Details for: HOXA7

Gene ID: 3204

Symbol: HOXA7

Ensembl ID: ENSG00000122592

Description: homeobox A7

Associated with

  • Angiogenesis
    (GO:0001525)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Negative regulation of cell-matrix adhesion
    (GO:0001953)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of keratinocyte differentiation
    (GO:0045617)
  • Negative regulation of leukocyte migration
    (GO:0002686)
  • Negative regulation of monocyte differentiation
    (GO:0045656)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear membrane
    (GO:0031965)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Stem cell differentiation
    (GO:0048863)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 13.34
    Marker Score: 13971
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.72
    Marker Score: 3007.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.35
    Marker Score: 388
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.21
    Marker Score: 2532
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.2
    Marker Score: 282
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.15
    Marker Score: 767
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7502
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.98
    Marker Score: 650
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5310
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.91
    Marker Score: 1309
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9
    Marker Score: 9107
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.86
    Marker Score: 570.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.86
    Marker Score: 3527
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.8
    Marker Score: 637
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.79
    Marker Score: 1342
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.77
    Marker Score: 2056
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 584
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.75
    Marker Score: 798
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.71
    Marker Score: 1184
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 409
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.57
    Marker Score: 410
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.57
    Marker Score: 1331
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.56
    Marker Score: 820
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.52
    Marker Score: 1041
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.52
    Marker Score: 194.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.51
    Marker Score: 162
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1170
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.49
    Marker Score: 6407
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.48
    Marker Score: 118
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.47
    Marker Score: 476
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.47
    Marker Score: 164
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.46
    Marker Score: 225
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.45
    Marker Score: 379
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.45
    Marker Score: 636
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 894
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.44
    Marker Score: 832
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.44
    Marker Score: 550
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.42
    Marker Score: 416
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.41
    Marker Score: 981
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.4
    Marker Score: 89
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.39
    Marker Score: 1388
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.39
    Marker Score: 596
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.38
    Marker Score: 272
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.37
    Marker Score: 255
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.37
    Marker Score: 128
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.36
    Marker Score: 673
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.35
    Marker Score: 375
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.34
    Marker Score: 361
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.33
    Marker Score: 645
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.32
    Marker Score: 171
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.32
    Marker Score: 840
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 312
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.29
    Marker Score: 281
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.28
    Marker Score: 251
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.28
    Marker Score: 135
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.28
    Marker Score: 337
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.28
    Marker Score: 2390
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.27
    Marker Score: 171
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.27
    Marker Score: 145
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.27
    Marker Score: 112
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.27
    Marker Score: 195
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.26
    Marker Score: 831
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.26
    Marker Score: 169
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.25
    Marker Score: 171
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.25
    Marker Score: 268
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.25
    Marker Score: 231
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.24
    Marker Score: 118
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.24
    Marker Score: 232
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.24
    Marker Score: 67
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.24
    Marker Score: 400
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.23
    Marker Score: 86
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.23
    Marker Score: 79
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 131
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.22
    Marker Score: 201
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.22
    Marker Score: 168
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.22
    Marker Score: 222

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Other Information

**Key characteristics:** * The HOXA7 gene is located on chromosome 17q21.1. * It is a homeobox gene, which is a family of genes that are involved in early development. * The protein encoded by HOXA7 is a transcription factor that is expressed in a variety of cell types. * It is a key regulator of cell migration and differentiation. **Pathways and functions:** * The HOXA7 protein is involved in angiogenesis by promoting the migration of endothelial cells to form new blood vessels. * It is also involved in anterior/posterior pattern specification by regulating the expression of genes that control the development of the anterior and posterior ends of the body. * The protein is also involved in DNA-binding transcription activator activity, which is essential for the expression of many genes involved in cell differentiation and migration. * It is involved in cell migration by regulating the expression of genes that control the direction of cell movement. * The protein is also involved in the regulation of cell cycle progression and apoptosis. **Clinical significance:** HOXA7 mutations are associated with a number of human diseases, including: * Congenital heart defects * Kidney cancer * Breast cancer * Prostate cancer * T cell leukemia HOXA7 is an important gene that is involved in a variety of cellular processes. Its mutations can lead to a number of diseases, highlighting its importance in human health.

Genular Protein ID: 3261381844

Symbol: HXA7_HUMAN

Name: Homeobox protein Hox-A7

UniProtKB Accession Codes:

P31268 A4D191 O43368 O43486 O95655 Q9NSC8 Q9UDM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11435435

Title: Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation.

PubMed ID: 11435435

DOI: 10.1074/jbc.m104598200

PubMed ID: 9804983

Title: Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1.

PubMed ID: 9804983

DOI: 10.1016/s0167-4781(98)00170-5

PubMed ID: 10911612

Title: Sequence analysis and tissue specific expression of human HOXA7.

PubMed ID: 10911612

DOI: 10.1385/mb:14:1:19

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 230
  • Mass: 25355
  • Checksum: 8F77A6B0AFB516D5
  • Sequence:
    • MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP 
LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY 
PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN 
RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.