Details for: HARS1

Gene ID: 3035

Symbol: HARS1

Ensembl ID: ENSG00000170445

Description: histidyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.8255
    Cell Significance Index: -26.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.4089
    Cell Significance Index: -29.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.8990
    Cell Significance Index: -37.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.9710
    Cell Significance Index: -31.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 69.2866
    Cell Significance Index: -35.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.6017
    Cell Significance Index: -37.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.0979
    Cell Significance Index: -31.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8437
    Cell Significance Index: -34.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9761
    Cell Significance Index: -35.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.7767
    Cell Significance Index: -17.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5050
    Cell Significance Index: 301.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9987
    Cell Significance Index: 162.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9268
    Cell Significance Index: 836.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8634
    Cell Significance Index: 11.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5980
    Cell Significance Index: 214.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5798
    Cell Significance Index: 79.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5531
    Cell Significance Index: 29.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5496
    Cell Significance Index: 14.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5405
    Cell Significance Index: 37.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5393
    Cell Significance Index: 107.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5333
    Cell Significance Index: 4.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5230
    Cell Significance Index: 15.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4619
    Cell Significance Index: 252.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4139
    Cell Significance Index: 19.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4004
    Cell Significance Index: 177.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3930
    Cell Significance Index: 25.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3484
    Cell Significance Index: 24.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3399
    Cell Significance Index: 40.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3371
    Cell Significance Index: 14.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3263
    Cell Significance Index: 7.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3196
    Cell Significance Index: 21.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3078
    Cell Significance Index: 11.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2960
    Cell Significance Index: 53.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2943
    Cell Significance Index: 36.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2593
    Cell Significance Index: 13.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2431
    Cell Significance Index: 31.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2145
    Cell Significance Index: 4.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1889
    Cell Significance Index: 5.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1676
    Cell Significance Index: 21.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1650
    Cell Significance Index: 16.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1630
    Cell Significance Index: 8.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1578
    Cell Significance Index: 4.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1507
    Cell Significance Index: 4.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1483
    Cell Significance Index: 5.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1385
    Cell Significance Index: 95.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1258
    Cell Significance Index: 23.9400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1155
    Cell Significance Index: 1.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0844
    Cell Significance Index: 2.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0556
    Cell Significance Index: 2.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0404
    Cell Significance Index: 3.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0385
    Cell Significance Index: 6.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0354
    Cell Significance Index: 1.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0231
    Cell Significance Index: 0.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0196
    Cell Significance Index: 36.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0109
    Cell Significance Index: 0.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0153
    Cell Significance Index: -9.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0199
    Cell Significance Index: -15.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0233
    Cell Significance Index: -17.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0313
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0431
    Cell Significance Index: -31.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0535
    Cell Significance Index: -5.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0601
    Cell Significance Index: -33.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0609
    Cell Significance Index: -38.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0659
    Cell Significance Index: -3.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0773
    Cell Significance Index: -1.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0926
    Cell Significance Index: -1.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0993
    Cell Significance Index: -4.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1035
    Cell Significance Index: -29.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1095
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1172
    Cell Significance Index: -13.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1327
    Cell Significance Index: -6.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1447
    Cell Significance Index: -21.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1837
    Cell Significance Index: -38.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2160
    Cell Significance Index: -4.7300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2278
    Cell Significance Index: -2.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2416
    Cell Significance Index: -4.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2454
    Cell Significance Index: -6.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2592
    Cell Significance Index: -6.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3079
    Cell Significance Index: -9.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3116
    Cell Significance Index: -32.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3200
    Cell Significance Index: -8.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3865
    Cell Significance Index: -30.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4237
    Cell Significance Index: -12.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4456
    Cell Significance Index: -7.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4566
    Cell Significance Index: -6.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5335
    Cell Significance Index: -32.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5557
    Cell Significance Index: -11.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5695
    Cell Significance Index: -11.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5914
    Cell Significance Index: -24.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6209
    Cell Significance Index: -15.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6361
    Cell Significance Index: -20.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6678
    Cell Significance Index: -7.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6891
    Cell Significance Index: -22.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.7202
    Cell Significance Index: -5.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7319
    Cell Significance Index: -10.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HARS1 is a cytosolic enzyme that catalyzes the aminoacylation of histidine tRNA, converting the amino acid histidine into its corresponding tRNA derivative. This enzyme is characterized by its ability to bind to ATP, histidine, and tRNA, facilitating the transfer of the histidine moiety to the tRNA molecule. HARS1 is also known to interact with other proteins, including identical proteins, and to participate in protein homodimerization. **Pathways and Functions:** HARS1 is involved in several cellular pathways, including: 1. **Aminoacylation of histidine tRNA**: HARS1 catalyzes the aminoacylation of histidine tRNA, which is essential for protein synthesis. 2. **Translation**: HARS1 is required for the translation of histidine-containing proteins, which are involved in various cellular processes, including metabolism and cell differentiation. 3. **Cytosolic tRNA aminoacylation**: HARS1 is a key player in the cytosolic tRNA aminoacylation pathway, which is responsible for the aminoacylation of tRNA molecules in the cytosol. 4. **Mitochondrial translation**: HARS1 has also been implicated in mitochondrial translation, where it may play a role in the translation of histidine-containing proteins in mitochondria. **Clinical Significance:** HARS1 has been implicated in various diseases, including: 1. **Neurological disorders**: Mutations in the HARS1 gene have been associated with neurological disorders, such as epilepsy and schizophrenia. 2. **Metabolic disorders**: HARS1 has been shown to play a role in metabolic disorders, such as diabetes and obesity. 3. **Cancer**: HARS1 has been implicated in cancer, where it may play a role in the regulation of protein synthesis and cell differentiation. **Significantly Expressed Cells:** HARS1 is expressed in various cell types, including: 1. **Extravillous trophoblast**: HARS1 is expressed in extravillous trophoblast cells, which are involved in the implantation of the placenta. 2. **Pancreatic A cell**: HARS1 is expressed in pancreatic A cells, which are responsible for the production of insulin. 3. **Pancreatic acinar cell**: HARS1 is expressed in pancreatic acinar cells, which are involved in the production of digestive enzymes. 4. **L2/3-6 intratelencephalic projecting glutamatergic neuron**: HARS1 is expressed in L2/3-6 intratelencephalic projecting glutamatergic neurons, which are involved in the regulation of motor function. 5. **Corticothalamic-projecting glutamatergic cortical neuron**: HARS1 is expressed in corticothalamic-projecting glutamatergic cortical neurons, which are involved in the regulation of sensory processing. 6. **Plasmablast**: HARS1 is expressed in plasmablast cells, which are involved in the activation of B cells. 7. **Dopaminergic neuron**: HARS1 is expressed in dopaminergic neurons, which are involved in the regulation of movement and reward processing. 8. **L6b glutamatergic cortical neuron**: HARS1 is expressed in L6b glutamatergic cortical neurons, which are involved in the regulation of motor function. 9. **Skeletal muscle satellite cell**: HARS1 is expressed in skeletal muscle satellite cells, which are involved in the regulation of muscle growth and differentiation. 10. **Near-projecting glutamatergic cortical neuron**: HARS1 is expressed in near-projecting glutamatergic cortical neurons, which are involved in the regulation of sensory processing. In conclusion, HARS1 is a multifunctional enzyme that plays a crucial role in various cellular processes, including aminoacylation, translation, and cell differentiation. Its expression in different cell types and its involvement in various diseases highlight the importance of further research into the function and regulation of HARS1.

Genular Protein ID: 3167441631

Symbol: HARS1_HUMAN

Name: Histidine--tRNA ligase, cytoplasmic

UniProtKB Accession Codes:

P12081 B4DHQ1 B4DY73 D6REN6 J3KNE5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 3 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1549469

Title: Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases.

PubMed ID: 1549469

DOI: 10.1093/nar/20.5.1075

PubMed ID: 3554142

Title: Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase.

PubMed ID: 3554142

DOI: 10.1093/nar/15.8.3349

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8406012

Title: Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element.

PubMed ID: 8406012

DOI: 10.1016/0378-1119(93)90294-d

PubMed ID: 7755634

Title: A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS.

PubMed ID: 7755634

DOI: 10.1006/bbrc.1995.1696

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22930593

Title: A loss-of-function variant in the human histidyl-tRNA synthetase (HARS) gene is neurotoxic in vivo.

PubMed ID: 22930593

DOI: 10.1002/humu.22210

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26072516

Title: Loss of function mutations in HARS cause a spectrum of inherited peripheral neuropathies.

PubMed ID: 26072516

DOI: 10.1093/brain/awv158

PubMed ID: 25151410

Title: Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.

PubMed ID: 25151410

DOI: 10.1016/j.biochi.2014.08.005

PubMed ID: 22279524

Title: Genetic mapping and exome sequencing identify variants associated with five novel diseases.

PubMed ID: 22279524

DOI: 10.1371/journal.pone.0028936

PubMed ID: 29235198

Title: Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy.

PubMed ID: 29235198

DOI: 10.1002/humu.23380

Sequence Information:

  • Length: 509
  • Mass: 57411
  • Checksum: 65D8BB71CE79B1FF
  • Sequence:
    • MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK 
GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK ETLMGKYGED SKLIYDLKDQ 
GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG 
NFDPMIPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVSDSK FRTICSSVDK 
LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG 
DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQTPAQAGEE PLGVGSVAAG 
GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKIRTTETQ VLVASAQKKL 
LEERLKLVSE LWDAGIKAEL LYKKNPKLLN QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS 
VTSREEVDVR REDLVEEIKR RTGQPLCIC

Genular Protein ID: 3538536841

Symbol: B4E1C5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E1C5

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 3 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SAM 1 SMART 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 395
  • Mass: 43879
  • Checksum: 2A282CBBC98845F4
  • Sequence:
    • MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK 
DFDIAGNFDP MIPDAECLKI MCEILSSLQI GDFLVKVNDR RILDGMFAIC GVSDSKFRTI 
CSSVDKLDKV SWEEVKNEMV GEKGLAPEVA DRIGDYVQQH GGVSLVEQLL QDPKLSQNKQ 
ALEGLGDLKL LFEYLTLFGI DDKISFDLSL ARGLDYYTGV IYEAVLLQTP AQAGEEPLGV 
GSVAAGGRYD GLVGMFDPKG RKVPCVGLSI GVERIFSIVE QRLEALEEKI RTTETQVLVA 
SAQKKLLEER LKLVSELWDA GIKAELLYKK NPKLLNQLQY CEEAGIPLVA IIGEQELKDG 
VIKLRSVTSR EEVDVRREDL VEEIKRRTGQ PLCIC

Genular Protein ID: 3011041153

Symbol: B4DDD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDD8

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 3 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SAM 1 SMART 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 435
  • Mass: 48569
  • Checksum: 35F075F833629F5A
  • Sequence:
    • MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK 
GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK DFDIAGNFDP MIPDAECLKI 
MCEILSSLQI GDFLVKVNDR RILDGMFAIC GVSDSKFRTI CSSVDKLDKV SWEEVKNEMV 
GEKGLAPEVA DRIGDYVQQH GGVSLVEQLL QDPKLSQNKQ ALEGLGDLKL LFEYLTLFGI 
DDKISFDLSL ARGLDYYTGV IYEAVLLQTP AQAGEEPLGV GSVAAGGRYD GLVGMFDPKG 
RKVPCVGLSI GVERIFSIVE QRLEALEEKI RTTETQVLVA SAQKKLLEER LKLVSELWDA 
GIKAELLYKK NPKLLNQLQY CEEAGIPLVA IIGEQELKDG VIKLRSVTSR EEVDVRREDL 
VEEIKRRTGQ PLCIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.