HINT1 | ENSG00000169567 | NCBI 3094

Details for: HINT1

Gene ID: 3094

Symbol: HINT1

Ensembl ID: ENSG00000169567

Description: histidine triad nucleotide binding protein 1

Associated with

Developmental biology
(R-HSA-1266738)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Regulation of mitf-m-dependent genes involved in apoptosis
(R-HSA-9824594)
Regulation of mitf-m-dependent genes involved in cell cycle and proliferation
(R-HSA-9825892)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Adenosine 5'-monophosphoramidase activity
(GO:0043530)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Desumoylase activity
(GO:0016929)
Extracellular exosome
(GO:0070062)
Histone deacetylase complex
(GO:0000118)
Hydrolase activity
(GO:0016787)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Protein binding
(GO:0005515)
Protein desumoylation
(GO:0016926)
Protein kinase c binding
(GO:0005080)
Proteolysis
(GO:0006508)
Purine ribonucleotide catabolic process
(GO:0009154)
Regulation of dna-templated transcription
(GO:0006355)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 3.87
Cell Significance Index: 7
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.07
Cell Significance Index: 3
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.45
Cell Significance Index: 2
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.37
Cell Significance Index: 2
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.36
Cell Significance Index: 1
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.26
Cell Significance Index: 1
Cell Name: lactocyte (CL0002325)
Fold Change: 1.26
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.19
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1
Cell Significance Index: 1
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: odontoblast (CL0000060)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: precursor cell (CL0011115)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.96
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** HINT1 is a nucleotide-binding protein that exhibits a unique histidine triad motif, which is essential for its function. This protein is predominantly expressed in the cytosol and nucleus, where it interacts with various proteins and regulates cellular processes. HINT1's expression is not limited to specific cell types, as it is found in cord blood hematopoietic stem cells, early promyelocytes, thyroid follicular cells, and mature T cells. Its widespread expression suggests a crucial role in maintaining cellular homeostasis and immune function. **Pathways and Functions:** HINT1 is involved in several cellular pathways, including: 1. **Regulation of calcium-mediated signaling**: HINT1 interacts with calcium channels and pumps, modulating calcium influx and signaling pathways. This function is essential for maintaining cellular homeostasis and regulating immune responses. 2. **Protein desumoylation**: HINT1 acts as a desumoylase, removing N-terminal ubiquitin-like modifier (NEDD8) from target proteins. This process regulates protein stability, localization, and activity, thereby influencing cellular processes. 3. **Histone deacetylase complex regulation**: HINT1 interacts with histone deacetylases, modulating chromatin structure and gene expression. This function is critical for maintaining genome stability and regulating immune responses. 4. **Nucleotide binding and catabolic processes**: HINT1 binds to nucleotides, regulating purine ribonucleotide catabolic processes. This function is essential for maintaining nucleotide homeostasis and regulating cellular metabolism. **Clinical Significance:** HINT1's involvement in various cellular pathways and its expression in multiple cell types suggest its potential role in various diseases. Some potential implications of HINT1 dysregulation include: 1. **Immune disorders**: Alterations in HINT1 expression or function may contribute to immune-related disorders, such as autoimmune diseases or immunodeficiency. 2. **Cancer**: HINT1's role in regulating protein desumoylation and histone deacetylase complex activity may be critical in cancer development and progression. 3. **Neurological disorders**: HINT1's interaction with calcium channels and pumps may contribute to the development of neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, HINT1 is a multifaceted protein that plays a crucial role in regulating immune responses, cellular processes, and maintaining genome stability. Further research is necessary to fully elucidate the functional significance of HINT1 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.