Details for: HINT1
Gene ID: 3094
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HINT1
Ensembl ID: ENSG00000169567
Description: histidine triad nucleotide binding protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 142.69rCSI 94.84%PRS 2.44
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CSI 132.99rCSI 92.86%PRS 2.16
-
CSI 128.35rCSI 86.47%PRS 2.48
-
CSI 120.35rCSI 71.08%PRS 2.87
-
CSI 116.45rCSI 94.16%PRS 2.01
-
CSI 110.32rCSI 92.47%PRS 2.47
-
CSI 107.29rCSI 84.41%PRS 2.44
-
CSI 105.65rCSI 91.48%PRS 2.29
-
CSI 105.19rCSI 73.87%PRS 6.28
-
CSI 104.42rCSI 91.71%PRS 2.29
-
CSI 103.9rCSI 91.37%PRS 1.49
-
CSI 103.83rCSI 93.76%PRS 1.8
-
CSI 98.75rCSI 81.87%PRS 1.93
-
CSI 97.47rCSI 75.56%PRS 1.97
-
CSI 96.87rCSI 100%PRS 1.92
-
CSI 96.7rCSI 76.43%PRS 1.42
-
CSI 92.65rCSI 96.84%PRS 2.21
-
CSI 88.65rCSI 71.01%PRS 3.85
-
CSI 88.34rCSI 73.16%PRS 2.05
-
CSI 88.15rCSI 78.25%PRS 2.06
-
CSI 86.92rCSI 83.68%PRS 2.14
-
CSI 86.65rCSI 83.55%PRS 0.6
-
CSI 85.65rCSI 85.48%PRS 1.74
-
CSI 85.18rCSI 63.28%PRS 3.06
-
CSI 84.5rCSI 86.13%PRS 2.99
-
CSI 82.55rCSI 62.45%PRS 2.88
-
CSI 82.41rCSI 87.56%PRS 3.72
-
CSI 81.87rCSI 61.52%PRS 2.11
-
CSI 81.72rCSI 80.7%PRS 9.12
-
CSI 81.19rCSI 60.88%PRS 6.2
-
CSI 80.36rCSI 69.86%PRS 2.52
-
CSI 79.34rCSI 93.18%PRS 2.51
-
CSI 79.15rCSI 90.61%PRS 4.28
-
CSI 78.02rCSI 58.24%PRS 3.48
-
CSI 76.94rCSI 55.23%PRS 2.8
-
CSI 76.42rCSI 53.13%PRS 2.4
-
CSI 75.95rCSI 95.32%PRS 2.6
-
CSI 75.56rCSI 59.99%PRS 3.65
-
CSI 75.48rCSI 64.74%PRS 6.68
-
CSI 75.28rCSI 78.87%PRS 2.22
-
CSI 75.07rCSI 56.18%PRS 3.37
-
CSI 73.8rCSI 77.01%PRS 2.1
-
CSI 71.9rCSI 67.94%PRS 2.15
-
CSI 71.21rCSI 91.33%PRS 2.37
-
CSI 69.84rCSI 72.34%PRS 2.4
-
CSI 69.36rCSI 56.04%PRS 5.39
-
CSI 69.14rCSI 53.78%PRS 2.95
-
CSI 68.11rCSI 78.76%PRS 1.49
-
CSI 67.24rCSI 91.62%PRS 1.88
-
CSI 65.91rCSI 64.82%PRS 2.27
-
CSI 64.36rCSI 63.21%PRS 3.28
-
CSI 64.29rCSI 87.85%PRS 2.27
-
CSI 63.92rCSI 55.99%PRS 2.77
-
CSI 62.72rCSI 90.46%PRS 2.85
-
CSI 62.27rCSI 52.39%PRS 3.46
-
CSI 61.94rCSI 74.35%PRS 2.05
-
CSI 61.89rCSI 43.07%PRS 3
-
CSI 61.17rCSI 87.3%PRS 2.35
-
CSI 60.48rCSI 69.85%PRS 1.92
-
CSI 60.28rCSI 92.2%PRS 3.37
-
CSI 60.02rCSI 72.5%PRS 2.38
-
CSI 59.07rCSI 90.77%PRS 2.99
-
CSI 58.09rCSI 77.63%PRS 3.93
-
CSI 57.38rCSI 92.52%PRS 3.34
-
CSI 57.19rCSI 78.19%PRS 3.84
-
CSI 56.63rCSI 47.27%PRS 6.86
-
CSI 56.36rCSI 80.79%PRS 2.89
-
CSI 55.56rCSI 71.31%PRS 2.07
-
CSI 55.29rCSI 68.39%PRS 1.82
-
CSI 54.91rCSI 79.13%PRS 3.35
-
CSI 53.64rCSI 35.75%PRS 5.83
-
CSI 52.9rCSI 54.16%PRS 3.89
-
CSI 52.75rCSI 77.27%PRS 2.43
-
CSI 52.56rCSI 66.04%PRS 11.33
-
CSI 52.23rCSI 71.14%PRS 5.16
-
CSI 51.51rCSI 98.32%PRS 5.09
-
CSI 51.32rCSI 62.47%PRS 2.6
-
CSI 51.13rCSI 37.86%PRS 1.95
-
CSI 50.56rCSI 77.21%PRS 3.6
-
CSI 50.07rCSI 73.42%PRS 2.72
-
CSI 49.93rCSI 76.69%PRS 2.38
-
CSI 49.67rCSI 75.86%PRS 2.07
-
CSI 49.38rCSI 45.33%PRS 2.35
-
CSI 48.17rCSI 71.6%PRS 2.76
-
CSI 47.89rCSI 36.43%PRS 2.73
-
CSI 47.63rCSI 84.94%PRS 3.59
-
CSI 47.6rCSI 38.67%PRS 2.16
-
CSI 47.32rCSI 65.74%PRS 2.21
-
CSI 46.97rCSI 68.72%PRS 2.17
-
CSI 46.2rCSI 92.1%PRS 3.58
-
CSI 45.77rCSI 46.36%PRS 13.89
-
CSI 45.52rCSI 56.08%PRS 6.88
-
CSI 45.25rCSI 77.52%PRS 2.74
-
CSI 45.14rCSI 87.78%PRS 2.1
-
CSI 45.01rCSI 43.28%PRS 4.49
-
CSI 44.94rCSI 46.24%PRS 3.35
-
CSI 44.66rCSI 71.24%PRS 1.82
-
CSI 43.43rCSI 40.15%PRS 3.77
-
CSI 43.17rCSI 68.56%PRS 2.69
-
CSI 42.88rCSI 49.73%PRS 3.07
-
CSI -43.4rCSI -56.0%PRS 1.4%
-
CSI -42.1rCSI -49.3%PRS 3.5%
-
CSI -39.5rCSI -47.2%PRS 1.4%
-
CSI -36.1rCSI -94.0%PRS 2.6%
-
CSI -33.2rCSI -41.3%PRS 1.2%
-
CSI -25.1rCSI -47.0%PRS 1.7%
-
CSI -24.6rCSI -46.9%PRS 3.3%
-
CSI -18.7rCSI -53.0%PRS 2.9%
-
CSI -18.4rCSI -32.3%PRS 1.7%
-
CSI -17.8rCSI -74.0%PRS 6.5%
-
CSI -17.1rCSI -68.9%PRS 2.5%
-
CSI -16.4rCSI -36.8%PRS 5.4%
-
CSI -13.8rCSI -30.0%PRS 0.6%
-
CSI -13.8rCSI -65.9%PRS 3.7%
-
CSI -13.4rCSI -54.4%PRS 2.9%
-
CSI -12.2rCSI -51.8%PRS 5.4%
-
CSI -11.8rCSI -26.4%PRS 1.4%
-
CSI -11.6rCSI -72.5%PRS 1.7%
-
CSI -11.5rCSI -18.6%PRS 1.6%
-
CSI -11.1rCSI -29.3%PRS 2.5%
-
CSI -11.0rCSI -41.5%PRS 4.9%
-
CSI -10.7rCSI -24.8%PRS 2.1%
-
CSI -9.4rCSI -22.2%PRS 2.8%
-
CSI -9.2rCSI -37.1%PRS 10.4%
-
CSI -9.2rCSI -42.2%PRS 8.3%
-
CSI -9.2rCSI -67.3%PRS 0.9%
-
CSI -8.9rCSI -15.0%PRS 1.3%
-
CSI -7.7rCSI -38.9%PRS 14.5%
-
CSI -7.4rCSI -12.7%PRS 4.3%
-
CSI -7.3rCSI -100.0%PRS 11.7%
-
CSI -6.7rCSI -18.4%PRS 2.4%
-
CSI -6.5rCSI -20.9%PRS 1.4%
-
CSI -5.9rCSI -18.5%PRS 1.6%
-
CSI -5.8rCSI -10.2%PRS 1.3%
-
CSI -5.6rCSI -9.2%PRS 1.6%
-
CSI -5.3rCSI -5.8%PRS 2.4%
-
CSI -5.3rCSI -100.0%PRS 18.2%
-
CSI -5.3rCSI -9.6%PRS 2.4%
-
CSI -4.7rCSI -17.5%PRS 1.8%
-
CSI -4.7rCSI -14.6%PRS 1.4%
-
CSI -4.0rCSI -13.9%PRS 9.6%
-
CSI -3.6rCSI -39.3%PRS 15.1%
-
CSI -2.9rCSI -20.0%PRS 5.1%
-
CSI -2.9rCSI -39.1%PRS 25.5%
-
CSI -2.8rCSI -17.9%PRS 5.9%
-
CSI -2.7rCSI -26.1%PRS 27.1%
-
CSI -2.5rCSI -3.2%PRS 2.7%
-
CSI -1.4rCSI -7.0%PRS 4.1%
-
CSI -1.4rCSI -20.1%PRS 25.3%
-
CSI -1.1rCSI -2.4%PRS 12.5%
-
CSI -1.1rCSI -21.1%PRS 51.6%
-
CSI -1.1rCSI -4.2%PRS 5.8%
-
CSI -0.5rCSI -0.9%PRS 1.6%
-
CSI -0.4rCSI -2.9%PRS 9.6%
-
CSI -0.3rCSI -6.7%PRS 1.5%
-
CSI -0.2rCSI -1.1%PRS 16.9%
-
CSI -0.2rCSI -0.7%PRS 3.0%
-
CSI 0.1rCSI 1.6%PRS 50.8%
-
CSI 0.1rCSI 0.3%PRS 3.0%
-
CSI 0.2rCSI 4.6%PRS 37.1%
-
CSI 0.4rCSI 0.9%PRS 1.3%
-
CSI 0.4rCSI 2.0%PRS 6.0%
-
CSI 0.5rCSI 2.8%PRS 5.6%
-
CSI 0.6rCSI 15.0%PRS 20.6%
-
CSI 0.7rCSI 1.6%PRS 1.2%
-
CSI 0.8rCSI 9.2%PRS 8.7%
-
CSI 0.8rCSI 10.9%PRS 14.7%
-
CSI 0.9rCSI 3.3%PRS 1.4%
-
CSI 1.0rCSI 5.7%PRS 1.6%
-
CSI 1.0rCSI 5.2%PRS 5.4%
-
CSI 1.4rCSI 19.9%PRS 1.7%
-
CSI 1.5rCSI 21.4%PRS 34.3%
-
CSI 1.5rCSI 3.1%PRS 6.1%
-
CSI 1.6rCSI 5.7%PRS 1.1%
-
CSI 1.8rCSI 14.7%PRS 29.8%
-
CSI 1.9rCSI 59.7%PRS 29.0%
-
CSI 2.0rCSI 11.0%PRS 11.1%
-
CSI 2.0rCSI 11.6%PRS 3.3%
-
CSI 2.1rCSI 3.7%PRS 2.9%
-
CSI 2.1rCSI 18.7%PRS 20.5%
-
CSI 2.2rCSI 4.8%PRS 1.6%
-
CSI 2.2rCSI 50.4%PRS 12.5%
-
CSI 2.2rCSI 6.0%PRS 2.2%
-
CSI 2.2rCSI 3.9%PRS 2.8%
-
CSI 2.4rCSI 48.3%PRS 2.8%
-
CSI 2.4rCSI 25.9%PRS 31.8%
-
CSI 2.5rCSI 33.3%PRS 28.8%
-
CSI 2.6rCSI 66.9%PRS 12.1%
-
CSI 2.6rCSI 26.6%PRS 19.9%
-
CSI 2.7rCSI 55.3%PRS 2.6%
-
CSI 2.7rCSI 6.0%PRS 2.9%
-
CSI 2.8rCSI 4.3%PRS 2.0%
-
CSI 3.0rCSI 22.6%PRS 12.2%
-
CSI 3.0rCSI 63.1%PRS 19.2%
-
CSI 3.0rCSI 58.6%PRS 7.6%
-
CSI 3.2rCSI 96.2%PRS 5.4%
-
CSI 3.2rCSI 8.3%PRS 3.1%
-
CSI 3.2rCSI 5.8%PRS 1.8%
-
CSI 3.4rCSI 78.0%PRS 15.5%
-
CSI 3.5rCSI 21.5%PRS 10.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3387687506
Symbol: HINT1_HUMAN
Name: Histidine triad nucleotide-binding protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8812426
Title: Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1).
PubMed ID: 8812426
PubMed ID: 7644499
Title: The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.
PubMed ID: 7644499
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8643579
Title: Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins.
PubMed ID: 8643579
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 9770345
Title: Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family.
PubMed ID: 9770345
PubMed ID: 10958787
Title: Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.
PubMed ID: 10958787
PubMed ID: 15703176
Title: 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.
PubMed ID: 15703176
PubMed ID: 16014379
Title: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription.
PubMed ID: 16014379
DOI: 10.1242/jcs.02437
PubMed ID: 16835243
Title: The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity.
PubMed ID: 16835243
PubMed ID: 17337452
Title: Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate.
PubMed ID: 17337452
PubMed ID: 17217311
Title: Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.
PubMed ID: 17217311
DOI: 10.1021/mp060070y
PubMed ID: 19112177
Title: Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src.
PubMed ID: 19112177
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22647378
Title: The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells.
PubMed ID: 22647378
DOI: 10.4161/cc.20765
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23614568
Title: Kinetic mechanism of human histidine triad nucleotide binding protein 1.
PubMed ID: 23614568
DOI: 10.1021/bi301616c
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28691797
Title: Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).
PubMed ID: 28691797
PubMed ID: 29787766
Title: Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia.
PubMed ID: 29787766
PubMed ID: 31088288
Title: The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease.
PubMed ID: 31088288
PubMed ID: 30772266
Title: The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H2S under cellular conditions.
PubMed ID: 30772266
PubMed ID: 31990367
Title: Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A.
PubMed ID: 31990367
PubMed ID: 9323207
Title: Structure-based analysis of catalysis and substrate definition in the HIT protein family.
PubMed ID: 9323207
PubMed ID: 22869114
Title: A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution.
PubMed ID: 22869114
PubMed ID: 22329685
Title: Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor.
PubMed ID: 22329685
DOI: 10.1021/jp212457w
PubMed ID: 22961002
Title: Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia.
PubMed ID: 22961002
DOI: 10.1038/ng.2406
Sequence Information:
- Length: 126
- Mass: 13802
- Checksum: 6C2B0119370384AA
- Sequence:
MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ MHWPPG