Details for: ST6GALNAC6

Gene ID: 30815

Symbol: ST6GALNAC6

Ensembl ID: ENSG00000160408

Description: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.2164
    Cell Significance Index: -13.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.9804
    Cell Significance Index: -14.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.5686
    Cell Significance Index: -14.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.0634
    Cell Significance Index: -15.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.3768
    Cell Significance Index: -15.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5926
    Cell Significance Index: -12.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9097
    Cell Significance Index: -15.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8528
    Cell Significance Index: -13.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9508
    Cell Significance Index: -15.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.2447
    Cell Significance Index: 36.9900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.9302
    Cell Significance Index: 11.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6643
    Cell Significance Index: 75.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0661
    Cell Significance Index: 30.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9088
    Cell Significance Index: 124.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6974
    Cell Significance Index: 10.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6096
    Cell Significance Index: 122.2900
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.5447
    Cell Significance Index: 3.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5278
    Cell Significance Index: 151.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4965
    Cell Significance Index: 26.0700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4122
    Cell Significance Index: 4.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3431
    Cell Significance Index: 65.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3088
    Cell Significance Index: 278.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2982
    Cell Significance Index: 106.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2697
    Cell Significance Index: 7.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2638
    Cell Significance Index: 26.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2581
    Cell Significance Index: 140.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2474
    Cell Significance Index: 44.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2407
    Cell Significance Index: 5.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2149
    Cell Significance Index: 26.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2022
    Cell Significance Index: 25.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1935
    Cell Significance Index: 2.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1579
    Cell Significance Index: 17.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1414
    Cell Significance Index: 22.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1189
    Cell Significance Index: 4.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0912
    Cell Significance Index: 10.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0713
    Cell Significance Index: 4.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0660
    Cell Significance Index: 2.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0628
    Cell Significance Index: 1.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0620
    Cell Significance Index: 3.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0512
    Cell Significance Index: 1.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0370
    Cell Significance Index: 0.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0137
    Cell Significance Index: 0.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0022
    Cell Significance Index: -0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0099
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0199
    Cell Significance Index: -14.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0209
    Cell Significance Index: -15.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0230
    Cell Significance Index: -1.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0259
    Cell Significance Index: -11.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0264
    Cell Significance Index: -16.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0340
    Cell Significance Index: -3.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0455
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0573
    Cell Significance Index: -9.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0698
    Cell Significance Index: -5.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0720
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0752
    Cell Significance Index: -15.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0875
    Cell Significance Index: -10.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0910
    Cell Significance Index: -10.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0937
    Cell Significance Index: -2.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1201
    Cell Significance Index: -15.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1353
    Cell Significance Index: -6.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1465
    Cell Significance Index: -9.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1528
    Cell Significance Index: -7.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1592
    Cell Significance Index: -1.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1593
    Cell Significance Index: -8.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1635
    Cell Significance Index: -3.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1826
    Cell Significance Index: -8.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1831
    Cell Significance Index: -3.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1885
    Cell Significance Index: -5.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1961
    Cell Significance Index: -15.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2016
    Cell Significance Index: -5.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2040
    Cell Significance Index: -14.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2078
    Cell Significance Index: -15.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2079
    Cell Significance Index: -13.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2110
    Cell Significance Index: -4.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2707
    Cell Significance Index: -8.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2750
    Cell Significance Index: -8.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2818
    Cell Significance Index: -9.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2836
    Cell Significance Index: -3.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2872
    Cell Significance Index: -6.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2940
    Cell Significance Index: -3.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2953
    Cell Significance Index: -5.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3042
    Cell Significance Index: -8.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3095
    Cell Significance Index: -8.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3178
    Cell Significance Index: -6.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3186
    Cell Significance Index: -11.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3305
    Cell Significance Index: -5.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3334
    Cell Significance Index: -12.2400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3410
    Cell Significance Index: -5.7400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3432
    Cell Significance Index: -2.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3446
    Cell Significance Index: -10.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3519
    Cell Significance Index: -8.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3545
    Cell Significance Index: -7.6600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3667
    Cell Significance Index: -7.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3764
    Cell Significance Index: -10.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3865
    Cell Significance Index: -9.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3950
    Cell Significance Index: -5.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ST6GALNAC6 enzyme exhibits several key characteristics, including: 1. **Specificity**: ST6GalNAc6 has a high specificity for the transfer of GalNAc to sialic acid residues, forming alpha-2,6-linked sialic acid derivatives. 2. **Isozyme specificity**: ST6GalNAc6 is a specific isoform of the ST6GalNAc enzyme family, which is distinct from other isoforms such as ST6GalNAc1 and ST6GalNAc2. 3. **Glycosylation patterns**: The ST6GALNAC6 enzyme is involved in the biosynthesis of sialylated glycoproteins and glycolipids, which are characterized by the presence of alpha-2,6-linked sialic acid residues. 4. **Cellular localization**: The ST6GALNAC6 enzyme is primarily localized to the Golgi apparatus and plasma membrane, where it can interact with target glycoproteins and glycolipids. **Pathways and Functions** The ST6GALNAC6 enzyme is involved in several cellular pathways, including: 1. **Cell-cell recognition**: The ST6GALNAC6 enzyme plays a crucial role in the recognition of cells, particularly in the context of immune responses and tissue development. 2. **Blood group system biosynthesis**: ST6GALNAC6 is involved in the biosynthesis of sialylated glycoproteins and glycolipids that are characteristic of specific blood group antigens. 3. **Glycoprotein metabolic process**: The ST6GALNAC6 enzyme is involved in the regulation of glycoprotein metabolism, including the synthesis and degradation of sialylated glycoproteins. 4. **Glycosphingolipid biosynthesis**: ST6GALNAC6 is involved in the biosynthesis of sialylated glycosphingolipids, which are important components of the cell membrane. **Clinical Significance** The ST6GALNAC6 gene has been implicated in several diseases and disorders, including: 1. **Blood group disorders**: Deficiencies in the ST6GALNAC6 enzyme have been associated with certain blood group disorders, such as the ABO blood group system. 2. **Cancer**: Alterations in the expression of ST6GALNAC6 have been observed in various types of cancer, including colorectal and breast cancer. 3. **Immune system disorders**: The ST6GALNAC6 enzyme plays a crucial role in the regulation of immune responses, and alterations in its expression have been implicated in autoimmune disorders, such as rheumatoid arthritis. 4. **Neurological disorders**: ST6GALNAC6 has been implicated in the regulation of neuronal function and development, and alterations in its expression have been observed in neurological disorders, such as Alzheimer's disease. In conclusion, the ST6GALNAC6 gene encodes a specific isoform of the ST6GalNAc6 enzyme, which plays a crucial role in various cellular processes, including cell-cell recognition, blood group system biosynthesis, and the regulation of immune responses. The clinical significance of the ST6GALNAC6 gene is evident in its involvement in several diseases and disorders, including blood group disorders, cancer, immune system disorders, and neurological disorders.

Genular Protein ID: 1923146621

Symbol: SIA7F_HUMAN

Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12668675

Title: Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides.

PubMed ID: 12668675

DOI: 10.1074/jbc.m211034200

PubMed ID: 15843597

Title: The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.

PubMed ID: 15843597

DOI: 10.1093/glycob/cwi063

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16207893

Title: Identification of linkage-specific sequence motifs in sialyltransferases.

PubMed ID: 16207893

DOI: 10.1093/glycob/cwj046

PubMed ID: 17123352

Title: Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers.

PubMed ID: 17123352

DOI: 10.1042/bj20061118

PubMed ID: 17760270

Title: Carbohydrate antigen sialyl Lewis a - its pathophysiological significance and induction mechanism in cancer progression.

PubMed ID: 17760270

Sequence Information:

  • Length: 333
  • Mass: 38068
  • Checksum: 5DB6FFA7D7A707C0
  • Sequence:
  • MACSRPPSQC EPTSLPPGPP AGRRHLPLSR RRREMSSNKE QRSAVFVILF ALITILILYS 
    SNSANEVFHY GSLRGRSRRP VNLKKWSITD GYVPILGNKT LPSRCHQCVI VSSSSHLLGT 
    KLGPEIERAE CTIRMNDAPT TGYSADVGNK TTYRVVAHSS VFRVLRRPQE FVNRTPETVF 
    IFWGPPSKMQ KPQGSLVRVI QRAGLVFPNM EAYAVSPGRM RQFDDLFRGE TGKDREKSHS 
    WLSTGWFTMV IAVELCDHVH VYGMVPPNYC SQRPRLQRMP YHYYEPKGPD ECVTYIQNEH 
    SRKGNHHRFI TEKRVFSSWA QLYGITFSHP SWT

Genular Protein ID: 2618411400

Symbol: B4DU80_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 133
  • Mass: 15142
  • Checksum: 7F9C65ED9B14F170
  • Sequence:
  • MRSSITAPCG AVAADLSTSR SGASLTAMSP FSATREKSHS WLSTGWFTMV IAVELCDHVH 
    VYGMVPPNYC SQRPRLQRMP YHYYEPKGPD ECVTYIQNEH SRKGNHHRFI TEKRVFSSWA 
    QLYGITFSHP SWT

Genular Protein ID: 3223210002

Symbol: F6SGE3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 86
  • Mass: 9651
  • Checksum: AB3384B392DBFEAA
  • Sequence:
  • MSSNKEQRSA VFVILFALIT ILILYSSNSA NEVFHYGSLR GRSRRPVNLK KWSITDGYVP 
    ILGNKGEVSF VVEHRLVYHG DRGGVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.