Details for: HINT1

Gene ID: 3094

Symbol: HINT1

Ensembl ID: ENSG00000169567

Description: histidine triad nucleotide binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 809.9895
    Cell Significance Index: -125.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 411.5815
    Cell Significance Index: -169.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 382.3676
    Cell Significance Index: -96.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 351.3282
    Cell Significance Index: -165.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 333.2133
    Cell Significance Index: -171.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 247.5030
    Cell Significance Index: -166.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 120.7424
    Cell Significance Index: -148.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 41.1969
    Cell Significance Index: -162.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.9349
    Cell Significance Index: -106.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 38.1350
    Cell Significance Index: -117.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.6284
    Cell Significance Index: -56.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.7126
    Cell Significance Index: 209.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.6550
    Cell Significance Index: 224.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 6.8450
    Cell Significance Index: 321.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.2251
    Cell Significance Index: 143.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.7663
    Cell Significance Index: 151.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.6280
    Cell Significance Index: 195.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.5328
    Cell Significance Index: 115.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.4456
    Cell Significance Index: 253.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.3031
    Cell Significance Index: 2896.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.0518
    Cell Significance Index: 265.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.0016
    Cell Significance Index: 615.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.7294
    Cell Significance Index: 611.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.5244
    Cell Significance Index: 621.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.3709
    Cell Significance Index: 1932.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.3308
    Cell Significance Index: 49.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.1313
    Cell Significance Index: 487.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.0705
    Cell Significance Index: 32.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.0405
    Cell Significance Index: 285.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.8838
    Cell Significance Index: 700.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.6619
    Cell Significance Index: 39.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.2344
    Cell Significance Index: 208.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9107
    Cell Significance Index: 216.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.9076
    Cell Significance Index: 2625.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6788
    Cell Significance Index: 76.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6736
    Cell Significance Index: 530.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1751
    Cell Significance Index: 278.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1715
    Cell Significance Index: 25.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1594
    Cell Significance Index: 197.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1225
    Cell Significance Index: 225.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9627
    Cell Significance Index: 50.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9448
    Cell Significance Index: 16.7000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9010
    Cell Significance Index: 5.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.7047
    Cell Significance Index: 533.3900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6645
    Cell Significance Index: 5.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6190
    Cell Significance Index: 117.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4456
    Cell Significance Index: 326.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3921
    Cell Significance Index: 10.4700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3205
    Cell Significance Index: 4.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2325
    Cell Significance Index: 83.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1852
    Cell Significance Index: 30.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1816
    Cell Significance Index: 8.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1192
    Cell Significance Index: 4.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0140
    Cell Significance Index: 0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0131
    Cell Significance Index: 24.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0218
    Cell Significance Index: -0.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0351
    Cell Significance Index: -64.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0429
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0431
    Cell Significance Index: -31.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0541
    Cell Significance Index: -83.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0624
    Cell Significance Index: -6.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0815
    Cell Significance Index: -110.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1155
    Cell Significance Index: -72.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1668
    Cell Significance Index: -105.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1897
    Cell Significance Index: -106.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2532
    Cell Significance Index: -53.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2658
    Cell Significance Index: -120.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3036
    Cell Significance Index: -18.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3717
    Cell Significance Index: -42.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4379
    Cell Significance Index: -125.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4462
    Cell Significance Index: -11.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4533
    Cell Significance Index: -35.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5392
    Cell Significance Index: -4.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6057
    Cell Significance Index: -19.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7826
    Cell Significance Index: -14.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8037
    Cell Significance Index: -22.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8857
    Cell Significance Index: -128.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9291
    Cell Significance Index: -108.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9319
    Cell Significance Index: -106.3800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9519
    Cell Significance Index: -16.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0807
    Cell Significance Index: -68.1100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.2695
    Cell Significance Index: -7.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.3488
    Cell Significance Index: -20.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4146
    Cell Significance Index: -19.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5136
    Cell Significance Index: -157.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5411
    Cell Significance Index: -86.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.6379
    Cell Significance Index: -110.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.8165
    Cell Significance Index: -31.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.8884
    Cell Significance Index: -144.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.9517
    Cell Significance Index: -134.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.2571
    Cell Significance Index: -138.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.4087
    Cell Significance Index: -64.4300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.7278
    Cell Significance Index: -56.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.9132
    Cell Significance Index: -85.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.3869
    Cell Significance Index: -149.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -3.7040
    Cell Significance Index: -99.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.7332
    Cell Significance Index: -95.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.8817
    Cell Significance Index: -142.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -4.0135
    Cell Significance Index: -140.6000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.0456
    Cell Significance Index: -22.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HINT1 is a nucleotide-binding protein that exhibits a unique histidine triad motif, which is essential for its function. This protein is predominantly expressed in the cytosol and nucleus, where it interacts with various proteins and regulates cellular processes. HINT1's expression is not limited to specific cell types, as it is found in cord blood hematopoietic stem cells, early promyelocytes, thyroid follicular cells, and mature T cells. Its widespread expression suggests a crucial role in maintaining cellular homeostasis and immune function. **Pathways and Functions:** HINT1 is involved in several cellular pathways, including: 1. **Regulation of calcium-mediated signaling**: HINT1 interacts with calcium channels and pumps, modulating calcium influx and signaling pathways. This function is essential for maintaining cellular homeostasis and regulating immune responses. 2. **Protein desumoylation**: HINT1 acts as a desumoylase, removing N-terminal ubiquitin-like modifier (NEDD8) from target proteins. This process regulates protein stability, localization, and activity, thereby influencing cellular processes. 3. **Histone deacetylase complex regulation**: HINT1 interacts with histone deacetylases, modulating chromatin structure and gene expression. This function is critical for maintaining genome stability and regulating immune responses. 4. **Nucleotide binding and catabolic processes**: HINT1 binds to nucleotides, regulating purine ribonucleotide catabolic processes. This function is essential for maintaining nucleotide homeostasis and regulating cellular metabolism. **Clinical Significance:** HINT1's involvement in various cellular pathways and its expression in multiple cell types suggest its potential role in various diseases. Some potential implications of HINT1 dysregulation include: 1. **Immune disorders**: Alterations in HINT1 expression or function may contribute to immune-related disorders, such as autoimmune diseases or immunodeficiency. 2. **Cancer**: HINT1's role in regulating protein desumoylation and histone deacetylase complex activity may be critical in cancer development and progression. 3. **Neurological disorders**: HINT1's interaction with calcium channels and pumps may contribute to the development of neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, HINT1 is a multifaceted protein that plays a crucial role in regulating immune responses, cellular processes, and maintaining genome stability. Further research is necessary to fully elucidate the functional significance of HINT1 in human health and disease.

Genular Protein ID: 3387687506

Symbol: HINT1_HUMAN

Name: Histidine triad nucleotide-binding protein 1

UniProtKB Accession Codes:

P49773 Q9H5W8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 56 PDBsum 56 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8812426

Title: Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1).

PubMed ID: 8812426

DOI: 10.1006/geno.1996.0435

PubMed ID: 7644499

Title: The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.

PubMed ID: 7644499

DOI: 10.1073/pnas.92.17.7824

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8643579

Title: Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins.

PubMed ID: 8643579

DOI: 10.1073/pnas.93.11.5357

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9770345

Title: Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family.

PubMed ID: 9770345

DOI: 10.1006/excr.1998.4153

PubMed ID: 10958787

Title: Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.

PubMed ID: 10958787

DOI: 10.1074/jbc.c000505200

PubMed ID: 15703176

Title: 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.

PubMed ID: 15703176

DOI: 10.1074/jbc.m500434200

PubMed ID: 16014379

Title: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription.

PubMed ID: 16014379

DOI: 10.1242/jcs.02437

PubMed ID: 16835243

Title: The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity.

PubMed ID: 16835243

DOI: 10.1074/jbc.m513452200

PubMed ID: 17337452

Title: Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate.

PubMed ID: 17337452

DOI: 10.1074/jbc.m606972200

PubMed ID: 17217311

Title: Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.

PubMed ID: 17217311

DOI: 10.1021/mp060070y

PubMed ID: 19112177

Title: Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src.

PubMed ID: 19112177

DOI: 10.1074/jbc.m804531200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22647378

Title: The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells.

PubMed ID: 22647378

DOI: 10.4161/cc.20765

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23614568

Title: Kinetic mechanism of human histidine triad nucleotide binding protein 1.

PubMed ID: 23614568

DOI: 10.1021/bi301616c

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28691797

Title: Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).

PubMed ID: 28691797

DOI: 10.1021/acs.biochem.7b00148

PubMed ID: 29787766

Title: Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia.

PubMed ID: 29787766

DOI: 10.1016/j.jmb.2018.05.028

PubMed ID: 31088288

Title: The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease.

PubMed ID: 31088288

DOI: 10.1089/ars.2019.7724

PubMed ID: 30772266

Title: The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H2S under cellular conditions.

PubMed ID: 30772266

DOI: 10.1016/j.bcp.2019.02.018

PubMed ID: 31990367

Title: Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A.

PubMed ID: 31990367

DOI: 10.1002/1873-3468.13745

PubMed ID: 9323207

Title: Structure-based analysis of catalysis and substrate definition in the HIT protein family.

PubMed ID: 9323207

DOI: 10.1126/science.278.5336.286

PubMed ID: 22869114

Title: A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution.

PubMed ID: 22869114

DOI: 10.1107/s1744309112029491

PubMed ID: 22329685

Title: Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor.

PubMed ID: 22329685

DOI: 10.1021/jp212457w

PubMed ID: 22961002

Title: Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia.

PubMed ID: 22961002

DOI: 10.1038/ng.2406

Sequence Information:

  • Length: 126
  • Mass: 13802
  • Checksum: 6C2B0119370384AA
  • Sequence:
    • MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI 
SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ 
MHWPPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.