Details for: HOXB7

Gene ID: 3217

Symbol: HOXB7

Ensembl ID: ENSG00000260027

Description: homeobox B7

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic organ development
    (GO:0048568)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Myeloid cell differentiation
    (GO:0030099)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.63
    Marker Score: 6473
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.64
    Marker Score: 2863
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.53
    Marker Score: 2257
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.5
    Marker Score: 4717
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.45
    Marker Score: 3663
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.45
    Marker Score: 1529
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.4
    Marker Score: 328
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.37
    Marker Score: 47300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.36
    Marker Score: 3235
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.34
    Marker Score: 6450
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.32
    Marker Score: 880
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.28
    Marker Score: 2667
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.2
    Marker Score: 1991
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.17
    Marker Score: 1169
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.15
    Marker Score: 226
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.14
    Marker Score: 2279
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.08
    Marker Score: 312
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.08
    Marker Score: 866.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.05
    Marker Score: 1010
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.05
    Marker Score: 987
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 663
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.01
    Marker Score: 379
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1
    Marker Score: 2678
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.92
    Marker Score: 1423
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.92
    Marker Score: 1326
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.91
    Marker Score: 1295
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.89
    Marker Score: 460
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.88
    Marker Score: 938
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 276
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.84
    Marker Score: 730
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.83
    Marker Score: 837
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3029
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.71
    Marker Score: 166
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.67
    Marker Score: 441.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.67
    Marker Score: 1135
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1352
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1202
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.63
    Marker Score: 2239
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.63
    Marker Score: 1481
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 772
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.61
    Marker Score: 123
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.61
    Marker Score: 155
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.61
    Marker Score: 324
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 397
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.58
    Marker Score: 1407
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.57
    Marker Score: 264
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.57
    Marker Score: 138
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1245.5
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.5
    Marker Score: 116
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.49
    Marker Score: 6458.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 287
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.48
    Marker Score: 107
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.47
    Marker Score: 125
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.46
    Marker Score: 732
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7152
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.46
    Marker Score: 3037
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.44
    Marker Score: 154
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.44
    Marker Score: 109
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 138
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.42
    Marker Score: 308
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.41
    Marker Score: 228
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.41
    Marker Score: 443
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.41
    Marker Score: 558
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4
    Marker Score: 107
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.4
    Marker Score: 305
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 380
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.38
    Marker Score: 104
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.38
    Marker Score: 107
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.38
    Marker Score: 108
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.37
    Marker Score: 84
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.37
    Marker Score: 110
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.37
    Marker Score: 168
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.35
    Marker Score: 146
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.35
    Marker Score: 218
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.34
    Marker Score: 330
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 160
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.33
    Marker Score: 194
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.33
    Marker Score: 236
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.33
    Marker Score: 91
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 288

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Other Information

**Key characteristics:** * HOXB7 is a transmembrane protein with a conserved homeobox DNA-binding domain. * It is expressed in a variety of cell types, including epithelial cells, germ cells, and stem cells. * It is involved in the specification of anterior/posterior patterns during embryonic development. * It is also involved in the regulation of transcription by RNA polymerase II. **Pathways and functions:** * HOXB7 is a key regulator of anterior/posterior pattern specification in the developing embryo. * It is required for the formation of the heart, kidneys, and other tissues in the posterior region of the embryo. * It also plays a role in the development of the gut and other organs in the abdomen. * HOXB7 is also involved in the regulation of transcription by RNA polymerase II. * It binds to specific DNA sequences and recruits RNA polymerase II to regulate the expression of target genes. **Clinical significance:** HOXB7 is a potential therapeutic target for a variety of diseases. For example, mutations in the HOXB7 gene have been linked to several human cancers, including breast cancer and kidney cancer. Targeting HOXB7 with antibodies or small molecules could provide a new treatment for these diseases. **Additional information:** * HOXB7 is a member of the homeobox family of transcription factors. * It is expressed in high levels in early-stage embryos and gradually declines during development. * It is a highly conserved protein, with a similar gene found in other vertebrates.

Genular Protein ID: 2511116133

Symbol: HXB7_HUMAN

Name: Homeobox protein Hox-B7

UniProtKB Accession Codes:

P09629 A8K3N8 Q15957 Q53FN3 Q96BQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2885844

Title: Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.

PubMed ID: 2885844

DOI: 10.1073/pnas.84.14.4914

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1678287

Title: Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain.

PubMed ID: 1678287

PubMed ID: 2573064

Title: Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.

PubMed ID: 2573064

DOI: 10.1073/pnas.86.21.8536

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 7791786

Title: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

PubMed ID: 7791786

DOI: 10.1128/mcb.15.7.3786

PubMed ID: 9191052

Title: The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements.

PubMed ID: 9191052

DOI: 10.1038/sj.onc.1201097

Sequence Information:

  • Length: 217
  • Mass: 24015
  • Checksum: E92D63F437D34628
  • Sequence:
    • MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS FAASMQGLYP 
GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDSAKAAGA KEQRDSDLAA 
ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ 
IKIWFQNRRM KWKKENKTAG PGTTGQDRAE AEEEEEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.