Details for: HK1

Gene ID: 3098

Symbol: HK1

Ensembl ID: ENSG00000156515

Description: hexokinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 183.2265
    Cell Significance Index: -28.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.4759
    Cell Significance Index: -40.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 103.0592
    Cell Significance Index: -42.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.7093
    Cell Significance Index: -34.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.4711
    Cell Significance Index: -39.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 62.1887
    Cell Significance Index: -41.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.0466
    Cell Significance Index: -35.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.4553
    Cell Significance Index: -37.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8454
    Cell Significance Index: -37.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.0231
    Cell Significance Index: -40.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.0025
    Cell Significance Index: -24.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9375
    Cell Significance Index: -43.1600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 4.7417
    Cell Significance Index: 10.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.2938
    Cell Significance Index: 44.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.9814
    Cell Significance Index: 83.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2403
    Cell Significance Index: 59.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2337
    Cell Significance Index: 117.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0300
    Cell Significance Index: 407.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.7851
    Cell Significance Index: 21.2800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.6177
    Cell Significance Index: 14.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5484
    Cell Significance Index: 1398.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4299
    Cell Significance Index: 109.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1101
    Cell Significance Index: 398.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0320
    Cell Significance Index: 186.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0180
    Cell Significance Index: 52.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0070
    Cell Significance Index: 12.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9899
    Cell Significance Index: 66.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9834
    Cell Significance Index: 120.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9611
    Cell Significance Index: 156.3200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.9004
    Cell Significance Index: 6.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8363
    Cell Significance Index: 52.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8083
    Cell Significance Index: 87.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8018
    Cell Significance Index: 17.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7701
    Cell Significance Index: 21.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7664
    Cell Significance Index: 20.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6577
    Cell Significance Index: 34.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5816
    Cell Significance Index: 14.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5744
    Cell Significance Index: 16.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5182
    Cell Significance Index: 7.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4268
    Cell Significance Index: 18.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3880
    Cell Significance Index: 6.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3871
    Cell Significance Index: 211.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3751
    Cell Significance Index: 22.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3508
    Cell Significance Index: 21.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3378
    Cell Significance Index: 23.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3346
    Cell Significance Index: 12.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3206
    Cell Significance Index: 141.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3181
    Cell Significance Index: 23.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2679
    Cell Significance Index: 12.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2375
    Cell Significance Index: 11.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2273
    Cell Significance Index: 349.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1983
    Cell Significance Index: 8.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1921
    Cell Significance Index: 36.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1823
    Cell Significance Index: 3.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1569
    Cell Significance Index: 18.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1438
    Cell Significance Index: 3.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1243
    Cell Significance Index: 12.3000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1199
    Cell Significance Index: 1.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1114
    Cell Significance Index: 15.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1018
    Cell Significance Index: 64.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0871
    Cell Significance Index: 160.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0808
    Cell Significance Index: 152.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0787
    Cell Significance Index: 10.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0715
    Cell Significance Index: 97.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0700
    Cell Significance Index: 31.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0358
    Cell Significance Index: 0.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0298
    Cell Significance Index: 0.1800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0093
    Cell Significance Index: 0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0022
    Cell Significance Index: -0.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0088
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0219
    Cell Significance Index: -0.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0230
    Cell Significance Index: -16.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0275
    Cell Significance Index: -20.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0362
    Cell Significance Index: -22.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0582
    Cell Significance Index: -32.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0602
    Cell Significance Index: -1.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0692
    Cell Significance Index: -2.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0791
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0796
    Cell Significance Index: -13.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0803
    Cell Significance Index: -4.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0821
    Cell Significance Index: -10.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0880
    Cell Significance Index: -5.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1220
    Cell Significance Index: -17.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1285
    Cell Significance Index: -36.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1381
    Cell Significance Index: -29.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1558
    Cell Significance Index: -11.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1621
    Cell Significance Index: -3.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1910
    Cell Significance Index: -4.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2409
    Cell Significance Index: -6.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2480
    Cell Significance Index: -28.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2761
    Cell Significance Index: -31.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3119
    Cell Significance Index: -32.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3169
    Cell Significance Index: -36.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3540
    Cell Significance Index: -9.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4154
    Cell Significance Index: -9.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4358
    Cell Significance Index: -9.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4427
    Cell Significance Index: -35.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4535
    Cell Significance Index: -15.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4997
    Cell Significance Index: -8.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HK1 is a type II hexokinase, which is distinct from hexokinase I (HKI), the primary isoform in liver and muscle tissues. HK1 has a higher Km value for glucose, indicating a lower affinity for glucose, and is more efficient at catalyzing the conversion of glucose to glucose-6-phosphate. The enzyme is also more sensitive to inhibition by glucose-6-phosphate, which can regulate its activity in response to changes in glucose availability. HK1 is primarily localized to the cytosol, but can also be found on the mitochondrial outer membrane, where it may play a role in regulating mitochondrial glucose metabolism. **Pathways and Functions** HK1 is involved in several key metabolic pathways, including: 1. **Glycolysis**: HK1 catalyzes the first step in glycolysis, converting glucose to glucose-6-phosphate, which is then converted to pyruvate through the action of phosphoglycerate kinase and other enzymes. 2. **Glucose metabolism**: HK1 plays a critical role in regulating glucose metabolism in response to changes in glucose availability. It can also be involved in the regulation of glycolytic flux through feedback inhibition by glucose-6-phosphate. 3. **Innate immune response**: HK1 has been shown to be involved in the regulation of the innate immune response, particularly in the production of cytokines and the activation of immune cells. 4. **Mitochondrial function**: HK1 may also play a role in regulating mitochondrial function, particularly in the context of glucose metabolism. **Clinical Significance** Deficiency in HK1 has been associated with hexokinase deficiency, a rare genetic disorder characterized by impaired glucose metabolism and a range of clinical symptoms. These symptoms can include: 1. **Glucose intolerance**: Deficiency in HK1 can lead to impaired glucose metabolism, resulting in glucose intolerance and an increased risk of developing type 2 diabetes. 2. **Neuropathy**: Hexokinase deficiency can also cause neuropathy, particularly in the context of impaired glucose metabolism. 3. **Cognitive impairment**: Some cases of hexokinase deficiency have been associated with cognitive impairment and developmental delays. In conclusion, the HK1 gene plays a critical role in regulating glucose metabolism and is involved in several key metabolic pathways. Deficiency in HK1 can have significant clinical consequences, including impaired glucose metabolism and a range of neurological symptoms. Further research is needed to fully understand the role of HK1 in human health and disease.

Genular Protein ID: 3118089889

Symbol: HXK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P19367 E9PCK0 O43443 O43444 O75574 Q5VTC3 Q96HC8 Q9NNZ4 Q9NNZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 56 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 5 EMBL 73 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 Rhea 10 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3207429

Title: Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous.

PubMed ID: 3207429

DOI: 10.1016/s0006-291x(88)80964-1

PubMed ID: 9531504

Title: Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region.

PubMed ID: 9531504

DOI: 10.1042/bj3310607

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10978502

Title: Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA.

PubMed ID: 10978502

DOI: 10.1016/s0167-4781(00)00147-0

PubMed ID: 1985912

Title: Human hexokinase type I microheterogeneity is due to different amino-terminal sequences.

PubMed ID: 1985912

DOI: 10.1016/s0021-9258(18)52464-9

PubMed ID: 1637300

Title: A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates.

PubMed ID: 1637300

DOI: 10.1042/bj2850193

PubMed ID: 9028305

Title: Identification of the cDNA for human red blood cell-specific hexokinase isozyme.

PubMed ID: 9028305

PubMed ID: 8706938

Title: Crystallization and preliminary X-ray analysis of human brain hexokinase.

PubMed ID: 8706938

DOI: 10.1016/0014-5793(96)00688-6

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19536174

Title: A mutation in an alternative untranslated exon of hexokinase 1 associated with hereditary motor and sensory neuropathy -- Russe (HMSNR).

PubMed ID: 19536174

DOI: 10.1038/ejhg.2009.99

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22304920

Title: PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.

PubMed ID: 22304920

DOI: 10.1016/j.cell.2012.01.016

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27374331

Title: Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan.

PubMed ID: 27374331

DOI: 10.1016/j.cell.2016.05.076

PubMed ID: 28675158

Title: Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis.

PubMed ID: 28675158

DOI: 10.1038/cr.2017.85

PubMed ID: 9493266

Title: The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.

PubMed ID: 9493266

DOI: 10.1016/s0969-2126(98)00006-9

PubMed ID: 9735292

Title: Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.

PubMed ID: 9735292

DOI: 10.1006/jmbi.1998.2017

PubMed ID: 10574795

Title: Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control.

PubMed ID: 10574795

DOI: 10.1016/s0969-2126(00)80032-5

PubMed ID: 10686099

Title: Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.

PubMed ID: 10686099

DOI: 10.1006/jmbi.1999.3494

PubMed ID: 7655856

Title: Hexokinase mutations that produce nonspherocytic hemolytic anemia.

PubMed ID: 7655856

DOI: 10.1006/bcmd.1995.0002

PubMed ID: 12393545

Title: HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia.

PubMed ID: 12393545

DOI: 10.1182/blood-2002-06-1851

PubMed ID: 25190649

Title: A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa.

PubMed ID: 25190649

DOI: 10.1167/iovs.14-15419

PubMed ID: 25316723

Title: A missense mutation in HK1 leads to autosomal dominant retinitis pigmentosa.

PubMed ID: 25316723

DOI: 10.1167/iovs.14-15520

PubMed ID: 30778173

Title: De novo variants in HK1 associated with neurodevelopmental abnormalities and visual impairment.

PubMed ID: 30778173

DOI: 10.1038/s41431-019-0366-9

PubMed ID: 34193129

Title: Novel homozygous mutations in Pakistani families with Charcot-Marie-Tooth disease.

PubMed ID: 34193129

DOI: 10.1186/s12920-021-01019-5

Sequence Information:

  • Length: 917
  • Mass: 102486
  • Checksum: F29A6837531C0594
  • Sequence:
    • MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDETLIDIM TRFRKEMKNG LSRDFNPTAT 
VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE KNQNVHMESE VYDTPENIVH 
GSGSQLFDHV AECLGDFMEK RKIKDKKLPV GFTFSFPCQQ SKIDEAILIT WTKRFKASGV 
EGADVVKLLN KAIKKRGDYD ANIVAVVNDT VGTMMTCGYD DQHCEVGLII GTGTNACYME 
ELRHIDLVEG DEGRMCINTE WGAFGDDGSL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM 
YLGELVRLIL VKMAKEGLLF EGRITPELLT RGKFNTSDVS AIEKNKEGLH NAKEILTRLG 
VEPSDDDCVS VQHVCTIVSF RSANLVAATL GAILNRLRDN KGTPRLRTTV GVDGSLYKTH 
PQYSRRFHKT LRRLVPDSDV RFLLSESGSG KGAAMVTAVA YRLAEQHRQI EETLAHFHLT 
KDMLLEVKKR MRAEMELGLR KQTHNNAVVK MLPSFVRRTP DGTENGDFLA LDLGGTNFRV 
LLVKIRSGKK RTVEMHNKIY AIPIEIMQGT GEELFDHIVS CISDFLDYMG IKGPRMPLGF 
TFSFPCQQTS LDAGILITWT KGFKATDCVG HDVVTLLRDA IKRREEFDLD VVAVVNDTVG 
TMMTCAYEEP TCEVGLIVGT GSNACYMEEM KNVEMVEGDQ GQMCINMEWG AFGDNGCLDD 
IRTHYDRLVD EYSLNAGKQR YEKMISGMYL GEIVRNILID FTKKGFLFRG QISETLKTRG 
IFETKFLSQI ESDRLALLQV RAILQQLGLN STCDDSILVK TVCGVVSRRA AQLCGAGMAA 
VVDKIRENRG LDRLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCNVSF LLSEDGSGKG 
AALITAVGVR LRTEASS

Genular Protein ID: 3277480494

Symbol: P78542_HUMAN

Name: N/A

UniProtKB Accession Codes:

P78542 B1AR61

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 1 GeneTree 1 HGNC 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 8722688

Title: Testis-specific expression of mRNAs for a unique human type 1 hexokinase lacking the porin-binding domain.

PubMed ID: 8722688

DOI: 10.1002/(SICI)1098-2795(199605)44:1<14::AID-MRD2>3.0.CO;2-W

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 30
  • Mass: 3374
  • Checksum: E84D89B518AD02FC
  • Sequence:
    • MGQICQRESA TAAEKPKLHL LAESEIDKYL

Genular Protein ID: 2954810854

Symbol: Q59FD4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FD4

Database IDs:

ARBA 22 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 DNASU 1 DisGeNET 1 EC 4 EMBL 2 GO 10 Gene3D 2 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 8 SAM 1 SMR 1 SUPFAM 1 UniPathway 2

Sequence Information:

  • Length: 949
  • Mass: 105804
  • Checksum: 54972BD394467EA3
  • Sequence:
    • GAAEQPPEDH GSPGLRRTDR PHACRPATPT ASMIAAQLLA YYFTELKDDQ VKKIDKYLYA 
MRLSDETLID IMTRFRKEMK NGLSRDFNPT ATVKMLPTFV RSIPDGSEKG DFIALDLGGS 
SFRILRVQVN HEKNQNVHME SEVYDTPENI VHGSGSQLFD HVAECLGDFM EKRKIKDKKL 
PVGFTFSFPC QQSKIDEAIL ITWTKRFKAS GVEGADVVKL LNKAIKKRGD YDANIVAVVN 
DTVGTMMTCG YDDQHCEVGL IIGTGTNACY MEELRHIDLV EGDEGRMCIN TEWGAFGDDG 
SLEDIRTEFD REIDRGSLNP GKQLFEKMVS GMYLGELVRL ILVKMAKEGL LFEGRITPEL 
LTRGKFNTSD VSAIEKNKEG LHNAKEILTR LGVEPSDDDC VSVQHVCTIV SFRSANLVAA 
TLGAILNRLR DNKGTPRLRT TVGVDGSLYK THPQYSRRFH KTLRRLVPDS DVRFLLSESG 
SGKGAAMVTA VAYRLAEQHR QIEETLAHFH LTKDMLLEVK KRMRAEMELG LRKQTHNNAV 
VKMLPSFVRR TPDGTENGDF LALDLGGTNF RVLLVKIRSG KKRTVEMHNK IYAIPIEIMQ 
GTGEELFDHI VSCISDFLDY MGIKGPRMPL GFTFSFPCQQ TSLDAGILIT WTKGFKATDC 
VGHDVVTLLR DAIKRREEFD LDVVAVVNDT VGTMMTCAYE EPTCEVGLIV GTGSNACYME 
EMKNVEMVEG DQGQMCINME WGAFGDNGCL DDIRTHYDRL VDEYSLNAGK QRYEKMISGM 
YLGEIVRNIL IDFTKKGFLF RGQISETLKT RGIFETKFLS QIESDRLALL QVRAILQQLG 
LNSTCDDSIL VKTVCGVVSR RAAQLCGAGM AAVVDKIREN RGLDRLNVTV GVDGTLYKLH 
PHFSRIMHQT VKELSPKCNV SFLLSEDGSG KGAALITAVG VRLRTEASS

Genular Protein ID: 2655623070

Symbol: B3KXY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KXY9

Database IDs:

ARBA 22 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 DNASU 1 DisGeNET 1 EC 4 EMBL 2 GO 12 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 5 Rhea 8 SUPFAM 1 UniPathway 2

Sequence Information:

  • Length: 952
  • Mass: 106251
  • Checksum: A94B1EA9F55547E7
  • Sequence:
    • MGQICQRESR QGLAMLPRLF LNPWRQVILL PQPPKVLGLQ ATAAEKPKLH LLAESEIDKY 
LYAMRLSDET LIDIMTRFRK EMKNGLSRDF NPTATVKMLP TFVRPIPDGS EKGDFIALDL 
GGSSFRILRV QVNHEKNQNV HMESEVYDTP ENIVHGSGSQ LFDHVAECLG DFMEKRKIKD 
KKLPVGFTFS FPCQQSKIDE AILITWTKRF KASGVEGADV VKLLNKAIKK RGDYDANIVA 
VVNDTVGTMM TCGYDDQHCE VGLIIGTGTN ACYMEELRHI DLVEGDEGRM CINTEWGAFG 
DDGSLEDIRT EFDREIDRGS LNPGKQLFEK MVSGMYLGEL VRLILVKMAK EGLLFEGRIT 
PELLTRGKFN TSDVSAIEKN KEGLHNAKEI LTRLGVEPSD DDCVSVQHVC TIVSFRSANL 
VAATLGAILN RLRDNKGTPR LRTTVGVDGS LYKTHPQYSR RFHKTLRRLV PDSDVRFLLS 
ESGSGKGAAM VTAVAYRLAE QHRQIEETLA HFHLTKDMLL EVKKRMRAEM ELGLRKQTHN 
NAVVKMLPSF VRRTPDGTEN GDFLALDLGG TNFRVLLVKI RSGKKRTVEM HNKIYAIPIE 
IMQGTGEELF DHIVSCISDF LDYMGIKGPR MPLGFTFSFP CQQTSLDAGI LITWTKGFKA 
TDCVGHDVVT LLRDAIKRRE EFDLDVVAVV NDTVGTMMTC AYGEPTCEVG LIVGTGSNAC 
YMEEMKNVEM VEGDQGQMCI NMEWGAFGDN GCLDDIRTHY DRLVDEYSLN AGKQRYEKMI 
SGMYLGEIVR NILIDFTKKG FLFRGQISET LKTRGIFETK FLSQIESDRL ALLQVRAILQ 
QLGLNSTCDD SILVKTVCGV VSRRAAQLCG AGMAAVVDKI RENRGLDRLN VTVGVDGTLY 
KLHPHFSRIM HQTVKELSPK CNVSFLLSED GSGKGAALIT AVGVRLRTEA SS

Genular Protein ID: 734820901

Symbol: A8K7J7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K7J7

Database IDs:

ARBA 22 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 DNASU 1 DisGeNET 1 EC 4 EMBL 2 GO 10 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 8 SMR 1 SUPFAM 1 UniPathway 2

Sequence Information:

  • Length: 917
  • Mass: 102387
  • Checksum: 0795D838ECB91F3E
  • Sequence:
    • MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDETLIDIM TRFRKEMKNG LSRDFNPTAT 
VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE KNQNVHMESE VYDTPENIVH 
GSGSQLFDHV AECLGDFMEK RKIKDKKLPV GFTFSFPCQQ SKIDEAILIT WTKRFKASGV 
EGADVVKLLN KAIKKRGDYD ANIVAVVNDT VGTMMTCGYD DQHCEVGLII GTGTNACYME 
ELRHIDLVEG DEGRMCINTE WGAFGDDGSL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM 
YLGELVRLIL VKMAKEGLLF EGRITPELLT RGKFNTSDVS AIEKNKEGLH NAKEILTRLG 
VEPSDDDCVS VQHVCTIVSF RSANLVAATL GAILNRLRDN KGTPRLRTTV GVDGSLYKTH 
PQYSRRFHKT LRRLVPDSDV RFLLSESGSG KGAAMVTAVA YRLAEQHRQI EETLAHFHLT 
KDMLLEVKKR MRAEMELGLR KQTHNNAVVK MLPSFVRRTP DGTENGDFLA LDLGGTNFRV 
LLVKIRSGKK RTVEMHNKIY AIPIEIMQGT GEELFDHIVS CISDFLDYMG IKGPRMPLGF 
TFSFPCQQTS LDAGILITWT KGFKATDCVG HDVVTLLRDA IKRREEFDLD VVAVVNDTVG 
TMMTCAYEEP TCEVGLIVGT GSNACYMEEM KNVEMVEGDQ GQMCINMEWG AFGDNGCLDD 
IRTHYDRLVD EYSLNAGKQG YEKMISGMYL GEIVRNILID FTKKGFLFRG QISETLKTRG 
IFETKFLSQI ESDRLALLQV RAILQQLGLN STCDDSILVK TVCGVVSRRA AQLCGAGMAA 
VVDKIRENRG LDRLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCNVSF LLSEDGSGKG 
AALITAVGVR LRTEASS

Genular Protein ID: 3210814083

Symbol: A0A994J753_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J753

Database IDs:

ARBA 22 CDD 1 CTD 1 ChEBI 20 EC 4 EMBL 3 Ensembl 2 GO 9 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 2 Rhea 8 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 889
  • Mass: 99148
  • Checksum: 68CA5022123C1B0C
  • Sequence:
    • MRLSDETLID IMTRFRKEMK NGLSRDFNPT ATVKMLPTFV RSIPDGSEKG DFIALDLGGS 
SFRILRVQVN HEKNQNVHME SEVYDTPENI VHGSGSQLFD HVAECLGDFM EKRKIKDKKL 
PVGFTFSFPC QQSKIDEAIL ITWTKRFKAS GVEGADVVKL LNKAIKKRGD YDANIVAVVN 
DTVGTMMTCG YDDQHCEVGL IIGTGTNACY MEELRHIDLV EGDEGRMCIN TEWGAFGDDG 
SLEDIRTEFD REIDRGSLNP GKQLFEKMVS GMYLGELVRL ILVKMAKEGL LFEGRITPEL 
LTRGKFNTSD VSAIEKNKEG LHNAKEILTR LGVEPSDDDC VSVQHVCTIV SFRSANLVAA 
TLGAILNRLR DNKGTPRLRT TVGVDGSLYK THPQYSRRFH KTLRRLVPDS DVRFLLSESG 
SGKGAAMVTA VAYRLAEQHR QIEETLAHFH LTKDMLLEVK KRMRAEMELG LRKQTHNNAV 
VKMLPSFVRR TPDGTENGDF LALDLGGTNF RVLLVKIRSG KKRTVEMHNK IYAIPIEIMQ 
GTGEELFDHI VSCISDFLDY MGIKGPRMPL GFTFSFPCQQ TSLDAGILIT WTKGFKATDC 
VGHDVVTLLR DAIKRREEFD LDVVAVVNDT VGTMMTCAYE EPTCEVGLIV GTGSNACYME 
EMKNVEMVEG DQGQMCINME WGAFGDNGCL DDIRTHYDRL VDEYSLNAGK QRYEKMISGM 
YLGEIVRNIL IDFTKKGFLF RGQISETLKT RGIFETKFLS QIESDRLALL QVRAILQQLG 
LNSTCDDSIL VKTVCGVVSR RAAQLCGAGM AAVVDKIREN RGLDRLNVTV GVDGTLYKLH 
PHFSRIMHQT VKELSPKCNV SFLLSEDGSG KGAALITAVG VRLRTEASS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.