HBA2 | ENSG00000188536 | NCBI 3040

Details for: HBA2

Gene ID: 3040

Symbol: HBA2

Ensembl ID: ENSG00000188536

Description: hemoglobin subunit alpha 2

Associated with

Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Erythrocytes take up carbon dioxide and release oxygen
(R-HSA-1237044)
Erythrocytes take up oxygen and release carbon dioxide
(R-HSA-1247673)
Heme signaling
(R-HSA-9707616)
O2/co2 exchange in erythrocytes
(R-HSA-1480926)
Scavenging of heme from plasma
(R-HSA-2168880)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)
Blood microparticle
(GO:0072562)
Carbon dioxide transport
(GO:0015670)
Cellular oxidant detoxification
(GO:0098869)
Cytosol
(GO:0005829)
Endocytic vesicle lumen
(GO:0071682)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor binding
(GO:0001664)
Haptoglobin-hemoglobin complex
(GO:0031838)
Haptoglobin binding
(GO:0031720)
Heme binding
(GO:0020037)
Hemoglobin complex
(GO:0005833)
Hydrogen peroxide catabolic process
(GO:0042744)
Iron ion binding
(GO:0005506)
Membrane
(GO:0016020)
Nitric oxide transport
(GO:0030185)
Organic acid binding
(GO:0043177)
Oxygen binding
(GO:0019825)
Oxygen carrier activity
(GO:0005344)
Oxygen transport
(GO:0015671)
Peroxidase activity
(GO:0004601)
Protein binding
(GO:0005515)
Response to hydrogen peroxide
(GO:0042542)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 188.7545
Cell Significance Index: 85.9600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 49.8732
Cell Significance Index: -12.6500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 41.9592
Cell Significance Index: -17.2900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 36.8240
Cell Significance Index: -14.9600
Cell Name: hepatoblast (CL0005026)
Fold Change: 23.9067
Cell Significance Index: 402.1000
Cell Name: liver dendritic cell (CL2000055)
Fold Change: 15.1822
Cell Significance Index: 40.0500
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 13.4151
Cell Significance Index: 38.4500
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 7.0846
Cell Significance Index: 61.2800
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 4.5521
Cell Significance Index: 37.1200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.8950
Cell Significance Index: -15.3700
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 2.3899
Cell Significance Index: 27.0600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.2028
Cell Significance Index: 59.0300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.1416
Cell Significance Index: 53.5400
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.7069
Cell Significance Index: 10.5600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.4877
Cell Significance Index: 31.1400
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.4532
Cell Significance Index: 8.5800
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.2762
Cell Significance Index: 16.0700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8927
Cell Significance Index: 9.7100
Cell Name: chondroblast (CL0000058)
Fold Change: 0.8501
Cell Significance Index: 4.9900
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.8252
Cell Significance Index: 8.7800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.7736
Cell Significance Index: 48.7600
Cell Name: kidney cell (CL1000497)
Fold Change: 0.6632
Cell Significance Index: 5.3000
Cell Name: reticulocyte (CL0000558)
Fold Change: 0.5190
Cell Significance Index: 2.7300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5001
Cell Significance Index: 95.1800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4708
Cell Significance Index: 425.0600
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.4193
Cell Significance Index: 1.7900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3163
Cell Significance Index: 19.4400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2790
Cell Significance Index: 7.4500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2236
Cell Significance Index: 44.3700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2160
Cell Significance Index: 21.3700
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.1613
Cell Significance Index: 1.0100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1473
Cell Significance Index: 0.8900
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.1275
Cell Significance Index: 0.6100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1147
Cell Significance Index: 14.7100
Cell Name: glioblast (CL0000030)
Fold Change: 0.1051
Cell Significance Index: 0.6600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0742
Cell Significance Index: 12.0800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0364
Cell Significance Index: 0.6100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0319
Cell Significance Index: 3.4800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0205
Cell Significance Index: 3.7000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0145
Cell Significance Index: 11.0000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0108
Cell Significance Index: 1.3300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0084
Cell Significance Index: 2.4300
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: -0.0079
Cell Significance Index: -0.0300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0080
Cell Significance Index: -15.0600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0090
Cell Significance Index: -0.5500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0124
Cell Significance Index: -22.8100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0137
Cell Significance Index: -0.4800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0155
Cell Significance Index: -23.8900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0177
Cell Significance Index: -24.0500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0178
Cell Significance Index: -0.8100
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0178
Cell Significance Index: -9.7100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0210
Cell Significance Index: -9.2700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0219
Cell Significance Index: -16.2100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0250
Cell Significance Index: -15.8900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0260
Cell Significance Index: -16.2400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0289
Cell Significance Index: -10.3600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0342
Cell Significance Index: -19.2700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0369
Cell Significance Index: -16.7500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0387
Cell Significance Index: -1.1200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0458
Cell Significance Index: -0.5200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0638
Cell Significance Index: -12.8000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0771
Cell Significance Index: -16.2300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0829
Cell Significance Index: -8.4700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0880
Cell Significance Index: -12.0800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1009
Cell Significance Index: -14.6600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1157
Cell Significance Index: -19.7600
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1180
Cell Significance Index: -0.7000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1197
Cell Significance Index: -15.4600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1269
Cell Significance Index: -8.7800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1306
Cell Significance Index: -2.8300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1488
Cell Significance Index: -17.5500
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1547
Cell Significance Index: -3.0200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1558
Cell Significance Index: -11.0200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1568
Cell Significance Index: -16.3300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1693
Cell Significance Index: -12.6200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1720
Cell Significance Index: -19.7000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1723
Cell Significance Index: -4.3900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1735
Cell Significance Index: -4.1600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1748
Cell Significance Index: -13.4200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1860
Cell Significance Index: -6.4700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2161
Cell Significance Index: -10.1600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2164
Cell Significance Index: -2.2400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2179
Cell Significance Index: -2.7900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2331
Cell Significance Index: -12.2400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2351
Cell Significance Index: -15.8100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2384
Cell Significance Index: -15.3800
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.2663
Cell Significance Index: -4.1200
Cell Name: keratocyte (CL0002363)
Fold Change: -0.2729
Cell Significance Index: -4.3300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2768
Cell Significance Index: -14.4200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3045
Cell Significance Index: -8.5100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3078
Cell Significance Index: -17.2700
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.3127
Cell Significance Index: -2.9700
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.3167
Cell Significance Index: -1.9400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3369
Cell Significance Index: -7.1800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3494
Cell Significance Index: -8.9800
Cell Name: erythroblast (CL0000765)
Fold Change: -0.3556
Cell Significance Index: -4.2400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3713
Cell Significance Index: -19.2900
Cell Name: mononuclear cell (CL0000842)
Fold Change: -0.3772
Cell Significance Index: -1.5700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3894
Cell Significance Index: -12.7500
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.4035
Cell Significance Index: -3.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Hemoglobin structure:** The HBA2 gene encodes for the alpha-2 subunit of hemoglobin, which forms a tetrameric complex with the beta-2 subunit to create the oxygen-binding protein hemoglobin. 2. **Erythropoiesis:** The HBA2 gene is essential for the production of red blood cells, as it regulates the expression of genes involved in erythropoiesis, including those involved in hemoglobin synthesis and erythrocyte maturation. 3. **Cellular stress response:** The HBA2 gene is involved in the cellular response to stress, including oxidative stress, through its interaction with the heme oxygenase-1 (HO-1) pathway. 4. **Signaling pathways:** The HBA2 gene is involved in various signaling pathways, including those related to oxygen binding, carbon dioxide transport, and nitric oxide transport. **Pathways and Functions:** 1. **Oxygen transport:** The HBA2 gene plays a critical role in oxygen transport, as the alpha-2 subunit of hemoglobin binds to oxygen and facilitates its transport to tissues. 2. **Carbon dioxide transport:** The HBA2 gene is involved in the transport of carbon dioxide, which is essential for maintaining acid-base balance in the body. 3. **Nitric oxide transport:** The HBA2 gene regulates the transport of nitric oxide, a potent vasodilator, which plays a crucial role in vascular tone regulation. 4. **Cellular oxidant detoxification:** The HBA2 gene is involved in the cellular response to oxidative stress, as it interacts with the HO-1 pathway to detoxify reactive oxygen species. 5. **Heme signaling:** The HBA2 gene regulates the signaling pathways involved in heme signaling, which plays a critical role in various cellular processes, including cell growth and differentiation. **Clinical Significance:** 1. **Anemia:** Mutations in the HBA2 gene can lead to anemia, a condition characterized by a decrease in red blood cell production or function. 2. **Hemoglobinopathies:** The HBA2 gene is involved in the development of hemoglobinopathies, such as sickle cell disease and beta-thalassemia, which are characterized by abnormal hemoglobin production. 3. **Oxidative stress:** The HBA2 gene's interaction with the HO-1 pathway makes it an important player in the cellular response to oxidative stress, which is implicated in various diseases, including cancer and neurodegenerative disorders. 4. **Cardiovascular disease:** The HBA2 gene's role in nitric oxide transport and oxygen binding makes it an important regulator of cardiovascular function, and alterations in the HBA2 gene have been implicated in the development of cardiovascular disease. In conclusion, the HBA2 gene plays a critical role in erythropoiesis, cellular stress response, and various cellular processes. Its clinical significance extends to anemia, hemoglobinopathies, oxidative stress, and cardiovascular disease, highlighting the importance of this gene in maintaining human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.