Details for: HOXB7

Gene ID: 3217

Symbol: HOXB7

Ensembl ID: ENSG00000260027

Description: homeobox B7

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic organ development
    (GO:0048568)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Myeloid cell differentiation
    (GO:0030099)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 64.8686
    Cell Significance Index: -10.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.0957
    Cell Significance Index: -10.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 15.5435
    Cell Significance Index: -10.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2566
    Cell Significance Index: -10.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5523
    Cell Significance Index: -12.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.4869
    Cell Significance Index: 27.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.1226
    Cell Significance Index: 162.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.0880
    Cell Significance Index: 139.9700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 3.0048
    Cell Significance Index: 17.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.6825
    Cell Significance Index: 57.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6203
    Cell Significance Index: -10.3400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.0289
    Cell Significance Index: 23.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8086
    Cell Significance Index: 16.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7958
    Cell Significance Index: 177.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5681
    Cell Significance Index: 94.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1730
    Cell Significance Index: 190.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0531
    Cell Significance Index: 15.7800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.9768
    Cell Significance Index: 3.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9343
    Cell Significance Index: 32.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9300
    Cell Significance Index: 507.8900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8961
    Cell Significance Index: 13.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7975
    Cell Significance Index: 143.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6744
    Cell Significance Index: 46.6400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.5878
    Cell Significance Index: 6.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5717
    Cell Significance Index: 18.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5713
    Cell Significance Index: 13.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5004
    Cell Significance Index: 61.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3268
    Cell Significance Index: 5.7800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.3032
    Cell Significance Index: 1.1300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2780
    Cell Significance Index: 1.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2769
    Cell Significance Index: 52.7100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.2501
    Cell Significance Index: 2.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1500
    Cell Significance Index: 2.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0891
    Cell Significance Index: 80.5000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0620
    Cell Significance Index: 0.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0509
    Cell Significance Index: 37.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0469
    Cell Significance Index: 1.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0364
    Cell Significance Index: 0.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0223
    Cell Significance Index: 1.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0194
    Cell Significance Index: 0.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0135
    Cell Significance Index: 0.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0120
    Cell Significance Index: 0.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -10.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0073
    Cell Significance Index: -0.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0095
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0119
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0131
    Cell Significance Index: -9.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0134
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0146
    Cell Significance Index: -10.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0147
    Cell Significance Index: -0.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0165
    Cell Significance Index: -10.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0187
    Cell Significance Index: -10.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0200
    Cell Significance Index: -9.0800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0237
    Cell Significance Index: -0.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0248
    Cell Significance Index: -0.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0251
    Cell Significance Index: -0.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0321
    Cell Significance Index: -11.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0326
    Cell Significance Index: -0.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0334
    Cell Significance Index: -4.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0363
    Cell Significance Index: -10.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0373
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0375
    Cell Significance Index: -0.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0389
    Cell Significance Index: -0.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0417
    Cell Significance Index: -5.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0427
    Cell Significance Index: -8.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0472
    Cell Significance Index: -5.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0473
    Cell Significance Index: -9.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0483
    Cell Significance Index: -10.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0487
    Cell Significance Index: -1.9900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0528
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0573
    Cell Significance Index: -9.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0628
    Cell Significance Index: -7.4100
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0661
    Cell Significance Index: -0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0721
    Cell Significance Index: -10.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0800
    Cell Significance Index: -1.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0848
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0863
    Cell Significance Index: -9.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0873
    Cell Significance Index: -1.2500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0913
    Cell Significance Index: -1.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0933
    Cell Significance Index: -2.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0938
    Cell Significance Index: -12.1200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0941
    Cell Significance Index: -0.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1021
    Cell Significance Index: -6.2600
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.1038
    Cell Significance Index: -0.6500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1048
    Cell Significance Index: -0.6500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1219
    Cell Significance Index: -0.9700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1303
    Cell Significance Index: -1.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1434
    Cell Significance Index: -3.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1460
    Cell Significance Index: -11.2000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1470
    Cell Significance Index: -0.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1499
    Cell Significance Index: -10.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1585
    Cell Significance Index: -7.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1646
    Cell Significance Index: -12.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1681
    Cell Significance Index: -1.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1774
    Cell Significance Index: -1.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1795
    Cell Significance Index: -11.5800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1830
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1880
    Cell Significance Index: -3.9000
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1945
    Cell Significance Index: -2.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription factor**: HOXB7 is a transcription factor that regulates gene expression by binding to specific DNA sequences. 2. **Developmental role**: HOXB7 is essential for embryonic development, particularly in the formation of the anterior/posterior pattern and embryonic organ development. 3. **Cell type specificity**: HOXB7 is highly expressed in various cell types, including glandular epithelial cells, germ cells, and stem cells. 4. **Tissue-specific expression**: HOXB7 is also expressed in specific tissues, such as the kidney collecting duct and nephron tubule epithelial cells. **Pathways and Functions:** 1. **Anterior/posterior pattern specification**: HOXB7 plays a critical role in the establishment of the anterior/posterior axis during embryonic development. 2. **Embryonic organ development**: HOXB7 is involved in the morphogenesis of various embryonic organs, including the skeletal system. 3. **Myeloid cell differentiation**: HOXB7 regulates the differentiation of myeloid cells, which are essential for the immune system. 4. **Chromatin regulation**: HOXB7 interacts with chromatin to regulate gene expression and maintain tissue homeostasis. **Functions:** 1. **Transcriptional activation**: HOXB7 acts as a transcriptional activator, promoting the expression of target genes. 2. **DNA binding**: HOXB7 binds to specific DNA sequences, regulating gene expression and chromatin structure. 3. **Protein binding**: HOXB7 interacts with other proteins to modulate its activity and target gene expression. **Clinical Significance:** 1. **Cancer association**: HOXB7 is overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Immunological disorders**: HOXB7 is involved in the regulation of myeloid cell differentiation, which is critical for immune function. 3. **Developmental disorders**: Abnormal expression of HOXB7 has been linked to developmental disorders, such as congenital heart defects and skeletal abnormalities. 4. **Therapeutic potential**: HOXB7 is a potential target for cancer therapy and immunomodulation, highlighting its importance in disease prevention and treatment. In conclusion, the HOXB7 gene is a vital transcription factor involved in various developmental and cellular processes. Its dysregulation has significant implications for human disease, making it an attractive target for therapeutic intervention. Further research is needed to fully elucidate the mechanisms of HOXB7 and its role in human health and disease.

Genular Protein ID: 2511116133

Symbol: HXB7_HUMAN

Name: Homeobox protein Hox-B7

UniProtKB Accession Codes:

P09629 A8K3N8 Q15957 Q53FN3 Q96BQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2885844

Title: Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.

PubMed ID: 2885844

DOI: 10.1073/pnas.84.14.4914

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1678287

Title: Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain.

PubMed ID: 1678287

PubMed ID: 2573064

Title: Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.

PubMed ID: 2573064

DOI: 10.1073/pnas.86.21.8536

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 7791786

Title: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

PubMed ID: 7791786

DOI: 10.1128/mcb.15.7.3786

PubMed ID: 9191052

Title: The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements.

PubMed ID: 9191052

DOI: 10.1038/sj.onc.1201097

Sequence Information:

  • Length: 217
  • Mass: 24015
  • Checksum: E92D63F437D34628
  • Sequence:
    • MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS FAASMQGLYP 
GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDSAKAAGA KEQRDSDLAA 
ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ 
IKIWFQNRRM KWKKENKTAG PGTTGQDRAE AEEEEEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.