Details for: HOXA3

Gene ID: 3200

Symbol: HOXA3

Ensembl ID: ENSG00000105997

Description: homeobox A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 70.2690
    Cell Significance Index: -10.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.1100
    Cell Significance Index: -9.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 17.4531
    Cell Significance Index: -8.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 12.2798
    Cell Significance Index: -8.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8730
    Cell Significance Index: -10.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.8206
    Cell Significance Index: 46.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7775
    Cell Significance Index: -10.9600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.7058
    Cell Significance Index: 16.7400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8424
    Cell Significance Index: 14.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3599
    Cell Significance Index: 147.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3397
    Cell Significance Index: 217.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2652
    Cell Significance Index: 43.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0151
    Cell Significance Index: 60.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9801
    Cell Significance Index: 9.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7773
    Cell Significance Index: 40.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7479
    Cell Significance Index: 22.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7101
    Cell Significance Index: 82.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7098
    Cell Significance Index: 49.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6654
    Cell Significance Index: 42.9300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.6314
    Cell Significance Index: 6.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6284
    Cell Significance Index: 124.7100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.6281
    Cell Significance Index: 3.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5999
    Cell Significance Index: 27.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.5163
    Cell Significance Index: 8.6400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.4856
    Cell Significance Index: 3.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4801
    Cell Significance Index: 9.3700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.3668
    Cell Significance Index: 1.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3332
    Cell Significance Index: 60.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3056
    Cell Significance Index: 6.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2852
    Cell Significance Index: 14.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2674
    Cell Significance Index: 26.4500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.2563
    Cell Significance Index: 2.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2154
    Cell Significance Index: 6.9000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2009
    Cell Significance Index: 2.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1894
    Cell Significance Index: 23.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1610
    Cell Significance Index: 3.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1603
    Cell Significance Index: 4.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1554
    Cell Significance Index: 4.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1483
    Cell Significance Index: 28.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1444
    Cell Significance Index: 4.1600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1223
    Cell Significance Index: 1.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0856
    Cell Significance Index: 4.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0644
    Cell Significance Index: 0.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0407
    Cell Significance Index: 1.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0368
    Cell Significance Index: 16.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0219
    Cell Significance Index: 3.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0214
    Cell Significance Index: 0.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0204
    Cell Significance Index: 11.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0127
    Cell Significance Index: 0.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0092
    Cell Significance Index: 0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0002
    Cell Significance Index: -0.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0050
    Cell Significance Index: -0.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0058
    Cell Significance Index: -10.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0157
    Cell Significance Index: -8.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0203
    Cell Significance Index: -9.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0299
    Cell Significance Index: -8.5900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0340
    Cell Significance Index: -0.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0364
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0535
    Cell Significance Index: -11.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0548
    Cell Significance Index: -11.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0552
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0555
    Cell Significance Index: -9.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0556
    Cell Significance Index: -3.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0590
    Cell Significance Index: -6.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0633
    Cell Significance Index: -9.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0691
    Cell Significance Index: -8.1500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0695
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0837
    Cell Significance Index: -9.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1026
    Cell Significance Index: -8.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1124
    Cell Significance Index: -1.6100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1126
    Cell Significance Index: -0.8800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1138
    Cell Significance Index: -2.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1153
    Cell Significance Index: -8.5900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1218
    Cell Significance Index: -1.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1302
    Cell Significance Index: -7.9800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1387
    Cell Significance Index: -1.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1415
    Cell Significance Index: -3.2700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1447
    Cell Significance Index: -1.2300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1467
    Cell Significance Index: -1.6900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1587
    Cell Significance Index: -1.9300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1593
    Cell Significance Index: -1.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1603
    Cell Significance Index: -12.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1809
    Cell Significance Index: -4.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2000
    Cell Significance Index: -1.6800
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.2060
    Cell Significance Index: -2.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2094
    Cell Significance Index: -5.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2130
    Cell Significance Index: -3.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2165
    Cell Significance Index: -5.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2272
    Cell Significance Index: -12.7500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.2281
    Cell Significance Index: -2.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2619
    Cell Significance Index: -12.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2669
    Cell Significance Index: -7.6500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.2763
    Cell Significance Index: -3.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2868
    Cell Significance Index: -10.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2989
    Cell Significance Index: -10.4700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.3119
    Cell Significance Index: -3.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3254
    Cell Significance Index: -5.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3254
    Cell Significance Index: -8.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HOXA3 gene belongs to the homeobox gene family, which encodes transcription factors essential for the development and patterning of various tissues and organs. HOXA3 is specifically involved in the regulation of anterior-posterior pattern specification, anterior/hindbrain development, and the differentiation of neural crest cells. Its expression is highly specific, with significant levels found in pulmonary interstitial fibroblasts, kidney capillary endothelial cells, and peripheral nervous system neurons. **Pathways and Functions:** HOXA3 plays a crucial role in several signaling pathways, including: 1. **Activation of anterior hox genes in hindbrain development**: HOXA3, along with other homeobox genes, regulates the expression of key transcription factors involved in the development of the hindbrain and the formation of cranial nerves. 2. **Angiogenesis**: HOXA3 has been implicated in the regulation of blood vessel remodeling and angiogenesis, a critical process in tissue development and repair. 3. **Developmental biology**: HOXA3 is involved in the specification of animal organ position and the morphogenesis of the embryonic skeletal system. 4. **Gene expression**: HOXA3 regulates the expression of target genes involved in various biological processes, including stem cell proliferation and differentiation. **Functions:** 1. **Transcriptional regulation**: HOXA3 acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes. 2. **Cell differentiation**: HOXA3 plays a crucial role in the differentiation of neural crest cells, which give rise to various cell types, including neurons, glial cells, and melanocytes. 3. **Stem cell proliferation**: HOXA3 has been shown to regulate the proliferation and differentiation of stem cells in various tissues. **Clinical Significance:** Dysregulation of HOXA3 has been implicated in several human diseases, including: 1. **Congenital heart defects**: Mutations in HOXA3 have been associated with congenital heart defects, including atrial septal defects and ventricular septal defects. 2. **Neurodevelopmental disorders**: HOXA3 has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer**: HOXA3 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. **Therapeutic Potential:** Given its involvement in various biological processes, HOXA3 has potential as a therapeutic target for the treatment of diseases associated with its dysregulation. For example, inhibition of HOXA3 signaling has been shown to be effective in reducing the proliferation of cancer cells. Additionally, the use of HOXA3 as a biomarker for disease diagnosis and prognosis may also have therapeutic implications. In conclusion, the HOXA3 gene plays a complex and multifaceted role in developmental biology and immunology. Its dysregulation has been implicated in various human diseases, and its potential as a therapeutic target makes it an area of active research. Further studies are needed to fully elucidate the functions and clinical significance of HOXA3, but its importance in understanding human disease and developing novel therapeutic strategies cannot be overstated.

Genular Protein ID: 3220255965

Symbol: HXA3_HUMAN

Name: Homeobox protein Hox-A3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 443
  • Mass: 46369
  • Checksum: 365C93E65CA8E8FE
  • Sequence:
  • MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC SLQSPSSAGG 
    HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP APQPPQPAPQ PPAPTPAAPP 
    PPSSASPPQN ASNNPTPANA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SSSSSGESCA 
    GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ 
    NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP 
    PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ GNGSYGTPHI 
    QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG AGPLGSGHHH GPGPGEPHPT 
    YTDLTGHHPS QGRIQEAPKL THL

Genular Protein ID: 3485524781

Symbol: B3KPN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 443
  • Mass: 46381
  • Checksum: 63AC9F1FCB838026
  • Sequence:
  • MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC SLQSPSSAGG 
    HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP APQPPQPAPQ PPAPTPAAPP 
    PPSSASPPQN ASNNPIPANA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SSSSSGESCA 
    GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ 
    NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP 
    PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ GNGSYGTPHI 
    QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG AGPLGSGHHH GPGPGEPHPT 
    YTDLTGHHPS QGRIQEAPKL THL

Genular Protein ID: 817170117

Symbol: A4D182_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 285
  • Mass: 30208
  • Checksum: 5177D5CAB69B5177
  • Sequence:
  • MKESRQNTKQ KTSSSSSGES CAGDKSPPGQ ASSKRARTAY TSAQLVELEK EFHFNRYLCR 
    PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGKGMLTS SGGQSPSRSP VPPGAGGYLN 
    SMHSLVNSVP YEPQSPPPFS KPPQGTYGLP PASYPASLPS CAPPPPPQKR YTAAGAGAGG 
    TPDYDPHAHG LQGNGSYGTP HIQGSPVFVG GSYVEPMSNS GPALFGLTHL PHAASGAMDY 
    GGAGPLGSGH HHGPGPGEPH PTYTDLTGHH PSQGRIQEAP KLTHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.