976

Title: A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences.

PubMed ID: 8003976

DOI: 10.1002/pro.5560030406

PubMed ID: 14985337

Title: The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo.

PubMed ID: 14985337

DOI: 10.1074/jbc.m400070200

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 19882353

Title: Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells.

PubMed ID: 19882353

DOI: 10.1007/s10495-009-0418-7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 215
  • Mass: 21842
  • Checksum: 854B03622D78774A
  • Sequence:
    • MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA ASSSKERGGV 
SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK GTGASGSFKL NKKASSVETK 
PGASKVATKT KATGASKKLK KATGASKKSV KTPKKAKKPA ATRKSSKNPK KPKTVKPKKV 
AKSPAKAKAV KPKAAKARVT KPKTAKPKKA APKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.