Gene HBA2 - ENSG00000188536 | NCBI Gene ID: 3040

Details for: HBA2

Gene ID: 3040

Symbol: HBA2

Ensembl ID: ENSG00000188536

Description: hemoglobin subunit alpha 2

Associated with

Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Erythrocytes take up carbon dioxide and release oxygen
(R-HSA-1237044)
Erythrocytes take up oxygen and release carbon dioxide
(R-HSA-1247673)
Heme signaling
(R-HSA-9707616)
O2/co2 exchange in erythrocytes
(R-HSA-1480926)
Scavenging of heme from plasma
(R-HSA-2168880)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)
Blood microparticle
(GO:0072562)
Carbon dioxide transport
(GO:0015670)
Cellular oxidant detoxification
(GO:0098869)
Cytosol
(GO:0005829)
Endocytic vesicle lumen
(GO:0071682)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Haptoglobin-hemoglobin complex
(GO:0031838)
Haptoglobin binding
(GO:0031720)
Heme binding
(GO:0020037)
Hemoglobin complex
(GO:0005833)
Hydrogen peroxide catabolic process
(GO:0042744)
Iron ion binding
(GO:0005506)
Membrane
(GO:0016020)
Nitric oxide transport
(GO:0030185)
Organic acid binding
(GO:0043177)
Oxygen binding
(GO:0019825)
Oxygen carrier activity
(GO:0005344)
Oxygen transport
(GO:0015671)
Peroxidase activity
(GO:0004601)
Protein binding
(GO:0005515)
Response to hydrogen peroxide
(GO:0042542)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hepatoblast (CL0005026)
Fold Change: 15.11
Marker Score: 49516
Cell Name: endocardial cell (CL0002350)
Fold Change: 3.88
Marker Score: 2193
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 3.86
Marker Score: 3092
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 3.61
Marker Score: 2749
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.05
Marker Score: 1316
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.98
Marker Score: 52889.5
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 2.92
Marker Score: 962.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.42
Marker Score: 777
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.8
Marker Score: 2527
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.7
Marker Score: 1152.5
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.62
Marker Score: 536
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.51
Marker Score: 6313
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.51
Marker Score: 1238
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168993
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.4
Marker Score: 1457
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.33
Marker Score: 645
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.23
Marker Score: 1312
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.23
Marker Score: 1376
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.15
Marker Score: 1652
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.15
Marker Score: 763
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.09
Marker Score: 269
Cell Name: erythroblast (CL0000765)
Fold Change: 1.08
Marker Score: 673
Cell Name: trophoblast giant cell (CL0002488)
Fold Change: 1.08
Marker Score: 349
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.02
Marker Score: 386
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71784
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48009
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 447
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5237
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2727
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.91
Marker Score: 449
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 362
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 315
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5281
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.86
Marker Score: 476
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.85
Marker Score: 1995
Cell Name: kidney cell (CL1000497)
Fold Change: 0.83
Marker Score: 557
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.79
Marker Score: 528
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.78
Marker Score: 183
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.77
Marker Score: 178
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.77
Marker Score: 150
Cell Name: enucleated reticulocyte (CL0002422)
Fold Change: 0.75
Marker Score: 280
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 384
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.72
Marker Score: 551
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.71
Marker Score: 534
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2858
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: reticulocyte (CL0000558)
Fold Change: 0.66
Marker Score: 278
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.66
Marker Score: 1012
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.61
Marker Score: 8070
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.61
Marker Score: 133
Cell Name: osteoblast (CL0000062)
Fold Change: 0.6
Marker Score: 321
Cell Name: brush cell (CL0002204)
Fold Change: 0.59
Marker Score: 539
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.57
Marker Score: 177
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.57
Marker Score: 276
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.56
Marker Score: 253
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.56
Marker Score: 232
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.56
Marker Score: 945
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.55
Marker Score: 1153
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.55
Marker Score: 292
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.51
Marker Score: 1986
Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
Fold Change: 0.51
Marker Score: 165
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.5
Marker Score: 503
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.5
Marker Score: 247
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.49
Marker Score: 130
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.49
Marker Score: 232
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.48
Marker Score: 144
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.48
Marker Score: 123
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.47
Marker Score: 262
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.46
Marker Score: 330
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.46
Marker Score: 212
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.45
Marker Score: 266
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.45
Marker Score: 1675
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.44
Marker Score: 138
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.43
Marker Score: 1810
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.43
Marker Score: 1256
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.43
Marker Score: 144
Cell Name: keratocyte (CL0002363)
Fold Change: 0.43
Marker Score: 98
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.42
Marker Score: 265
Cell Name: myelocyte (CL0002193)
Fold Change: 0.42
Marker Score: 182
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.41
Marker Score: 301.5
Cell Name: enucleate erythrocyte (CL0000595)
Fold Change: 0.41
Marker Score: 163
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.41
Marker Score: 120
Cell Name: germ cell (CL0000586)
Fold Change: 0.41
Marker Score: 716
Cell Name: motor neuron (CL0000100)
Fold Change: 0.41
Marker Score: 243
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.4
Marker Score: 195
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.39
Marker Score: 631
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.39
Marker Score: 136
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.39
Marker Score: 213
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.38
Marker Score: 384
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.38
Marker Score: 92
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.38
Marker Score: 130
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.38
Marker Score: 363
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.38
Marker Score: 275
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.38
Marker Score: 254
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.37
Marker Score: 236

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Other Information

Description

**Key characteristics:** - The HBA2 gene is located on chromosome 1 and is composed of 14 exons and 13 intronic sequences. - The protein encoded by HBA2 is a glycoprotein with a molecular weight of approximately 64,500 Da. - The gene product is a single polypeptide chain with a unique structure that allows it to bind to oxygen and transport it through the bloodstream. **Pathways and functions:** - The HBA2 gene is involved in the transport of oxygen from the lungs to the tissues. - It is a key regulator of oxygen metabolism and is responsible for maintaining oxygenated blood levels in the body. - The protein encoded by HBA2 is also involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in the HBA2 gene have been linked to several blood disorders, including sickle cell anemia and thalassemia. - These disorders are caused by mutations in the genes encoding the beta-globin protein, which is the other subunit of hemoglobin. - The HBA2 gene is also a target for therapeutic interventions in the treatment of these disorders. **Additional notes:** - The HBA2 gene is also involved in the regulation of erythropoiesis, the development of red blood cells. - Mutations in the HBA2 gene can also lead to the production of abnormal hemoglobin variants, such as sickle cell hemoglobin and thalassemia. - The HBA2 gene is a highly important gene in human health, and its proper function is essential for life.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.