Details for: PRMT1

Gene ID: 3276

Symbol: PRMT1

Ensembl ID: ENSG00000126457

Description: protein arginine methyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.74
    Marker Score: 2863.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.7
    Marker Score: 17552
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.68
    Marker Score: 13170.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.65
    Marker Score: 90005
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.64
    Marker Score: 6454
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.61
    Marker Score: 34387
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.57
    Marker Score: 5362
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.52
    Marker Score: 6410
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.4
    Marker Score: 9834
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.35
    Marker Score: 81465
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.32
    Marker Score: 3938
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.31
    Marker Score: 6296
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.28
    Marker Score: 811
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.27
    Marker Score: 2415
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.27
    Marker Score: 1516
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.27
    Marker Score: 1426
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.24
    Marker Score: 9644
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.22
    Marker Score: 2490
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.21
    Marker Score: 4423
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.21
    Marker Score: 815
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.2
    Marker Score: 1254
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.15
    Marker Score: 3534
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.15
    Marker Score: 24207
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.15
    Marker Score: 2294
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.13
    Marker Score: 2575
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.11
    Marker Score: 21278
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.09
    Marker Score: 624
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.08
    Marker Score: 4401
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.08
    Marker Score: 7705
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.08
    Marker Score: 1956
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.08
    Marker Score: 2943
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.06
    Marker Score: 2073
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.05
    Marker Score: 4161
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.04
    Marker Score: 2157.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.04
    Marker Score: 1923
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.03
    Marker Score: 2191
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2
    Marker Score: 1885
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.99
    Marker Score: 7823
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.97
    Marker Score: 7598
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.96
    Marker Score: 1164.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.95
    Marker Score: 1539
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.95
    Marker Score: 4596
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.95
    Marker Score: 11573
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.93
    Marker Score: 2842
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.91
    Marker Score: 797
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.91
    Marker Score: 2463
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.9
    Marker Score: 896
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.9
    Marker Score: 1631
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.89
    Marker Score: 2036
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.88
    Marker Score: 19093
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.86
    Marker Score: 1025
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.84
    Marker Score: 619
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.84
    Marker Score: 3456
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.83
    Marker Score: 693
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.83
    Marker Score: 942
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.83
    Marker Score: 2432
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.82
    Marker Score: 5197.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.81
    Marker Score: 3207
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.8
    Marker Score: 1307
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.8
    Marker Score: 881
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.8
    Marker Score: 1612
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.8
    Marker Score: 427
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.79
    Marker Score: 3119
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.77
    Marker Score: 930
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.75
    Marker Score: 2700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.75
    Marker Score: 561
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.74
    Marker Score: 409
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.74
    Marker Score: 559
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.74
    Marker Score: 2767
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.74
    Marker Score: 2038
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.73
    Marker Score: 2507
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.73
    Marker Score: 819
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.73
    Marker Score: 2920.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.72
    Marker Score: 583
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.71
    Marker Score: 485
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.71
    Marker Score: 425
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.7
    Marker Score: 561
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.69
    Marker Score: 425
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.69
    Marker Score: 1275
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.69
    Marker Score: 12552
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.68
    Marker Score: 654
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.67
    Marker Score: 3977
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.66
    Marker Score: 1419
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.66
    Marker Score: 884
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.66
    Marker Score: 1936
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.66
    Marker Score: 2381
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.64
    Marker Score: 4876
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.64
    Marker Score: 574
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.64
    Marker Score: 19048
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.63
    Marker Score: 1169
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.63
    Marker Score: 1739
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.63
    Marker Score: 1230
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.63
    Marker Score: 21840
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.62
    Marker Score: 604
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.62
    Marker Score: 1180
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.61
    Marker Score: 2677
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.61
    Marker Score: 1455
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.61
    Marker Score: 2019.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.61
    Marker Score: 970
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.61
    Marker Score: 10264

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Other Information

**Key characteristics:** - PRMT1 is a serine-threonine protein with a molecular weight of approximately 120 kDa. - It is highly expressed in germ cells and early-stage embryos. - It is expressed in various cell types throughout the body, including embryonic stem cells, hematopoietic cells, and cancer cells. **Pathways and functions:** - PRMT1 is a key regulator of the expression of genes involved in embryonic development, including those involved in hematopoiesis, differentiation, and tissue specification. - It is involved in the regulation of cell cycle progression and apoptosis. - It is also involved in the regulation of inflammation and tissue remodeling. **Clinical significance:** - Mutations in PRMT1 have been linked to several human diseases, including cancer, cardiovascular disease, and developmental disorders. - PRMT1 inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional information:** - PRMT1 is a member of the PRMT family of protein arginine methyltransferases. - It is regulated by various transcription factors, including Runt-like transcription factor 1 (Runt1). - It is also regulated by the steroid hormone estrogen.

Genular Protein ID: 2253502033

Symbol: ANM1_HUMAN

Name: Histone-arginine N-methyltransferase PRMT1

UniProtKB Accession Codes:

Q99873 A0A087X1W2 B4E3C3 G5E9B6 H7C2I1 Q15529 Q2VP93 Q6LEU5 Q8WUW5 Q99872 Q99874 Q9NZ04 Q9NZ05 Q9NZ06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 15 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 Rhea 12 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9545638

Title: Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).

PubMed ID: 9545638

DOI: 10.1006/geno.1997.5190

PubMed ID: 8675017

Title: Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant.

PubMed ID: 8675017

DOI: 10.1016/0378-1119(96)00073-x

PubMed ID: 11097842

Title: Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene.

PubMed ID: 11097842

DOI: 10.1006/bbrc.2000.3807

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10749851

Title: Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3.

PubMed ID: 10749851

DOI: 10.1074/jbc.m000023200

PubMed ID: 11101900

Title: The structure and oligomerization of the yeast arginine methyltransferase, Hmt1.

PubMed ID: 11101900

DOI: 10.1038/82028

PubMed ID: 11448779

Title: Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1.

PubMed ID: 11448779

DOI: 10.1016/s0960-9822(01)00294-9

PubMed ID: 11387442

Title: Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor.

PubMed ID: 11387442

DOI: 10.1126/science.1060781

PubMed ID: 12718890

Title: Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

PubMed ID: 12718890

DOI: 10.1016/s1097-2765(03)00101-1

PubMed ID: 15084609

Title: Arginine methylation of RNA helicase a determines its subcellular localization.

PubMed ID: 15084609

DOI: 10.1074/jbc.c300512200

PubMed ID: 16879614

Title: Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation.

PubMed ID: 16879614

DOI: 10.1111/j.1742-4658.2006.05399.x

PubMed ID: 18657504

Title: Regulation of estrogen rapid signaling through arginine methylation by PRMT1.

PubMed ID: 18657504

DOI: 10.1016/j.molcel.2008.05.025

PubMed ID: 18951090

Title: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

PubMed ID: 18951090

DOI: 10.1016/j.molcel.2008.09.013

PubMed ID: 18773938

Title: PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells.

PubMed ID: 18773938

DOI: 10.1016/j.neulet.2008.08.065

PubMed ID: 18320585

Title: Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.

PubMed ID: 18320585

DOI: 10.1002/prot.22004

PubMed ID: 19124016

Title: PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function.

PubMed ID: 19124016

DOI: 10.1016/j.yexcr.2008.12.008

PubMed ID: 19136629

Title: PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.

PubMed ID: 19136629

DOI: 10.1101/gad.489409

PubMed ID: 21724836

Title: Retraction. PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.

PubMed ID: 21724836

PubMed ID: 20442406

Title: Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.

PubMed ID: 20442406

DOI: 10.1074/jbc.m109.092411

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22095282

Title: Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.

PubMed ID: 22095282

DOI: 10.1038/cdd.2011.168

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25284789

Title: 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.

PubMed ID: 25284789

DOI: 10.1016/j.celrep.2014.08.071

PubMed ID: 26575292

Title: Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

PubMed ID: 26575292

DOI: 10.7554/elife.07938

PubMed ID: 25748791

Title: PRMT1-mediated arginine methylation controls ATXN2L localization.

PubMed ID: 25748791

DOI: 10.1016/j.yexcr.2015.02.022

PubMed ID: 26876602

Title: Novel helical assembly in arginine methyltransferase 8.

PubMed ID: 26876602

DOI: 10.1016/j.jmb.2016.02.007

PubMed ID: 29186683

Title: TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

PubMed ID: 29186683

DOI: 10.1016/j.celrep.2017.11.007

PubMed ID: 28040436

Title: FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.

PubMed ID: 28040436

DOI: 10.1016/j.biocel.2016.12.013

PubMed ID: 30765518

Title: Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.

PubMed ID: 30765518

DOI: 10.1073/pnas.1814385116

Sequence Information:

  • Length: 371
  • Mass: 42462
  • Checksum: 544349801B0E1396
  • Sequence:
    • MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF 
GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS 
SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA 
RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV 
DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG 
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC 
ELSCSTDYRM R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.