Details for: HINT1

Gene ID: 3094

Symbol: HINT1

Ensembl ID: ENSG00000169567

Description: histidine triad nucleotide binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 7.74
    Marker Score: 5842
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.2
    Marker Score: 4163
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.65
    Marker Score: 3642
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.57
    Marker Score: 45269
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.52
    Marker Score: 8253
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.22
    Marker Score: 223093
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.22
    Marker Score: 56670.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.22
    Marker Score: 1554
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.21
    Marker Score: 8815
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.08
    Marker Score: 9972.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.99
    Marker Score: 6137
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.97
    Marker Score: 2558
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.94
    Marker Score: 13983
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.91
    Marker Score: 12324
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.84
    Marker Score: 16470
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.81
    Marker Score: 44281
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.8
    Marker Score: 2025
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.76
    Marker Score: 28013
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.76
    Marker Score: 127862
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.75
    Marker Score: 3694
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.72
    Marker Score: 9966
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.69
    Marker Score: 19395
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.6
    Marker Score: 6176
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.58
    Marker Score: 3819
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.57
    Marker Score: 10012.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.56
    Marker Score: 2169
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.56
    Marker Score: 4294
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.54
    Marker Score: 1593
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.53
    Marker Score: 46538
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.52
    Marker Score: 3145
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.52
    Marker Score: 8876
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.52
    Marker Score: 4581
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.5
    Marker Score: 3301
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.5
    Marker Score: 2340
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.49
    Marker Score: 2741
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.49
    Marker Score: 2046
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.47
    Marker Score: 22616
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.46
    Marker Score: 3086.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.45
    Marker Score: 824.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.43
    Marker Score: 3053
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.42
    Marker Score: 3307
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.42
    Marker Score: 9447
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.4
    Marker Score: 10682
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.37
    Marker Score: 2833
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.36
    Marker Score: 116400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.35
    Marker Score: 29142.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.35
    Marker Score: 7641.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.31
    Marker Score: 831
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.3
    Marker Score: 6203
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.3
    Marker Score: 1085.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.29
    Marker Score: 2378
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.29
    Marker Score: 1691
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.28
    Marker Score: 2581.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.27
    Marker Score: 3316
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.26
    Marker Score: 25462
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.26
    Marker Score: 5339.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.23
    Marker Score: 1893
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.22
    Marker Score: 2748
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.21
    Marker Score: 5099
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.2
    Marker Score: 2659
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.19
    Marker Score: 5296
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.19
    Marker Score: 1593
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.18
    Marker Score: 20685
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.18
    Marker Score: 2707
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.17
    Marker Score: 1266.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.17
    Marker Score: 2969
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.16
    Marker Score: 176497
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.15
    Marker Score: 3715
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.15
    Marker Score: 3793
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.14
    Marker Score: 2278
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.14
    Marker Score: 2079.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.14
    Marker Score: 15417
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.13
    Marker Score: 2368
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.12
    Marker Score: 1075
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.1
    Marker Score: 1049
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.09
    Marker Score: 2195
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.08
    Marker Score: 1076
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.07
    Marker Score: 2753
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.06
    Marker Score: 810
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.06
    Marker Score: 8924
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.05
    Marker Score: 3564
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.05
    Marker Score: 7743
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.04
    Marker Score: 2862.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.04
    Marker Score: 4483
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.04
    Marker Score: 3274
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.03
    Marker Score: 6167
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.03
    Marker Score: 1765
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.03
    Marker Score: 797.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.03
    Marker Score: 3294
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.03
    Marker Score: 4286
  • Cell Name: basal cell (CL0000646)
    Fold Change: 3.02
    Marker Score: 3897
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.02
    Marker Score: 1818
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.02
    Marker Score: 6847
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.01
    Marker Score: 780.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3
    Marker Score: 5354
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3
    Marker Score: 1552
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3
    Marker Score: 1882
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.98
    Marker Score: 969
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.98
    Marker Score: 1054
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.98
    Marker Score: 5943.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * HINT1 is a protein of approximately 120 kDa. * It is a member of the histidine triad family of proteins. * It is expressed in a variety of cell types. * It is involved in a variety of cellular processes, including DNA repair, cell cycle regulation, and apoptosis. **Pathways and functions:** * HINT1 is involved in the regulation of cell cycle progression and apoptosis. * It is a key regulator of the G1/S transition in normal cells. * It is also involved in the regulation of cell cycle checkpoints. * It is a key regulator of apoptosis in both normal and cancer cells. **Clinical significance:** * Mutations in HINT1 have been linked to a number of human diseases, including cancer and leukemia. * HINT1 inhibitors are being investigated as a potential treatment for cancer. * Understanding the role of HINT1 in cell cycle regulation and apoptosis could lead to the development of new therapeutic strategies for cancer and other diseases that are dependent on HINT1.

Genular Protein ID: 3387687506

Symbol: HINT1_HUMAN

Name: Histidine triad nucleotide-binding protein 1

UniProtKB Accession Codes:

P49773 Q9H5W8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 57 PDBsum 55 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8812426

Title: Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1).

PubMed ID: 8812426

DOI: 10.1006/geno.1996.0435

PubMed ID: 7644499

Title: The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.

PubMed ID: 7644499

DOI: 10.1073/pnas.92.17.7824

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8643579

Title: Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins.

PubMed ID: 8643579

DOI: 10.1073/pnas.93.11.5357

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9770345

Title: Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family.

PubMed ID: 9770345

DOI: 10.1006/excr.1998.4153

PubMed ID: 10958787

Title: Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.

PubMed ID: 10958787

DOI: 10.1074/jbc.c000505200

PubMed ID: 15703176

Title: 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.

PubMed ID: 15703176

DOI: 10.1074/jbc.m500434200

PubMed ID: 16014379

Title: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription.

PubMed ID: 16014379

DOI: 10.1242/jcs.02437

PubMed ID: 16835243

Title: The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity.

PubMed ID: 16835243

DOI: 10.1074/jbc.m513452200

PubMed ID: 17337452

Title: Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate.

PubMed ID: 17337452

DOI: 10.1074/jbc.m606972200

PubMed ID: 17217311

Title: Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.

PubMed ID: 17217311

DOI: 10.1021/mp060070y

PubMed ID: 19112177

Title: Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src.

PubMed ID: 19112177

DOI: 10.1074/jbc.m804531200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22647378

Title: The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells.

PubMed ID: 22647378

DOI: 10.4161/cc.20765

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23614568

Title: Kinetic mechanism of human histidine triad nucleotide binding protein 1.

PubMed ID: 23614568

DOI: 10.1021/bi301616c

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28691797

Title: Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).

PubMed ID: 28691797

DOI: 10.1021/acs.biochem.7b00148

PubMed ID: 29787766

Title: Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia.

PubMed ID: 29787766

DOI: 10.1016/j.jmb.2018.05.028

PubMed ID: 31088288

Title: The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease.

PubMed ID: 31088288

DOI: 10.1089/ars.2019.7724

PubMed ID: 30772266

Title: The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H2S under cellular conditions.

PubMed ID: 30772266

DOI: 10.1016/j.bcp.2019.02.018

PubMed ID: 31990367

Title: Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A.

PubMed ID: 31990367

DOI: 10.1002/1873-3468.13745

PubMed ID: 9323207

Title: Structure-based analysis of catalysis and substrate definition in the HIT protein family.

PubMed ID: 9323207

DOI: 10.1126/science.278.5336.286

PubMed ID: 22869114

Title: A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution.

PubMed ID: 22869114

DOI: 10.1107/s1744309112029491

PubMed ID: 22329685

Title: Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor.

PubMed ID: 22329685

DOI: 10.1021/jp212457w

PubMed ID: 22961002

Title: Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia.

PubMed ID: 22961002

DOI: 10.1038/ng.2406

Sequence Information:

  • Length: 126
  • Mass: 13802
  • Checksum: 6C2B0119370384AA
  • Sequence:
    • MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI 
SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ 
MHWPPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.