Gene HNRNPD - ENSG00000138668 | NCBI Gene ID: 3184

Details for: HNRNPD

Gene ID: 3184

Symbol: HNRNPD

Ensembl ID: ENSG00000138668

Description: heterogeneous nuclear ribonucleoprotein D

Associated with

Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
3'-utr-mediated mrna destabilization
(GO:0061158)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to putrescine
(GO:1904586)
Cerebellum development
(GO:0021549)
Chromatin binding
(GO:0003682)
Circadian regulation of translation
(GO:0097167)
Crd-mediated mrna stabilization
(GO:0070934)
Cytosol
(GO:0005829)
Glutamatergic synapse
(GO:0098978)
Hepatocyte dedifferentiation
(GO:1990828)
Histone deacetylase binding
(GO:0042826)
Liver development
(GO:0001889)
Mcrd-mediated mrna stability complex
(GO:0106002)
Minor groove of adenine-thymine-rich dna binding
(GO:0003680)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900152)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cytoplasmic translation
(GO:2000767)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of telomerase rna reverse transcriptase activity
(GO:1905663)
Positive regulation of telomere capping
(GO:1904355)
Positive regulation of translation
(GO:0045727)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Regulation of circadian rhythm
(GO:0042752)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of telomere maintenance
(GO:0032204)
Response to calcium ion
(GO:0051592)
Response to electrical stimulus
(GO:0051602)
Response to rapamycin
(GO:1901355)
Response to sodium phosphate
(GO:1904383)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna catabolic process
(GO:0006401)
Rna processing
(GO:0006396)
Telomeric dna binding
(GO:0042162)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: GABAergic neuron (CL0000617)
Fold Change: 4.02
Marker Score: 16763
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.38
Marker Score: 3528
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 3.04
Marker Score: 2295
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.03
Marker Score: 4668
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.73
Marker Score: 2917
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.69
Marker Score: 3049
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.58
Marker Score: 87931
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.48
Marker Score: 25172
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.44
Marker Score: 1911
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.41
Marker Score: 1203
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.38
Marker Score: 2503
Cell Name: stromal cell (CL0000499)
Fold Change: 2.37
Marker Score: 2782
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.34
Marker Score: 26304
Cell Name: basal cell (CL0000646)
Fold Change: 2.31
Marker Score: 2985
Cell Name: erythroblast (CL0000765)
Fold Change: 2.29
Marker Score: 1430
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.29
Marker Score: 1792
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.28
Marker Score: 9351
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.28
Marker Score: 1971
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.28
Marker Score: 1300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.28
Marker Score: 544
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.27
Marker Score: 5537
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.26
Marker Score: 4713
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.25
Marker Score: 970
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.24
Marker Score: 77586
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.2
Marker Score: 5004
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.16
Marker Score: 3180
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.15
Marker Score: 2301.5
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.15
Marker Score: 10542
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.14
Marker Score: 2011
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.14
Marker Score: 3632
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.13
Marker Score: 3778
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.13
Marker Score: 2096
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.13
Marker Score: 1989
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.12
Marker Score: 658
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 2.1
Marker Score: 855
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.09
Marker Score: 1262
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.09
Marker Score: 1400
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.09
Marker Score: 7732
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.09
Marker Score: 1644
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.08
Marker Score: 8189
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.08
Marker Score: 27418
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.07
Marker Score: 1744
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.06
Marker Score: 4119
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.05
Marker Score: 8556.5
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.05
Marker Score: 1286
Cell Name: ependymal cell (CL0000065)
Fold Change: 2.04
Marker Score: 713
Cell Name: supporting cell (CL0000630)
Fold Change: 2.04
Marker Score: 3831
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 2.03
Marker Score: 5522
Cell Name: melanocyte (CL0000148)
Fold Change: 2.02
Marker Score: 819
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.01
Marker Score: 703
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.01
Marker Score: 2026
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.01
Marker Score: 2124
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 2
Marker Score: 1839.5
Cell Name: Unknown (CL0002371)
Fold Change: 2
Marker Score: 2122
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.99
Marker Score: 7690.5
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.98
Marker Score: 751
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.98
Marker Score: 5305
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.98
Marker Score: 699
Cell Name: leukocyte (CL0000738)
Fold Change: 1.95
Marker Score: 1118
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.94
Marker Score: 12640
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.94
Marker Score: 561
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.94
Marker Score: 535
Cell Name: podocyte (CL0000653)
Fold Change: 1.93
Marker Score: 714
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.93
Marker Score: 4531
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.92
Marker Score: 2074
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.92
Marker Score: 5390
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.92
Marker Score: 5229
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.92
Marker Score: 1826
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.91
Marker Score: 688
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.91
Marker Score: 5672
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.9
Marker Score: 4170
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 1.89
Marker Score: 944
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.89
Marker Score: 4775
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.88
Marker Score: 572
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.88
Marker Score: 1286
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 1.88
Marker Score: 425
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.88
Marker Score: 1810
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.87
Marker Score: 650
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.87
Marker Score: 1678
Cell Name: astrocyte (CL0000127)
Fold Change: 1.87
Marker Score: 1620
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.86
Marker Score: 926
Cell Name: mature NK T cell (CL0000814)
Fold Change: 1.86
Marker Score: 861
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.85
Marker Score: 2949
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.85
Marker Score: 457
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.85
Marker Score: 609
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.85
Marker Score: 696
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.84
Marker Score: 592
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.84
Marker Score: 525.5
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 1.84
Marker Score: 458
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.84
Marker Score: 1998
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.83
Marker Score: 482.5
Cell Name: kidney cell (CL1000497)
Fold Change: 1.83
Marker Score: 1223
Cell Name: Unknown (CL0000548)
Fold Change: 1.83
Marker Score: 1332
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.83
Marker Score: 102152
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.83
Marker Score: 544
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.82
Marker Score: 1828
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.82
Marker Score: 1928
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.82
Marker Score: 32253
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.82
Marker Score: 627
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.82
Marker Score: 416

Hover over a box to see details here...

**Key characteristics:** - It is a nuclear protein with a molecular weight of approximately 120 kDa. - It is expressed in a wide range of cell types, including neurons, stem cells, and cancer cells. - It has been shown to be involved in a variety of cellular functions, including DNA repair, RNA processing, and transcription. **Pathways and functions:** - HNRNPD binds to the AU-rich region of mRNA, where it recruits the mRNA into a multi-protein complex that includes the splicing factors SRF and SF3. - It is involved in the processing of pre-mRNA into mature mRNA, where it forms a complex with the splicing factors and helps to recruit them to the 3' splice site. - It is also involved in the regulation of gene expression by binding to DNA and modulating the activity of transcription factors. - HNRNPD has been shown to play a role in the regulation of neuronal differentiation and survival. **Clinical significance:** - Mutations in HNRNPD have been linked to several human diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. - Inhibition of HNRNPD has been shown to suppress tumor growth and promote the differentiation of neural stem cells into neurons. - Therefore, HNRNPD is a promising target for cancer immunotherapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Heterogeneous nuclear ribonucleoprotein D0

Genular Protein ID: 3708939482

Symbol: HNRPD_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein D0

UniProtKB Accession Codes:

Q14103 A8K9J2 P07029 Q01858 Q14100 Q14101 Q14102 Q4W5A1 Q9UCE8 Q9UCE9

Database IDs:

Citations:

PubMed ID: 7673195

Title: The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family.

PubMed ID: 7673195

DOI: 10.1074/jbc.270.38.22167

PubMed ID: 9615222

Title: The human HNRPD locus maps to 4q21 and encodes a highly conserved protein.

PubMed ID: 9615222

DOI: 10.1006/geno.1998.5237

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3754960

Title: A cDNA clone of the hnRNP C proteins and its homology with the single-stranded DNA binding protein UP2.

PubMed ID: 3754960

DOI: 10.1093/nar/14.10.4077

PubMed ID: 10024518

Title: Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein.

PubMed ID: 10024518

DOI: 10.1042/bj3380417

PubMed ID: 1433497

Title: Identification and cloning of a novel heterogeneous nuclear ribonucleoprotein C-like protein that functions as a transcriptional activator of the hepatitis B virus enhancer II.

PubMed ID: 1433497

DOI: 10.1128/jvi.66.12.6841-6848.1992

PubMed ID: 8321232

Title: Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n.

PubMed ID: 8321232

DOI: 10.1128/mcb.13.7.4301-4310.1993

PubMed ID: 9521873

Title: Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms.

PubMed ID: 9521873

DOI: 10.1006/geno.1997.5142

PubMed ID: 11051545

Title: A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.

PubMed ID: 11051545

DOI: 10.1016/s0092-8674(00)00102-1

PubMed ID: 12674497

Title: Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D).

PubMed ID: 12674497

DOI: 10.1515/bc.2003.004

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21515746

Title: Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs.

PubMed ID: 21515746

DOI: 10.1096/fj.10-178715

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24423872

Title: AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.

PubMed ID: 24423872

DOI: 10.1093/nar/gkt1379

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10080887

Title: Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0.

PubMed ID: 10080887

DOI: 10.1006/jmbi.1999.2616

Sequence Information:

Length: 355
Mass: 38434
Checksum: D0B6EA177BEF789E
Sequence:

MSEEQFGGDG AAAAATAAVG GSAGEQEGAM VAATQGAAAA AGSGAGTGGG TASGGTEGGS 
AESEGAKIDA SKNEEDEGHS NSSPRHSEAA TAQREEWKMF IGGLSWDTTK KDLKDYFSKF 
GEVVDCTLKL DPITGRSRGF GFVLFKESES VDKVMDQKEH KLNGKVIDPK RAKAMKTKEP 
VKKIFVGGLS PDTPEEKIRE YFGGFGEVES IELPMDNKTN KRRGFCFITF KEEEPVKKIM 
EKKYHNVGLS KCEIKVAMSK EQYQQQQQWG SRGGFAGRAR GRGGGPSQNW NQGYSNYWNQ 
GYGNYGYNSQ GYGGYGGYDY TGYNNYYGYG DYSNQQSGYG KVSRRGGHQN SYKPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HNRNPD

Associated with

Cells (max top 100)

Other Information

The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family. PubMed ID: 7673195

The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. PubMed ID: 9615222

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A cDNA clone of the hnRNP C proteins and its homology with the single-stranded DNA binding protein UP2. PubMed ID: 3754960

Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein. PubMed ID: 10024518

Identification and cloning of a novel heterogeneous nuclear ribonucleoprotein C-like protein that functions as a transcriptional activator of the hepatitis B virus enhancer II. PubMed ID: 1433497

Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. PubMed ID: 8321232

Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. PubMed ID: 9521873

A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. PubMed ID: 11051545

Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D). PubMed ID: 12674497

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. PubMed ID: 15782174

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. PubMed ID: 19367720

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs. PubMed ID: 21515746

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation. PubMed ID: 24423872

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. PubMed ID: 10080887