Details for: HOXA3

Gene ID: 3200

Symbol: HOXA3

Ensembl ID: ENSG00000105997

Description: homeobox A3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.3
    Marker Score: 3,445
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.76
    Marker Score: 550
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.57
    Marker Score: 3,702
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.56
    Marker Score: 1,663
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.5
    Marker Score: 1,682
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.33
    Marker Score: 883
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.32
    Marker Score: 1,246
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.3
    Marker Score: 2,503
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.19
    Marker Score: 749
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.11
    Marker Score: 1,938
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.07
    Marker Score: 636
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.06
    Marker Score: 2,215
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.04
    Marker Score: 490
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,804
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,029
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Marker Score: 1,883
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.98
    Marker Score: 998
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.95
    Marker Score: 634
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,259
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.91
    Marker Score: 11,982
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.9
    Marker Score: 212
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.86
    Marker Score: 2,022
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.8
    Marker Score: 268
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.79
    Marker Score: 2,916
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 252
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 509
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.75
    Marker Score: 719
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.74
    Marker Score: 270
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.74
    Marker Score: 572
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.74
    Marker Score: 1,064
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.73
    Marker Score: 770
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 643
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.67
    Marker Score: 233
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.66
    Marker Score: 708
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2,754
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.64
    Marker Score: 461
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.62
    Marker Score: 6,309
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.61
    Marker Score: 1,631
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1,233
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.61
    Marker Score: 228
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.59
    Marker Score: 412
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.57
    Marker Score: 148
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.57
    Marker Score: 698
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.56
    Marker Score: 324
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.53
    Marker Score: 904
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.51
    Marker Score: 285
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.51
    Marker Score: 267
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.5
    Marker Score: 725
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.5
    Marker Score: 141
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.49
    Marker Score: 759
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.48
    Marker Score: 680
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.47
    Marker Score: 166
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.47
    Marker Score: 250
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 451
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.46
    Marker Score: 174
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.46
    Marker Score: 441
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.46
    Marker Score: 1,195
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.45
    Marker Score: 549
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.45
    Marker Score: 115
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.45
    Marker Score: 1,401
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.44
    Marker Score: 4,920
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.44
    Marker Score: 1,550
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.43
    Marker Score: 629
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.42
    Marker Score: 132
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.39
    Marker Score: 636
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.38
    Marker Score: 905
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 340
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.38
    Marker Score: 173
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.38
    Marker Score: 93
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 223
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.37
    Marker Score: 388
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.37
    Marker Score: 542
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.36
    Marker Score: 358
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.36
    Marker Score: 242
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.35
    Marker Score: 121
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.34
    Marker Score: 92
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.33
    Marker Score: 152
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.33
    Marker Score: 396
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.32
    Marker Score: 120
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 140
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.31
    Marker Score: 165

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HOXA3 gene belongs to the homeobox gene family, which encodes transcription factors essential for the development and patterning of various tissues and organs. HOXA3 is specifically involved in the regulation of anterior-posterior pattern specification, anterior/hindbrain development, and the differentiation of neural crest cells. Its expression is highly specific, with significant levels found in pulmonary interstitial fibroblasts, kidney capillary endothelial cells, and peripheral nervous system neurons. **Pathways and Functions:** HOXA3 plays a crucial role in several signaling pathways, including: 1. **Activation of anterior hox genes in hindbrain development**: HOXA3, along with other homeobox genes, regulates the expression of key transcription factors involved in the development of the hindbrain and the formation of cranial nerves. 2. **Angiogenesis**: HOXA3 has been implicated in the regulation of blood vessel remodeling and angiogenesis, a critical process in tissue development and repair. 3. **Developmental biology**: HOXA3 is involved in the specification of animal organ position and the morphogenesis of the embryonic skeletal system. 4. **Gene expression**: HOXA3 regulates the expression of target genes involved in various biological processes, including stem cell proliferation and differentiation. **Functions:** 1. **Transcriptional regulation**: HOXA3 acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes. 2. **Cell differentiation**: HOXA3 plays a crucial role in the differentiation of neural crest cells, which give rise to various cell types, including neurons, glial cells, and melanocytes. 3. **Stem cell proliferation**: HOXA3 has been shown to regulate the proliferation and differentiation of stem cells in various tissues. **Clinical Significance:** Dysregulation of HOXA3 has been implicated in several human diseases, including: 1. **Congenital heart defects**: Mutations in HOXA3 have been associated with congenital heart defects, including atrial septal defects and ventricular septal defects. 2. **Neurodevelopmental disorders**: HOXA3 has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer**: HOXA3 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. **Therapeutic Potential:** Given its involvement in various biological processes, HOXA3 has potential as a therapeutic target for the treatment of diseases associated with its dysregulation. For example, inhibition of HOXA3 signaling has been shown to be effective in reducing the proliferation of cancer cells. Additionally, the use of HOXA3 as a biomarker for disease diagnosis and prognosis may also have therapeutic implications. In conclusion, the HOXA3 gene plays a complex and multifaceted role in developmental biology and immunology. Its dysregulation has been implicated in various human diseases, and its potential as a therapeutic target makes it an area of active research. Further studies are needed to fully elucidate the functions and clinical significance of HOXA3, but its importance in understanding human disease and developing novel therapeutic strategies cannot be overstated.

Genular Protein ID: 3220255965

Symbol: HXA3_HUMAN

Name: Homeobox protein Hox-A3

UniProtKB Accession Codes:

O43365 A4D181

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 443
  • Mass: 46369
  • Checksum: 365C93E65CA8E8FE
  • Sequence:
    • MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC SLQSPSSAGG 
HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP APQPPQPAPQ PPAPTPAAPP 
PPSSASPPQN ASNNPTPANA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SSSSSGESCA 
GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ 
NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP 
PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ GNGSYGTPHI 
QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG AGPLGSGHHH GPGPGEPHPT 
YTDLTGHHPS QGRIQEAPKL THL

Genular Protein ID: 3485524781

Symbol: B3KPN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPN8

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 443
  • Mass: 46381
  • Checksum: 63AC9F1FCB838026
  • Sequence:
    • MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC SLQSPSSAGG 
HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP APQPPQPAPQ PPAPTPAAPP 
PPSSASPPQN ASNNPIPANA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SSSSSGESCA 
GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ 
NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP 
PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ GNGSYGTPHI 
QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG AGPLGSGHHH GPGPGEPHPT 
YTDLTGHHPS QGRIQEAPKL THL

Genular Protein ID: 817170117

Symbol: A4D182_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4D182

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 285
  • Mass: 30208
  • Checksum: 5177D5CAB69B5177
  • Sequence:
    • MKESRQNTKQ KTSSSSSGES CAGDKSPPGQ ASSKRARTAY TSAQLVELEK EFHFNRYLCR 
PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGKGMLTS SGGQSPSRSP VPPGAGGYLN 
SMHSLVNSVP YEPQSPPPFS KPPQGTYGLP PASYPASLPS CAPPPPPQKR YTAAGAGAGG 
TPDYDPHAHG LQGNGSYGTP HIQGSPVFVG GSYVEPMSNS GPALFGLTHL PHAASGAMDY 
GGAGPLGSGH HHGPGPGEPH PTYTDLTGHH PSQGRIQEAP KLTHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.