Details for: HOXA7

Gene ID: 3204

Symbol: HOXA7

Ensembl ID: ENSG00000122592

Description: homeobox A7

Associated with

  • Angiogenesis
    (GO:0001525)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Negative regulation of cell-matrix adhesion
    (GO:0001953)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of keratinocyte differentiation
    (GO:0045617)
  • Negative regulation of leukocyte migration
    (GO:0002686)
  • Negative regulation of monocyte differentiation
    (GO:0045656)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear membrane
    (GO:0031965)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Stem cell differentiation
    (GO:0048863)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.9317
    Cell Significance Index: -7.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.4858
    Cell Significance Index: -7.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 12.2053
    Cell Significance Index: -8.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.0284
    Cell Significance Index: -2.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9856
    Cell Significance Index: -7.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 5.7340
    Cell Significance Index: 124.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5239
    Cell Significance Index: -9.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.0923
    Cell Significance Index: 24.6900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.1991
    Cell Significance Index: 12.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8550
    Cell Significance Index: -7.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.5072
    Cell Significance Index: 32.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.4996
    Cell Significance Index: 38.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2815
    Cell Significance Index: 44.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1962
    Cell Significance Index: 62.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1569
    Cell Significance Index: 114.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1343
    Cell Significance Index: 30.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0891
    Cell Significance Index: 11.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0098
    Cell Significance Index: 65.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.9099
    Cell Significance Index: 26.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8963
    Cell Significance Index: 809.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8826
    Cell Significance Index: 14.1600
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.8370
    Cell Significance Index: 3.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7714
    Cell Significance Index: 83.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6296
    Cell Significance Index: 102.3900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5633
    Cell Significance Index: 7.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4637
    Cell Significance Index: 21.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4294
    Cell Significance Index: 29.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3312
    Cell Significance Index: 6.8700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.2444
    Cell Significance Index: 1.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2329
    Cell Significance Index: 6.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2111
    Cell Significance Index: 6.7600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1867
    Cell Significance Index: 1.4100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1779
    Cell Significance Index: 1.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1105
    Cell Significance Index: 21.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0710
    Cell Significance Index: 31.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0709
    Cell Significance Index: 2.4900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0580
    Cell Significance Index: 0.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0573
    Cell Significance Index: 42.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0559
    Cell Significance Index: 1.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0518
    Cell Significance Index: 3.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0504
    Cell Significance Index: 3.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0435
    Cell Significance Index: 5.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0423
    Cell Significance Index: 7.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0407
    Cell Significance Index: 1.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0324
    Cell Significance Index: 3.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0182
    Cell Significance Index: 2.3500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0174
    Cell Significance Index: 0.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0167
    Cell Significance Index: 0.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0155
    Cell Significance Index: 0.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0146
    Cell Significance Index: 0.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0020
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0084
    Cell Significance Index: -1.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0108
    Cell Significance Index: -5.9100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0141
    Cell Significance Index: -0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0155
    Cell Significance Index: -8.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0187
    Cell Significance Index: -8.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0203
    Cell Significance Index: -0.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0252
    Cell Significance Index: -7.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0299
    Cell Significance Index: -5.9900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0316
    Cell Significance Index: -0.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0348
    Cell Significance Index: -0.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0373
    Cell Significance Index: -7.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0405
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0422
    Cell Significance Index: -7.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0458
    Cell Significance Index: -1.1100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0460
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0465
    Cell Significance Index: -4.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0530
    Cell Significance Index: -1.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0572
    Cell Significance Index: -8.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0603
    Cell Significance Index: -2.8100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0637
    Cell Significance Index: -0.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0696
    Cell Significance Index: -1.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0709
    Cell Significance Index: -8.2600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0740
    Cell Significance Index: -1.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0776
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0789
    Cell Significance Index: -9.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0963
    Cell Significance Index: -1.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1024
    Cell Significance Index: -5.3400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1048
    Cell Significance Index: -0.7100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1169
    Cell Significance Index: -0.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1392
    Cell Significance Index: -3.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1467
    Cell Significance Index: -8.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1503
    Cell Significance Index: -2.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1669
    Cell Significance Index: -2.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1672
    Cell Significance Index: -1.5400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1695
    Cell Significance Index: -1.7700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1753
    Cell Significance Index: -1.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1850
    Cell Significance Index: -4.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1856
    Cell Significance Index: -6.8100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1907
    Cell Significance Index: -0.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1950
    Cell Significance Index: -3.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1965
    Cell Significance Index: -3.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2069
    Cell Significance Index: -4.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2126
    Cell Significance Index: -2.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2170
    Cell Significance Index: -2.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2184
    Cell Significance Index: -2.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2402
    Cell Significance Index: -5.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXA7 is a highly conserved homeobox gene that encodes a transcription factor protein. It is primarily expressed in cells of the hematopoietic, neural, and epithelial lineages. The gene is characterized by its high degree of sequence similarity to other homeobox genes, which suggests its conserved function across species. HOXA7 is also known to be involved in the regulation of stem cell differentiation, with studies demonstrating its ability to induce the differentiation of stem cells into specific cell types. **Pathways and Functions:** HOXA7 plays a critical role in regulating various cellular processes, including: 1. **Angiogenesis**: HOXA7 modulates the expression of genes involved in angiogenesis, a process essential for the formation of new blood vessels. 2. **Anterior-Posterior Pattern Specification**: HOXA7 is involved in the specification of anterior-posterior patterning during embryonic development. 3. **Chromatin Regulation**: HOXA7 interacts with chromatin-modifying enzymes to regulate gene expression. 4. **Transcriptional Regulation**: HOXA7 acts as a transcriptional activator or repressor, depending on the context, to regulate the expression of target genes. 5. **Immune Function**: HOXA7 is expressed in immune cells, including thymocytes and leukocytes, and plays a role in regulating immune responses. **Clinical Significance:** Dysregulation of HOXA7 has been implicated in several diseases, including: 1. **Cancer**: HOXA7 is overexpressed in various types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Cardiovascular Disorders**: HOXA7 has been linked to cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 3. **Autoimmune Conditions**: HOXA7 has been implicated in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, HOXA7 is a critical regulator of developmental processes and immune function. Its dysregulation has significant implications for human health, and further research is needed to fully understand the mechanisms by which HOXA7 contributes to disease pathogenesis.

Genular Protein ID: 3261381844

Symbol: HXA7_HUMAN

Name: Homeobox protein Hox-A7

UniProtKB Accession Codes:

P31268 A4D191 O43368 O43486 O95655 Q9NSC8 Q9UDM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11435435

Title: Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation.

PubMed ID: 11435435

DOI: 10.1074/jbc.m104598200

PubMed ID: 9804983

Title: Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1.

PubMed ID: 9804983

DOI: 10.1016/s0167-4781(98)00170-5

PubMed ID: 10911612

Title: Sequence analysis and tissue specific expression of human HOXA7.

PubMed ID: 10911612

DOI: 10.1385/mb:14:1:19

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 230
  • Mass: 25355
  • Checksum: 8F77A6B0AFB516D5
  • Sequence:
    • MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP 
LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY 
PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN 
RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.