PRMT1 | ENSG00000126457 | NCBI 3276

Details for: PRMT1

Gene ID: 3276

Symbol: PRMT1

Ensembl ID: ENSG00000126457

Description: protein arginine methyltransferase 1

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Late sars-cov-2 infection events
(R-HSA-9772573)
Maturation of nucleoprotein
(R-HSA-9694631)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translation of structural proteins
(R-HSA-9694635)
Viral infection pathways
(R-HSA-9824446)
Cardiac muscle tissue development
(GO:0048738)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to methionine
(GO:0061431)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Enzyme binding
(GO:0019899)
Gator1 complex binding
(GO:0106080)
Histone h4r3 methyltransferase activity
(GO:0044020)
Histone methyltransferase activity
(GO:0042054)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Lysosomal membrane
(GO:0005765)
Methyl-cpg binding
(GO:0008327)
Methylosome
(GO:0034709)
Methyltransferase activity
(GO:0008168)
Mitogen-activated protein kinase p38 binding
(GO:0048273)
N-methyltransferase activity
(GO:0008170)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of megakaryocyte differentiation
(GO:0045653)
Neuron projection development
(GO:0031175)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-arginine methylation
(GO:0018216)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of hemoglobin biosynthetic process
(GO:0046985)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of torc1 signaling
(GO:1904263)
Positive regulation of translation
(GO:0045727)
Protein-arginine n-methyltransferase activity
(GO:0016274)
Protein-arginine omega-n asymmetric methyltransferase activity
(GO:0035242)
Protein-arginine omega-n monomethyltransferase activity
(GO:0035241)
Protein binding
(GO:0005515)
Protein homooligomerization
(GO:0051260)
Protein methylation
(GO:0006479)
Protein methyltransferase activity
(GO:0008276)
Regulation of bmp signaling pathway
(GO:0030510)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of megakaryocyte differentiation
(GO:0045652)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
S-adenosyl-l-methionine binding
(GO:1904047)
Viral protein processing
(GO:0019082)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 354.9450
Cell Significance Index: -55.2100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 173.0382
Cell Significance Index: -43.8900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 150.4075
Cell Significance Index: -61.9600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 130.4746
Cell Significance Index: -61.6000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 124.8963
Cell Significance Index: -50.7400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 117.3051
Cell Significance Index: -60.3400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 92.1430
Cell Significance Index: -61.8300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 54.1612
Cell Significance Index: -51.7100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 48.5419
Cell Significance Index: -59.8500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.3988
Cell Significance Index: -43.9300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.6688
Cell Significance Index: -61.8300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.1669
Cell Significance Index: -37.3700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.9960
Cell Significance Index: -17.5000
Cell Name: kidney cell (CL1000497)
Fold Change: 6.9712
Cell Significance Index: 55.6600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 4.3288
Cell Significance Index: 47.0600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.0560
Cell Significance Index: 280.5000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 4.0452
Cell Significance Index: 51.8100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.4015
Cell Significance Index: 118.2000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.0012
Cell Significance Index: 62.8200
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.8093
Cell Significance Index: 73.8700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.6254
Cell Significance Index: 75.2600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.3817
Cell Significance Index: 327.0800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.3710
Cell Significance Index: 142.3400
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.3184
Cell Significance Index: 17.8700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.2077
Cell Significance Index: 25.0800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.2006
Cell Significance Index: 115.5400
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.0714
Cell Significance Index: 1131.2300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.9506
Cell Significance Index: 34.4700
Cell Name: lactocyte (CL0002325)
Fold Change: 1.8630
Cell Significance Index: 240.6800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.7866
Cell Significance Index: 83.9700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.7690
Cell Significance Index: 114.1300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.7499
Cell Significance Index: 47.6300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.7488
Cell Significance Index: 23.8600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.7178
Cell Significance Index: 108.2700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.7111
Cell Significance Index: 121.0200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.5848
Cell Significance Index: 194.8600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.5679
Cell Significance Index: 282.6400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.5672
Cell Significance Index: 116.8000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.5413
Cell Significance Index: 681.4300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.3419
Cell Significance Index: 69.9000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.3410
Cell Significance Index: 158.1500
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.1492
Cell Significance Index: 7.1100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1235
Cell Significance Index: 58.3600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9849
Cell Significance Index: 160.1900
Cell Name: peg cell (CL4033014)
Fold Change: 0.9522
Cell Significance Index: 22.0000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9210
Cell Significance Index: 27.0500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8526
Cell Significance Index: 39.7500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.7678
Cell Significance Index: 98.4300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7003
Cell Significance Index: 18.7000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6202
Cell Significance Index: 123.0900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3355
Cell Significance Index: 9.6700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3064
Cell Significance Index: 61.4700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2503
Cell Significance Index: 47.6400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1850
Cell Significance Index: 5.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1726
Cell Significance Index: 61.9200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1097
Cell Significance Index: 1.0100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0459
Cell Significance Index: 34.7800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0413
Cell Significance Index: 4.0900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0108
Cell Significance Index: 0.1800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0107
Cell Significance Index: 0.2800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0010
Cell Significance Index: 0.7300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0092
Cell Significance Index: -17.2400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0182
Cell Significance Index: -0.1100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0202
Cell Significance Index: -1.2400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0302
Cell Significance Index: -55.6700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0329
Cell Significance Index: -0.8400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0343
Cell Significance Index: -1.2100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0375
Cell Significance Index: -57.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0531
Cell Significance Index: -72.1400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0601
Cell Significance Index: -6.1400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0628
Cell Significance Index: -39.9000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0628
Cell Significance Index: -46.4900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1006
Cell Significance Index: -56.7300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1093
Cell Significance Index: -49.5900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1096
Cell Significance Index: -68.4400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1261
Cell Significance Index: -21.5300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1348
Cell Significance Index: -2.3100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1646
Cell Significance Index: -47.3700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1733
Cell Significance Index: -5.5500
Cell Name: perivascular cell (CL4033054)
Fold Change: -0.2772
Cell Significance Index: -1.2800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2775
Cell Significance Index: -32.3400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3226
Cell Significance Index: -46.9000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3337
Cell Significance Index: -70.2800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3638
Cell Significance Index: -41.6800
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.3729
Cell Significance Index: -5.2300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3804
Cell Significance Index: -4.5400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3953
Cell Significance Index: -22.1800
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.5463
Cell Significance Index: -3.4200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5471
Cell Significance Index: -43.3300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5592
Cell Significance Index: -42.9100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5772
Cell Significance Index: -60.1000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6792
Cell Significance Index: -18.2000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6813
Cell Significance Index: -14.5100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7000
Cell Significance Index: -47.0700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.7459
Cell Significance Index: -33.8100
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.7605
Cell Significance Index: -4.6800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.7870
Cell Significance Index: -23.1800
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.8623
Cell Significance Index: -5.6100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8659
Cell Significance Index: -53.0900
Cell Name: theca cell (CL0000503)
Fold Change: -1.0077
Cell Significance Index: -5.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PRMT1 is a type II protein arginine methyltransferase enzyme that catalyzes the transfer of methyl groups to arginine residues in proteins. This post-translational modification plays a significant role in regulating protein function, stability, and interactions. PRMT1 is highly expressed in various tissues, including the heart, liver, and immune cells, and is involved in the regulation of numerous signaling pathways. **Pathways and Functions** PRMT1 is involved in various cellular processes, including: 1. **Chromatin remodeling**: PRMT1 regulates the structure and function of chromatin by methylating histones, which in turn affects gene expression and transcription. 2. **Protein modification**: PRMT1 modifies proteins by adding methyl groups to arginine residues, which can alter protein function, stability, and interactions. 3. **Cell signaling**: PRMT1 regulates signaling pathways, including estrogen-dependent gene expression, ER-mediated signaling, and the BMP signaling pathway. 4. **Immune cell development**: PRMT1 plays a crucial role in the development and function of immune cells, including T cells, B cells, and natural killer cells. 5. **Cancer development**: PRMT1 has been implicated in the development and progression of various cancers, including breast, lung, and prostate cancer. **Clinical Significance** PRMT1 has been implicated in various diseases, including: 1. **Cancer**: PRMT1 overexpression has been linked to poor prognosis and increased cancer progression in several types of cancer. 2. **Autoimmune diseases**: PRMT1 has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders**: PRMT1 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease**: PRMT1 has been implicated in the development of cardiovascular disease, including atherosclerosis and hypertension. 5. **Infectious diseases**: PRMT1 has been linked to the regulation of viral infections, including SARS-CoV-2 and HIV. In conclusion, PRMT1 is a multifunctional gene that plays a crucial role in various cellular processes, including protein modification, chromatin remodeling, and cell signaling. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, neurological disorders, cardiovascular disease, and infectious diseases. Further research is needed to fully understand the mechanisms of PRMT1 and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone-arginine N-methyltransferase PRMT1

Genular Protein ID: 2253502033

Symbol: ANM1_HUMAN

Name: Histone-arginine N-methyltransferase PRMT1

UniProtKB Accession Codes:

Q99873 A0A087X1W2 B4E3C3 G5E9B6 H7C2I1 Q15529 Q2VP93 Q6LEU5 Q8WUW5 Q99872 Q99874 Q9NZ04 Q9NZ05 Q9NZ06

Database IDs:

Citations:

PubMed ID: 9545638

Title: Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).

PubMed ID: 9545638

DOI: 10.1006/geno.1997.5190

PubMed ID: 8675017

Title: Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant.

PubMed ID: 8675017

DOI: 10.1016/0378-1119(96)00073-x

PubMed ID: 11097842

Title: Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene.

PubMed ID: 11097842

DOI: 10.1006/bbrc.2000.3807

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10749851

Title: Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3.

PubMed ID: 10749851

DOI: 10.1074/jbc.m000023200

PubMed ID: 11101900

Title: The structure and oligomerization of the yeast arginine methyltransferase, Hmt1.

PubMed ID: 11101900

DOI: 10.1038/82028

PubMed ID: 11448779

Title: Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1.

PubMed ID: 11448779

DOI: 10.1016/s0960-9822(01)00294-9

PubMed ID: 11387442

Title: Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor.

PubMed ID: 11387442

DOI: 10.1126/science.1060781

PubMed ID: 12718890

Title: Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

PubMed ID: 12718890

DOI: 10.1016/s1097-2765(03)00101-1

PubMed ID: 15084609

Title: Arginine methylation of RNA helicase a determines its subcellular localization.

PubMed ID: 15084609

DOI: 10.1074/jbc.c300512200

PubMed ID: 16294045

Title: The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity.

PubMed ID: 16294045

DOI: 10.4161/cc.4.12.2250

PubMed ID: 15741314

Title: Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.

PubMed ID: 15741314

DOI: 10.1101/gad.1279805

PubMed ID: 16879614

Title: Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation.

PubMed ID: 16879614

DOI: 10.1111/j.1742-4658.2006.05399.x

PubMed ID: 18657504

Title: Regulation of estrogen rapid signaling through arginine methylation by PRMT1.

PubMed ID: 18657504

DOI: 10.1016/j.molcel.2008.05.025

PubMed ID: 18951090

Title: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

PubMed ID: 18951090

DOI: 10.1016/j.molcel.2008.09.013

PubMed ID: 18773938

Title: PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells.

PubMed ID: 18773938

DOI: 10.1016/j.neulet.2008.08.065

PubMed ID: 18320585

Title: Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.

PubMed ID: 18320585

DOI: 10.1002/prot.22004

PubMed ID: 19124016

Title: PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function.

PubMed ID: 19124016

DOI: 10.1016/j.yexcr.2008.12.008

PubMed ID: 19136629

Title: PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.

PubMed ID: 19136629

DOI: 10.1101/gad.489409

PubMed ID: 21724836

Title: Retraction. PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.

PubMed ID: 21724836

PubMed ID: 20442406

Title: Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.

PubMed ID: 20442406

DOI: 10.1074/jbc.m109.092411

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22095282

Title: Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.

PubMed ID: 22095282

DOI: 10.1038/cdd.2011.168

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25284789

Title: 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.

PubMed ID: 25284789

DOI: 10.1016/j.celrep.2014.08.071

PubMed ID: 26575292

Title: Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

PubMed ID: 26575292

DOI: 10.7554/elife.07938

PubMed ID: 25748791

Title: PRMT1-mediated arginine methylation controls ATXN2L localization.

PubMed ID: 25748791

DOI: 10.1016/j.yexcr.2015.02.022

PubMed ID: 26876602

Title: Novel helical assembly in arginine methyltransferase 8.

PubMed ID: 26876602

DOI: 10.1016/j.jmb.2016.02.007

PubMed ID: 27642082

Title: PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.

PubMed ID: 27642082

DOI: 10.1038/ncomms12897

PubMed ID: 29186683

Title: TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

PubMed ID: 29186683

DOI: 10.1016/j.celrep.2017.11.007

PubMed ID: 28040436

Title: FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.

PubMed ID: 28040436

DOI: 10.1016/j.biocel.2016.12.013

PubMed ID: 29651020

Title: GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

PubMed ID: 29651020

DOI: 10.1038/s41467-018-03817-5

PubMed ID: 30765518

Title: Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.

PubMed ID: 30765518

DOI: 10.1073/pnas.1814385116

PubMed ID: 38006878

Title: PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.

PubMed ID: 38006878

DOI: 10.1016/j.cmet.2023.11.001

PubMed ID: 31257072

Title: Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.

PubMed ID: 31257072

DOI: 10.1016/j.ccell.2019.05.014

Sequence Information:

Length: 371
Mass: 42462
Checksum: 544349801B0E1396
Sequence:

MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF 
GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS 
SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA 
RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV 
DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG 
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC 
ELSCSTDYRM R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRMT1

Associated with

Cells (max top 100)

Other Information

Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). PubMed ID: 9545638

Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant. PubMed ID: 8675017

Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene. PubMed ID: 11097842

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. PubMed ID: 10749851

The structure and oligomerization of the yeast arginine methyltransferase, Hmt1. PubMed ID: 11101900

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. PubMed ID: 11448779

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. PubMed ID: 11387442

Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties. PubMed ID: 12718890

Arginine methylation of RNA helicase a determines its subcellular localization. PubMed ID: 15084609

The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. PubMed ID: 16294045

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. PubMed ID: 15741314

Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation. PubMed ID: 16879614

Regulation of estrogen rapid signaling through arginine methylation by PRMT1. PubMed ID: 18657504

Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. PubMed ID: 18951090

PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. PubMed ID: 18773938

Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state. PubMed ID: 18320585

PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. PubMed ID: 19124016

PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling. PubMed ID: 19136629

Retraction. PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling. PubMed ID: 21724836

Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. PubMed ID: 20442406

Initial characterization of the human central proteome. PubMed ID: 21269460

Arginine methylation-dependent regulation of ASK1 signaling by PRMT1. PubMed ID: 22095282

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. PubMed ID: 25284789

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. PubMed ID: 26575292

PRMT1-mediated arginine methylation controls ATXN2L localization. PubMed ID: 25748791

Novel helical assembly in arginine methyltransferase 8. PubMed ID: 26876602

PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells. PubMed ID: 27642082

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1. PubMed ID: 29186683

FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. PubMed ID: 28040436

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. PubMed ID: 29651020

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation. PubMed ID: 30765518

PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2. PubMed ID: 38006878

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. PubMed ID: 31257072