Details for: HARS1

Gene ID: 3035

Symbol: HARS1

Ensembl ID: ENSG00000170445

Description: histidyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.18
    Marker Score: 1946
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.18
    Marker Score: 2132
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.63
    Marker Score: 3448
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.55
    Marker Score: 95225
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.46
    Marker Score: 13869
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.44
    Marker Score: 1915
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.44
    Marker Score: 14855
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.4
    Marker Score: 12015
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.39
    Marker Score: 931
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.36
    Marker Score: 12800.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.33
    Marker Score: 904
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2034
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.31
    Marker Score: 981
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.31
    Marker Score: 48237
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.24
    Marker Score: 24610.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.22
    Marker Score: 16290
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.22
    Marker Score: 2545
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.22
    Marker Score: 18176
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.21
    Marker Score: 509
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.21
    Marker Score: 1361
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2
    Marker Score: 5185
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.18
    Marker Score: 1252
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.17
    Marker Score: 44305
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.16
    Marker Score: 1458.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.16
    Marker Score: 616
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.15
    Marker Score: 332
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.15
    Marker Score: 8829.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.15
    Marker Score: 7363
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.15
    Marker Score: 4756
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.15
    Marker Score: 1195
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.14
    Marker Score: 4677
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.14
    Marker Score: 4399
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.11
    Marker Score: 739
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.1
    Marker Score: 2242
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.09
    Marker Score: 1860
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.09
    Marker Score: 410
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.09
    Marker Score: 365
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.08
    Marker Score: 991.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.08
    Marker Score: 1551.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.07
    Marker Score: 1081
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.04
    Marker Score: 8991
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.04
    Marker Score: 1102
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.03
    Marker Score: 3832
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.03
    Marker Score: 4067
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.03
    Marker Score: 4210
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.03
    Marker Score: 11944
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.01
    Marker Score: 237
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1
    Marker Score: 2280
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1
    Marker Score: 2353
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1
    Marker Score: 728
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71637.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47861.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.99
    Marker Score: 271
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.99
    Marker Score: 580
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.99
    Marker Score: 1065
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30379
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.97
    Marker Score: 1020
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.97
    Marker Score: 2634
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.96
    Marker Score: 1580.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.96
    Marker Score: 1158
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.96
    Marker Score: 4435
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.95
    Marker Score: 1392
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.94
    Marker Score: 233
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2389
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.93
    Marker Score: 381
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.93
    Marker Score: 511
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.91
    Marker Score: 430
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.91
    Marker Score: 1779
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.91
    Marker Score: 478
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.91
    Marker Score: 451
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.9
    Marker Score: 660
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.9
    Marker Score: 1273
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.9
    Marker Score: 1687
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2681
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.89
    Marker Score: 928
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5080
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.89
    Marker Score: 11714
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.89
    Marker Score: 836
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.89
    Marker Score: 741
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.89
    Marker Score: 8927.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.88
    Marker Score: 588
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.88
    Marker Score: 9934
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.88
    Marker Score: 523
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.88
    Marker Score: 1351.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.87
    Marker Score: 945
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.87
    Marker Score: 305
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.87
    Marker Score: 8822.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.87
    Marker Score: 2366
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.87
    Marker Score: 549
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.87
    Marker Score: 5642
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.86
    Marker Score: 918
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.85
    Marker Score: 1103
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.85
    Marker Score: 18105
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.83
    Marker Score: 236
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.83
    Marker Score: 199

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Other Information

**Key characteristics:** * HARS1 is a protein of the HARS family of proteins, which are involved in the aminoacylation of tRNA molecules. * It is a cytoplasmic protein that is found in the cytoplasm of cells. * It is responsible for the post-translational modification of tRNA molecules by adding a histidine residue to the amino terminus of the tRNA. * It is a highly conserved protein that is found in mammals, birds, and reptiles. **Pathways and functions:** * HARS1 is involved in the translation of mRNA molecules. * It is a key regulator of protein synthesis. * It is involved in the regulation of cell growth and differentiation. * It is involved in the regulation of apoptosis. **Clinical significance:** * Mutations in HARS1 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * HARS1 is a potential target for the treatment of these diseases. * Studies of HARS1 have shown that it can be used to inhibit cancer cell growth.

Genular Protein ID: 3167441631

Symbol: HARS1_HUMAN

Name: Histidine--tRNA ligase, cytoplasmic

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1549469

Title: Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases.

PubMed ID: 1549469

DOI: 10.1093/nar/20.5.1075

PubMed ID: 3554142

Title: Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase.

PubMed ID: 3554142

DOI: 10.1093/nar/15.8.3349

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8406012

Title: Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element.

PubMed ID: 8406012

DOI: 10.1016/0378-1119(93)90294-d

PubMed ID: 7755634

Title: A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS.

PubMed ID: 7755634

DOI: 10.1006/bbrc.1995.1696

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22930593

Title: A loss-of-function variant in the human histidyl-tRNA synthetase (HARS) gene is neurotoxic in vivo.

PubMed ID: 22930593

DOI: 10.1002/humu.22210

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26072516

Title: Loss of function mutations in HARS cause a spectrum of inherited peripheral neuropathies.

PubMed ID: 26072516

DOI: 10.1093/brain/awv158

PubMed ID: 25151410

Title: Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.

PubMed ID: 25151410

DOI: 10.1016/j.biochi.2014.08.005

PubMed ID: 22279524

Title: Genetic mapping and exome sequencing identify variants associated with five novel diseases.

PubMed ID: 22279524

DOI: 10.1371/journal.pone.0028936

PubMed ID: 29235198

Title: Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy.

PubMed ID: 29235198

DOI: 10.1002/humu.23380

Sequence Information:

  • Length: 509
  • Mass: 57411
  • Checksum: 65D8BB71CE79B1FF
  • Sequence:
  • MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK 
    GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK ETLMGKYGED SKLIYDLKDQ 
    GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG 
    NFDPMIPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVSDSK FRTICSSVDK 
    LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG 
    DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQTPAQAGEE PLGVGSVAAG 
    GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKIRTTETQ VLVASAQKKL 
    LEERLKLVSE LWDAGIKAEL LYKKNPKLLN QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS 
    VTSREEVDVR REDLVEEIKR RTGQPLCIC

Genular Protein ID: 3538536841

Symbol: B4E1C5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 395
  • Mass: 43879
  • Checksum: 2A282CBBC98845F4
  • Sequence:
  • MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK 
    DFDIAGNFDP MIPDAECLKI MCEILSSLQI GDFLVKVNDR RILDGMFAIC GVSDSKFRTI 
    CSSVDKLDKV SWEEVKNEMV GEKGLAPEVA DRIGDYVQQH GGVSLVEQLL QDPKLSQNKQ 
    ALEGLGDLKL LFEYLTLFGI DDKISFDLSL ARGLDYYTGV IYEAVLLQTP AQAGEEPLGV 
    GSVAAGGRYD GLVGMFDPKG RKVPCVGLSI GVERIFSIVE QRLEALEEKI RTTETQVLVA 
    SAQKKLLEER LKLVSELWDA GIKAELLYKK NPKLLNQLQY CEEAGIPLVA IIGEQELKDG 
    VIKLRSVTSR EEVDVRREDL VEEIKRRTGQ PLCIC

Genular Protein ID: 3011041153

Symbol: B4DDD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 435
  • Mass: 48569
  • Checksum: 35F075F833629F5A
  • Sequence:
  • MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK 
    GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK DFDIAGNFDP MIPDAECLKI 
    MCEILSSLQI GDFLVKVNDR RILDGMFAIC GVSDSKFRTI CSSVDKLDKV SWEEVKNEMV 
    GEKGLAPEVA DRIGDYVQQH GGVSLVEQLL QDPKLSQNKQ ALEGLGDLKL LFEYLTLFGI 
    DDKISFDLSL ARGLDYYTGV IYEAVLLQTP AQAGEEPLGV GSVAAGGRYD GLVGMFDPKG 
    RKVPCVGLSI GVERIFSIVE QRLEALEEKI RTTETQVLVA SAQKKLLEER LKLVSELWDA 
    GIKAELLYKK NPKLLNQLQY CEEAGIPLVA IIGEQELKDG VIKLRSVTSR EEVDVRREDL 
    VEEIKRRTGQ PLCIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.