Details for: HLCS

Gene ID: 3141

Symbol: HLCS

Ensembl ID: ENSG00000159267

Description: holocarboxylase synthetase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 249.2201
    Cell Significance Index: -38.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.4725
    Cell Significance Index: -38.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.9279
    Cell Significance Index: -38.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.8048
    Cell Significance Index: -30.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.8306
    Cell Significance Index: -30.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.5624
    Cell Significance Index: -38.9200
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 22.5071
    Cell Significance Index: 29.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.7596
    Cell Significance Index: -36.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3399
    Cell Significance Index: -34.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8833
    Cell Significance Index: -39.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8191
    Cell Significance Index: -21.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.5816
    Cell Significance Index: 173.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.5261
    Cell Significance Index: 480.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.4873
    Cell Significance Index: 110.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.2803
    Cell Significance Index: 86.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2759
    Cell Significance Index: 456.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.9801
    Cell Significance Index: 32.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9369
    Cell Significance Index: 694.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.7872
    Cell Significance Index: 51.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6990
    Cell Significance Index: 47.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5634
    Cell Significance Index: 310.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1332
    Cell Significance Index: 783.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1327
    Cell Significance Index: 112.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1218
    Cell Significance Index: 77.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1159
    Cell Significance Index: 62.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0511
    Cell Significance Index: 23.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9917
    Cell Significance Index: 13.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9453
    Cell Significance Index: 853.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8272
    Cell Significance Index: 22.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7859
    Cell Significance Index: 60.3100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.7390
    Cell Significance Index: 6.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6641
    Cell Significance Index: 16.6000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.6500
    Cell Significance Index: 4.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6404
    Cell Significance Index: 39.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5555
    Cell Significance Index: 90.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5346
    Cell Significance Index: 58.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5123
    Cell Significance Index: 696.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3310
    Cell Significance Index: 509.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3200
    Cell Significance Index: 5.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2987
    Cell Significance Index: 53.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2573
    Cell Significance Index: 6.1700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2568
    Cell Significance Index: 2.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2387
    Cell Significance Index: 4.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2131
    Cell Significance Index: 401.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2102
    Cell Significance Index: 9.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2031
    Cell Significance Index: 374.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1953
    Cell Significance Index: 10.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1949
    Cell Significance Index: 123.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1785
    Cell Significance Index: 21.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1525
    Cell Significance Index: 3.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1186
    Cell Significance Index: 64.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1121
    Cell Significance Index: 3.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0237
    Cell Significance Index: 10.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0033
    Cell Significance Index: 0.1500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0031
    Cell Significance Index: 0.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0031
    Cell Significance Index: 0.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0121
    Cell Significance Index: -1.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0275
    Cell Significance Index: -12.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0283
    Cell Significance Index: -4.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0353
    Cell Significance Index: -26.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0372
    Cell Significance Index: -27.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0479
    Cell Significance Index: -36.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0618
    Cell Significance Index: -34.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0689
    Cell Significance Index: -43.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0732
    Cell Significance Index: -10.0500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0977
    Cell Significance Index: -1.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0977
    Cell Significance Index: -2.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0979
    Cell Significance Index: -2.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1111
    Cell Significance Index: -2.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1118
    Cell Significance Index: -32.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1123
    Cell Significance Index: -1.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1187
    Cell Significance Index: -7.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1235
    Cell Significance Index: -4.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1407
    Cell Significance Index: -2.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1644
    Cell Significance Index: -19.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1867
    Cell Significance Index: -3.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1870
    Cell Significance Index: -8.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1871
    Cell Significance Index: -39.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1908
    Cell Significance Index: -19.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2132
    Cell Significance Index: -27.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2187
    Cell Significance Index: -28.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2453
    Cell Significance Index: -4.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2509
    Cell Significance Index: -28.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2593
    Cell Significance Index: -27.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2626
    Cell Significance Index: -18.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2686
    Cell Significance Index: -5.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2719
    Cell Significance Index: -32.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2720
    Cell Significance Index: -3.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2972
    Cell Significance Index: -6.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3173
    Cell Significance Index: -6.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3228
    Cell Significance Index: -19.7900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3367
    Cell Significance Index: -4.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3439
    Cell Significance Index: -25.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3459
    Cell Significance Index: -5.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4141
    Cell Significance Index: -13.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4260
    Cell Significance Index: -33.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4314
    Cell Significance Index: -8.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4393
    Cell Significance Index: -22.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4432
    Cell Significance Index: -14.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4706
    Cell Significance Index: -30.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HLCS is a biotin-dependent enzyme that catalyzes the formation of biotinylated proteins, a process essential for the activation of biotin-dependent enzymes. The enzyme is composed of two subunits, A and B, which interact to form a biotinylating enzyme. HLCS has a high affinity for biotin, allowing it to efficiently transfer biotinyl groups to target proteins. The enzyme is predominantly expressed in the cytosol and nucleus, where it plays a crucial role in various metabolic processes. **Pathways and Functions:** HLCS is involved in several biotin metabolic pathways, including: 1. **Biotin-protein ligase activity**: HLCS catalyzes the formation of biotinylated proteins, which are essential for the activation of biotin-dependent enzymes. 2. **Biotin-[acetyl-coa-carboxylase] ligase activity**: HLCS is involved in the regulation of fatty acid synthesis by activating biotin-dependent acetyl-CoA carboxylase. 3. **Biotin-[methylcrotonoyl-coa-carboxylase] ligase activity**: HLCS plays a role in the metabolism of branched-chain amino acids by activating biotin-dependent methylcrotonoyl-CoA carboxylase. 4. **Biotin-[methylmalonyl-coa-carboxytransferase] ligase activity**: HLCS is involved in the metabolism of branched-chain amino acids and the regulation of methylmalonyl-CoA mutase. HLCS also interacts with other proteins, including biotin-binding proteins, to regulate biotin metabolism. The enzyme is involved in various cellular processes, including: 1. **Cell growth and differentiation**: HLCS is essential for the proper functioning of biotin-dependent enzymes, which are involved in cell growth and differentiation. 2. **Metabolism of water-soluble vitamins**: HLCS plays a role in the metabolism of biotin and other water-soluble vitamins, including vitamin B12 and folic acid. 3. **Response to biotin**: HLCS is involved in the regulation of biotin metabolism in response to changes in biotin availability. **Clinical Significance:** Defects in HLCS have been linked to multiple carboxylase deficiency, a condition characterized by impaired biotin-dependent enzyme activity. This condition can lead to a range of symptoms, including: 1. **Neurological disorders**: Defects in HLCS have been linked to neurological disorders, including seizures, developmental delays, and cognitive impairment. 2. **Metabolic disorders**: Impaired biotin metabolism can lead to metabolic disorders, including fatty acid oxidation deficiency and branched-chain ketoaciduria. 3. **Cancer**: Defects in HLCS have been linked to an increased risk of cancer, particularly in the context of impaired biotin-dependent enzyme activity. In conclusion, HLCS is a critical enzyme involved in biotin metabolism, and defects in this enzyme have significant implications for human health. Further research is needed to fully understand the role of HLCS in biotin metabolism and its implications for human disease.

Genular Protein ID: 4279228024

Symbol: BPL1_HUMAN

Name: Biotin--protein ligase

UniProtKB Accession Codes:

P50747 B2RAH1 D3DSG6 Q99451

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 4 EMBL 15 Ensembl 5 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 11 Rhea 16 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7842009

Title: Isolation and characterization of mutations in the human holocarboxylase synthetase cDNA.

PubMed ID: 7842009

DOI: 10.1038/ng1094-122

PubMed ID: 9037601

Title: Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.

PubMed ID: 9037601

DOI: 10.1101/gr.7.1.47

PubMed ID: 11735028

Title: Structure of human holocarboxylase synthetase gene and mutation spectrum of holocarboxylase synthetase deficiency.

PubMed ID: 11735028

DOI: 10.1007/s004390100603

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9503011

Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.

PubMed ID: 9503011

DOI: 10.1006/geno.1997.5146

PubMed ID: 7753853

Title: Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli.

PubMed ID: 7753853

DOI: 10.1073/pnas.92.10.4626

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8541348

Title: Molecular analysis of holocarboxylase synthetase deficiency: a missense mutation and a single base deletion are predominant in Japanese patients.

PubMed ID: 8541348

DOI: 10.1016/0925-4439(95)00082-8

PubMed ID: 8817339

Title: Clustering of mutations in the biotin-binding region of holocarboxylase synthetase in biotin-responsive multiple carboxylase deficiency.

PubMed ID: 8817339

DOI: 10.1093/hmg/5.7.1011

PubMed ID: 9396568

Title: Characterization of mutant holocarboxylase synthetase (HCS): a Km for biotin was not elevated in a patient with HCS deficiency.

PubMed ID: 9396568

DOI: 10.1203/00006450-199712000-00021

PubMed ID: 10190325

Title: Identification and characterization of mutations in patients with holocarboxylase synthetase deficiency.

PubMed ID: 10190325

DOI: 10.1007/s004390050927

PubMed ID: 10590022

Title: Relationship between kinetic properties of mutant enzyme and biochemical and clinical responsiveness to biotin in holocarboxylase synthetase deficiency.

PubMed ID: 10590022

DOI: 10.1203/00006450-199912000-00004

PubMed ID: 12124727

Title: Clinical findings and biochemical and molecular analysis of four patients with holocarboxylase synthetase deficiency.

PubMed ID: 12124727

DOI: 10.1002/ajmg.10532

PubMed ID: 12633764

Title: A genomic approach to mutation analysis of holocarboxylase synthetase gene in three Chinese patients with late-onset holocarboxylase synthetase deficiency.

PubMed ID: 12633764

DOI: 10.1016/s0009-9120(02)00432-0

PubMed ID: 16134170

Title: Mutations in the holocarboxylase synthetase gene HLCS.

PubMed ID: 16134170

DOI: 10.1002/humu.20204

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18429047

Title: Reduced half-life of holocarboxylase synthetase from patients with severe multiple carboxylase deficiency.

PubMed ID: 18429047

DOI: 10.1002/humu.20766

PubMed ID: 20095979

Title: Holocarboxylase synthetase deficiency: novel clinical and molecular findings.

PubMed ID: 20095979

DOI: 10.1111/j.1399-0004.2009.01357.x

PubMed ID: 25690727

Title: Severe neonatal holocarboxylase synthetase deficiency in west african siblings.

PubMed ID: 25690727

DOI: 10.1007/8904_2014_367

Sequence Information:

  • Length: 726
  • Mass: 80760
  • Checksum: 855B8E52106D675F
  • Sequence:
    • MEDRLHMDNG LVPQKIVSVH LQDSTLKEVK DQVSNKQAQI LEPKPEPSLE IKPEQDGMEH 
VGRDDPKALG EEPKQRRGSA SGSEPAGDSD RGGGPVEHYH LHLSSCHECL ELENSTIESV 
KFASAENIPD LPYDYSSSLE SVADETSPER EGRRVNLTGK APNILLYVGS DSQEALGRFH 
EVRSVLADCV DIDSYILYHL LEDSALRDPW TDNCLLLVIA TRESIPEDLY QKFMAYLSQG 
GKVLGLSSSF TFGGFQVTSK GALHKTVQNL VFSKADQSEV KLSVLSSGCR YQEGPVRLSP 
GRLQGHLENE DKDRMIVHVP FGTRGGEAVL CQVHLELPPS SNIVQTPEDF NLLKSSNFRR 
YEVLREILTT LGLSCDMKQV PALTPLYLLS AAEEIRDPLM QWLGKHVDSE GEIKSGQLSL 
RFVSSYVSEV EITPSCIPVV TNMEAFSSEH FNLEIYRQNL QTKQLGKVIL FAEVTPTTMR 
LLDGLMFQTP QEMGLIVIAA RQTEGKGRGG NVWLSPVGCA LSTLLISIPL RSQLGQRIPF 
VQHLMSVAVV EAVRSIPEYQ DINLRVKWPN DIYYSDLMKI GGVLVNSTLM GETFYILIGC 
GFNVTNSNPT ICINDLITEY NKQHKAELKP LRADYLIARV VTVLEKLIKE FQDKGPNSVL 
PLYYRYWVHS GQQVHLGSAE GPKVSIVGLD DSGFLQVHQE GGEVVTVHPD GNSFDMLRNL 
ILPKRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.